Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer

Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells

(2014) Tiffany A. Katz et al.   BREAST CANCER RESEARCH AND TREATMENT

JARID1B Is a Luminal Lineage-Driving Oncogene in Breast Cancer

(2014) Shoji Yamamoto et al.   CANCER CELL

A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36

(2014) Zhongjun Cheng et al.   GENES & DEVELOPMENT

Interactions between JARID2 and Noncoding RNAs Regulate PRC2 Recruitment to Chromatin

(2014) Syuzo Kaneko et al.   MOLECULAR CELL

An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer

(2014) Michael L Gatza et al.   NATURE GENETICS

Integrated Genomic and Epigenomic Analysis of Breast Cancer Brain Metastasis

(2014) Bodour Salhia et al.   PLoS One

Mammalian Lysine Histone Demethylase KDM2A Regulates E2F1-Mediated Gene Transcription in Breast Cancer Cells

(2014) Wasia Rizwani et al.   PLoS One

Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer

(2014) Yufeng Huang et al.   TUMOR BIOLOGY

The roles of Jumonji-type oxygenases in human disease

(2014) Catrine Johansson et al.   Epigenomics

Mutations in EGFR, BRAF and RAS are rare in triple-negative and basal-like breast cancers from Caucasian women

(2013) E. Tilch et al.   BREAST CANCER RESEARCH AND TREATMENT

Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes

(2013) Aleix Prat et al.   BREAST CANCER RESEARCH AND TREATMENT

Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis

(2013) Y.-C. Teng et al.   CANCER RESEARCH

Genetic Ablation of the Fatty Acid-Binding Protein FABP5 Suppresses HER2-Induced Mammary Tumorigenesis

(2013) L. Levi et al.   CANCER RESEARCH

KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells

(2013) W. L. Berry et al.   CANCER RESEARCH

KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors

(2013) Joshua C. Black et al.   CELL

Kdm4b Histone Demethylase Is a DNA Damage Response Protein and Confers a Survival Advantage following γ-Irradiation

(2013) Leah C. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling

(2013) Klaus W. Wagner et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional regulation by Polycomb group proteins

(2013) Luciano Di Croce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Misregulation of Pre-mRNA Alternative Splicing in Cancer

(2013) J. Zhang et al.   Cancer Discovery

The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression

(2012) Leah C. Young et al.   Biochemistry and Cell Biology

Polycomb Protein EZH2 Regulates Tumor Invasion via the Transcriptional Repression of the Metastasis Suppressor RKIP in Breast and Prostate Cancer

(2012) G. Ren et al.   CANCER RESEARCH

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

The UCSC Cancer Genomics Browser: update 2013

(2012) Mary Goldman et al.   NUCLEIC ACIDS RESEARCH

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

(2012) W. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Histone Demethylase JMJD2B Functions as a Co-Factor of Estrogen Receptor in Breast Cancer Proliferation and Mammary Gland Development

(2011) Masahito Kawazu et al.   PLoS One

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

(2011) W. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis

(2011) L. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cooperative Epigenetic Modulation by Cancer Amplicon Genes

(2010) Lixin Rui et al.   CANCER CELL

The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor   and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth

(2010) J. Yang et al.   CANCER RESEARCH

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

Human LSD2/KDM1b/AOF1 Regulates Gene Transcription by Modulating Intragenic H3K4me2 Methylation

(2010) Rui Fang et al.   MOLECULAR CELL

CpG Islands Recruit a Histone H3 Lysine 36 Demethylase

(2010) Neil P. Blackledge et al.   MOLECULAR CELL

PIK3CA and PIK3CB Inhibition Produce Synthetic Lethality when Combined with Estrogen Deprivation in Estrogen Receptor-Positive Breast Cancer

(2009) R. J. Crowder et al.   CANCER RESEARCH

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

(2009) Paul A Northcott et al.   NATURE GENETICS

Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer

(2009) G Liu et al.   ONCOGENE

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NF B

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of NF- B by NSD1/FBXL11-dependent reversible lysine methylation of p65

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucosa-Associated Lymphoid Tissue Lymphoma: Novel Translocations Including Rearrangements of ODZ2, JMJD2C, and CNN3

(2008) U. Vinatzer et al.   CLINICAL CANCER RESEARCH