Article
Biochemistry & Molecular Biology
Sachi Oshima, Shunichi Asai, Naohiko Seki, Chikashi Minemura, Takashi Kinoshita, Yusuke Goto, Naoko Kikkawa, Shogo Moriya, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa
Summary: The miRNAs miR-31-5p and miR-31-3p play important roles in regulating the oncogenic properties of HNSCC cells, affecting patient prognosis by controlling a series of genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chikashi Minemura, Shunichi Asai, Ayaka Koma, Ikuko Kase-Kato, Nozomi Tanaka, Naoko Kikkawa, Atsushi Kasamatsu, Hidetaka Yokoe, Toyoyuki Hanazawa, Katsuhiro Uzawa, Naohiko Seki
Summary: Our recent study focused on the passenger strand of pre-miR-30e, miR-30e-3p, which was found to be downregulated in cancer tissues. We identified 11 target genes of miR-30e-3p that were highly expressed in head and neck squamous cell carcinoma (HNSCC) patients, and these genes were associated with poor survival rates. Silencing the expression of one of the target genes, SERPINE1, suppressed the malignant phenotypes of HNSCC cells. This study contributes to our understanding of the molecular pathogenesis of HNSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ayaka Koma, Shunichi Asai, Chikashi Minemura, Sachi Oshima, Takashi Kinoshita, Naoko Kikkawa, Keiichi Koshizuka, Shogo Moriya, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa, Naohiko Seki
Summary: The study identified downregulated miR-139 in head and neck squamous cell carcinoma and demonstrated its role in attenuating cancer cell aggressiveness by regulating GNA12 and OLR1 expression, which are associated with patient survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Chikashi Minemura, Shunichi Asai, Ayaka Koma, Naoko Kikkawa, Mayuko Kato, Atsushi Kasamatsu, Katsuhiro Uzawa, Toyoyuki Hanazawa, Naohiko Seki
Summary: Analysis of miRNA expression in head and neck squamous cell carcinoma (HNSCC) revealed downregulation of the miR-30 family, especially miR-30e-5p and miR-30c-1-3p, which are associated with shorter patient survival. Further investigation showed that miR-30e-5p suppresses HNSCC cell migration and controls multiple oncogenic genes, including FOXD1. Knockdown of FOXD1 inhibited malignant phenotypes of HNSCC cells. These findings provide potential prognostic markers and therapeutic targets for HNSCC.
Article
Biochemistry & Molecular Biology
Shunichi Asai, Ayaka Koma, Nijiro Nohata, Takashi Kinoshita, Naoko Kikkawa, Mayuko Kato, Chikashi Minemura, Katsuhiro Uzawa, Toyoyuki Hanazawa, Naohiko Seki
Summary: Based on RNA sequence analysis, the expression of miR-1-3p, miR-206, miR-133a-3p, and miR-133b was found to be suppressed in HNSCC. In silico analysis identified 28 genes that were potentially regulated by these miRNAs and were upregulated in HNSCC tissues. The expression of PFN2 and PSEN1 was found to be independent prognostic factors for HNSCC patients, and miR-1-3p, miR-206, miR-133a-3p, and miR-133b directly controlled PFN2 expression, affecting the migration and invasion abilities of cancer cells.
Article
Oncology
Sanjib Chaudhary, Ramesh Pothuraju, Satyanarayana Rachagani, Jawed A. Siddiqui, Pranita Atri, Kavita Mallya, Mohd W. Nasser, Zafar Sayed, Elizabeth R. Lyden, Lynette Smith, Siddhartha D. Gupta, Ranju Ralhan, Imayavaramban Lakshmanan, Dwight T. Jones, Apar Kishor Ganti, Muzafar A. Macha, Surinder K. Batra
Summary: This study demonstrates that the combination therapy of CDK4/6 and panEGFR inhibitors can significantly reduce tumor growth, induce cellular senescence, and regulate metabolic pathways in HNSCC, suggesting that dual targeting may be a critical therapeutic strategy in blocking tumor progression.
Article
Medicine, Research & Experimental
Qingling Zheng, Jin Zhang, Ting Zhang, Yanxiang Liu, Xiuluan Du, Xin Dai, Donghua Gu
Summary: The study found that hsa_circ_0000520 and CDK2 were highly expressed in cervical cancer tissues, and hsa_circ_0000520 could competitively bind to miR-1296 to affect CDK2 expression, thereby inhibiting cell proliferation and promoting apoptosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Sindhu Nair, James A. Bonner, Markus Bredel
Summary: EGFR is overexpressed in head and neck squamous cell carcinoma and anti-EGFR strategies have shown some clinical benefit but often lead to resistance. Mutations in various domains of the EGFR gene can impact drug binding, radiation response, and overall survival in HNSCC patients. Understanding the EGFR mutational landscape and its effects on treatment resistance can help stratify patients for targeted therapies and maximize therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Nozomi Tanaka, Chikashi Minemura, Shunichi Asai, Naoko Kikkawa, Takashi Kinoshita, Sachi Oshima, Ayaka Koma, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa, Naohiko Seki
Summary: The miR-199 family acts as tumor-suppressive miRNAs in head and neck squamous cell carcinoma by regulating the expression of paxillin (PXN) which contributes to cancer cell aggressiveness.
Article
Medicine, General & Internal
Cheng-Ming Hsu, Hui-Chen Su, Ming-Yu Yang, Yao-Te Tsai, Ming-Shao Tsai, Yao-Hsu Yang, Ching -Yuan Wu, Shun -Fu Chang
Summary: This study aimed to investigate the potential anticancer effects of 6-shogaol, a major ginger derivative, on head and neck squamous cell carcinomas (HNSCCs) and the underlying mechanisms. The results showed that 6-shogaol significantly induced G2/M phase arrest and apoptosis in HNSCC cells, thereby inhibiting tumor cell survival. These responses could be regulated by the ERK1/2 and p38 signaling pathways. Additionally, 6-shogaol was found to enhance the cytotoxicity of cisplatin in HNSCC cells.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Chi Zhang, Hongfei Wang, Miao Deng, Lihong He, Fan Ping, Yuan He, Zhaona Fan, Bin Cheng, Juan Xia
Summary: miR-411-5p plays a crucial role in promoting metastasis in HNSCC by downregulating RYBP expression levels, indicating it as a potential novel target for HNSCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Nadine De Godoy Torso, Julia Coelho Franca Quintanilha, Maria Aparecida Cursino, Eder De Carvalho Pincinato, Pia Loren, Luis A. Salazar, Carmen Silvia Passos Lima, Patricia Moriel
Summary: The use of miRNAs as renal biomarkers shows promise for evaluating cisplatin-induced nephrotoxicity.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Xueping Wang, Xiaoyuan Zhu, Yulin Zhao
Summary: The study reveals that exosomal miR-185-3p promotes tumor growth by mediating RAB25, which can be effectively targeted for HNSCC treatment. Targeting miR-185-3p/RAB25 significantly inhibits tumor growth and enhances drug response to chemotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biology
Mario Dioguardi, Francesca Spirito, Diego Sovereto, Lucia La Femina, Alessandra Campobasso, Angela Pia Cazzolla, Michele Di Cosola, Khrystyna Zhurakivska, Stefania Cantore, Andrea Ballini, Lorenzo Lo Muzio, Giuseppe Troiano
Summary: Head and neck squamous cell carcinoma (HNSCC) is a common and challenging cancer with poor prognosis. Deregulation of non-coding RNAs, particularly miR-155, has been associated with HNSCC survival. This systematic review and meta-analysis provide the most up-to-date data on miR-155 expression and its correlation with prognostic indices in HNSCC.
Article
Oncology
Chengzhi Xu, Yunbin Zhang, Yupeng Shen, Yong Shi, Ming Zhang, Liang Zhou
Summary: This study identified ENDOU as a biomarker with prognostic significance in HNSCC progression. Overexpression of ENDOU inhibited proliferation and migration of FaDu and Cal-27 cells, indicating its tumor-suppressing role in HNSCC progression. GSEA analysis revealed ENDOU downstream pathways such as DNA replication, mismatch repair, cell cycle, and IL-17 signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zhiyong Wang, Xiaodong Feng, Alfredo A. Molinolo, Daniel Martin, Lynn Vitale-Cross, Nijiro Nohata, Mizuo Ando, Amy Wahba, Panomwat Amornphimoltham, Xingyu Wu, Mara Gilardi, Michael Allevato, Victoria Wu, Dana J. Steffen, Philip Tofilon, Nahum Sonenberg, Joseph Califano, Qianming Chen, Scott M. Lippman, J. Silvio Gutkind
Article
Oncology
Damiano Cosimo Rigiracciolo, Maria Francesca Santolla, Rosamaria Lappano, Adele Vivacqua, Francesca Cirillo, Giulia Raffaella Galli, Marianna Talia, Lucia Muglia, Michele Pellegrino, Nijiro Nohata, Maria Teresa Di Martino, Marcello Maggiolini
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Hiroko Toda, Naohiko Seki, Sasagu Kurozumi, Yoshiaki Shinden, Yasutaka Yamada, Nijiro Nohata, Shogo Moriya, Tetsuya Idichi, Kosei Maemura, Takaaki Fujii, Jun Horiguchi, Yuko Kijima, Shoji Natsugoe
MOLECULAR ONCOLOGY
(2020)
Article
Oncology
Yasutaka Yamada, Nijiro Nohata, Akifumi Uchida, Mayuko Kato, Takayuki Arai, Shogo Moriya, Keiko Mizuno, Satoko Kojima, Kazuto Yamazaki, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki
Article
Oncology
Hirofumi Yoshino, Hideki Enokida, Yoichi Osako, Nijiro Nohata, Masaya Yonemori, Satoshi Sugita, Kazuki Kuroshima, Masafumi Tsuruda, Shuichi Tatarano, Masayuki Nakagawa
MOLECULAR ONCOLOGY
(2020)
Article
Cell Biology
Damiano Cosimo Rigiracciolo, Nijiro Nohata, Rosamaria Lappano, Francesca Cirillo, Marianna Talia, Domenica Scordamaglia, J. Silvio Gutkind, Marcello Maggiolini
Article
Cell Biology
Keiko Mizuno, Kengo Tanigawa, Nijiro Nohata, Shunsuke Misono, Reona Okada, Shunichi Asai, Shogo Moriya, Takayuki Suetsugu, Hiromasa Inoue, Naohiko Seki
Article
Oncology
Shunsuke Misono, Keiko Mizuno, Takayuki Suetsugu, Kengo Tanigawa, Nijiro Nohata, Akifumi Uchida, Hiroki Sanada, Reona Okada, Shogo Moriya, Hiromasa Inoue, Naohiko Seki
Summary: Small cell lung cancer (SCLC) is a fatal tumor with poor prognosis in patients who relapse after initial treatment. This study identified a molecular signature of SCLC after treatment failure, focusing on genes related to the cell cycle pathway. The overexpression of MCM2, MCM4, MCM6, and MCM7 was detected in SCLC clinical specimens, suggesting their potential as therapeutic targets. Knockdown of these MCM genes attenuated cancer cell proliferation and enhanced cisplatin sensitivity in SCLC cells, indicating their role in treatment resistance.
Article
Oncology
Damiano Cosimo Rigiracciolo, Nijiro Nohata, Rosamaria Lappano, Francesca Cirillo, Marianna Talia, Sendi Rafael Adame-Garcia, Nadia Arang, Simone Lubrano, Ernestina Marianna De Francesco, Antonino Belfiore, J. Silvio Gutkind, Marcello Maggiolini
Summary: This study aimed to explore the function of the S100A8/A9-RAGE system in TNBC. The results showed that S100A8 and S100A9 were highly expressed in BC, particularly in HER2-positive and TNBC, and were associated with poor clinical outcomes. High RAGE expression was also correlated with poor overall survival in BC patients. The study further revealed that the S100A8/A9-RAGE system triggers FAK activation by engaging a cytoskeleton mechanosensing complex in TNBC cells, and identified the Hippo pathway as the most enriched in BC patients expressing high RAGE levels. The findings suggest that the RAGE-FAK-YAP transduction pathway could be a potential target for halting the aggressive TNBC subtype.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shunichi Asai, Ayaka Koma, Nijiro Nohata, Takashi Kinoshita, Naoko Kikkawa, Mayuko Kato, Chikashi Minemura, Katsuhiro Uzawa, Toyoyuki Hanazawa, Naohiko Seki
Summary: Based on RNA sequence analysis, the expression of miR-1-3p, miR-206, miR-133a-3p, and miR-133b was found to be suppressed in HNSCC. In silico analysis identified 28 genes that were potentially regulated by these miRNAs and were upregulated in HNSCC tissues. The expression of PFN2 and PSEN1 was found to be independent prognostic factors for HNSCC patients, and miR-1-3p, miR-206, miR-133a-3p, and miR-133b directly controlled PFN2 expression, affecting the migration and invasion abilities of cancer cells.
Article
Biochemistry & Molecular Biology
Tomoaki Saito, Shunichi Asai, Nozomi Tanaka, Nijiro Nohata, Chikashi Minemura, Ayaka Koma, Naoko Kikkawa, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa, Naohiko Seki
Summary: This study utilized ChIP-Seq to analyze active enhancers and identified genes associated with drug resistance and prognosis in oral squamous cell carcinoma, providing crucial genetic information for improving treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Shunji Takahashi, Nobuhiko Oridate, Kaoru Tanaka, Yasushi Shimizu, Yasushi Fujimoto, Koji Matsumoto, Tomoya Yokota, Tomoko Yamazaki, Masanobu Takahashi, Tsutomu Ueda, Nobuhiro Hanai, Hironori Yamaguchi, Hiroki Hara, Tomokazu Yoshizaki, Ryuji Yasumatsu, Masahiro Nakayama, Kiyoto Shiga, Takashi Fujii, Kenji Mitsugi, Kenichi Takahashi, Nijiro Nohata, Burak Gumuscu, Ramona F. Swaby, Makato Tahara
Summary: The study reports the efficacy of pembrolizumab in Japanese patients with R/M HNSCC, suggesting it as a first-line treatment option. Treatment-related adverse events occurred at a relatively high rate, but the overall safety profile was acceptable.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Alimasi Aersilan, Naoko Hashimoto, Kazuyuki Yamagata, Masataka Yokoyama, Akitoshi Nakayama, Xiaoyan Shi, Hidekazu Nagano, Ikki Sakuma, Nijiro Nohata, Takashi Kinoshita, Naohiko Seki, Bahityar Rahmutulla, Atsushi Kaneda, Siti Nurul Zhahara, Yingbo Gong, Motoi Nishimura, Shoichiro Kawauchi, Eiryo Kawakami, Tomoaki Tanaka
Summary: The microRNA miR-874 acts as a potential tumor suppressor by suppressing target genes in various cancer types. This study reveals the relationship between miR-874-induced apoptosis and the mevalonate pathway, as well as its association with the tumor suppressor p53. The findings suggest that miR-874 suppresses the mevalonate pathway by targeting SREBF2 and PMVK, leading to the activation of the p53 pathway and promoting cell cycle arrest or apoptosis.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Raphaelly Venzel, Maria Clara Paulino Campos, Larissa Pessoa de Oliveira, Rodrigo Vasquez Dan Lins, Adamo Davi Diogenes Siena, Kim Tavares Mesquita, Talita Pollyana Moreira dos Santos, Nijiro Nohata, Lucas Coelho Marliere Arruda, Helioswilton Sales-Campos, Marinaldo Pacifico Cavalcanti Neto
Summary: Traditional therapeutic approaches for malignant melanoma have limitations and ineffectiveness in improving patient survival and tumor recurrence. Immunotherapy, as a promising alternative, modulates cell signaling pathways involved in the immune system's effector mechanisms, known as immunological checkpoints, to boost antitumor responses. Clinical studies on immunotherapeutic regimens have shown encouraging results in recent decades. This review discusses current immunotherapeutic regimens, molecular and cellular mechanisms, and clinical studies of immunotherapy in melanoma.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Genetics & Heredity
Yoshiaki Shinden, Tadahiro Hirashima, Nijiro Nohata, Hiroko Toda, Reona Okada, Shunichi Asai, Takako Tanaka, Yuto Hozaka, Takao Ohtsuka, Yuko Kijima, Naohiko Seki
Summary: Our recent research identified certain passenger strands of miRNAs that function as tumor-suppressive miRNAs in cancer cells, and analyzed the miRNA expression signature of breast cancer (BrCa) to identify oncogenic genes controlled by pre-miR-99a. The study revealed FAM64A as a potential target and highlighted the importance of aberrant expression of FAM64A in the malignant transformation of BrCa.
JOURNAL OF HUMAN GENETICS
(2021)