Mal, more than a bridge to MyD88

MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C

(2013) S C Corr et al.   Mucosal Immunology

Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis

(2013) C L Kennedy et al.   ONCOGENE

Association of Mal/TIRAP S180L variant polymorphism with decreased infection risk in patients with advanced HIV-1 infection

(2012) Antonios I. Papadopoulos et al.   CYTOKINE

Phosphoinositide Binding by the Toll Adaptor dMyD88 Controls Antibacterial Responses in Drosophila

(2012) Lorri R. Marek et al.   IMMUNITY

TRAF6 Protein Couples Toll-like Receptor 4 Signaling to Src Family Kinase Activation and Opening of Paracellular Pathway in Human Lung Microvascular Endothelia

(2012) Anguo Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

(2012) Ezra Aksoy et al.   NATURE IMMUNOLOGY

Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling

(2012) Zhijie Lin et al.   PLoS One

Lipoteichoic Acid from Staphylococcus aureus Induces Lung Endothelial Cell Barrier Dysfunction: Role of Reactive Oxygen and Nitrogen Species

(2012) Amy Barton Pai et al.   PLoS One

TLR13 Recognizes Bacterial 23S rRNA Devoid of Erythromycin Resistance-Forming Modification

(2012) M. Oldenburg et al.   SCIENCE

Protein kinase Cζ phosphorylates occludin and promotes assembly of epithelial tight junctions

(2011) Suneet Jain et al.   BIOCHEMICAL JOURNAL

Association of TIRAP (MAL) gene polymorhisms with susceptibility to tuberculosis in a Chinese population

(2011) Y.X. Zhang et al.   GENETICS AND MOLECULAR RESEARCH

Mal Mediates TLR-Induced Activation of CREB and Expression of IL-10

(2011) M. Mellett et al.   JOURNAL OF IMMUNOLOGY

TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding

(2011) Masakiyo Sakaguchi et al.   PLoS One

B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K

(2011) M. Ni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt

(2011) T. D. Troutman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

(2011) E. Valkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TIRAP Ser180Leu polymorphism is associated with Behcet's disease

(2011) O. Durrani et al.   RHEUMATOLOGY

What the Myddosome structure tells us about the initiation of innate immunity

(2011) Nicholas J. Gay et al.   TRENDS IN IMMUNOLOGY

Meta-analysis on the association of TIRAP S180L variant and tuberculosis susceptibility

(2011) Ruifen Miao et al.   TUBERCULOSIS

Association between Single‐Nucleotide Polymorphisms inMal/TIRAPandInterleukin‐10Genes and Susceptibility to InvasiveHaemophilus influenzaeSerotype b Infection in Immunized Children

(2010) Shamez N. Ladhani et al.   CLINICAL INFECTIOUS DISEASES

IRAK1 and IRAK4 Promote Phosphorylation, Ubiquitination, and Degradation of MyD88 Adaptor-like (Mal)

(2010) Aisling Dunne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site

(2010) P. Ulrichts et al.   JOURNAL OF CELL SCIENCE

MyD88 Adaptor-Like D96N Is a Naturally Occurring Loss-of-Function Variant of TIRAP

(2010) J. George et al.   JOURNAL OF IMMUNOLOGY

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

Mal connects TLR2 to PI3Kinase activation and phagocyte polarization

(2009) S Santos-Sierra et al.   EMBO JOURNAL

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

(2009) Jin Young Kang et al.   IMMUNITY

Toll-like receptor 4 signalling through MyD88 is essential to controlSalmonella entericaserovar Typhimurium infection, but not for the initiation of bacterial clearance

(2009) Suzanne Talbot et al.   IMMUNOLOGY

BrucellaTIR Domain-containing Protein Mimics Properties of the Toll-like Receptor Adaptor Protein TIRAP

(2009) Girish K. Radhakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A TIR Domain Variant of MyD88 Adapter-like (Mal)/TIRAP Results in Loss of MyD88 Binding and Reduced TLR2/TLR4 Signaling

(2009) Kamalpreet Nagpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MyD88 Adapter-like (Mal)/TIRAP Interaction with TRAF6 Is Critical for TLR2- and TLR4-mediated NF-κB Proinflammatory Responses

(2009) Brett Verstak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subversion of Innate Immune Responses by Brucella through the Targeted Degradation of the TLR Signaling Adapter, MAL

(2009) D. Sengupta et al.   JOURNAL OF IMMUNOLOGY

MyD88 Adaptor-Like Is Not Essential for TLR2 Signaling and Inhibits Signaling by TLR3

(2009) E. F. Kenny et al.   JOURNAL OF IMMUNOLOGY

Heterozygosity for the S180L Variant ofMAL/TIRAP,a Gene Expressing an Adaptor Protein in the Toll‐Like Receptor Pathway, Is Associated with Lower Risk of Developing Chronic Chagas Cardiomyopathy

(2009) Rajendranath Ramasawmy et al.   JOURNAL OF INFECTIOUS DISEASES

IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38α-dependent pathway

(2009) Kelly M. Kroeger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling

(2009) Leah E. Cole et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock

(2009) B. Ferwerda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

(2009) H. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases

(2008) M Rebsamen et al.   CELL DEATH AND DIFFERENTIATION

TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus

(2008) John Castiblanco et al.   INFECTION GENETICS AND EVOLUTION

TLR4 Signaling Is Coupled to SRC Family Kinase Activation, Tyrosine Phosphorylation of Zonula Adherens Proteins, and Opening of the Paracellular Pathway in Human Lung Microvascular Endothelia

(2008) Ping Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer

(2008) Tomas Nyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase C Enhances Tight Junction Barrier Function of Human Nasal Epithelial Cells in Primary Culture by Transcriptional Regulation

(2008) J.-i. Koizumi et al.   MOLECULAR PHARMACOLOGY

Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations

(2008) Sergey Nejentsev et al.   NATURE GENETICS

Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain–containing proteins

(2008) Christine Cirl et al.   NATURE MEDICINE

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

Expression of Toll/IL-1R domain-containing adaptor protein (TIRAP) is detrimental to primary clearance of Salmonella and is not required for the generation of protective immunity

(2007) Stu Jerke et al.   IMMUNOLOGY LETTERS