The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

A Novel MAPT Mutation Associated with the Clinical Phenotype of Progressive Nonfluent Aphasia

(2018) Chiara Villa et al.   JOURNAL OF ALZHEIMERS DISEASE

Clinical, Neuropathological, and Biochemical Characterization of the Novel Tau Mutation P332S

(2018) Vincent Deramecourt et al.   JOURNAL OF ALZHEIMERS DISEASE

Juvenile Frontotemporal Dementia with Parkinsonism Associated with Tau Mutation G389R

(2018) Marie-Pierre Chaunu et al.   JOURNAL OF ALZHEIMERS DISEASE

Nmnat2 Attenuates Tau Phosphorylation Through Activation of PP2A

(2018) Xiang-Shu Cheng et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Alterations, Oxidative Stress and Neuroinflammation in Alzheimer's Disease

(2017) M. Verri et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Binding of Hsp90 to Tau Promotes a Conformational Change and Aggregation of Tau Protein

(2017) Elena Tortosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Anti-Inflammatory Action of Donepezil Ameliorates Tau Pathology, Synaptic Loss, and Neurodegeneration in a Tauopathy Mouse Model

(2017) Yasumasa Yoshiyama et al.   JOURNAL OF ALZHEIMERS DISEASE

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

(2015) Adam C. Kaufman et al.   ANNALS OF NEUROLOGY

Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases

(2015) William B. Pratt et al.   Annual Review of Pharmacology and Toxicology

Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients withMAPTmutations

(2015) Mariangela Iovino et al.   BRAIN

Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau

(2015) Ismael Santa-Maria et al.   JOURNAL OF CLINICAL INVESTIGATION

The Essential Role of Soluble Aβ Oligomers in Alzheimer’s Disease

(2015) Zi-Xuan Wang et al.   MOLECULAR NEUROBIOLOGY

Abeta(1-42) induces abnormal alternative splicing of tau exons 2/3 in NGF-induced PC12 cells

(2014) TERESA LAGUNES et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Apolipoprotein E in Alzheimer's Disease: An Update

(2014) Jin-Tai Yu et al.   Annual Review of Neuroscience

Tau Silencing by siRNA in the P301S Mouse Model of Tauopathy

(2014) Hong Xu et al.   CURRENT GENE THERAPY

Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies

(2014) Michel Goedert et al.   Current Neurology and Neuroscience Reports

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice

(2014) M. V. Rao et al.   JOURNAL OF NEUROSCIENCE

Folic acid inhibits tau phosphorylation through regulation of PP2A methylation in SH-SY5Y cells

(2014) W. Li et al.   Journal of Nutrition Health & Aging

Telmisartan Reduces Progressive Accumulation of Cellular Amyloid Beta and Phosphorylated Tau with Inflammatory Responses in Aged Spontaneously Hypertensive Stroke Resistant Rat

(2014) Tomoko Kurata et al.   Journal of Stroke & Cerebrovascular Diseases

Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial

(2014) Adam L Boxer et al.   LANCET NEUROLOGY

Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases

(2014) Lin Tan et al.   MOLECULAR NEUROBIOLOGY

Axonal Transport Defects in Alzheimer’s Disease

(2014) Zi-Xuan Wang et al.   MOLECULAR NEUROBIOLOGY

A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy

(2014) Eduardo Tolosa et al.   MOVEMENT DISORDERS

Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons

(2014) Rodrigo A. Quintanilla et al.   NEUROBIOLOGY OF DISEASE

Lower motor neuron disease with respiratory failure caused by a novel MAPT mutation

(2014) A. Di Fonzo et al.   NEUROLOGY

Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy

(2014) Tara L. Spires-Jones et al.   NEUROSCIENCE LETTERS

Fyn kinase inhibition as a novel therapy for Alzheimer’s disease

(2014) Haakon B Nygaard et al.   Alzheimers Research & Therapy

An Epigenetic Signature in Peripheral Blood Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy

(2014) Yun Li et al.   PLoS Genetics

Microglia in Alzheimer’s Disease

(2014) Ying Li et al.   Biomed Research International

Antisense-mediated Exon Skipping Decreases Tau Protein Expression: A Potential Therapy For Tauopathies

(2014) Reeteka Sud et al.   Molecular Therapy-Nucleic Acids

Neuropathological characterization of two siblings carrying the MAPT S305S mutation demonstrates features resembling argyrophilic grain disease

(2013) Annica Rönnbäck et al.   ACTA NEUROPATHOLOGICA

Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration

(2013) Naomi Kouri et al.   ACTA NEUROPATHOLOGICA

“Prion-Like” Templated Misfolding in Tauopathies

(2013) Florence Clavaguera et al.   BRAIN PATHOLOGY

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission

(2013) Nguyen-Vi Mohamed et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cornel Iridoid Glycoside Attenuates Tau Hyperphosphorylation by Inhibition of PP2A Demethylation

(2013) Cui-cui Yang et al.   Evidence-based Complementary and Alternative Medicine

Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulation

(2013) Atsushi Iwata et al.   HUMAN MOLECULAR GENETICS

Two Novel Tau Antibodies Targeting the 396/404 Region Are Primarily Taken Up by Neurons and Reduce Tau Protein Pathology

(2013) Jiaping Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Troglitazone, a thiazolidinedione, decreases tau phosphorylation through the inhibition of cyclin-dependent kinase 5 activity in SH-SY5Y neuroblastoma cells and primary neurons

(2013) Du-Hyong Cho et al.   JOURNAL OF NEUROCHEMISTRY

Specific Inhibition of p25/Cdk5 Activity by the Cdk5 Inhibitory Peptide Reduces Neurodegeneration In Vivo

(2013) J. R. Sundaram et al.   JOURNAL OF NEUROSCIENCE

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

DNA methylation of theMAPTgene in Parkinson's disease cohorts and modulation by vitamin EIn Vitro

(2013) Kirsten G. Coupland et al.   MOVEMENT DISORDERS

TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E MAPT

(2013) Helen Ling et al.   NEUROBIOLOGY OF AGING

5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5

(2013) Jin Chu et al.   NEUROBIOLOGY OF AGING

Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy

(2013) Kevin R. Nash et al.   NEUROBIOLOGY OF AGING

Different mutations at V363 MAPT codon are associated with atypical clinical phenotypes and show unusual structural and functional features

(2013) Giacomina Rossi et al.   NEUROBIOLOGY OF AGING

A cognitive chameleon: Lessons from a novelMAPTmutation case

(2013) Yuying Liang et al.   NEUROCASE

Mutations in MAPT give rise to aneuploidy in animal models of tauopathy

(2013) Giacomina Rossi et al.   NEUROGENETICS

Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy

(2013) Danielle L. Graham et al.   NEUROPHARMACOLOGY

Antisense Oligonucleotides: Treating Neurodegeneration at the Level of RNA

(2013) Sarah L. DeVos et al.   Neurotherapeutics

A Novel MAPT Mutation, G55R, in a Frontotemporal Dementia Patient Leads to Altered Tau Function

(2013) Abhinaya Iyer et al.   PLoS One

Increasing Brain Protein O-GlcNAc-ylation Mitigates Breathing Defects and Mortality of Tau.P301L Mice

(2013) Peter Borghgraef et al.   PLoS One

Minocycline alleviates beta-amyloid protein and tau pathology via restraining neuroinflammation induced by diabetic metabolic disorder

(2013) Zhiyou Cai et al.   Clinical Interventions in Aging

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

(2012) Erin E. Congdon et al.   Autophagy

Targeting Phospho-Ser422 by Active Tau Immunotherapy in the THYTau22 Mouse Model: A Suitable Therapeutic Approach

(2012) Nadege Zommer et al.   Current Alzheimer Research

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

(2012) Giovanni Coppola et al.   HUMAN MOLECULAR GENETICS

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Hyperdynamic Microtubules, Cognitive Deficits, and Pathology Are Improved in Tau Transgenic Mice with Low Doses of the Microtubule-Stabilizing Agent BMS-241027

(2012) D. M. Barten et al.   JOURNAL OF NEUROSCIENCE

The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice

(2012) B. Zhang et al.   JOURNAL OF NEUROSCIENCE

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

MicroRNAs in Alzheimer's disease

(2012) Charlotte Delay et al.   NEUROBIOLOGY OF DISEASE

Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion

(2012) Kohei Shimada et al.   NEUROBIOLOGY OF DISEASE

Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo

(2012) Brian DuBoff et al.   NEURON

Targeting a pre-mRNA structure with bipartite antisense molecules modulates tau alternative splicing

(2012) Eleanor Peacey et al.   NUCLEIC ACIDS RESEARCH

MicroRNAs and neurodegeneration: role and impact

(2012) Masashi Abe et al.   TRENDS IN CELL BIOLOGY

Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?

(2011) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain

(2011) Katherine J. Kopeikina et al.   AMERICAN JOURNAL OF PATHOLOGY

Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

(2011) P. Hemachandra Reddy   BRAIN RESEARCH

NAP (Davunetide) Provides Functional and Structural Neuroprotection

(2011) Illana Gozes   CURRENT PHARMACEUTICAL DESIGN

Familial Semantic Dementia with P301L Mutation in the Tau Gene

(2011) Takanori Ishizuka et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Genome-wide association study confirms extant PD risk loci among the Dutch

(2011) Javier Simón-Sánchez et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models

(2011) Xiyun Chai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

(2011) Allal Boutajangout et al.   JOURNAL OF NEUROCHEMISTRY

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

Truncated tau and Aβ cooperatively impair mitochondria in primary neurons

(2011) Rodrigo A. Quintanilla et al.   NEUROBIOLOGY OF AGING

Oleuropein and derivatives from olives as Tau aggregation inhibitors

(2011) Anthony Daccache et al.   NEUROCHEMISTRY INTERNATIONAL

Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice

(2011) Mian Bi et al.   PLoS One

Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model

(2011) Pavan K. Krishnamurthy et al.   Frontiers in Psychiatry

Genome-Wide Association Study Confirms SNPs inSNCAand theMAPTRegion as Common Risk Factors for Parkinson Disease

(2010) Todd L. Edwards et al.   ANNALS OF HUMAN GENETICS

The Revitalized Tau Hypothesis on Alzheimer's Disease

(2010) Ricardo B. Maccioni et al.   ARCHIVES OF MEDICAL RESEARCH

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

17q21.31 Microdeletion Syndrome: Further Expanding the Clinical Phenotype

(2010) F.H. Sharkey et al.   CYTOGENETIC AND GENOME RESEARCH

Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice

(2010) Moran Boimel et al.   EXPERIMENTAL NEUROLOGY

Nuclear Tau, a Key Player in Neuronal DNA Protection

(2010) Audrey Sultan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-Mediated Neuroprotection in a Mouse Model of Human Tauopathy

(2010) D. W. Hampton et al.   JOURNAL OF NEUROSCIENCE

Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

(2010) K. R. Brunden et al.   JOURNAL OF NEUROSCIENCE

Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice

(2010) D. Piedrahita et al.   JOURNAL OF NEUROSCIENCE

Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model

(2010) A. Boutajangout et al.   JOURNAL OF NEUROSCIENCE

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish

(2010) Frauke van Bebber et al.   NEUROBIOLOGY OF DISEASE

Novel L284R MAPT Mutation in a Family with an Autosomal Dominant Progressive Supranuclear Palsy Syndrome

(2010) Jonathan D. Rohrer et al.   Neurodegenerative Diseases

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

(2010) J. van Eersel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

Memantine Improves Cognition and Reduces Alzheimer’s-Like Neuropathology in Transgenic Mice

(2009) Hilda Martinez-Coria et al.   AMERICAN JOURNAL OF PATHOLOGY

Modulation and Detection of Tau Aggregation with Small-Molecule Ligands

(2009) Edward Chang et al.   Current Alzheimer Research

Lithium Trial in Alzheimer's Disease

(2009) Harald Hampel et al.   JOURNAL OF CLINICAL PSYCHIATRY

Challenges in the conduct of disease-modifying trials in ad: Practical experience from a phase 2 trial of TAU-aggregation inhibitor therapy

(2009) C. Wischik et al.   Journal of Nutrition Health & Aging

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model

(2009) Natalia Shiryaev et al.   NEUROBIOLOGY OF DISEASE

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative splicing of exon 10 in the tau gene as a target for treatment of tauopathies

(2008) Jianhua Zhou et al.   BMC NEUROSCIENCE

Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells

(2008) A. Gómez-Ramos et al.   MOLECULAR AND CELLULAR NEUROSCIENCE