Enantioselective Construction of Spiro[2H-pyran-3,4′-indoline] by a Systematic Michael/Reduction/Cyclization Sequence Triggered by the Asymmetric Conjugate Addition of Ketones to Isatylidenemalononitriles

Organocatalytic Asymmetric α-Amination of Unprotected 3-Aryl and 3-Aliphatic Substituted Oxindoles using Di-tert-butyl Azodicarboxylate

(2011) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

N-Heterocyclic Carbene-Catalyzed Cyclization of Unsaturated Acyl Chlorides and Ketones

(2011) Li-Tao Shen et al.   ADVANCED SYNTHESIS & CATALYSIS

One-Pot Synthesis of Spirooxindole Derivatives Catalyzed by Lipase in the Presence of Water

(2011) She-Jie Chai et al.   ADVANCED SYNTHESIS & CATALYSIS

An Easy Entry to Optically Active Spiroindolinones: Chiral Brønsted Acid-Catalysed Pictet-Spengler Reactions of Isatins

(2011) Sara Duce et al.   ADVANCED SYNTHESIS & CATALYSIS

A Novel Entry to Spirofurooxindoles Involving Tandem Dearomatization of Furan Ring and Intramolecular Friedel- Crafts Reaction

(2011) Biao-Lin Yin et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Michael/Cyclization Reaction Sequence: Scaffold-Inspired Synthesis of Spirooxindoles with Multiple Stereocenters

(2011) Yiming Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective [3+2] Annulation of Morita-Baylis-Hillman Adducts Mediated by L-Threonine-Derived Phosphines: Synthesis of 3-Spirocyclopentene-2-oxindoles having Two Contiguous Quaternary Centers

(2011) Fangrui Zhong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multiple Catalysis with Two Chiral Units: An Additional Dimension for Asymmetric Synthesis

(2011) Susy Piovesana et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A highly organocatalytic stereoselective double Michael reaction: efficient construction of optically enriched spirocyclic oxindoles

(2011) Liang-Liang Wang et al.   CHEMICAL COMMUNICATIONS

Organocatalytic enantioselective conjugate addition of ketones to isatylidine malononitriles

(2011) Lu Liu et al.   CHEMICAL COMMUNICATIONS

Syntheses of Spirocyclic Oxindole-Butenolides by Using Three-Component Cycloadditions of Isocyanides, Allenoates, and Isatins

(2011) Jian Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diastereoselective Access to Tri- and Pentacyclic Spiro-γ-lactam-oxindole Cores through a Tandem Aza-Michael Initiated Ring Closure Sequence

(2011) Iyad Allous et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Core-Structure-Motivated Design of a Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles

(2011) Bin Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters

(2011) Wen-Bing Chen et al.   ORGANIC LETTERS

Chiral Counteranion Synergistic Organocatalysis under High Temperature: Efficient Construction of Optically Pure Spiro[cyclohexanone-oxindole] Backbone

(2011) Yu-Bao Lan et al.   ORGANIC LETTERS

Highly Stereoselective Brønsted Acid Catalyzed Synthesis of Spirooxindole Pyrans

(2011) Jingqi Wang et al.   ORGANIC LETTERS

A Hg(ClO4)2·3H2O Catalyzed Sakurai–Hosomi Allylation of Isatins and Isatin Ketoimines Using Allyltrimethylsilane

(2011) Zhong-Yan Cao et al.   ORGANIC LETTERS

Iodo-Carbocyclization of Electron-Deficient Alkenes: Synthesis of Oxindoles and Spirooxindoles

(2011) Hai-Long Wei et al.   ORGANIC LETTERS

Primary Amine/CSA Ion Pair: A Powerful Catalytic System for the Asymmetric Enamine Catalysis

(2011) Chen Liu et al.   ORGANIC LETTERS

Asymmetic Organocatalytic 1,3-Dipolar Cycloaddition of Azomethine Ylide to Methyl 2-(2-Nitrophenyl)acrylate for the Synthesis of Diastereoisomers of Spirotryprostatin A

(2011) Mou-Nuo Cheng et al.   ORGANIC LETTERS

Efficient one-pot synthesis of spiro[indoline-3,4′-pyrazolo[3,4-e][1,4]thiazepine]dione via three-component reaction

(2011) Hui Chen et al.   TETRAHEDRON

Ambient synthesis of spiro[4H-pyran-oxindole] derivatives under [BMIm]BF4 catalysis

(2011) Kurosh Rad-Moghadam et al.   TETRAHEDRON

Recent advances in asymmetric catalysis with cinchona alkaloid-based primary amines

(2011) Lin Jiang et al.   Catalysis Science & Technology

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Stereocontrolled Creation of All-Carbon Quaternary Stereocenters by Organocatalytic Conjugate Addition of Oxindoles to Vinyl Sulfone

(2010) Qiang Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Tandem Reaction to Construct Six-Membered Spirocyclic Oxindoles with Multiple Chiral Centres through a Formal [2+2+2] Annulation

(2010) Kun Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Unique Approach to the Concise Synthesis of Highly Optically Active Spirooxazolines and the Discovery of a More Potent Oxindole-Type Phytoalexin Analogue

(2010) Xianxing Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Asymmetric Synthesis of Substituted 3-Hydroxy-2-oxindoles via Morita−Baylis−Hillman Reaction

(2010) Yun-Lin Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic asymmetric 1,3-dipolar cycloaddition of N-unprotected 2-oxoindolin-3-ylidene derivatives and azomethine ylides for the construction of spirooxindole-pyrrolidines

(2010) Tang-Lin Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric Quadruple Aminocatalytic Domino Reactions to Fused Carbocycles Incorporating a Spirooxindole Motif

(2010) Kun Jiang et al.   ORGANIC LETTERS

Primary Amine/(+)-CSA Salt-Promoted Organocatalytic Conjugate Addition of Nitro Esters to Enones

(2010) Chen Liu et al.   ORGANIC LETTERS

Multicomponent Reaction Discovery: Three-Component Synthesis of Spirooxindoles

(2010) Bo Liang et al.   ORGANIC LETTERS

Highly Enantioselective Construction of Spiro[4H-pyran-3,3′-oxindoles] Through a Domino Knoevenagel/Michael/Cyclization Sequence Catalyzed by Cupreine

(2010) Wen-Bing Chen et al.   ORGANIC LETTERS

Palladium-Catalyzed Carbo-Heterofunctionalization of Alkenes for the Synthesis of Oxindoles and Spirooxindoles

(2010) Stéphanie Jaegli et al.   ORGANIC LETTERS

Cinchona Alkaloids in Asymmetric Organocatalysis

(2010) Tommaso Marcelli et al.   SYNTHESIS-STUTTGART

Asymmetric construction of quaternary stereocenters by direct conjugate addition of oxindoles to enone

(2010) Wangsheng Sun et al.   TETRAHEDRON-ASYMMETRY

Efficient Method for the Synthesis of Optically Active 2-Amino-2-chromene Derivatives via One-Pot Tandem Reactions

(2009) Jian-Wu Xie et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthetic approaches to the bicyclo[2.2.2]diazaoctane ring system common to the paraherquamides, stephacidins and related prenylated indole alkaloids

(2009) Kenneth A. Miller et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of Small Glycopeptides by Decarboxylative Condensation and Insight into the Reaction Mechanism

(2009) Aditya K. Sanki et al.   JOURNAL OF ORGANIC CHEMISTRY

Reductions of Aliphatic and Aromatic Nitriles to Primary Amines with Diisopropylaminoborane

(2009) Dustin Haddenham et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

(2009) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiourea-Catalyzed Highly Enantio- and Diastereoselective Additions of Oxindoles to Nitroolefins: Application to the Formal Synthesis of (+)-Physostigmine

(2009) Tommy Bui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Homodinuclear Mn(III)2−Schiff Base Complex for Catalytic Asymmetric 1,4-Additions of Oxindoles to Nitroalkenes

(2009) Yuko Kato et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric total syntheses of (+)- and (−)-versicolamide B and biosynthetic implications

(2009) Kenneth A. Miller et al.   Nature Chemistry

Asymmetric Michael addition reaction of 3-substituted-N-Boc oxindoles to activated terminal alkenes catalyzed by a bifunctional tertiary-amine thiourea catalyst

(2009) Xin Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stereoselective Synthesis of Spirooxindoles by Palladium-Catalyzed Decarboxylative Cyclization of γ-Methylidene-δ-valerolactones with Isatins

(2009) Ryo Shintani et al.   ORGANIC LETTERS

Stereoselective Synthesis of Spirocyclic Oxindoles via Prins Cyclizations

(2009) M. Paola Castaldi et al.   ORGANIC LETTERS

Stereocontrolled Synthesis of Spirooxindoles through Lewis Acid-Promoted [5 + 2]-Annulation of Chiral Silyl Alcohols

(2009) Yun Zhang et al.   ORGANIC LETTERS

Organocatalytic Formation of Quaternary Stereocenters

(2009) Marco Bella et al.   SYNTHESIS-STUTTGART

Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

(2009) Barry Trost et al.   SYNTHESIS-STUTTGART

Selected Synthetic Strategies to Spirocyclics

(2009) Sambasivarao Kotha et al.   SYNTHESIS-STUTTGART

Sodium stearate-catalyzed multicomponent reactions for efficient synthesis of spirooxindoles in aqueous micellar media

(2009) Li-Min Wang et al.   TETRAHEDRON

Design, Synthesis, and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)

(2008) Andrew Fensome et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Development of Asymmetric Primary Amine Catalysts Based on Cinchona Alkaloids

(2008) Ying-Chun Chen   SYNLETT

Organocatalytic Asymmetric Sulfa-Michael Addition to α,β-Unsaturated Ketones

(2007) Paolo Ricci et al.   ADVANCED SYNTHESIS & CATALYSIS