Article
Biophysics
Xiaofei Wang, Hongxiu Wei, Yangcen Ou, Zhen Li, Feng Luo, Hong Tan, Jiehua Li
Summary: The development of an inflammation modulating PP mesh for pelvic floor repair is an urgent clinical need. In this study, a PP composite mesh was successfully prepared that can scavenge ROS and inhibit inflammation. The composite mesh exhibited excellent ROS scavenging and anti-inflammatory properties in vitro and in vivo. Thus, this PP mesh with ROS scavenging and anti-inflammatory properties provides a promising approach for mitigating FBR.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Medicine, General & Internal
Aleksandra Kaminska, Katarzyna Skorupska, Agnieszka Kubik-Komar, Konrad Futyma, Joanna Filipczak, Tomasz Rechberger
Summary: This study compared the effects of VNTR and TVM surgeries on quality of sexual life after pelvic organ prolapse treatment, showing significant improvements in both groups. However, there were no significant differences in the assessment of quality of sexual life between the analyzed groups of patients, indicating that both surgical methods are effective in improving quality of life in sexually active patients with symptomatic POP.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Materials Science, Biomaterials
Chenghao Wu, Zixuan Zhou, Xi You, Yi Guo, Ping Chen, Huaifang Li, Xiaowen Tong
Summary: This study developed a novel hydrogel-mesh complex by coating polypropylene mesh with a tannic acid-loaded gelatin hydrogel. The coated mesh exhibited improved hydrophilicity and cytocompatibility. The results showed that this complex had hemostatic, anti-inflammatory, and tissue repair-promoting effects, and could regulate macrophage polarization during tissue repair.
REGENERATIVE BIOMATERIALS
(2022)
Article
Multidisciplinary Sciences
Marta Pero, Laura Casani, Cristina Castells-Sala, Maria Luisa Perez, Esther Moga Naranjo, Oriol Juan-Babot, Leticia Alserawan De Lamo, Patricia Lopez-Chicon, Anna Vilarrodona Serrat, Lina Badimon, Oriol Porta Roda
Summary: The study aimed to evaluate the feasibility of using New Zealand White rabbits for studying implanted biomaterials in pelvic reconstructive surgery, and to compare the occurrence of graft-related complications between a commercial polypropylene mesh and a newly developed human dermal matrix. Results showed that NZW rabbits are a suitable model for evaluating graft materials, with hADM associated with fewer complications and better tissue integration compared to PP mesh.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Kim W. J. Verhorstert, Martijn Riool, Tess Bulten, Zeliha Guler, Leonie De Boer, Jan -Paul W. R. Roovers, Sebastian A. J. Zaat
Summary: This study compared the host response to delayed absorbable P4HB and a latest generation PP implant in a mouse implant infection model. The results showed that bacterial contamination negatively affected mesh integration for both P4HB and PP implants. Despite the larger surface area of P4HB implants, infection clearance was similarly delayed compared to PP implants. Additionally, collagen deposition was significantly increased around infected P4HB implants.
MATERIALS TODAY BIO
(2022)
Article
Medicine, General & Internal
Zhi-Jing Sun, Xiu-Qi Wang, Jing-He Lang, Tao Xu, Yong-Xian Lu, Ke-Qin Hua, Jin-Song Han, Huai-Fang Li, Xiao-Wen Tong, Ping Wang, Jian-Liu Wang, Xin Yang, Xiang-Hua Huang, Pei-Shu Liu, Yan-Feng Song, Hang-Mei Jin, Jing-Yan Xie, Lu-Wen Wang, Qing-Kai Wu, Jian Gong, Yan Wang, Li-Qun Wang, Zhao-Ai Li, Hui-Cheng Xu, Zhi-Jun Xia, Li-Na Gu, Qing Liu, Lan Zhu
Summary: This study outlined the development of Chinese pelvic floor surgeries related to pelvic organ prolapse over the past 14 years and found that the rate of synthetic mesh procedures increased while that of non-mesh procedures decreased significantly. The rate of transvaginal placement of surgical mesh procedures decreased while the rate of laparoscopic sacrocolpopexy procedures increased significantly.
CHINESE MEDICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Marta Pero, Cristina Castells-Sala, Leticia Alserawan, Laura Casani, Josep Oriol Juan Babot, Ignasi Jorba, Maria Luisa Perez, Esther Moga, Jorge Otero, Patricia Lopez-Chicon, Lina Badimon, Anna Vilarrodona Serrat, Oriol Porta-Roda
Summary: This study compares the biological performance of PP mesh and a newly developed hADM in pelvic floor reconstruction. The results show that hADM has better tissue integration and fewer clinical complications, but its biomechanical properties decrease after 6 months of implantation.
SCIENTIFIC REPORTS
(2022)
Article
Materials Science, Multidisciplinary
Mengqin Yuan, Min Hu, Fangfang Dai, Yaqi Fan, Zhimin Deng, Hongbing Deng, Yanxiang Cheng
Summary: Pelvic floor dysfunction is a common gynecological problem, with treatment options including non-operative and surgical methods to restore anatomical structure. Material type selection is crucial for the development of ideal pelvic floor repair mesh, as it has a significant impact on mechanical strength, biodegradation rate, and biocompatibility of the implants. Suitable materials for vaginal meshes are broadly classified into synthetic polymers, natural polymers, and polymer blends.
MATERIALS & DESIGN
(2021)
Article
Gastroenterology & Hepatology
Alison J. Hainsworth, Yaamini S. Premakumar, Nyree Griffin, Deepa Solanki, Samantha J. Morris, Linda Ferrari, Anton Emmanuel, Stuart Taylor, Alexis M. P. Schizas, Andrew B. Williams
Summary: The aim of this study was to determine the range of normal imaging features during total pelvic floor ultrasound (TPFUS) and defaecation MRI (dMRI). Results showed that abnormal structures and functional features were detected by both dMRI and TPFUS in asymptomatic individuals. These findings contribute to understanding the wide range of results seen in healthy individuals.
COLORECTAL DISEASE
(2023)
Article
Medicine, General & Internal
Anne-Cecile Pizzoferrato, Stephanie Ragot, Louis Verite, Nicolas Naiditch, Xavier Fritel
Summary: The study aimed to assess women's perception of postoperative pelvic floor repair complications and compare it to the Clavien-Dindo classification. The results showed that women's perception of surgical complications differed from the Clavien-Dindo classification, with lack of repair and long-term disability being two major factors contributing to the perception of seriousness.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Obstetrics & Gynecology
Yair Daykan, Reut Rotem, Barry A. O'Reilly
Summary: Minimally invasive surgical techniques, particularly robotic-assisted surgery, are increasingly common in pelvic floor reconstructive urogynaecological surgery. Robotic-assisted surgery provides easier access to complex surgical skills needed for repairing female pelvic floor issues, such as sacrocolpopexy. Despite its growing use and evident benefits, there is a lack of data from literature, especially randomized controlled trials.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Surgery
Dimitrios Bolovis, Wolfgang Hitzl, Cosima Brucker
Summary: Pectopexy is a new surgical procedure for correcting apical prolapse, which has been translated into a robotic procedure. The robotic technique for pectopexy is safe and provides excellent anatomical outcomes.
JOURNAL OF ROBOTIC SURGERY
(2022)
Article
Chemistry, Physical
Shuang Yu, Wentao Shi, Shadi Houshyar, Xin Wang, Pibo Ma
Summary: This study successfully improved the biocompatibility of polypropylene mesh by using chitosan and sodium alginate as coatings, promoting cell attachment and proliferation.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2021)
Review
Urology & Nephrology
Roxanna E. Abhari, Matthew L. Izett-Kay, Hayley L. Morris, Rufus Cartwright, Sarah J. B. Snelling
Summary: Complications following transvaginal implantation of polypropylene mesh in pelvic floor reconstructive surgery are linked to the host immune response, the biomaterial properties of the mesh, patient-specific and surgical risk factors, as well as shortcomings in mesh development. These factors contribute to pain and other complications experienced by patients after transvaginal mesh placement.
NATURE REVIEWS UROLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yansha Qiao, Qian Zhang, Qian Wang, Jing Lin, Junshuo Wang, Yan Li, Lu Wang
Summary: The study introduces a two-layer coating with synergistic anti-inflammatory effects for polypropylene hernia meshes. The coating, consisting of an antioxidant layer and an antifouling layer, shows promising potential in improving biocompatibility and reducing inflammation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Cell Biology
Elenice M. Alvarenga, Carlos H. L. Imperador, Vanessa B. Bardella, Vera L. C. C. Rodrigues, Mateus Mondin, Diogo C. Cabral-de-Mello, Alberto S. Moraes, Maria Luiza S. Mello
Review
Cell Biology
Benedicto de Campos Vidal, Maria Luiza S. Mello
Article
Cell Biology
Katleen Frauz, Luis Felipe R. Teodoro, Giane Daniela Carneiro, Fernanda Cristina da Veiga, Danilo Lopes Ferrucci, Andre Luis Bombeiro, Priscyla Waleska Simoes, Lucia Elvira Alvares, Alexandre Leite R. de Oliveira, Cristina Pontes Vicente, Rui Seabra Ferreira Jr, Benedito Barraviera, Maria Esmeria C. do Amaral, Marcelo Augusto M. Esquisatto, Benedicto de Campos Vidal, Edson Rosa Pimentel, Andrea Aparecida de Aro
Article
Biochemistry & Molecular Biology
Benedicto de Campos Vidal, Maria Luiza Silveira Mello
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Multidisciplinary Sciences
Marina Amorim Rocha, Giovana Maria Breda Veronezi, Marina Barreto Felisbino, Maria Silvia Viccari Gatti, Wirla M. S. C. Tamashiro, Maria Luiza Silveira Mello
SCIENTIFIC REPORTS
(2019)
Article
Materials Science, Multidisciplinary
Carlos Henrique L. Imperador, Vanessa B. Bardella, Eli Heber M. dos Anjos, Vera L. C. C. Rodrigues, Diogo C. Cabral-de-Mello, Maria Luiza S. Mello
MICROSCOPY AND MICROANALYSIS
(2020)
Article
Multidisciplinary Sciences
Marina Barreto Felisbino, Mark Ziemann, Ishant Khurana, Jun Okabe, Keith Al-Hasani, Scott Maxwell, K. N. Harikrishnan, Camila Borges Martins de Oliveira, Maria Luiza S. Mello, Assam El-Osta
Summary: The study found that the histone deacetylase inhibitor valproic acid (VPA) can attenuate gene activation in hepatocytes under hyperglycaemia, and epigenetic regulation is involved in VPA action.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Alessandra Bassani, Marina Amorim Rocha, Vera Lucia C. C. Rodrigues, Douglas S. Santos, Juliana Damieli Nascimento, Joao Aristeu da Rosa, Maria Luiza S. Mello
Summary: The study revealed that cultivation of T. infestans Malpighian tubules in vitro for 24 hours was insufficient for cell preservation even in the absence of the drug. Additionally, when VPA affects chromocenter heterochromatin in this animal cell model, it occurs through a pathway that excludes a classic global H3K9ac mark. Further investigation of nonhistone proteins associated with histone methylation marks is still needed to fully explain the differential response of T. infestans chromatin to VPA.
Article
Cell Biology
Carlos Henrique L. Imperador, Vera L. C. C. Rodrigues, Maria Luiza S. Mello
Summary: This study investigated the differences in chromosomal structure between Panstrongylus megistus and Triatoma infestans, which are vectors of Chagas disease. It was found that the chromocenters in both species are located near the nuclear periphery, but this positioning is not directly related to gene silencing.
Review
Cell Biology
Maria Luiza S. Mello
Summary: Valproic acid/sodium valproate can affect chromatin remodeling by inducing histone acetylation and altering gene expression, ultimately modulating gene expression levels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Hematology
Caroline Fernanda Sanches Dal Pozzo, Micheli Severo Sielski, Benedicto de Campos Vidal, Claudio C. Werneck, Cristina Pontes Vicente
Summary: The peptide p1158/59 was found to increase thrombus size and gelatinase activity, exacerbate vascular lesion, and not recover endothelial loss. It also promoted neointima growth and collagen birefringence, indicating collagen fibers reorganization. After 14 days, the peptide promoted increased re-endothelization and decreased gelatinase activity.
THROMBOSIS RESEARCH
(2022)
Article
Cell Biology
Eli Heber Martins dos Anjos, Maria Luiza Silveira Mello, Benedicto de Campos Vidal
Summary: Polarization microscopy was used to evaluate the birefringence and linear dichroism characteristics of collagen bundles in rat calcaneal tendons cultured on different substrates. The results showed that tendon explants cultivated on plastic substrates exhibited structural remodeling of collagen bundles and irregular alignment, which may have facilitated cell migration from the lateral regions. This phenomenon was not observed in tendon explants cultivated on glass substrates.
Article
Cell Biology
Eli Heber Martins dos Anjos, Marina Amorim Rocha, Benedicto de Campos Vidal, Maria Luiza Silveira Mello
Summary: Sodium valproate (VPA) induces chromatin remodeling by inhibiting histone deacetylases and promoting DNA demethylation. It causes heterochromatin decondensation in Triatoma infestans, but this is not due to histone acetylation. Instead, VPA promotes DNA demethylation, leading to chromatin remodeling in euchromatin.
Review
Microbiology
Maria Luiza S. Mello
Summary: This review highlights the cellular processes and epigenetic characteristics of Triatoma infestans, an important vector of Chagas disease. These processes include somatic polyploidy, nuclear phenotypic diversification, heterochromatin compartmentalization, chromatin remodeling, co-occurrence of necrosis and apoptosis, and response to valproic acid. Despite the limitations of insect supply and drug injection, T. infestans serves as an attractive model for cellular research.
Article
Biochemistry & Molecular Biology
Benedicto de Campos Vidal, Maria Luiza S. Mello
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)