From microbiology to cancer biology: the Rid protein family prevents cellular damage caused by endogenously generated reactive nitrogen species

Endogenous Synthesis of 2-Aminoacrylate Contributes to Cysteine Sensitivity in Salmonella enterica

(2014) D. C. Ernst et al.   JOURNAL OF BACTERIOLOGY

Differential Effects of a Mutation on the Normal and Promiscuous Activities of Orthologs: Implications for Natural and Directed Evolution

(2014) Akhil Khanal et al.   MOLECULAR BIOLOGY AND EVOLUTION

Arabidopsisand Maize RidA Proteins Preempt Reactive Enamine/Imine Damage to Branched-Chain Amino Acid Biosynthesis in Plastids

(2014) Thomas D. Niehaus et al.   PLANT CELL

Network-level architecture and the evolutionary potential of underground metabolism

(2014) R. A. Notebaart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serine and glycine metabolism in cancer

(2014) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells

(2014) Christiaan F. Labuschagne et al.   Cell Reports

Amino-4-Imidazolecarboxamide Ribotide Directly Inhibits Coenzyme A Biosynthesis in Salmonella enterica

(2013) J. V. Bazurto et al.   JOURNAL OF BACTERIOLOGY

In the Absence of RidA, Endogenous 2-Aminoacrylate Inactivates Alanine Racemases by Modifying the Pyridoxal 5'-Phosphate Cofactor

(2013) J. M. Flynn et al.   JOURNAL OF BACTERIOLOGY

Decreased coenzyme A levels inridAmutant strains ofSalmonella entericaresult from inactivated serine hydroxymethyltransferase

(2013) Jeffrey M. Flynn et al.   MOLECULAR MICROBIOLOGY

Methylglyoxal resistance inBacillus subtilis: contributions of bacillithiol-dependent and independent pathways

(2013) Pete Chandrangsu et al.   MOLECULAR MICROBIOLOGY

Metabolite damage and its repair or pre-emption

(2013) Carole L Linster et al.   Nature Chemical Biology

RidA Proteins Prevent Metabolic Damage Inflicted by PLP-Dependent Dehydratases in All Domains of Life

(2013) J. A. Lambrecht et al.   mBio

Anthranilate Phosphoribosyl Transferase (TrpD) Generates Phosphoribosylamine for Thiamine Synthesis from Enamines and Phosphoribosyl Pyrophosphate

(2012) Jennifer A. Lambrecht et al.   ACS Chemical Biology

Structure ofEscherichia coliRutC, a member of the YjgF family and putative aminoacrylate peracid reductase of therutoperon

(2012) Aleksandra Alicja Knapik et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Suppressor Analyses Identify Threonine as a Modulator of ridA Mutant Phenotypes in Salmonella enterica

(2012) Melissa R. Christopherson et al.   PLoS One

Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network

(2012) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of robustness in phenotypic adaptation and innovation

(2012) A. Wagner   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters

(2011) Arren Bar-Even et al.   BIOCHEMISTRY

Biocatalytic Promiscuity

(2011) Maria Svedendahl Humble et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Toward a Systems Biology Perspective on Enzyme Evolution

(2011) Shelley D. Copley   JOURNAL OF BIOLOGICAL CHEMISTRY

Conserved YjgF Protein Family Deaminates Reactive Enamine/Imine Intermediates of Pyridoxal 5′-Phosphate (PLP)-dependent Enzyme Reactions

(2011) Jennifer A. Lambrecht et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structures and putative interface of Saccharomyces cerevisiae mitochondrial matrix proteins Mmf1 and Mam33

(2011) You-Guang Pu et al.   JOURNAL OF STRUCTURAL BIOLOGY

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Crystal structure of the PSPTO-PSP protein from Pseudomonas syringae pv. tomato str. DC3000 in complex with d-glucose

(2010) Hong-mei Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deficiency in L-Serine Deaminase Interferes with One-Carbon Metabolism and Cell Wall Synthesis in Escherichia coli K-12

(2010) X. Zhang et al.   JOURNAL OF BACTERIOLOGY

Members of the YjgF/YER057c/UK114 Family of Proteins Inhibit Phosphoribosylamine Synthesisin Vitro

(2010) Jennifer A. Lambrecht et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational effects and the evolution of new protein functions

(2010) Misha Soskine et al.   NATURE REVIEWS GENETICS

Protein promiscuity and its implications for biotechnology

(2009) Irene Nobeli et al.   NATURE BIOTECHNOLOGY

A test case for structure-based functional assignment: The 1.2 Å crystal structure of the yjgF gene product from Escherichia coli

(2009) Karl Volz   PROTEIN SCIENCE

Decreased Expression of UK114 Is Related to the Differentiation Status of Human Hepatocellular Carcinoma

(2008) C.-L. Chong et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

YjgF Is Required for Isoleucine Biosynthesis when Salmonella enterica Is Grown on Pyruvate Medium

(2008) M. R. Christopherson et al.   JOURNAL OF BACTERIOLOGY