Sodium valproate and 5-aza-2′-deoxycytidine differentially modulate DNA demethylation in G1 phase-arrested and proliferative HeLa cells

Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells

(2019) Rodolfo Soria-Castro et al.   Journal of Immunology Research

Valproic acid as an adjunctive therapeutic agent for the treatment of breast cancer

(2018) Hayley Heers et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation

(2017) Frank Lyko   NATURE REVIEWS GENETICS

TET-mediated active DNA demethylation: mechanism, function and beyond

(2017) Xiaoji Wu et al.   NATURE REVIEWS GENETICS

Regulation of Active DNA Demethylation through RAR-Mediated Recruitment of a TET/TDG Complex

(2017) Haider M. Hassan et al.   Cell Reports

PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications

(2017) Xi Zhang et al.   Stem Cell Reports

DNA Methylation Changes in Valproic Acid-Treated HeLa Cells as Assessed by Image Analysis, Immunofluorescence and Vibrational Microspectroscopy

(2017) Giovana M. B. Veronezi et al.   PLoS One

Active DNA demethylation by DNA repair: Facts and uncertainties

(2016) David Schuermann et al.   DNA REPAIR

5-azacytidine affects TET2 and histone transcription and reshapes morphology of human skin fibroblasts

(2016) Elena F. M. Manzoni et al.   Scientific Reports

TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells

(2016) Masahiro Kai et al.   PLoS One

Combined analysis of DNA methylation and cell cycle in cancer cells

(2015) Cécile Desjobert et al.   Epigenetics

The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells

(2015) Basudev Chowdhury et al.   Scientific Reports

Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients

(2015) Jian-Liang Chou et al.   Clinical Epigenetics

Phase I study of anti-VEGF monoclonal antibody bevacizumab and histone deacetylase inhibitor valproic acid in patients with advanced cancers

(2014) Jennifer J. Wheler et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions

(2014) Hao Wu et al.   CELL

Synchronization of the cell cycle using Lovastatin

(2014) Sonia JavanMoghadam-Kamrani et al.   CELL CYCLE

Folate Deficiency and Aberrant Expression of DNA Methyltransferase 1 were Associated with Cervical Cancerization

(2014) Wang Jin-tao et al.   CURRENT PHARMACEUTICAL DESIGN

Valproic acid suppresses Nrf2/Keap1 dependent antioxidant protection through induction of endoplasmic reticulum stress and Keap1 promoter DNA demethylation in human lens epithelial cells

(2014) Periyasamy Palsamy et al.   EXPERIMENTAL EYE RESEARCH

HDAC inhibition through valproic acid modulates the methylation profiles in human embryonic kidney cells

(2014) Shabir Ahmad Ganai et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

(2013) William A. Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Getting rid of DNA methylation

(2013) Francesco M. Piccolo et al.   TRENDS IN CELL BIOLOGY

Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy

(2013) Metin Karahoca et al.   Clinical Epigenetics

Valproic acid shows a potent antitumor effect with alteration of DNA methylation in neuroblastoma

(2012) Song Gu et al.   ANTI-CANCER DRUGS

Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond

(2011) Junjie U. Guo et al.   CELL CYCLE

Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells

(2011) Yi Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A Pilot Phase II Study of Valproic Acid for Treatment of Low-Grade Neuroendocrine Carcinoma

(2011) T. A. Mohammed et al.   ONCOLOGIST

Chromatin Remodeling, Cell Proliferation and Cell Death in Valproic Acid-Treated HeLa Cells

(2011) Marina Barreto Felisbino et al.   PLoS One

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

DNA methylation and the formation of heterochromatin in Neurospora crassa

(2010) M R Rountree et al.   HEREDITY

Molecular and Therapeutic Potential and Toxicity of Valproic Acid

(2010) Sébastien Chateauvieux et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents

(2010) Jiahuai Tan et al.   Journal of Hematology & Oncology

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Establishing, maintaining and modifying DNA methylation patterns in plants and animals

(2010) Julie A. Law et al.   NATURE REVIEWS GENETICS

Active DNA demethylation: many roads lead to Rome

(2010) Susan C. Wu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons

(2010) Zoya Marinova et al.   NEUROPHARMACOLOGY

A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation

(2009) J. Datta et al.   CANCER RESEARCH

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing

(2008) Xudong Wu et al.   NUCLEIC ACIDS RESEARCH