Toward a Systems Biology Perspective on Enzyme Evolution

Divergence and Convergence in Enzyme Evolution: Parallel Evolution of Paraoxonases from Quorum-quenching Lactonases

(2011) Mikael Elias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Initial Mutations Direct Alternative Pathways of Protein Evolution

(2011) Merijn L. M. Salverda et al.   PLoS Genetics

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Experimental Evolution of Adenylate Kinase Reveals Contrasting Strategies toward Protein Thermostability

(2010) Corwin Miller et al.   BIOPHYSICAL JOURNAL

Duplication Frequency in a Population of Salmonella enterica Rapidly Approaches Steady State With or Without Recombination

(2010) A. B. Reams et al.   GENETICS

Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5′-phosphate synthesis

(2010) Juhan Kim et al.   Molecular Systems Biology

Laboratory evolution of glutathione biosynthesis reveals natural compensatory pathways

(2010) Karthik Veeravalli et al.   Nature Chemical Biology

Artificial gene amplification reveals an abundance of promiscuous resistance determinants in Escherichia coli

(2010) V. W. C. Soo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pervasive Cryptic Epistasis in Molecular Evolution

(2010) Mark Lunzer et al.   PLoS Genetics

Epistasis among Deleterious Mutations in the HIV-1 Protease

(2009) Mariona Parera et al.   JOURNAL OF MOLECULAR BIOLOGY

Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism

(2009) Kenji Nakahigashi et al.   Molecular Systems Biology

Genome evolution and adaptation in a long-term experiment with Escherichia coli

(2009) Jeffrey E. Barrick et al.   NATURE

A Metabolic Bypass of the Triosephosphate Isomerase Reaction

(2008) Kevin K. Desai et al.   BIOCHEMISTRY

A Study in Molecular Contingency: Glutamine Phosphoribosylpyrophosphate Amidotransferase is a Promiscuous and Evolvable Phosphoribosylanthranilate Isomerase

(2008) Wayne M. Patrick et al.   JOURNAL OF MOLECULAR BIOLOGY

Intense Neutral Drifts Yield Robust and Evolvable Consensus Proteins

(2008) Shimon Bershtein et al.   JOURNAL OF MOLECULAR BIOLOGY

A compromise required by gene sharing enables survival: Implications for evolution of new enzyme activities

(2008) S. Y. McLoughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA