Article
Biochemistry & Molecular Biology
Ion Udroiu, Antonella Sgura
Summary: A century of research has shown that the biological effect of radiation is determined by the magnitude of the radiation dose. Different types of radiation, however, have different levels of effectiveness. This study compared the biological effectiveness of X-rays with different photon energies and dose rates, and found that both dose rate and photon energy influence the effectiveness of X-rays. The study also highlighted the limitations of using dose as the sole parameter in in vitro studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Nina I. Niebuhr, Mona Splinter, Tilman Bostel, Joao Seco, Clemens M. Hentschke, Ralf O. Floca, Juliane Horner-Rieber, Markus Alber, Peter Huber, Nils H. Nicolay, Asja Pfaffenberger
Summary: This study addresses an inconsistency in dose accumulation in radiotherapy based on the linear quadratic model. By introducing the concept of total biological dose (bEQD(d), the study demonstrates that bEQD(d) can overcome potential systematic inaccuracies in biological effect prediction based on accumulated dose.
RADIATION ONCOLOGY
(2021)
Article
Oncology
Heng Li
Summary: The study found that the linear quadratic (LQ) model, which is commonly used in radiobiological modeling, suffers from nonmonotonic behavior and poor extrapolation. It also leads to unrealistic predictions with negative beta values. In comparison, the power model and the linear model perform better in cross-validation. Therefore, the LQ model is not a valid predictive dose-response model for cell survival and alternative models need to be investigated.
Article
Oncology
Amit Ben Antony Bennan, Jan Unkelbach, Niklas Wahl, Patrick Salome, Mark Bangert
Summary: This study demonstrates the optimization of combined photon-carbon ion treatments for infiltrative tumors, aiming for more targeted application of carbon ions while reducing radiation dose in healthy tissues. The joint optimization of IMRT-CIRT treatments leads to a new spectrum of plans that better address physical and radiobiological treatment planning challenges.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Arjun Sahgal, Joe H. Chang, Lijun Ma, Lawrence B. Marks, Michael T. Milano, Paul Medin, Andrzej Niemierko, Scott G. Soltys, Wolfgang A. Tome, C. Shun Wong, Ellen Yorke, Jimm Grimm, Andrew Jackson
Summary: The study shows that the spinal cord tolerance data for SBRT in different fractions and the factors associated with a lower risk of radiation myelopathy for reirradiation SBRT, such as dose control and time intervals, are important for reducing risks.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Sasidharan Swarnalatha Lucky, Martin Law, Ming Hong Lui, Jamie Mong, Junli Shi, Sidney Yu, Do Kun Yoon, Shih Kien Djeng, Jiguang Wang, Chwee Ming Lim, Min Han Tan
Summary: The study established two NPC organoid lines, confirming that hypoxic NPC organoids are highly radioresistant and require higher radiation doses to compensate for oxygen deficiency. The results demonstrated that these organoid models can mimic inter-tumoral heterogeneity and exhibit RNA sequence correlations with patient tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biology
Joshua W. Moore, Thomas E. Woolley, John W. Hopewell, Bleddyn Jones
Summary: The developed GUI provides assistance in evaluating radiation tolerance changes in spinal cord and similar central nervous tissues, offering guidance for retreatment dose fractionation schedules with photons, protons, or ions.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Archya Dasgupta, Murtuza Saifuddin, Evan Mcnabb, Ling Ho, Lin Lu, Danny Vesprini, Irene Karam, Hany Soliman, Edward Chow, Sonal Gandhi, Maureen Trudeau, William Tran, Belinda Curpen, Greg Stanisz, Arjun Sahgal, Michael Kolios, Gregory J. Czarnota
Summary: Preclinical studies have shown that focused ultrasound stimulated microbubble rupture can activate the acid sphingomyelinase-ceramide pathway in endothelial cells. When delivered concurrently with radiotherapy, it leads to increased cell death and strong radiosensitization. This is the first human trial of using magnetic resonance imaging guided focused ultrasound microbubble treatment for breast malignancies.
SCIENTIFIC REPORTS
(2023)
Review
Biology
Andrea Borghini, Cecilia Vecoli, Luca Labate, Daniele Panetta, Maria Grazia Andreassi, Leonida A. Gizzi
Summary: FLASH radiotherapy is considered a breakthrough in cancer treatment, delivering ultrahigh radiation doses in a short time while sparing normal tissues. Preclinical studies show reduced toxicity and equivalent tumor responses, but further research is needed to understand the molecular radiobiology of the FLASH effect. Collaborative efforts across disciplines are crucial for rapid clinical translation.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Physics, Multidisciplinary
Ramin Abolfath, Alexander Baikalov, Alberto Fraile, Stefan Bartzsch, Emil Schueler, Radhe Mohan
Summary: The study proposes a theory based on the topology and geometry of diffusion channels in tissue to enhance the understanding of normal tissue sparing at ultra-high dose rates (UHDRs) and investigates the interaction between intra- and inter-track radical recombination through a reaction-diffusion mechanism. The time evolution of particle track structures is calculated using a random network designed for molecular transport in porous and disordered media, representing intra- and inter-cellular diffusion channels in tissues.
FRONTIERS IN PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Juan Pardo-Montero, Martin Parga-Pazos, John D. Fenwick
Summary: The purpose of this study is to develop a biomathematical model for predicting the tolerability/intolerability of mucosal toxicity in head-and-neck radiotherapy based on cell population dynamics. The model incorporates three As: Accelerated proliferation, loss of Asymmetric proliferation, and Abortive divisions. The predictive values of the model are comparable to phenomenological models when fitted to a dataset of radiotherapy schedules.
Review
Oncology
Laura Vanderwaeren, Ruveyda Dok, Kevin Verstrepen, Sandra Nuyts
Summary: Proton radiation therapy is a modern radiotherapy method that offers more precision in treating tumors with lower toxicity to healthy tissue. Despite growing clinical experience, the radiobiological effects of proton radiation remain not fully understood.
Review
Oncology
Maxime Loo, Jean-Baptiste Clavier, Justine Attal Khalifa, Elisabeth Moyal, Jonathan Khalifa
Summary: Brain metastases are a common complication for cancer patients, with stereotactic radiosurgery considered a cornerstone treatment. The ideal dose and fractionation schedule remain unknown, with ongoing debates regarding the use of hypofractionated schedules and the linear-quadratic model. Recent studies have shown the importance of radiation schedule in immunomodulatory responses. Efficacy and toxicity data suggest that hypofractionated schedules may offer benefits in terms of reducing toxicity and improving local control rates compared to single-fraction treatment.
Article
Oncology
Y. Zhang, Z. Ding, J. P. Perentesis, D. Khuntia, S. X. Pfister, R. A. Sharma
Summary: FLASH radiotherapy delivers radiation treatment at an ultra-high dose rate and has shown normal tissue sparing effects and equivalent antitumour activity in preclinical studies. Research suggests that FLASH irradiation may be a rational partner to combine with immune modulating drugs to improve clinical outcomes.
Article
Oncology
Mark Ka Heng Chan, Chi-Leung Chiang
Summary: The study aimed to examine the EUD formalism using USC for high-dose SBRT and estimate TCP. Results showed small deviations between USC and LQ models, but significant differences in EUDCFRT calculation. Further investigation into optimal formalism for EUD derivation is needed.
STRAHLENTHERAPIE UND ONKOLOGIE
(2021)
Article
Otorhinolaryngology
Yuji Nakamaru, Masanobu Suzuki, Satoshi Kano, Takatsugu Mizumachi, Nayuta Tsushima, Takayoshi Suzuki, Aya Honma, Akira Nakazono, Shogo Kimura, Rikiya Onimaru, Koichi Yasuda, Hiroki Shirato, Akihiro Homma
Summary: The study evaluated the efficacy of endoscopic surgery for 15 SNSCC patients, finding that patients with negative surgical margins had better disease-specific survival rates. Endoscopic surgery appears to be an effective method for selected cases of SNSCC patients, emphasizing the importance of achieving negative surgical margins with a good view of the tumor attachment site.
AURIS NASUS LARYNX
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hideki Minatogawa, Koichi Yasuda, Yasuhiro Dekura, Seishin Takao, Taeko Matsuura, Takaaki Yoshimura, Ryusuke Suzuki, Isao Yokota, Noriyuki Fujima, Rikiya Onimaru, Shinichi Shimizu, Hidefumi Aoyama, Hiroki Shirato
Summary: Comparing adaptive intensity-modulated proton beam therapy (A-IMPT) with adaptive intensity-modulated X-ray therapy (A-IMXT) for nasopharyngeal carcinomas (NPC), it was found that A-IMPT significantly reduced the doses to multiple organs compared to A-IMXT. In both treatment methods, the mean doses to the oral cavity, supraglottic larynx, and glottic larynx were significantly reduced.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2021)
Article
Biology
Koichi Yasuda, Hideki Minatogawa, Yasuhiro Dekura, Seishin Takao, Masaya Tamura, Nayuta Tsushima, Takayoshi Suzuki, Satoshi Kano, Takatsugu Mizumachi, Takashi Mori, Kentaro Nishioka, Motoyasu Shido, Norio Katoh, Hiroshi Taguchi, Noriyuki Fujima, Rikiya Onimaru, Isao Yokota, Keiji Kobashi, Shinichi Shimizu, Akihiro Homma, Hiroki Shirato, Hidefumi Aoyama
Summary: Pharyngeal cancer patients treated with IMPT using a model-based approach showed lower acute toxicities compared to those treated with IMXT. Multivariate analysis revealed that IMPT was independently associated with lower rates of grade 2 or worse dysphagia and dysgeusia. IMPT may have clinical benefits for acute dysphagia.
JOURNAL OF RADIATION RESEARCH
(2021)
Article
Oncology
Sheng-Yung Fu, Fang-Hsin Chen, Chun-Chieh Wang, Ching-Fang Yu, Chi-Shiun Chiang, Ji-Hong Hong
Summary: The study demonstrates that PMN-MDSCs infiltrate TRAMP-C1 tumors after high-dose radiation therapy, promoting tumor growth. Their spatial distribution within the tumor suggests their involvement in the development of tumor necrosis.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Yi-Hsiu Chung, Cheng-Kun Tsai, Ching-Fang Yu, Wan-Ling Wang, Chung-Lin Yang, Ji-Hong Hong, Tzu-Chen Yen, Fang-Hsin Chen, Gigin Lin
Summary: By utilizing 18F-FDG PET imaging and tissue NMR metabolomics, this study investigated the metabolic alterations induced by liver irradiation in a mouse model for HCC. The results showed a metabolic shift from impaired gluconeogenesis to enhanced glycolysis in the liver parenchyma as early as the first post-irradiation day. Radiation-induced metabolic changes were dynamic over time, with glucose concentrations peaking on day one post-irradiation and alterations in gene expression associated with inflammation and glucose metabolism.
Article
Medicine, Research & Experimental
Shu-Hsuan Liu, Kai-Wen Hsu, Yo-Liang Lai, Yu-Feng Lin, Fang-Hsin Chen, Pei-Hwa Peng, Li-Jie Lin, Heng-Hsiung Wu, Chia-Yang Li, Shu-Chi Wang, Min-Zu Wu, Yuh-Pyng Sher, Wei-Chung Cheng
Summary: The study found that both individual miRNA mimics and the combination of the three miRNA mimics were effective in inhibiting tumor growth and progression, with the combination being more effective than the single miRNA mimics. In lung cancer animal models, the combined miRNA mimics provided significant therapeutic effects in terms of reduced tumor volume and metastasis nodules.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Ching-Fang Yu, Chun-Hsiang Chang, Chun-Chieh Wang, Ji-Hong Hong, Chi-Shiun Chiang, Fang-Hsin Chen
Summary: The combination of radiation therapy and local IL-12 therapy enhances the host immune response, promotes vascular maturation and function, and is associated with less systemic toxicity compared to IL-12 therapy alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Yukinori Matsuo, Yasushi Nagata, Masashi Wakabayashi, Satoshi Ishikura, Hiroshi Onishi, Masaki Kokubo, Katsuyuki Karasawa, Yoshiyuki Shioyama, Rikiya Onimaru, Masahiro Hiraoka
Summary: This study suggests that pretreatment CRP level may provide prognostic information in operable patients receiving SBRT for early-stage NSCLC, and that the low SMM group may experience higher incidence of severe toxicities.
JOURNAL OF RADIATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Wen-Jen Lin, Pei-Chun Shen, Hsiu-Cheng Liu, Yi-Chun Cho, Min-Kung Hsu, I-Chen Lin, Fang-Hsin Chen, Juan-Cheng Yang, Wen-Lung Ma, Wei-Chung Cheng
Summary: LipidSig is a flexible and user-friendly web server designed to help users identify significant lipid-related features and advance the field of lipid biology through efficient data analysis and exploration of lipid characteristics.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Oncology
Chun-Chieh Chan, Fang-Hsin Chen, Ya-Yun Hsiao
Summary: The study proposes an algorithm to estimate the relative biological effectiveness (RBE) of proton beams for cell survival under different oxygen conditions, with RBE values varying with linear energy transfer (LET) ranges. The RBE values under severe hypoxia are higher, indicating a greater contribution of direct effects from protons.
Article
Biochemistry & Molecular Biology
Ying-Chieh Lai, Ching-Yi Hsieh, Kuan-Ying Lu, Cheng-Hsuan Sung, Hung-Yao Ho, Mei-Ling Cheng, Albert P. Chen, Shu-Hang Ng, Fang-Hsin Chen, Gigin Lin
Summary: The study utilized a new imaging technique, DNP C-13-MRI, to explore the metabolic effects of radiation on cancer cells and immune cells. The results showed significant changes in glycolytic flux rates in different types of cells after irradiation, suggesting the potential clinical utility of DNP C-13-MRI for future treatments.
Article
Cardiac & Cardiovascular Systems
Shin Iwamoto, Moe Ohashi, Haruki Shirato, Mami Ho, Misti Malone, Kenneth Cavanaugh
Summary: Regulatory approval processes for medical devices in Japan and the United States often require similar clinical trials. The Harmonization by Doing (HBD) program facilitates communication between regulators, academics, and industry, supporting the design and conduct of US/Japanese clinical trials for approval in both countries.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2022)
Article
Oncology
Chun-Chieh Chan, Fang-Hsin Chen, Kuang-Lung Hsueh, Ya-Yun Hsiao
Summary: This study calculates the relative biological effectiveness (RBE) and oxygen enhancement ratio (OER) for DNA double-strand break (DSB) induction and cell survival under hypoxic conditions for Grenz-ray therapy (GT). The results show that GT can cause more DSB induction and effectively control superficial and hypoxic tumors.
Article
Cardiac & Cardiovascular Systems
Ryo Inuzuka, Hisateru Tachimori, Sung-Hae Kim, Hikoro Matsui, Tohru Kobayashi, Atsuko Kato, Takanari Fujii, Mami Ho, Hanako Morikawa, Sara Takahashi, Haruki Shirato, Yuji Haishima, Yoshihiro Okamoto, Hideyuki Sakoda, Hideshi Tomita
Summary: This study revealed differences in patient background between static and pull-through BAS, as well as a higher incidence of adverse events related to static BAS. Patients weighing <3 kg are at high risk for adverse events after static BAS.
CIRCULATION JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Jeffrey Yung-chuan Chao, Hsin-Chuan Chang, Jeng-Kai Jiang, Chih-Yung Yang, Fang-Hsin Chen, Yo-Liang Lai, Wen -Jen Lin, Chia-Yang Li, Shu-Chi Wang, Muh-Hwa Yang, Yu-Feng Lin, Wei-Chung Cheng
Summary: This study identified CRC driver genes and prognostic genes through bioinformatics analysis of sequencing profiles and verified their presence in Taiwanese CRC patients, showing potential for early cancer detection and prognosis assessment.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)