Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes

PathVisio 3: An Extendable Pathway Analysis Toolbox

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Classification of Hepatotoxicants Using HepG2 Cells: A Proof of Principle Study

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The effects of environmental chemical carcinogens on the microRNA machinery

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To be, or not to be

(2013) Shang-Jui Wang et al.   CURRENT OPINION IN ONCOLOGY

MicroRNA miR-24 enhances tumor invasion and metastasis by targeting PTPN9 and PTPRF to promote EGF signaling

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A Metabolomics Investigation of Non-genotoxic Carcinogenicity in the Rat

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MicroRNA-503 inhibits the G1/S transition by downregulating cyclin D3 and E2F3 in hepatocellular carcinoma

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User-friendly solutions for microarray quality control and pre-processing on ArrayAnalysis.org

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Histone Deacetylases and NF-kB Signaling Coordinate Expression of CX3CL1 in Epithelial Cells in Response to Microbial Challenge by Suppressing miR-424 and miR-503

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Distinguishing between genotoxic and non-genotoxic hepatocarcinogens by gene expression profiling and bioinformatic pathway analysis

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A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo

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Benzo[a]pyrene-Induced Changes in MicroRNA–mRNA Networks

(2012) Daneida Lizarraga et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Transcriptomic fingerprints in human peripheral blood mononuclear cells indicative of genotoxic and non-genotoxic carcinogenic exposure

(2012) K. Hochstenbach et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis

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Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells

(2011) Danyel Jennen et al.   BMC Systems Biology

Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma

(2011) Jin Hou et al.   CANCER CELL

MicroRNA-301 Mediates Proliferation and Invasion in Human Breast Cancer

(2011) W. Shi et al.   CANCER RESEARCH

Glucose Regulates Cyclin D2 Expression in Quiescent and Replicating Pancreatic β-Cells Through Glycolysis and Calcium Channels

(2011) Seth J. Salpeter et al.   ENDOCRINOLOGY

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling

(2011) P. P. Provenzano et al.   JOURNAL OF CELL SCIENCE

Metabolic regulation by p53

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A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins

(2011) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Development and Evaluation of a Genomic Signature for the Prediction and Mechanistic Assessment of Nongenotoxic Hepatocarcinogens in the Rat

(2011) Mark R. Fielden et al.   TOXICOLOGICAL SCIENCES

Tumor suppressor p53 meets microRNAs

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Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea

(2010) Zhiguang Li et al.   BMC GENOMICS

Distinct proliferative and transcriptional effects of the D-type cyclins in vivo

(2010) Lisa K. Mullany et al.   CELL CYCLE

Filamin A mediates interactions between cytoskeletal proteins that control cell adhesion

(2010) Hugh Kim et al.   FEBS LETTERS

miR-29b and miR-125a regulate podoplanin and suppress invasion in glioblastoma

(2010) Maria Angelica Cortez et al.   GENES CHROMOSOMES & CANCER

Gene expression profiling in primary mouse hepatocytes discriminates true from false-positive genotoxic compounds

(2010) K. Mathijs et al.   MUTAGENESIS

Dose-responsiveness and persistence of microRNA expression alterations induced by cigarette smoke in mouse lung

(2010) Alberto Izzotti et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Lack of change in microRNA expression in adult mouse liver following treatment with benzo(a)pyrene despite robust mRNA transcriptional response

(2010) Carole Lyn Yauk et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

miRTarBase: a database curates experimentally validated microRNA–target interactions

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The Tumor Suppressors p53, p63, and p73 Are Regulators of MicroRNA Processing Complex

(2010) Lakshmanane Boominathan   PLoS One

Independent filtering increases detection power for high-throughput experiments

(2010) R. Bourgon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification

(2010) Danyel G. J. Jennen et al.   TOXICOLOGICAL SCIENCES

MicroRNAs: new players in the DNA damage response

(2010) H. Hu et al.   Journal of Molecular Cell Biology

Effects of upregulated expression of microRNA-16 on biological properties of culture-activated hepatic stellate cells

(2009) Can-Jie Guo et al.   APOPTOSIS

Systematic validation of predicted microRNAs for cyclin D1

(2009) Qiong Jiang et al.   BMC CANCER

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response

(2009) Joris Pothof et al.   EMBO JOURNAL

Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation

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miR-221 overexpression contributes to liver tumorigenesis

(2009) P. Pineau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discrimination for Genotoxic and Nongenotoxic Carcinogens by Gene Expression Profiling in Primary Mouse Hepatocytes Improves with Exposure Time

(2009) Karen Mathijs et al.   TOXICOLOGICAL SCIENCES

Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer

(2008) S. J. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Association of MicroRNA Expression in Hepatocellular Carcinomas with Hepatitis Infection, Cirrhosis, and Patient Survival

(2008) J. Jiang et al.   CLINICAL CANCER RESEARCH

RDX Induces Aberrant Expression of MicroRNAs in Mouse Brain and Liver

(2008) Baohong Zhang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

ECVAM retrospective validation of in vitro micronucleus test (MNT)

(2008) R. Corvi et al.   MUTAGENESIS

Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: A follow-up to an ECVAM workshop

(2008) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes

(2008) Q. Liu et al.   NUCLEIC ACIDS RESEARCH

ConsensusPathDB—a database for integrating human functional interaction networks

(2008) Atanas Kamburov et al.   NUCLEIC ACIDS RESEARCH

Interlaboratory Evaluation of Genomic Signatures for Predicting Carcinogenicity in the Rat

(2008) Mark R. Fielden et al.   TOXICOLOGICAL SCIENCES

Can systems toxicology identify common biomarkers of non-genotoxic carcinogenesis?

(2008) Nick Plant   TOXICOLOGY