A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo

Summary of major conclusions from the 5th IWGT, Basel, Switzerland, 17–19 August 2009

(2011) D.J. Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins

(2011) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Environmental and Occupational Causes of Cancer: New Evidence 2005-2007

(2011) Richard W. Clapp et al.   REVIEWS ON ENVIRONMENTAL HEALTH

Guidelines for the welfare and use of animals in cancer research

(2010) P Workman et al.   BRITISH JOURNAL OF CANCER

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Biotransformation pathway maps in WikiPathways enable direct visualization of drug metabolism related expression changes

(2010) Danyel G.J. Jennen et al.   DRUG DISCOVERY TODAY

Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes

(2010) L. Guo et al.   DRUG METABOLISM AND DISPOSITION

Strategies for the follow-up of positive results in the in vitro genotoxicity assays-An international collaborative initiative

(2010) B. Bhaskar Gollapudi et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Hereditary breast and ovarian cancer due to mutations in BRCA1 and BRCA2

(2010) Nancie Petrucelli et al.   GENETICS IN MEDICINE

Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals

(2010) Daniel M. Rotroff et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies

(2010) Andreas Rothfuss et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification

(2010) Danyel G. J. Jennen et al.   TOXICOLOGICAL SCIENCES

Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

(2010) Karen E. Knudsen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The development of RAD51C, Cystatin A, p53 and Nrf2 luciferase-reporter assays in metabolically competent HepG2 cells for the assessment of mechanism-based genotoxicity and of oxidative stress in the early research phase of drug development

(2009) Walter M.A. Westerink et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach

(2009) Lya G. Hernández et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast™ chemicals

(2009) Andrew W. Knight et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Discrimination for Genotoxic and Nongenotoxic Carcinogens by Gene Expression Profiling in Primary Mouse Hepatocytes Improves with Exposure Time

(2009) Karen Mathijs et al.   TOXICOLOGICAL SCIENCES

Genistein Induction of Human Sulfotransferases in HepG2 and Caco-2 Cells

(2008) Yue Chen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites

(2008) Satoko Iwahori et al.   CELLULAR SIGNALLING

Regulation of Hepatocyte Nuclear Factor 4α-mediated Transcription

(2008) Frank J. Gonzalez   Drug Metabolism and Pharmacokinetics

Epigenetic Inhibition of Nuclear Receptor Small Heterodimer Partner Is Associated With and Regulates Hepatocellular Carcinoma Growth

(2008) Nan He et al.   GASTROENTEROLOGY

NuGO contributions to GenePattern

(2008) P. J. De Groot et al.   Genes and Nutrition

An in vivo comet assay of multiple organs (liver, kidney and bone marrow) in mice treated with methyl methanesulfonate and acetaminophen accompanied by hematology and/or blood chemistry

(2008) Keiyu Oshida et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development

(2008) Pallavi B Limaye et al.   LABORATORY INVESTIGATION

Use of four new human-derived liver-cell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assay

(2008) Heike K. Winter et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The carcinoGENOMICS project: Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays

(2008) M VINKEN et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Inherited Susceptibility to Common Cancers

(2008) William D. Foulkes   NEW ENGLAND JOURNAL OF MEDICINE