Article
Chemistry, Analytical
Won-Chul Lee, Eun Hye Koh, Dong-Ho Kim, Sung-Gyu Park, Ho Sang Jung
Summary: The SERS-LM developed is capable of detecting glucose in human tears using a layer-by-layer structure composed of SF, AgNWs coated with MPBA, and PF. With a high density of hotspots for Raman signal enhancement, the SERS-LM demonstrates excellent glucose sensing performance within the concentration range of 500 nM - 1 mM. Furthermore, the tear glucose levels measured by the SERS-LM reflect trends of corresponding blood glucose levels, verifying its feasibility for noninvasive glucose sensing and potential application in various wearable personal health monitoring systems.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Ophthalmology
Mark Willcox, Nancy Keir, Vinod Maseedupally, Simin Masoudi, Alison McDermott, Rabia Mobeen, Christine Purslow, Jacinto Santodomingo-Rubido, Silvia Tavazzi, Fabrizio Zeri, Lyndon Jones
Summary: Contact lens materials have undergone significant changes in the past 20 years with the introduction of silicone hydrogel materials. However, research is still needed to improve comfort, as the association between contact lens wettability and comfort is not clear. The interactions between lens materials, tear film, and disinfection solution play an important role in biocompatibility, but whether this can be altered to improve comfort remains debatable.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Pharmacology & Pharmacy
Erika Ponzini, Silvia Tavazzi, Giacomo Musile, Franco Tagliaro, Rita Grandori, Carlo Santambrogio
Summary: Contact lens wear can alter the balance and functionality of tear proteins, including lactoferrin. This study investigates the changes in lactoferrin's structure and affinity for terbium during contact lens wear, providing insights for the development of more biocompatible and comfortable contact lens devices.
Article
Microbiology
Anna Niedzwiedz, Ewa Pius-Sadowska, Milosz Kawa, Agnieszka Kuligowska, Milosz Parczewski, Krzysztof Safranow, Krzysztof Kozlowski, Boguslaw Machalinski, Anna Machalinska
Summary: Mucosal immunity, including secretory IgA (sIgA), plays an important role in the early defense against SARS-CoV-2 infection. Tear-based sIgA levels can serve as a biomarker of external mucosal immunity to SARS-CoV-2 and are closely related to individual immune responses to the virus.
Article
Ophthalmology
Pardis Kiani, Asieh Soozanipour, Azam Rezayat, Asghar Taheri-Kafrani
Summary: This study evaluated the effect of lysozyme on bacterial biofilm formation on bandage contact lenses. The results showed that lysozyme has the potential to inhibit the growth of Staphylococcus aureus and Pseudomonas aeruginosa, as well as reduce biofilm formations of these bacteria. SEM and AFM imaging techniques were used to visualize the antibacterial activity of lysozyme and topography changes on the contact lens surface. Lysozyme-functionalized bandage contact lenses can therefore reduce the risk of ocular infection after eye surgery.
EXPERIMENTAL EYE RESEARCH
(2023)
Review
Microbiology
Herbert L. L. DuPont, Zhi-Dong Jiang, Ashley S. S. Alexander, Andrew W. W. DuPont, Eric L. L. Brown
Summary: IgA-coated bacteria in the gut provide important homeostatic functions and their impairment is associated with dysbiosis. Fecal microbiota transplantation has been successful in engrafting healthy microbiota and metabolites, with IgA-coated bacteria being transferred to recipients. The evaluation of the IgA-biome should be included in FMT studies, using metagenomic methods to better identify and compare microbiota data.
Article
Ophthalmology
Sultan Alotaibi, Eric Papas, Jerome Ozkan, Stuti L. Misra, Maria Markoulli
Summary: This study investigated the behavior of telomerase reverse transcriptase (hTERT) in the tears of healthy individuals wearing contact lenses. The results showed that the levels of hTERT increased after contact lens wear, but this change was small compared to the impact of overnight eye closure. In addition, the inflammatory mediators IL-6 and TNF-alpha showed minimal response at the same time points.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Ophthalmology
Simin Masoudi, Todd W. Mitchell, Mark D. Willcox
Summary: This study found that levels of certain TAG and WE species decreased during the day without contact lens wear, while levels of CE and WE increased from morning to evening with contact lens wear. The level of non-polar lipids did not correlate with ocular comfort.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Ophthalmology
Jaehee Jeon, Sihyun Park
Summary: This study compared the efficacy of artificial tears and warm compress with an eyelid warming mask (EWM) in alleviating dry eye syndrome in contact lens wearers. The results showed that both the EWM and artificial tears groups had significantly decreased OSDI scores after treatment, indicating a positive effect on DES.
CONTACT LENS & ANTERIOR EYE
(2021)
Review
Ophthalmology
Michelle K. Rhee, Deborah S. Jacobs, Deepinder K. Dhaliwal, Loretta Szczotka-Flynn, Christina R. Prescott, Vishal Jhanji, Thomas L. Steinemann, Bruce H. Koffler, Bennie H. Jeng
Summary: Contact lenses are a safe and effective method for correcting refractive error and are regulated by the U.S. Food and Drug Administration (FDA). The type of contact lens material and wear and care regimens have a significant impact on the risk of corneal inflammatory events and microbial keratitis. This article focuses on the safety of contact lens correction for refractive error in healthy eyes.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2022)
Article
Green & Sustainable Science & Technology
Mayank Gupta, Atyant Bhatnagar, Atul Kumar Dubey, Virendra Kumar, Dalip Singh Mehta
Summary: This study proposes and demonstrates a system that combines large Fresnel lenses and segmented mirrors to efficiently concentrate sunlight without the need for mechanical sun tracking. The system is used for solar thermal power generation and efficient water heating. The angular position of the lenses is designed to maximize sunlight collection throughout the day. The system significantly enhances the efficiency of solar thermal systems by exposing the thermal receiver unit to both concentrated and direct sunlight. The results show that this system is highly efficient and useful for countries with abundant sunlight, contributing to sustainable development.
ENERGY FOR SUSTAINABLE DEVELOPMENT
(2022)
Article
Ophthalmology
Mathias Roth, Christoph Holtmann, Loay Daas, Vinodh Kakkassery, Oliver Kurzai, Gerd Geerling, Sebastian Baeurle, Wesal Bayoudh, Viktoria Bruecher, Nadezhda Cvetkova-Fischer, Matthias Dias Blak, Agnes Bornstein, Charlotte Fischer, Matthias Fuest, Salvatore Grisanti, Martina C. Herwig-Carl, Sandra Kroll, Janine Lenk, Claudia Lommatzsch, Colin R. MacKenzie, Mario Matthaei, Juliane Mehlan, Elisabeth M. Messmer, Violetta Mueller, Vera Pawlik, Mahdy Ranjbar, Anna Renner-Wilde, Annekatrin Rickmann, Mark Saeger, Marc Schargus, Luisa Schwarz, Berthold Seitz, Friedrich Steindor, Jan Darius Unterlauf, Arne Viestenz, Marie von Lilienfeld-Toal, Grit Walther
Summary: Fungal keratitis is a serious ophthalmic disease with a potentially devastating outcome, and the use of contact lenses is the most important risk factor for FK in Germany. Infections among contact lens users are often caused by molds, and patients are usually younger and healthier. Extensive surgery is often required for treatment.
Article
Ophthalmology
Tingting Yang, Baikai Ma, Jianyang Xie, Yifan Zhou, Rongjun Liu, Hongyu Duan, Yitian Zhao, Hong Qi
Summary: This study investigated ocular surface alterations and in vivo confocal microscopic characteristics of the cornea in dry eye disease (DED) with contact lens wear (CLW). Patients with DED and CLW showed greater epithelial damage, elevated inflammatory cytokines and neuromediators in tears, and higher corneal dendritic cell density compared to patients with DED without CLW.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2022)
Article
Ophthalmology
Billy R. Hammond, John Buch, Leilani Sonoda, Lisa Renzi-Hammond
Summary: The study directly compared the visual effects of wearing photochromic contact lenses with nonphotochromic lenses, finding that the former was more effective in reducing positive dysphotopsia (such as halos and starbursts), especially in older subjects.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
Zachary Ballard, Sarah Bazargan, Diane Jung, Shyama Sathianathan, Ashley Clemens, Daniel Shir, Saba Al-Hashimi, Aydogan Ozcan
Summary: Quantification of lysozyme in tear fluid was reported using contact lenses and a mobile-phone well-plate reader. Lower levels of lysozyme were observed in human participants with dry eye disease compared to healthy controls.
2021 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO)
(2021)
