Review
Clinical Neurology
Leanne M. Holt, Eric J. Nestler
Summary: Addiction is a major global disease burden and a challenge in neuroscience research. This review focuses on the transcriptional and epigenetic mechanisms of drug action in astrocytes, highlighting their role in regulating drug-seeking behaviors and their robust transcriptional response to substances of abuse.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Review
Biochemistry & Molecular Biology
Michael T. McCoy, Subramaniam Jayanthi, Jean Lud Cadet
Summary: The potential of using potassium channel activators in SUD treatment has been discussed, as they have been shown to reduce alcohol intake and augment the behavioral effects of opioid drugs. Studies focusing on the role of potassium channels as targets for therapeutic interventions against SUDs are warranted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Behavioral Sciences
Ernest T. Chivero, Susmita Sil, Mohit Kumar, Shilpa Buch
Summary: Accumulating evidence suggests that substance use, dysregulation of the microbiome, and psychiatric disorders are interconnected. Abused substances can alter immune signaling pathways and cause inflammation, while also affecting the composition and function of the gut microbiome. These interactions may contribute to the development of psychiatric disorders, such as anxiety, depression, and psychosis. Understanding this relationship could lead to potential therapeutic targets to mitigate these adverse outcomes.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Review
Biochemistry & Molecular Biology
Ernest T. Chivero, Raghubendra Singh Dagur, Eric S. Peeples, Susmita Sil, Ke Liao, Rong Ma, Liang Chen, Channabasavaiah B. Gurumurthy, Shilpa Buch, Guoku Hu
Summary: Substance use disorder (SUD) is a growing health problem affecting millions worldwide, with extracellular vesicles (EVs) playing a crucial role in its pathogenesis. EVs have the potential to serve as biomarkers or therapeutic targets in SUD.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Mette Kruse Klausen, Morgane Thomsen, Gitta Wortwein, Anders Fink-Jensen
Summary: Drug, alcohol and tobacco use disorders are a global burden. GLP-1 receptor agonists have potential as anti-addiction treatment. Animal and clinical studies have shown a reduction in alcohol and drug abuse with GLP-1 treatment.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Substance Abuse
Olivia C. Ahearn, Mia N. Watson, Scott M. Rawls
Summary: This review discusses the role of cytokines and chemokines in the rewarding and reinforcing effects of drugs, as well as their potential as therapeutic targets for substance use disorders. Emerging cytokine- and chemokine-based therapeutic strategies show promise for impacting treatment outcomes.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Review
Psychology, Clinical
Mariangela Antonelli, Liana Fattore, Luisa Sestito, Daniela Di Giuda, Marco Diana, Giovanni Addolorato
Summary: Repetitive TMS has shown promising results in patients with alcohol, tobacco, and cocaine use disorder, indicating a potential role in the treatment of SUD.
ADDICTIVE BEHAVIORS
(2021)
Review
Neurosciences
Gigliola Marrero-Cristobal, Ursula Gelpi-Dominguez, Roberto Morales-Silva, John Alvarado-Torres, Joshua Perez-Torres, Yobet Perez-Perez, Marian Sepulveda-Orengo
Summary: Aerobic exercise is being studied as a promising non-pharmacological treatment for SUDs, showing potential in reducing drug relapse. It can be included as part of comprehensive treatment regimens for people with substance abuse disorders.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Francisco Navarrete, Maria S. Garcia-Gutierrez, Ani Gasparyan, Daniela Navarro, Jorge Manzanares
Summary: The discovery of CB2r in brain areas related to reward system and its influence on anxiety and depression behavioral traits in animal studies make CB2r modulation a promising area for drug research in treating addictive disorders.
Review
Behavioral Sciences
Radhouene Doggui, Wafaa Elsawy, Aldo Alberto Conti, Alex Baldacchino
Summary: This study found that there is no significant association between chronic substance abuse and inflammatory levels, except for chronic smokers. There was evidence of publication bias for studies measuring the association between IL-6 and IL-10 with cocaine, and IL-6 with cannabis. More research is needed to inform policymakers and decision-makers about the effectiveness of anti-inflammatory interventions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Medicine, Legal
Lambert K. Sorensen, Jorgen B. Hasselstrom, Line S. Larsen, Dorthe A. Bindslev
Summary: A sensitive and broadly applicable UHPLC-ESI-MS/MS method was developed for the investigation of drugs and metabolites in archaeological and contemporary dental calculus. The method was validated on hydroxyapatite for the analysis of 67 drugs and metabolites, and tested using dental calculus material sampled from 10 corpses undergoing forensic autopsy. Drug residues were found trapped in the interior of the calculus material, with higher drug concentrations in the dental calculus than in the blood for 82 drug detections.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Article
Public, Environmental & Occupational Health
David Kline, Amanda M. Bunting, Staci A. Hepler, Ariadne Rivera-Aguirre, Noa Krawczyk, Magdalena Cerda
Summary: This study examines overdose deaths involving stimulants with and without opioids in the US from 1999 to 2020. The findings show that death rates involving cocaine and opioids sharply increased around 2015, particularly in the Northeast and Mid-Atlantic regions. There were also steady increases in deaths involving psychostimulants without opioids just before 2010, particularly in states in the West and South. Deaths involving psychostimulants with opioids increased around 2015, with the largest increases concentrated in Appalachian states.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Carla Occhipinti, Raffaele La Russa, Naomi Iacoponi, Julia Lazzari, Andrea Costantino, Nicola Di Fazio, Fabio Del Duca, Aniello Maiese, Vittorio Fineschi
Summary: This article provides an overview of the role of miRNAs in substance addiction, evaluating their regulatory role in neuroadaptation and synaptic plasticity. It also explores the potential diagnostic role of miRNAs in various stages of drug and substance addiction, and discusses future prospects for miRNAs as potential novel therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Alessandra Matzeu, Remi Martin-Fardon
Summary: The study found that OrxA administration in the pPVT induced cocaine-seeking behavior after an intermediate abstinence period, but this priming effect was absent after a protracted abstinence period. Furthermore, a higher number of cells expressing Orx was observed in the LH/DMH/PFA during both intermediate and protracted abstinence, while in the pPVT, the number of OrxR2-expressing cells was significantly higher only during intermediate abstinence.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Candan Yasemin Eren-Yazicioglu, Arya Yigit, Ramazan Efe Dogruoz, Hale Yapici-Eser
Summary: GLP-1 plays a crucial role in the reward pathways by modulating dopamine levels and glutamatergic neurotransmission, resulting in observed behavioral changes. It has shown potential efficacy in reducing food cravings, substance abuse, and improving activity deficits related to food anticipation in obese patients with diabetes. More translational research is required to further evaluate its impact on human reward system related disorders.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)