Article
Pharmacology & Pharmacy
Yuhan Cao, Meng Liu, Shouyan Wu, Junjiu Xu, Wenjie Wang, Xinming Qi, Jin Ren, Jianhua Sun, Jing Chen, Likun Gong
Summary: This study reveals the role of Kupffer cells (KCs) in monocrotaline (MCT)-induced liver injury. By depleting KCs and administering anti-TNF-alpha antibody, researchers found that KCs depletion can reduce liver injury and lower TNF-alpha levels. Further investigation revealed that KCs can induce hepatocyte necrosis by activating the RIPK3/MLKL pathway. Additionally, ER stress and NF-kappa B pathways were also found to be involved in KCs activation.
Article
Environmental Sciences
Jia-Xiang Zhang, Yi Yang, Hua Huang, Hai-Bo Xie, Meng Huang, Wei Jiang, Bai-Wang Ding, Qi-Xing Zhu
Summary: This study aimed to investigate the role of TNF-alpha and its receptors in regulating Kupffer cell polarization and downstream inflammation pathways during TCE sensitization, in order to clarify the mechanism of TCE-mediated immune liver injury. The results showed that TCE sensitization led to exacerbated liver injury, activation and polarization of M1 type Kupffer cells, increased expression of TNF-alpha and its receptors, and upregulation of downstream inflammatory factors. Inhibition of TNF-alpha/TNER1 pathway with R7050 reduced M1 Kupffer cell polarization, downstream signaling pathway activation, and inflammatory factor secretion, alleviating liver damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Immunology
Jing Zhao, Hyuneui Jeong, Daram Yang, Weishun Tian, Jong-Won Kim, Chae Woong Lim, Bumseok Kim
Summary: TLR7 plays a critical role in ConA-induced liver injury, and its deficiency attenuates liver damage and reduces the release of hepatic pro-inflammatory cytokines. TLR7 deficiency also inhibits the proliferation of CD4+ T cells stimulated by ConA and specifically suppresses the expression of TNF-alpha in liver Kupffer cells. Depletion of Kupffer cells abolishes the detrimental role of TLR7 in ConA-induced liver injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Liam M. Casey, Kevin R. Hughes, Michael N. Saunders, Stephen D. Miller, Ryan M. Pearson, Lonnie D. Shea
Summary: The delivery of disease-relevant antigens by polymeric nanoparticles has shown to induce immune tolerance in various disorders. This study investigated the contribution of liver sinusoidal endothelial cells and Kupffer cells in nanoparticle-induced tolerance in a mouse model of multiple sclerosis. The results suggest that both cell types play important roles in the induction of tolerance through the secretion of specific factors and interaction with CD4 T cells. This mechanistic support provides insights for the development of biomaterial platforms in clinical trials.
Review
Immunology
Yuhao Chen, Lihong Yang, Xihong Li
Summary: This review discusses the mechanisms and signaling pathways involved in the modulation of macrophage polarization by mesenchymal stem cells (MSCs), providing innovative directions for the treatment of sepsis-induced liver injury.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qin Zhang, Jiayi Wei, Zhuanhua Liu, Xiaoxia Huang, Maomao Sun, Wujiang Lai, Zhenfeng Chen, Jie Wu, Yanjia Chen, Xiaohua Guo, Qiaobing Huang
Summary: This study demonstrated the important role of STING signaling in septic liver injury, with significant effects on liver function protection and attenuation of systemic inflammatory response. In addition, STING signaling activation resulted in LPS-induced liver injury through promoting hepatocyte death. Release of mitochondrial DNA (mtDNA) was identified as one of the mechanisms for STING signaling activation.
Review
Immunology
Weiyang Li, Na Chang, Liying Li
Summary: Kupffer cells are key regulators of liver immunity, maintaining homeostasis and playing central roles in acute and chronic liver injury. Understanding their heterogeneity and functions may provide opportunities for liver injury therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hongyan Pei, Zhongmei He, Rui Du, Chenyang Han, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Chenxi Cao, Jian Sheng, Xiaoguang Wang
Summary: This study investigates the mechanism of liver injury induced by the environmental poison imidacloprid (IMI). The results show that IMI induces pyroptosis in liver Kupffer cells and this effect is suppressed by P2X7 inhibition. Animal experiments also demonstrate that both P2X7 inhibitor and pyroptosis inhibitor can reduce cell injury level.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Moonmun Dhara, Raja Majumder, Lopamudra Adhikari
Summary: The study confirmed the hepatoprotective and antioxidant efficacy of Heliconia rostrata rhizome extracts, with safety established through toxicity studies. The results demonstrated significant hepatoprotective potency of the extracts, indicating their potential therapeutic uses.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Cell Biology
Weixiong Zheng, Lingxiang Yang, Shiming Jiang, Mingxiang Chen, Jinzheng Li, Zuojing Liu, Zhongjun Wu, Jianping Gong, Yong Chen
Summary: Liver transplantation is a effective treatment for end-stage liver disease and significantly prolongs the survival time of patients, but acute and chronic rejection still remain major obstacles. Investigating induced immune tolerance is of crucial theoretical significance and socio-economic value. This paper comprehensively summarizes the important roles of Kupffer cells in establishing immune tolerance after transplantation, including phagocytosis, cell polarization, antigen presentation, and cell membrane proteins, providing a theoretical basis for further study and clinical application of Kupffer cells in liver transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Medicinal
Xiaolong Gu, Limei Zhang, Weixing Sun, Kai Liu, Hui Xu, Peng Wu, Mingying Gui, Weijie Qu
Summary: This study investigates the effect of autophagy on alpha-amanitin-induced apoptosis in Hepa1-6 liver cells. The results show that autophagy can promote apoptosis in alpha-amanitin-induced Hepa1-6 cells, independent of ROS levels.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Y. Chen, C. J. Ding, L. Q. Tang, Y. Z. Chen, J. D. Chen, Y. Li, H. S. Tong
Summary: Inhibiting TREM-1 of KCs improved severe HS-induced liver injury by regulating the imbalance of expressions in the TREMs/DAP12 pathway, reducing hepatocyte apoptosis and ameliorating pathological changes in the liver.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Environmental Sciences
Chenyang Han, Hongyan Pei, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Li Guo, Yun Kong, Yi Yang
Summary: In this study, it was found that triptolide (TRI) induces liver injury primarily through the Caspase-3-GSDME pyroptosis signal. TRI can promote Caspase-3 maturation and regulate kupffer cell pyroptosis. These findings provide a new perspective for the safe use of TRI.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Multidisciplinary
Kun Lu, Shipeng Dong, Tian Xia, Liang Mao
Summary: The study revealed that few-layer graphene primarily accumulated in the liver of mice, while larger graphene could be degraded into (CO2)-C-14 by Kupffer cells, possibly facilitated by hydroxyl radicals generated through a series of mechanisms.
Article
Multidisciplinary Sciences
Hye-Young Seo, So-Hee Lee, Ji Yeon Park, Eugene Han, Sol Han, Jae Seok Hwang, Mi Kyung Kim, Byoung Kuk Jang
Summary: This study demonstrates the potential of lobeglitazone in inhibiting liver inflammation and fibrosis by reducing NLRP3 inflammasome activation and production of proinflammatory cytokines.
Article
Gastroenterology & Hepatology
Yuan Fang, Yizhi Zhan, Yuwen Xie, Shisuo Du, Yuhan Chen, Zhaochong Zeng, Yaowei Zhang, Keli Chen, Yongjia Wang, Li Liang, Yi Ding, Dehua Wu
Summary: The study identified a link between radiation resistance and metabolic reprogramming in hepatocellular carcinoma (HCC). By targeting metabolic pathways, potential combination approaches for radiotherapy in HCC were suggested. Activation of glucose metabolism predicted poor response to radiotherapy in cancer patients.
Article
Oncology
Shi-Suo Du, Gen-Wen Chen, Ping Yang, Yi-Xing Chen, Yong Hu, Qian-Qian Zhao, Yang Zhang, Rong Liu, Dan-Xue Zheng, Jian Zhou, Jia Fan, Zhao-Chong Zeng
Summary: This study identified an immune-cloaking mechanism induced by radiation therapy (RT) and revealed the crucial role of the cGAS-STING pathway in this process. RT increased the expression of PD-L1 in liver cancer cells, inhibiting the activity of T cells and protecting tumor cells from immune clearance. The study also found that RT enhanced the antitumor effect of PD-L1 axis blockade and increased immune cell infiltration.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Gastroenterology & Hepatology
Hao Niu, Li Zhang, Biao Wang, Guang-Cong Zhang, Juan Liu, Zhi-Feng Wu, Shi-Suo Du, Zhao-Chong Zeng
Summary: The study reveals the mechanism and role of circTUBD1 in radiation-induced liver fibrosis (RILF) through a circTUBD1/ micro-203a-3p/Smad3 positive feedback loop, providing a novel therapeutic strategy for relieving RILF progression.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Oncology
Qi-Qiao Wu, Yi-Xing Chen, Shi-Suo Du, Yong Hu, Ping Yang, Jing Sun, Xin-Yue Wang, Wei-Xun Wu, Shu-Min Zhang, Zhao-Chong Zeng
Summary: This study evaluates the impact of dosimetric parameters on intrahepatic outfield recurrence and distant metastasis-free survival in patients with hepatocellular carcinoma (HCC) treated with stereotactic body radiation therapy (SBRT). The results suggest that higher dose received by the normal liver is associated with better intrahepatic out-field recurrence-free survival rate.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Zongjuan Li, Yang Zhang, Weifeng Hong, Biao Wang, Yixing Chen, Ping Yang, Jian Zhou, Jia Fan, Zhaochong Zeng, Shisuo Du
Summary: This study investigates the role of the gut microbiome in regulating response to radiotherapy in hepatocellular carcinoma (HCC) patients. The study found that dysbiosis of the gut microbiome impairs the antitumor immune response and leads to variations in the effectiveness of radiotherapy. The cGAS-STING-IFN-I pathway was identified as a key mechanism in this process. The study proposes cyclic-di-AMP as a potential target for modulating response to radiotherapy in HCC patients.
Article
Oncology
Yang Zhang, Zongjuan Li, Yixing Chen, Ping Yang, Yong Hu, Zhaochong Zeng, Shisuo Du
Summary: This study validates the upregulation of PD-L1 in tumor tissues after radiotherapy (RT) and demonstrates that higher post-RT serum sPD-L1 is associated with poor prognosis in hepatocellular carcinoma (HCC) patients. Additionally, patients with higher rate of sPD-L1 increase after RT show better treatment response and longer survival.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Bu-Fu Tang, Ruo-Chen Yan, Si-Wei Wang, Zhao -Chong Zeng, Shi-Suo Du
Summary: Maternal embryonic leucine zipper kinase (MELK) is a member of the AMPK protein family and is highly expressed in various cancers. It plays an important role in regulating tumor cell functions and the tumor microenvironment. Targeting MELK has shown promising results in anti-tumor therapy.
Article
Cardiac & Cardiovascular Systems
Wei Luo, Xiaoyi Zou, Yidan Wang, Zheng Dong, Xinyu Weng, Zhiqiang Pei, Shuai Song, Yongchao Zhao, Zilun Wei, Rifeng Gao, Beijian Zhang, Liwei Liu, Peiyuan Bai, Jin Liu, Xiang Wang, Tingwen Gao, Yang Zhang, Xiaolei Sun, Hang Chen, Kai Hu, Shisuo Du, Aijun Sun, Junbo Ge
Summary: The cardiac EC cGAS-STING pathway plays a critical role in doxorubicin-induced cardiotoxicity by reducing NAD levels and causing mitochondrial dysfunction. Targeting this pathway could be a potential therapeutic strategy for preventing cardiotoxicity.
CIRCULATION RESEARCH
(2023)
Article
Oncology
Xiaomei Zhao, Biao Wang, Yuan Zhuang, Shisuo Du, Zhaochong Zeng
Summary: This study investigates the immunomodulatory effects of different dose-fractionation schedules and finds that a single high-dose radiation schedule has a stronger antitumor effect. The study also reveals the involvement of the cGAS/STING signaling pathway in the immunomodulatory effects of single high-dose radiation.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Yang Zhang, Zongjuan Li, Weifeng Hong, Shujung Hsu, Biao Wang, Zhaochong Zeng, Shisuo Du
Summary: This study found that the cGAS-STING pathway is significantly upregulated after radiation therapy and plays a crucial role in radiation-induced lung injury. The study also discovered the key roles of NLRP3 and pyroptosis in the inflammatory response induced by radiation therapy. Moreover, Pulmozyme was shown to potentially mitigate RILI by degrading dsDNA and inhibiting the cGAS-STING-NLRP3 signaling pathway.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Shaonan Fan, Qi Zhang, Jingyao Chen, Gang Chen, Jiangyi Zhu, Tingting Li, Han Xiao, Shisuo Du, Zhaochong Zeng, Jian He
Summary: A comparative study on stereotactic body radiotherapy via helical tomotherapy (HT-SBRT) for early-stage lung cancer patients with or without a pathological diagnosis found that empirical SBRT is a safe and effective treatment option in a multidisciplinary setting when patients with suspicious solitary pulmonary nodules (SPNs) are unable or refuse to obtain a definitive pathological diagnosis.
RADIATION ONCOLOGY
(2023)
Article
Oncology
Qi-Qiao Wu, Yi-Xing Chen, Shi-Suo Du, Yong Hu, Ping Yang, Zhao-Chong Zeng
Summary: This study evaluated the different response patterns after Stereotactic Body Radiation Therapy (SBRT) and their predictive value in local control and progression of hepatocellular carcinoma (HCC). The results showed that early complete tumor response within 6 months after radiotherapy predicted better intrahepatic outfield-free survival, distant metastasis-free survival, and overall survival outcomes. This finding is important for guiding decision making.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yi-Xing Chen, Ping Yang, Shi-Suo Du, Yuan Zhuang, Cheng Huang, Yong Hu, Wen-Chao Zhu, Yi-Yi Yu, Tian-Shu Liu, Zhao-Chong Zeng
Summary: This study evaluated the efficacy of combining SBRT with sintilimab in the treatment of patients with recurrent or oligometastatic HCC. The results showed that the combination therapy was effective and well-tolerated.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Lili Wu, Yaolin Xu, Yuhong Zhou, Zhaochong Zeng, Yue Fan, Dansong Wang, Wenchuan Wu, Xi Guo, Minzhi Lv, Yuxiu Ouyang, Shisuo Du, Wenhui Lou
Summary: This retrospective study examined the role of adjuvant radiation therapy (RT) after radical resection of pancreatic ductal adenocarcinoma (PDAC) and found that it did not result in an overall survival (OS) benefit for all patients. However, a potential OS benefit was observed in the subgroup of patients with T4N2 disease or R1 resection who survived for more than 1 year after surgery.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Wei-feng Hong, Mou-yuan Liu, Li Liang, Yang Zhang, Zong-juan Li, Keqi Han, Shi-suo Du, Yan-jie Chen, Li-heng Ma
Summary: This study identified two subtypes of hepatocellular carcinoma based on the expression of genes related to T cell-mediated tumor killing (TTK). These subtypes showed differences in tumor microenvironment, metabolic properties, and genetic variation, and predicted the response to chemotherapy or immunotherapy and overall survival.
FRONTIERS IN IMMUNOLOGY
(2022)
