Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators

(2014) Joo In Jung et al.   BIOCHEMISTRY

Cholestenoic acids regulate motor neuron survival via liver X receptors

(2014) Spyridon Theofilopoulos et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of Cholesterol Metabolism in Alzheimer’s Disease

(2014) Jia-Hao Sun et al.   MOLECULAR NEUROBIOLOGY

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity

(2014) Joo In Jung et al.   PLoS One

Cholesterol and breast cancer pathophysiology

(2014) Erik R. Nelson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Suppression of amyloid-β production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking

(2013) Yasuomi Urano et al.   FASEB JOURNAL

Steroids as γ-secretase modulators

(2013) Joo In Jung et al.   FASEB JOURNAL

Plant Sterols the Better Cholesterol in Alzheimer's Disease? A Mechanistical Study

(2013) V. K. Burg et al.   JOURNAL OF NEUROSCIENCE

Allopregnanolone as regenerative therapeutic for Alzheimer's disease: Translational development and clinical promise

(2013) Ronald W. Irwin et al.   PROGRESS IN NEUROBIOLOGY

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) A. R. Price et al.   SCIENCE

Effects of Membrane Lipids on the Activity and Processivity of Purified γ-Secretase

(2012) Oliver Holmes et al.   BIOCHEMISTRY

Optimization of a Natural Product-Based Class of γ-Secretase Modulators

(2012) Jed L. Hubbs et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease

(2012) Julius Popp et al.   JOURNAL OF NEUROCHEMISTRY

Presenilin Is the Molecular Target of Acidic γ-Secretase Modulators in Living Cells

(2012) Thorsten Jumpertz et al.   PLoS One

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside

(2012) Nathan O. Fuller et al.   ACS Medicinal Chemistry Letters

Overlapping profiles of Abeta peptides in the Alzheimer's disease and pathological aging brains

(2012) Brenda D Moore et al.   Alzheimers Research & Therapy

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1

(2011) Yu Ohki et al.   EMBO JOURNAL

The Oxysterol, 27-Hydroxycholesterol, Links Cholesterol Metabolism to Bone Homeostasis Through Its Actions on the Estrogen and Liver X Receptors

(2011) Erik R. Nelson et al.   ENDOCRINOLOGY

Improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer

(2011) Qi Shen et al.   International Journal of Nanomedicine

Novel γ-Secretase Enzyme Modulators Directly Target Presenilin Protein

(2011) Amelie Ebke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein

(2011) Sarah A. Sagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine 624 of the Amyloid Precursor Protein (APP) Is a Critical Determinant of Amyloid β Peptide Length

(2011) Thomas L. Kukar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid–Alzheimer's disease relationships?

(2010) Andrew J. Beel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease

(2010) Z. Amtul et al.   NEUROSCIENCE

Cerebrospinal Fluid Steroidomics: Are Bioactive Bile Acids Present in Brain?

(2009) Michael Ogundare et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate specificity of γ-secretase and other intramembrane proteases

(2008) A. J. Beel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Possible Mechanisms of Action of NSAIDs and Related Compounds that Modulate γ - Secretase Cleavage

(2008) Thomas Kukar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Independent Inhibition of Alzheimer Disease β- and γ-Secretase Cleavage by Lowered Cholesterol Levels

(2008) Marcus O. W. Grimm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-targeting γ-secretase modulators

(2008) Thomas L. Kukar et al.   NATURE

Mechanisms of Disease: inborn errors of bile acid synthesis

(2008) Shikha S Sundaram et al.   Nature clinical practice. Gastroenterology & hepatology