Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair

Molecular pathogenesis of endometrial and ovarian cancer

(2017) Melissa A. Merritt et al.   Cancer Biomarkers

The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses

(2015) Bipasha Mukherjee et al.   NEOPLASIA

Therapeutic Targeting of Cancers with Loss of PTEN Function

(2014) Lloye Dillon et al.   CURRENT DRUG TARGETS

Activation of PI3K/Akt/mTOR Pathway and Dual Inhibitors of PI3K and mTOR in Endometrial Cancer

(2014) Jiezhong Chen et al.   CURRENT MEDICINAL CHEMISTRY

The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers

(2014) Arindam Paul   Frontiers in Bioscience-Landmark

BRCA1 And Estrogen/Estrogen Receptor In Breast Cancer: Where They Interact?

(2014) Li Wang et al.   International Journal of Biological Sciences

p53 Requires the Stress Sensor USF1 to Direct Appropriate Cell Fate Decision

(2014) Amine Bouafia et al.   PLoS Genetics

Link between PI3K/AKT/PTEN Pathway and NOX Protein in Diseases

(2014) Atsuko Nakanishi   Aging and Disease

BRCA and Early Events in the Development of Serous Ovarian Cancer

(2014) Sophia H. L. George et al.   Frontiers in Oncology

Differential regulation of cyclin-dependent kinase inhibitors in neuroblastoma cells

(2013) Lan Qiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PTEN sumo-wrestles human RAD52 to mystery land

(2013) Zhiyuan Shen   CELL CYCLE

Oral Contraceptives and Risk of Ovarian Cancer and Breast Cancer Among High-Risk Women: A Systematic Review and Meta-Analysis

(2013) Patricia G. Moorman et al.   JOURNAL OF CLINICAL ONCOLOGY

Cowden Syndrome and the PTEN Hamartoma Tumor Syndrome: Systematic Review and Revised Diagnostic Criteria

(2013) R. Pilarski et al.   JNCI-Journal of the National Cancer Institute

PD-1 Increases PTEN Phosphatase Activity While Decreasing PTEN Protein Stability by Inhibiting Casein Kinase 2

(2013) Nikolaos Patsoukis et al.   MOLECULAR AND CELLULAR BIOLOGY

Combination of liquiritin, isoliquiritin and isoliquirigenin induce apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells

(2013) YANLING ZHOU et al.   ONCOLOGY REPORTS

BRCA1 and p53 regulate critical prostate cancer pathways

(2013) P De Luca et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Dual inhibitor of phosphoinositide 3-kinase/mammalian target of rapamycin NVP-BEZ235 effectively inhibits cisplatin-resistant urothelial cancer cell growth through autophagic flux

(2013) Jian-ri Li et al.   TOXICOLOGY LETTERS

DNA Damage Response: Three Levels of DNA Repair Regulation

(2013) B. M. Sirbu et al.   Cold Spring Harbor Perspectives in Biology

New insights into PTEN regulation mechanisms and its potential function in targeted therapies

(2012) Peng Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

PTEN in DNA damage repair

(2012) Mei Ming et al.   CANCER LETTERS

Post-Translational Modifications of PTEN and their Potential Therapeutic Implications

(2012) G. Singh et al.   CURRENT CANCER DRUG TARGETS

Inhibition of constitutively activated phosphoinositide 3-kinase/AKT pathway enhances antitumor activity of chemotherapeutic agents in breast cancer susceptibility gene 1-defective breast cancer cells

(2012) Yong Weon Yi et al.   MOLECULAR CARCINOGENESIS

High-grade serous ovarian cancer arises from fallopian tube in a mouse model

(2012) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site

(2012) H J Kang et al.   Cell Death & Disease

Evolutionary Pathways in BRCA1-Associated Breast Tumors

(2012) Filipe C. Martins et al.   Cancer Discovery

Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability

(2012) Naihan Xu et al.   Journal of Oncology

STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1

(2012) Serena L. Clark et al.   Computational and Structural Biotechnology Journal

Mitochondrial ROS generation for regulation of autophagic pathways in cancer

(2011) Zi-yue Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

(2011) D. Blazek et al.   GENES & DEVELOPMENT

Prognostic Impact of Concomitant p53 and PTEN on Outcome in Early Stage (FIGO I-II) Epithelial Ovarian Cancer

(2011) Ingirídur Skírnisdóttir et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

IKBKE Protein Activates Akt Independent of Phosphatidylinositol 3-Kinase/PDK1/mTORC2 and the Pleckstrin Homology Domain to Sustain Malignant Transformation

(2011) Jian-Ping Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential requirements for c-Myc in chronic hematopoietic hyperplasia and acute hematopoietic malignancies in Pten-null mice

(2011) J Zhang et al.   LEUKEMIA

Targeting the Akt/mTOR pathway in Brca1-deficient cancers

(2011) T Xiang et al.   ONCOGENE

Lycopene Inhibits NF-kB-Mediated IL-8 Expression and Changes Redox and PPARγ Signalling in Cigarette Smoke–Stimulated Macrophages

(2011) Rossella E. Simone et al.   PLoS One

Suppression of leukemia development caused by PTEN loss

(2011) W. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Agents and Future Directions for Refractory Breast Cancer

(2011) Harold J. Burstein   SEMINARS IN ONCOLOGY

BRCA1-IRIS Overexpression Promotes Cisplatin Resistance in Ovarian Cancer Cells

(2010) K. L. Chock et al.   CANCER RESEARCH

BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair

(2010) P. J. O'Donovan et al.   CARCINOGENESIS

Germline BRCA Mutations Denote a Clinicopathologic Subset of Prostate Cancer

(2010) D. J. Gallagher et al.   CLINICAL CANCER RESEARCH

AKT regulates BRCA1 stability in response to hormone signaling

(2010) Andrew C. Nelson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The CHK2–BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells

(2010) Ailine Stolz et al.   NATURE CELL BIOLOGY

The PKB/AKT Pathway in Cancer

(2009) Amancio Carnero   CURRENT PHARMACEUTICAL DESIGN

PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality

(2009) Elena López-Knowles et al.   INTERNATIONAL JOURNAL OF CANCER

Nuclear PTEN levels and G2 progression in melanoma cells

(2009) Abraham I. Jacob et al.   MELANOMA RESEARCH

Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells

(2009) Hui-Fang Li et al.   Radiation Oncology

The PI3K–PTEN tug-of-war, oxidative stress and retinal degeneration

(2009) Kyung Hwa Kang et al.   TRENDS IN MOLECULAR MEDICINE

Negative Regulation of AKT Activation by BRCA1

(2008) T. Xiang et al.   CANCER RESEARCH

The PTEN/PI3K/AKT Signalling Pathway in Cancer, Therapeutic Implications

(2008) Amancio Carnero et al.   CURRENT CANCER DRUG TARGETS

Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium

(2008) J. W. Kim et al.   GENES & DEVELOPMENT

The nuclear affairs of PTEN

(2008) S. M. Planchon et al.   JOURNAL OF CELL SCIENCE

PTEN Nuclear Localization Is Regulated by Oxidative Stress and Mediates p53-Dependent Tumor Suppression

(2008) C.-J. Chang et al.   MOLECULAR AND CELLULAR BIOLOGY

BRCA1—sowing the seeds crooked in the furrow

(2007) William D Foulkes   NATURE GENETICS