Article
Environmental Sciences
Prabhakar Singh, Sakshi Singh, Priyanka Maurya, Abhishek Mohanta, Hardik Dubey, Sk. Riyazat Khadim, Ankit K. Singh, Adarsh K. Pandey, Arvind K. Singh, Ravi K. Asthana
Summary: Selenium is an essential element for living systems, but becomes toxic at higher concentrations. This study exposed Dunaliella salina cells to different selenium concentrations and found that 50 mg/L selenium had no significant effect on cell growth and selenium accumulation. However, higher selenium levels led to a decrease in photosynthetic efficiency, chlorophyll content, and an increase in reactive oxygen species, proline content, and lipid peroxidation. Superoxide dismutase and catalase played important roles in antioxidative defense. The accumulation of carotenoids varied at different selenium concentrations, and exposure to 200 mg/L selenium resulted in organelle disorganization. Therefore, the selenium-enriched biomass obtained at 50 mg/L could be used for biofortification of food and feed.
MARINE POLLUTION BULLETIN
(2023)
Article
Oncology
Emily A. Garcia, Ilsa Bhatti, Elizabeth S. Henson, Spencer B. Gibson
Summary: This study found that the lysosome-targeted drug, siramesine, induced cell death in prostate cancer cells through lipid peroxidation. In combination with the kinase inhibitor lapatinib, it increased cell death. This provides a new strategy to treat aggressive prostate cancer cells.
Review
Biochemistry & Molecular Biology
Kazutoshi Murotomi, Aya Umeno, Mototada Shichiri, Masaki Tanito, Yasukazu Yoshida
Summary: Reactive oxygen species, particularly singlet oxygen, have significant implications in the development of diseases and aging. Singlet oxygen can be formed through various reactions, both enzymatic and non-enzymatic, and its accumulation can result in oxidative stress and damage to biomolecules. This review explores the mechanisms of singlet oxygen production and methods for evaluating its induced damage. Additionally, it discusses the involvement of singlet oxygen in skin and eye diseases and the potential of singlet oxygen-derived products as biomarkers. Furthermore, recent advancements in singlet oxygen scavengers for disease prevention are described.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Manuel Aureliano, Ana Luisa De Sousa-Coelho, Connor C. Dolan, Deborah A. Roess, Debbie C. Crans
Summary: Lipid peroxidation (LPO), induced by exposure to vanadium salts and compounds, is a process that affects human health. The LPO reaction involves the oxidation of alkene bonds in polyunsaturated fatty acids, resulting in the formation of radical and reactive oxygen species (ROS). Vanadium species have both direct and indirect effects on ROS formation, making the study of LPO arising from increased ROS challenging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Mohd Saleem, Qazi Fariduddin
Summary: Selenium is a beneficial element in plants, but its concentration between toxic and optimal levels is narrow and uneven. High concentrations of selenium cause oxidative stress and toxicity symptoms, affecting photosynthesis and growth, while low concentrations of selenium improve plant growth and photosynthetic traits.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Sampurna Mukherjee, Suresh Babu Krishnamoorthy, Rengaraj Subrayan, Arunava Goswami, Sutanuka Mitra
Summary: Cerium oxide nanoparticles have been studied for their role as an antioxidant in inflammatory and oxidative stress-related diseases. However, their potential as a growth modulator and heavy metal stress reliever in plants and bacteria has been overlooked. This study highlights the ability of cerium oxide nanoparticles to reduce oxidative stress and promote growth in Vigna radiata and Bacillus coagulans in the presence of mercury. It also demonstrates the non-hazardous nature of nanoceria. These findings pave the way for the use of cerium oxide nanoparticles in combating abiotic stress in plants and other organisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Cell Biology
Hiromi Kurokawa, Atsushi Taninaka, Hidemi Shigekawa, Hirofumi Matsui
Summary: Dabigatran is a novel oral anticoagulant that inhibits thrombins, but its use may increase the risk of gastrointestinal bleeding. Research has shown that its main component, dabigatran etexilate, exhibits cytotoxicity that can be inhibited by ascorbic acid. These cytotoxic effects are likely mediated via mitROS production.
Article
Environmental Sciences
Javaid Akhter Bhat, Masroor Ahmad Bhat, Dyaaaldin Abdalmegeed, Deyue Yu, Jian Chen, Andrzej Bajguz, Ajaz Ahmad, Parvaiz Ahmad
Summary: The study demonstrated that the combined application of Fe2O3-NPs and CA had a better alleviating effect on As toxicity in soybean. Fe2O3-NPs and CA significantly reversed As-induced growth inhibition and oxidative stress responses, partially reducing the production of MDA and H2O2.
ENVIRONMENTAL POLLUTION
(2022)
Review
Cell Biology
Jia-Yue Duan, Xiao Lin, Feng Xu, Su-Kang Shan, Bei Guo, Fu-Xing-Zi Li, Yi Wang, Ming-Hui Zheng, Qiu-Shuang Xu, Li-Min Lei, Wen-Lu Ou-Yang, Yun-Yun Wu, Ke-Xin Tang, Ling-Qing Yuan
Summary: Ferroptosis, classified as an iron-dependent form of regulated cell death, has been suggested to play a vital role in the development of various metabolic diseases. However, the specific pathophysiological mechanism and precise therapeutic effect remain unclear. This review summarizes recent advances in understanding ferroptosis and discusses its potential as a therapeutic target in metabolic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Justin Chak Ting Cheung, Guangzheng Deng, Nathalie Wong, Yujuan Dong, Simon Siu Man Ng
Summary: Besides transcription, RNA molecules can be enzymatically modified to affect the biological functions of organisms, known as epitranscriptomics. The most widely studied modifications in epitranscriptomics are on adenosine (A), while modifications on other nucleotides are relatively fewer. It has been found that epitranscriptomic modifications also play a role in the signaling of ferroptosis, although the exact connection is still unclear.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Okhil K. Nag, Jawad Naciri, Kwahun Lee, Eunkeu Oh, Bethany Almeida, James B. Delehanty
Summary: In this study, a liquid crystal nanoparticle (LCNP) conjugate system was developed to enhance the cellular uptake and scavenging activity against reactive oxygen species (ROS) by combining the antioxidant TEMPO with the LCNP. The results showed that the TEMPO-conjugated LCNP effectively reduced ROS activity and lipid peroxidation in live cells, suggesting its potential in protecting cells from oxidative stress.
Review
Plant Sciences
Keliang Zhang, Yin Zhang, Jing Sun, Jiasong Meng, Jun Tao
Summary: Seed viability is crucial for agriculture, affecting seedling emergence and crop yield. Factors such as high temperature and humidity can accelerate seed deterioration, leading to membrane damage, reduced respiratory rates, and oxidative damage by free radicals and reactive oxygen species. Repair processes may occur during early stages, but if critical components are damaged, the seed may fail to germinate.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Immunology
Ting Zhao, Qi Yang, Yujiang Xi, Zhaohu Xie, Jiayan Shen, Zhenmin Li, Zhaofu Li, Dongdong Qin
Summary: This mini review discusses the relationship between ferroptosis and rheumatoid arthritis and evaluates the therapeutic applications of ferroptosis regulators. The article also raises some critical issues worth paying attention to, to guide future research efforts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Agustin Leonardo Lujan, Ombretta Foresti, Conor Sugden, Nathalie Brouwers, Alex Mateo Farre, Alessio Vignoli, Mahshid Azamian, Alicia Turner, Jose Wojnacki, Vivek Malhotra, Suzanne R. Pfeffer
Summary: TANGO2 primarily localizes to mitochondria and partially to mitochondria sites adjacent to lipid droplets and the endoplasmic reticulum. Cells lacking TANGO2 exhibit enlarged lipid droplets, with an increase in lysophosphatidic acid (LPA) and a decrease in its biosynthetic precursor phosphatidic acid (PA) observed through quantitative lipidomics. Our findings suggest that TANGO2 is linked to acyl-CoA metabolism, affecting the acylation of LPA to generate PA, and subsequently impacting the metabolism of fatty acids, generating reactive oxygen species and promoting lipid peroxidation. The enlarged lipid droplets result from the accumulation of peroxidized lipids and a defect in their catabolism. These insights help understand the physiological consequences of TANGO2 mutations and their association with metabolic crises and fatality under starvation and stress conditions.
Article
Biochemistry & Molecular Biology
Tahmina Akter Urmi, Md. Moshiul Islam, Kamrun Naher Zumur, Md. Anwarul Abedin, M. Moynul Haque, Manzer H. Siddiqui, Yoshiyuki Murata, Md. Anamul Hoque
Summary: Salicylic acid (SA) and proline show protective effects against drought stress in rice. The combined application of SA and proline has a more pronounced impact in alleviating the detrimental effects of drought stress, improving plant growth, biomass, and yield, and mitigating oxidative stress.
Article
Materials Science, Paper & Wood
Antti Koistinen, Josphat Phiri, Kavindra Kumar Kesari, Tapani Vuorinen, Thaddeus Maloney
Summary: This study investigates the impact of pulp prehydrolysis conditions on pulp structure, dissolution in a cold NaOH/ZnO solvent, and properties of regenerated cellulose films. The results show that hydrolysis significantly improves the dissolution of pulp and affects the swelling and pore structure of the resulting films. Surprisingly, higher hydrolysis temperature does not lead to increased fiber hornification, and low temperature hydrolysis results in more porous films after drying.
Article
Multidisciplinary Sciences
Sandip Debnath, Devesh Sharma, Somdatta Yashwant Chaudhari, Ritika Sharma, Amir Afzal Shaikh, Rahul Subhash Buchade, Kavindra Kumar Kesari, Abdel-Fattah M. Abdel-Fattah, Mohammad Algahtani, Mayyadah Mheidat, Rawidh Alsaidalani, Tapas Paul, Amany A. A. Sayed, Mohamed M. M. Abdel-Daim
Summary: Alzheimer's disease (AD) is a progressive dementia characterized by cognitive decline and increased inflammation. This study found that patients with AD have higher levels of inflammatory markers and TLR4 activation, leading to neurodegeneration. By using molecular docking and dynamics simulation, 2-Bromoergocryptine Mesylate, an FDA-approved antidiabetic drug, showed strong binding affinity to TLR4 and potential as a lead treatment for AD.
Review
Biology
Menka Kumari, Preeti Swarupa, Kavindra Kumar Kesari, Anil Kumar
Summary: Modern agriculture heavily depends on agrochemicals to increase crop production, but their indiscriminate use poses detrimental effects on plant growth and soil quality. To address these issues, the usage of plant biostimulants has emerged as an environmentally friendly approach to enhance crop productivity.
Editorial Material
Chemistry, Medicinal
Srushti Tambe, Kavindra Kumar Kesari, Yogendra Kumar Mishra, Purnima Amin, Sabya Sachi Das
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Bableen Flora, Rohit Kumar, Preeti Tiwari, Akhilesh Kumar, Janne Ruokolainen, Ashwin Kumar Narasimhan, Kavindra Kumar Kesari, Piyush Kumar Gupta, Anjuvan Singh
Summary: A successful attempt was made to improve the mechanical properties of Hydroxyapatite (HAp) and reduced graphene oxide (rGO) composite nanoparticles (NPs). Different proportions of HAp and rGO were synthesized to enhance the mechanical properties. The HAp NPs were prepared using the wet precipitation method and calcination, while the rGO-HA composites were prepared through ball milling. The strength of the variants significantly increased with the concentration of rGO, while the porosity also increased.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Review
Chemistry, Medicinal
Bhuvi Sachdeva, Punya Sachdeva, Arvind Negi, Shampa Ghosh, Sungsoo Han, Saikat Dewanjee, Saurabh Kumar Jha, Rakesh Bhaskar, Jitendra Kumar Sinha, Ana Claudia Paiva-Santos, Niraj Kumar Jha, Kavindra Kumar Kesari
Summary: Chitin is a biopolymer derived from marine crustaceans and organisms like bacteria, fungi, and algae, which offers biodegradability and biocompatibility properties suitable for biomedical applications. Its deacetylated derivative, chitosan, also possesses similar properties and can be used as a support material in biomedical applications. Additionally, both chitin and chitosan have intrinsic material properties such as antioxidant, antibacterial, and antitumor activities. This paper focuses on the use of chitin and chitosan biopolymers in drug delivery strategies for cancer treatment.
Article
Environmental Sciences
Jaspreet Kaur, Gaurav Mudgal, Arvind Negi, Jeewan Tamang, Shambhawi Singh, Gajendra Bahadur Singh, K. Jagadeesh Chandra Bose, Sandip Debnath, Mohammad Ahmad Wadaan, Muhammad Farooq Khan, Janne Ruokolainen, Kavindra Kumar Kesari
Summary: The commercial processing of biomaterials produces wastewater containing azo dyes and hydrolyzed by-products. Current treatment methods lack selectivity and efficiency. Microbial-assisted methods, such as the use of Agrobacterium strain JAS1, have been identified as a potential solution for degrading azo dyes and their by-products.
Review
Chemistry, Multidisciplinary
Brijendra Kumar Kashyap, Virendra Vikram Singh, Manoj Kumar Solanki, Anil Kumar, Janne Ruokolainen, Kavindra Kumar Kesari
Summary: Cancer, the second leading cause of death worldwide, requires improved targeting strategies to mitigate the toxicities of traditional therapies. Nanomaterials have shown promise in cancer theranostics, offering precise targeting and stability. The development of smart nanomaterials has revolutionized cancer diagnosis and treatment, allowing for encapsulation of multiple molecules and functionalization with various biosubstrates. This review highlights the advantages and challenges of utilizing smart nanomaterials in cancer theranostics and concludes that their use can significantly improve tumor detection and therapy.
Article
Chemistry, Multidisciplinary
Sabya Sachi Das, Priya Ranjan Prasad Verma, Viswanathan Sekarbabu, Satyajit Mohanty, Ashok Kumar Pattnaik, Janne Ruokolainen, Kavindra Kumar Kesari, Sandeep Kumar Singh
Summary: In this study, a liquid chromatography-electrospray ionization tandem mass spectrometry method was developed and validated for quantifying quercetin (QT) in rabbit plasma. The method showed high specificity, sensitivity, and reproducibility. Pharmacokinetic parameters and in vitro-in vivo correlation (IVIVC) of QTNE were analyzed and it was found that QTNE exhibited improved oral bioavailability compared to QTS. The Loo-Riegelman method was determined to be the best fitting model for establishing the IVIVC. Overall, this study suggests that QTNE is a potential carrier for enhancing the oral bioavailability of QT.
Article
Nanoscience & Nanotechnology
Rohit Kumar, Samir Bauri, Soumyamitra Sahu, Shaily Chauhan, Sunny Dholpuria, Janne Ruokolainen, Kavindra Kumar Kesari, Monalisa Mishra, Piyush Kumar Gupta
Summary: Nanocomposites have been synthesized and characterized for potential applications in drug delivery, tissue engineering, and environmental fields. The MnFe2O4@poly(tBGE-alt-PA) composite showed biocompatibility with mouse fibroblast cells and hemocompatibility with 2% RBC suspension. No abnormal neurological disorder or gut organ toxicity were observed in the fruit fly model, indicating its suitability for biomedical and environmental applications.
ACS APPLIED BIO MATERIALS
(2023)
Review
Polymer Science
Arvind Negi, Kavindra Kumar Kesari
Summary: Cellulose and hemicellulose are the main components of lignocellulosic biomass, and chemical derivatization can produce valuable C5 and C6 organic compounds, which are important for the development of sustainable chemical processes. However, the structural properties of cellulose, such as high crystallinity, abundant hydrogen bonding, and low solubility, limit the success of most depolymerization processes. Various chemical treatments, including acidic treatment and photocatalysis, have been developed to overcome these limitations. Photocatalysts, in particular, show great potential for efficient cellulose biomass conversion without the need for high temperatures.
Review
Pharmacology & Pharmacy
Roseleena Minz, Praveen Kumar Sharma, Arvind Negi, Kavindra Kumar Kesari
Summary: Various clinical reports indicate that prolonged exposure to general anesthetic-induced neurotoxicity leads to behavior changes in memory and cognition. However, engineered miRNAs have shown potential in mitigating neurotoxicity and could be used as prophylactics and therapeutics. Challenges and feasibility of using miRNAs as therapeutic agents are discussed, along with updates on the novel neuro-miRNAs related to therapy against neurotoxicity induced by amyloid beta and Parkinson's disease.
Article
Nanoscience & Nanotechnology
Somya Sinha, Rohit Kumar, Jigisha Anand, Rhythm Gupta, Akshima Gupta, Kumud Pant, Sushil Dohare, Preeti Tiwari, Kavindra Kumar Kesari, Saravanan Krishnan, Piyush Kumar Gupta
Summary: Biofouling is a serious concern in various settings and has led to the development of technologies such as toxic biocides and coatings. However, there are limitations due to environmental and health concerns. To overcome this, antifouling coatings using eco-friendly nanomaterials with antimicrobial and antibiofilm properties have been developed. This review provides an overview of these nanotechnology-enabled antifouling agents and their applications in different industries, along with the challenges and prospects.
ACS APPLIED NANO MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Sabya Sachi Das, Devanshi Sharma, Balaga Venkata Krishna Rao, Mandeep Kumar Arora, Janne Ruokolainen, Mukesh Dhanka, Hemant Singh, Kavindra Kumar Kesari
Summary: Injectable hydrogels have the potential to revolutionize therapeutics with their unique physicochemical properties. Compared to conventional therapies, drug-encapsulated injectable hydrogels offer significant advantages such as minimized adverse effects, enhanced therapeutic efficacy, and improved patient compliance. Natural cationic polymers also show promise in drug delivery due to their easy obtainability, high encapsulation efficiency, sustained drug release properties, and biocompatibility.
MATERIALS ADVANCES
(2023)
Review
Materials Science, Multidisciplinary
Chander Prakash, Lovi Raj Gupta, Amrinder Mehta, Hitesh Vasudev, Roman Tominov, Ekaterina Korman, Alexander Fedotov, Vladimir Smirnov, Kavindra Kumar Kesari
Summary: This paper presents a comprehensive survey of the potential of neuromorphic computing to revolutionize various disciplines and the current advancements in using machine learning techniques for developing neuromorphic materials. The amalgamation of neuromorphic technology and material design has the potential to bring about paradigm shifts in material science and engineering, enhance energy efficiency, and improve the efficacy of brain-machine interfaces.
MATERIALS ADVANCES
(2023)
