Lowering Endogenous Cathepsin D Abundance Results in Reactive Oxygen Species Accumulation and Cell Senescence

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(2014) Juan A Vizcaíno et al.   NATURE BIOTECHNOLOGY

Knockdown of cathepsin D in zebrafish fertilized eggs determines congenital myopathy

(2013) Carlo Follo et al.   BIOSCIENCE REPORTS

Novel Contributions of the Lysosomal Pathway to Autophagy, Neuronal Bioenergetics, Oxidative Stress and Neurodegeneration; the Role of Cathepsin D

(2013) Matthew Redmann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of nuclear factor-erythroid 2–related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence

(2013) Daniela Volonte et al.   MOLECULAR BIOLOGY OF THE CELL

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2

(2012) Guangdong Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells

(2012) Young-Sool Hah et al.   CANCER LETTERS

Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases

(2012) Z. Wang et al.   CARCINOGENESIS

Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain

(2012) Sabine Koch et al.   NEUROBIOLOGY OF DISEASE

Serum Oxidative Stress-Induced Repression of Nrf2 and GSH Depletion: A Mechanism Potentially Involved in Endothelial Dysfunction of Young Smokers

(2012) Anna Fratta Pasini et al.   PLoS One

Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells

(2011) Lin Zheng et al.   Autophagy

Proteomic Evaluation and Validation of Cathepsin D Regulated Proteins in Macrophages Exposed toStreptococcus pneumoniae

(2011) Martin A. Bewley et al.   MOLECULAR & CELLULAR PROTEOMICS

Regulation of apoptosis-associated lysosomal membrane permeabilization

(2010) Ann-Charlotte Johansson et al.   APOPTOSIS

Dysfunctional Nrf2–Keap1 redox signaling in skeletal muscle of the sedentary old

(2010) Adeel Safdar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidation in the nucleotide pool, the DNA damage response and cellular senescence: Defective bricks build a defective house

(2010) Priyamvada Rai   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Cathepsin D Is the Primary Protease for the Generation of Adenohypophyseal Vasoinhibins: Cleavage Occurs within the Prolactin Secretory Granules

(2009) Martha E. Cruz-Soto et al.   ENDOCRINOLOGY

Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†

(2008) Daniel Sevlever et al.   BIOCHEMISTRY

Cathepsin D—Many functions of one aspartic protease

(2008) Petr Benes et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE