Journal
CORNEA
Volume 27, Issue 8, Pages S9-S11Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ICO.0b013e31817f4075
Keywords
dry eye; ocular surface epithelium; immune system
Categories
Funding
- NEI NIH HHS [EY014553, R03 EY014553, EY016928-01, F32 EY016928, EY11915, R01 EY011915] Funding Source: Medline
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Dry eye is a potent stimulus of both innate and adaptive immune systems. At the nexus of the dry eye inflammatory/immune response is the dynamic interplay between the ocular surface epithelia and the bone marrow-derived immune cells. On the one hand, ocular surface epithelial cells play a key initiating role in this inflammatory reaction. On the other hand, they are targets of cytokines produced by activated T cells that are recruited to the ocular surface in response to dry eye. This interaction between epithelial and immune cells in dry eye will be thoroughly reviewed.
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