The Dietary Components Carnosic Acid and Carnosol as Neuroprotective Agents: a Mechanistic View

Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson’s disease: Involvement of antioxidative enzymes induction

(2015) Chi-Rei Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Inflammation-induced ROS generation causes pancreatic cell death through modulation of Nrf2/NF-κB and SAPK/JNK pathway

(2015) S. Choudhury et al.   FREE RADICAL RESEARCH

Immune mechanisms linked to depression via oxidative stress and neuroprogression

(2015) Nataliia Bakunina et al.   IMMUNOLOGY

Forsythiaside inhibits cigarette smoke-induced lung inflammation by activation of Nrf2 and inhibition of NF-κB

(2015) Li Cheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria

(2015) Ken Itoh et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Chronic Brain Inflammation: The Neurochemical Basis for Drugs to Reduce Inflammation

(2015) Bevyn Jarrott et al.   NEUROCHEMICAL RESEARCH

Carnosic acid

(2015) Simona Birtić et al.   PHYTOCHEMISTRY

Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape

(2015) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Impaired Aβ clearance: a potential link between atherosclerosis and Alzheimer’s disease

(2015) Ajay Gupta et al.   Frontiers in Aging Neuroscience

Induction of Pi Form of Glutathione S-Transferase by Carnosic Acid Is Mediated through PI3K/Akt/NF-κB Pathway and Protects against Neurotoxicity

(2014) Chia-Yuan Lin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs

(2013) Takumi Satoh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bioavailability of the major bioactive diterpenoids in a rosemary extract: Metabolic profile in the intestine, liver, plasma, and brain of Zucker rats

(2013) María Romo Vaquero et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells

(2013) Hidemi Yoshida et al.   NEUROSCIENCE RESEARCH

Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells

(2013) Roberta Foresti et al.   PHARMACOLOGICAL RESEARCH

Nrf2 participates in depressive disorders through an anti-inflammatory mechanism

(2013) María Dolores Martín-de-Saavedra et al.   PSYCHONEUROENDOCRINOLOGY

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The effects of acute administration of the hydroalcoholic extract of rosemary (Rosmarinus officinalis L.) (Lamiaceae) in animal models of memory

(2012) Camila Angela Zanella et al.   Brazilian Journal of Pharmaceutical Sciences

Carnosic Acid Prevents 6-Hydroxydopamine-Induced Cell Death in SH-SY5Y Cells via Mediation of Glutathione Synthesis

(2012) Jing-Hsien Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Antidepressant-like effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus officinalis L.

(2012) Daniele G. Machado et al.   FOOD CHEMISTRY

Rosmarinus officinalis L. hydroalcoholic extract, similar to fluoxetine, reverses depressive-like behavior without altering learning deficit in olfactory bulbectomized mice

(2012) Daniele G. Machado et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ubiquitin–Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice

(2012) Andreia Neves Carvalho et al.   MOLECULAR NEUROBIOLOGY

Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

(2012) Margarida Castro-Caldas et al.   MOLECULAR NEUROBIOLOGY

Heat shock protein 90 in neurodegenerative diseases

(2012) Wenjie Luo et al.   Molecular Neurodegeneration

Carnosic acid suppresses the production of amyloid-β 1–42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells

(2012) Pengfei Meng et al.   NEUROSCIENCE RESEARCH

Neuroprotective effects of carnosic acid on neuronal cells under ischemic and hypoxic stress

(2012) Chien-Wei Hou et al.   NUTRITIONAL NEUROSCIENCE

Immune changes and neurotransmitters: Possible interactions in depression?

(2012) Barbara Sperner-Unterweger et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Multifaceted roles of PGE2 in inflammation and cancer

(2012) Masako Nakanishi et al.   Seminars in Immunopathology

Go Green: The Anti-Inflammatory Effects of Biliverdin Reductase

(2012) Barbara Wegiel et al.   Frontiers in Pharmacology

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

(2012) Michael Maes et al.   INFLAMMOPHARMACOLOGY

Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia

(2011) Mika Yanagitai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Carnosol: A promising anti-cancer and anti-inflammatory agent

(2011) Jeremy J. Johnson   CANCER LETTERS

Down regulation effect of Rosmarinus officinalis polyphenols on cellular stress proteins in rat pheochromocytoma PC12 cells

(2011) Abdelfatteh E. L. Omri et al.   CYTOTECHNOLOGY

Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes

(2011) Junsei Mimura et al.   JOURNAL OF BIOCHEMISTRY

Low-molecular-weight compounds having neurotrophic activity in cultured PC12 cells and neurons

(2011) H. Maruoka et al.   JOURNAL OF BIOCHEMISTRY

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Upregulation of Endogenous Neurotrophin Levels in the Brain by Intranasal Administration of Carnosic Acid

(2011) Siva Ram Kiran Vaka et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Microinjection of sanguinarine into the ventrolateral orbital cortex inhibits Mkp-1 and exerts an antidepressant-like effect in rats

(2011) Yunchun Chen et al.   NEUROSCIENCE LETTERS

Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation

(2011) Hidemi Yoshida et al.   NEUROSCIENCE RESEARCH

Absorption, Distribution and Elimination of Carnosic Acid, A Natural Antioxidant from Rosmarinus officinalis, in Rats

(2011) Evelyne H. A. Doolaege et al.   PLANT FOODS FOR HUMAN NUTRITION

Suppression of COX-2, IL-1β and TNF-α expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L.

(2010) Eleonora S. Mengoni et al.   FITOTERAPIA

The Plant Phenolic Diterpene Carnosol Suppresses Sodium Nitroprusside-Induced Toxicity in C6 Glial Cells

(2010) Sang Yong Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Rosmarinus officinalis polyphenols activate cholinergic activities in PC12 cells through phosphorylation of ERK1/2

(2010) Abdelfatteh El Omri et al.   JOURNAL OF ETHNOPHARMACOLOGY

Dual mechanisms of NF-κB inhibition in carnosol-treated endothelial cells

(2010) Kai-Cheng Lian et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Edaravone for the treatment of acute cerebral infarction: role of endothelium-derived nitric oxide and oxidative stress

(2009) Yukihito Higashi   EXPERT OPINION ON PHARMACOTHERAPY

Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco–Sjögren syndrome

(2009) Lihong Zhao et al.   HUMAN MOLECULAR GENETICS

Relationship between the Antioxidant Capacity and Effect of Rosemary (Rosmarinus officinalis L.) Polyphenols on Membrane Phospholipid Order

(2009) Laura Pérez-Fons et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Beneficial effects of carnosic acid on dieldrin-induced dopaminergic neuronal cell death

(2009) Jeong Ae Park et al.   NEUROREPORT

Activated Glutathione Metabolism Participates in Protective Effects of Carnosic Acid against Oxidative Stress in Neuronal HT22 Cells

(2009) Yosei Tamaki et al.   PLANTA MEDICA

Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: Involvement of the monoaminergic system

(2009) Daniele G. Machado et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes

(2008) Daniel Poeckel et al.   BIOCHEMICAL PHARMACOLOGY

Antioxidant activities of rosemary (Rosmarinus Officinalis L.) extract, blackseed (Nigella sativa L.) essential oil, carnosic acid, rosmarinic acid and sesamol

(2008) Naciye Erkan et al.   FOOD CHEMISTRY

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners

(2008) Takumi Satoh et al.   NEUROSCIENCE LETTERS

Carnosic acid, acatechol-typeelectrophilic compound, protects neurons bothin vitroandin vivothrough activation of the Keap1/Nrf2 pathway viaS-alkylation of targeted cysteines on Keap1

(2007) Takumi Satoh et al.   JOURNAL OF NEUROCHEMISTRY