The antiviral lectin cyanovirin-N: probing multivalency and glycan recognition through experimental and computational approaches

Different 3D domain-swapped oligomeric cyanovirin-N structures suggest trapped folding intermediates

(2013) L. M. I. Koharudin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carbohydrate Recognition by the Antiviral Lectin Cyanovirin-N

(2012) Yukiji K. Fujimoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The binding affinities of proteins interacting with the PDZ domain of PICK1

(2012) Ashini Bolia et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Rational and Computational Design of Stabilized Variants of Cyanovirin-N That Retain Affinity and Specificity for Glycan Ligands

(2011) Vadim Patsalo et al.   BIOCHEMISTRY

Solution Structure of the Monovalent Lectin Microvirin in Complex with Manα(1–2)Man Provides a Basis for Anti-HIV Activity with Low Toxicity

(2011) Syed Shahzad-ul-Hussan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Designed oligomers of cyanovirin-N show enhanced HIV neutralization

(2011) J. R. Keeffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMR solution structure of a cyanovirin homolog from wheat head blight fungus

(2011) Elena Matei et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structure-Function Analysis of a CVNH-LysM Lectin Expressed during Plant Infection by the Rice Blast Fungus Magnaporthe oryzae

(2011) Leonardus M.I. Koharudin et al.   STRUCTURE

The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4+ cells

(2011) Kabamba B. Alexandre et al.   VIROLOGY

Change in Allosteric Network Affects Binding Affinities of PDZ Domains: Analysis through Perturbation Response Scanning

(2011) Z. Nevin Gerek et al.   PLoS Computational Biology

Manipulation of Conformational Change in Proteins by Single-Residue Perturbations

(2010) C. Atilgan et al.   BIOPHYSICAL JOURNAL

Anti-HIV Activity of Defective Cyanovirin-N Mutants Is Restored by Dimerization

(2010) Elena Matei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal molecular dynamics simulations to speed up MM/PB(GB)SA evaluation of binding free energies of di-mannose deoxy analogs with P51G-m4-Cyanovirin-N

(2010) Ivan I. Vorontsov et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin

(2010) Kabamba B. Alexandre et al.   VIROLOGY

Solution and Crystal Molecular Dynamics Simulation Study of m4-Cyanovirin-N Mutants Complexed with Di-Mannose

(2009) Ivan I. Vorontsov et al.   BIOPHYSICAL JOURNAL

Multivalent interactions with gp120 are required for the anti-HIV activity of Cyanovirin

(2009) Yinan Liu et al.   BIOPOLYMERS

When Sugars Get Wet. A Comprehensive Study of the Behavior of Water on the Surface of Oligosaccharides

(2009) Sai Kumar Ramadugu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

(2009) B. R. O'Keefe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational models explain the oligosaccharide specificity of cyanovirin-N

(2008) Yukiji K. Fujimoto et al.   PROTEIN SCIENCE

Conformational gating of dimannose binding to the antiviral protein cyanovirin revealed from the crystal structure at 1.35 Å resolution

(2008) Raimund Fromme et al.   PROTEIN SCIENCE

Solution and Crystal Structures of a Sugar Binding Site Mutant of Cyanovirin-N: No Evidence of Domain Swapping

(2008) Elena Matei et al.   STRUCTURE

The Evolutionarily Conserved Family of Cyanovirin-N Homologs: Structures and Carbohydrate Specificity

(2008) Leonardus M.I. Koharudin et al.   STRUCTURE