Dry Eye as a Mucosal Autoimmune Disease

Autoimmunity in Dry Eye Is Due to Resistance of Th17 to Treg Suppression

(2014) S. K. Chauhan et al.   JOURNAL OF IMMUNOLOGY

Efficacy of Topical Blockade of Interleukin-1 in Experimental Dry Eye Disease

(2012) Andre Okanobo et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

A Phase 2 Randomized, Double-Masked, Placebo-Controlled Study of a Novel Integrin Antagonist (SAR 1118) for the Treatment of Dry Eye

(2012) Charles P. Semba et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Expression of CCR5 and Its Ligands CCL3, -4, and -5 in the Tear Film and Ocular Surface of Patients with Dry Eye Disease

(2012) Won Choi et al.   CURRENT EYE RESEARCH

NK Cells Promote Th-17 Mediated Corneal Barrier Disruption in Dry Eye

(2012) Xiaobo Zhang et al.   PLoS One

Desiccating Stress Induces CD4+ T-Cell–Mediated Sjögren's Syndrome–Like Corneal Epithelial Apoptosis via Activation of the Extrinsic Apoptotic Pathway by Interferon-γ

(2011) Xiaobo Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Ocular Surface APCs Are Necessary for Autoreactive T Cell-Mediated Experimental Autoimmune Lacrimal Keratoconjunctivitis

(2011) C. S. Schaumburg et al.   JOURNAL OF IMMUNOLOGY

Intracellular Nucleic Acid Sensors and Autoimmunity

(2011) Argyrios N. Theofilopoulos et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Interferon-γ-secreting NK cells promote induction of dry eye disease

(2011) Yihe Chen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Complement activation by (auto-) antibodies

(2011) Nina A. Daha et al.   MOLECULAR IMMUNOLOGY

Cytokine and chemokine levels in tears from healthy subjects

(2010) Ester Carreño et al.   ACTA OPHTHALMOLOGICA

Evidence of Corneal Lymphangiogenesis in Dry Eye Disease

(2010) Sunali Goyal   ARCHIVES OF OPHTHALMOLOGY

Evaluation of the Transforming Growth Factor-β Activity in Normal and Dry Eye Human Tears by CCL-185 Cell Bioassay

(2010) Xiaofen Zheng et al.   CORNEA

Immune response in the conjunctival epithelium of patients with dry eye

(2010) Stefano Barabino et al.   EXPERIMENTAL EYE RESEARCH

Membrane-tethered mucins have multiple functions on the ocular surface

(2010) Bharathi Govindarajan et al.   EXPERIMENTAL EYE RESEARCH

Toll-like receptors in ocular surface disease

(2010) Rachel L. Redfern et al.   EXPERIMENTAL EYE RESEARCH

Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13

(2010) C S De Paiva et al.   Mucosal Immunology

Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea

(2010) Andrés Parra et al.   NATURE MEDICINE

Sensors of the innate immune system: their link to rheumatic diseases

(2010) Argyrios N. Theofilopoulos et al.   Nature Reviews Rheumatology

The concentration of lysozyme and secretory IgA in tears from healthy persons with and without contact lens use

(2009) Troels Vinding et al.   ACTA OPHTHALMOLOGICA

The concentration of lactoferrin in tears of normals and of diabetics

(2009) O. L. Jensen et al.   ACTA OPHTHALMOLOGICA

Systemic and Local Interleukin-17 and Linked Cytokines Associated with Sjögren’s Syndrome Immunopathogenesis

(2009) Gikas E. Katsifis et al.   AMERICAN JOURNAL OF PATHOLOGY

Amelioration of Murine Dry Eye Disease by Topical Antagonist to Chemokine Receptor 2

(2009) Sunali Goyal   ARCHIVES OF OPHTHALMOLOGY

Prevalence of Dry Eye Disease Among US Men

(2009) Debra A. Schaumberg   ARCHIVES OF OPHTHALMOLOGY

Effects of Sequential Artificial Tear and Cyclosporine Emulsion Therapy on Conjunctival Goblet Cell Density and Transforming Growth Factor-β2 Production

(2009) Stephen C Pflugfelder et al.   CORNEA

Interleukin-1 Receptor-1-deficient Mice Show Attenuated Production of Ocular Surface Inflammatory Cytokines in Experimental Dry Eye

(2009) Srihari Narayanan et al.   CORNEA

Analysis of Inflammatory Cytokines in the Tears of Dry Eye Patients

(2009) Morgan L Massingale et al.   CORNEA

Effect of pro-inflammatory mediators on membrane-associated mucins expressed by human ocular surface epithelial cells

(2009) Ann-Christin Albertsmeyer et al.   EXPERIMENTAL EYE RESEARCH

Plasticity of CD4+ T Cell Lineage Differentiation

(2009) Liang Zhou et al.   IMMUNITY

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Induction of Th17 differentiation by corneal epithelial-derived cytokines

(2009) Xiaofen Zheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Major Role of    T Cells in the Generation of IL-17+ Uveitogenic T Cells

(2009) Y. Cui et al.   JOURNAL OF IMMUNOLOGY

IL-17 disrupts corneal barrier following desiccating stress

(2009) C S De Paiva et al.   Mucosal Immunology

Conjunctiva-Associated Lymphoid Tissue – Current Knowledge, Animal Models and Experimental Prospects

(2009) Philipp Steven et al.   OPHTHALMIC RESEARCH

Tear Cytokine Profiles in Dysfunctional Tear Syndrome

(2008) Helene Lam et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Topical Omega-3 and Omega-6 Fatty Acids for Treatment of Dry Eye

(2008) Saadia Rashid   ARCHIVES OF OPHTHALMOLOGY

Modulation of Integrin α4β1 (VLA-4) in Dry Eye Disease

(2008) Tatiana Ecoiffier   ARCHIVES OF OPHTHALMOLOGY

Kinetics of immune cell migration at the human ocular surface

(2008) J H Chan et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Epithelial-Immune Cell Interaction in Dry Eye

(2008) Stephen C Pflugfelder et al.   CORNEA

Cytokine-producing B lymphocytes—key regulators of immunity

(2008) Frances E Lund   CURRENT OPINION IN IMMUNOLOGY

Cytokine responses by conjunctival epithelial cells: An in vitro model of ocular inflammation

(2008) Amalia Enríquez-de-Salamanca et al.   CYTOKINE

Alterations in corneal sensitivity and nerve morphology in patients with primary Sjögren's syndrome

(2008) Ilpo S. Tuisku et al.   EXPERIMENTAL EYE RESEARCH

Prevalence of Dry Eye Disease among Japanese Visual Display Terminal Users

(2008) Miki Uchino et al.   OPHTHALMOLOGY

Contributions of Evaporation and Other Mechanisms to Tear Film Thinning and Break-Up

(2008) P Ewen King-Smith et al.   OPTOMETRY AND VISION SCIENCE

Role of B7-H1 in Immune Privilege of the Eye

(2008) Junko Hori   JOURNAL OF NIPPON MEDICAL SCHOOL