The Role of Stroma in Cholangiocarcinoma: The Intriguing Interplay between Fibroblastic Component, Immune Cell Subsets and Tumor Epithelium

The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma

(2018) Massimiliano Cadamuro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

In VivoStudy of Natural Killer (NK) Cell Cytotoxicity Against Cholangiocarcinoma in a Nude Mouse Model

(2018) IN HYE JUNG et al.   IN VIVO

Tumor‑associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells

(2018) Jiehong Zeng et al.   Oncology Letters

Novel targeted treatment options for advanced cholangiocarcinoma

(2018) Amit Mahipal et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Characterisation of the immune-related transcriptome in resected biliary tract cancers

(2017) Michele Ghidini et al.   EUROPEAN JOURNAL OF CANCER

Cholangiocarcinoma: Current Knowledge and New Developments

(2017) Boris Blechacz   Gut and Liver

Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma

(2017) Massimiliano Cadamuro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Angiotensin receptor blocker telmisartan inhibits cell proliferation and tumor growth of cholangiocarcinoma through cell cycle arrest

(2017) Eri Samukawa et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages

(2017) Chiara Raggi et al.   JOURNAL OF HEPATOLOGY

Clonorchis sinensis lysophospholipase A upregulates IL-25 expression in macrophages as a potential pathway to liver fibrosis

(2017) Lina Zhou et al.   Parasites & Vectors

Secreted phospholipase A2 of Clonorchis sinensis activates hepatic stellate cells through a pathway involving JNK signalling

(2017) Yinjuan Wu et al.   Parasites & Vectors

A single-center experience of sorafenib monotherapy in patients with advanced intrahepatic cholangiocarcinoma

(2017) Ting-Ting Pan et al.   Oncology Letters

Tumor necrosis and infiltrating macrophages predict survival after curative resection for cholangiocarcinoma

(2017) Georgi Atanasov et al.   OncoImmunology

The roles of Toll-like receptor 4 in the pathogenesis of pathogen-associated biliary fibrosis caused by Clonorchis sinensis

(2017) Chao Yan et al.   Scientific Reports

Role of chemokine pathways in hepatobiliary cancer

(2016) Josef Ehling et al.   CANCER LETTERS

Clonorchiasis

(2016) Men-Bao Qian et al.   LANCET

Prognostic significance of macrophage invasion in hilar cholangiocarcinoma

(2015) Georgi Atanasov et al.   BMC CANCER

Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival

(2015) Thibault Desurmont et al.   CANCER SCIENCE

PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma

(2015) F. Sabbatino et al.   CLINICAL CANCER RESEARCH

Clonorchis sinensis lysophospholipase inhibits TGF-β1-induced expression of pro-fibrogenic genes through attenuating the activations of Smad3, JNK2, and ERK1/2 in hepatic stellate cell line LX-2

(2015) Lina Zhou et al.   PARASITOLOGY RESEARCH

Expression of Toll-like receptor (TLR) 2 and TLR4 in the livers of mice infected by Clonorchis sinensis

(2015) Chao Yan et al.   Journal of Infection in Developing Countries

Targeting Tumor Stroma: Exploiting Apoptotic Priming

(2015) Joachim C. Mertens et al.   Oncotarget

Hedgehog Signaling Between Cancer Cells and Hepatic Stellate Cells in Promoting Cholangiocarcinoma

(2014) Younjoo Kim et al.   ANNALS OF SURGICAL ONCOLOGY

Platelet-derived Growth Factor β-Receptor, Transforming Growth Factor β Type I Receptor, and CD44 Protein Modulate Each Other's Signaling and Stability

(2014) Helena Porsch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet-derived Growth Factor Primes Cancer-associated Fibroblasts for Apoptosis

(2014) Sumera Rizvi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of liver fluke infection as risk factor for cholangiocarcinoma

(2014) Paiboon Sithithaworn et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Clonorchis sinensis ferritin heavy chain triggers free radicals and mediates inflammation signaling in human hepatic stellate cells

(2014) Qiang Mao et al.   PARASITOLOGY RESEARCH

Macrophage density and macrophage colony-stimulating factor expression predict the postoperative prognosis in patients with intrahepatic cholangiocarcinoma

(2014) Kosuke Oishi et al.   SURGERY TODAY

Prognostic impact of tumour-infiltrating immune cells on biliary tract cancer

(2013) B Goeppert et al.   BRITISH JOURNAL OF CANCER

The CXCL7/CXCR1/2 Axis Is a Key Driver in the Growth of Clear Cell Renal Cell Carcinoma

(2013) R. Grepin et al.   CANCER RESEARCH

Integrative Molecular Analysis of Intrahepatic Cholangiocarcinoma Reveals 2 Classes That Have Different Outcomes

(2013) Daniela Sia et al.   GASTROENTEROLOGY

Molecular profiling of stroma identifies osteopontin as an independent predictor of poor prognosis in intrahepatic cholangiocarcinoma

(2013) Laurent Sulpice et al.   HEPATOLOGY

Hepatic myofibroblasts promote the progression of human cholangiocarcinoma through activation of epidermal growth factor receptor

(2013) Audrey Clapéron et al.   HEPATOLOGY

Desmoplastic stroma and cholangiocarcinoma: Clinical implications and therapeutic targeting

(2013) Alphonse E. Sirica et al.   HEPATOLOGY

Biochemical characterization and functional analysis of fructose-1,6-bisphosphatase from Clonorchis sinensis

(2013) Pei Liang et al.   MOLECULAR BIOLOGY REPORTS

Transforming Growth Factor β Neutralization Ameliorates Pre-Existing Hepatic Fibrosis and Reduces Cholangiocarcinoma in Thioacetamide-Treated Rats

(2013) Hong Ling et al.   PLoS One

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Therapeutic Effects of Deleting Cancer-Associated Fibroblasts in Cholangiocarcinoma

(2012) J. C. Mertens et al.   CANCER RESEARCH

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

(2012) J. B. Mitchem et al.   CANCER RESEARCH

Identification of CXCL5/ENA-78 as a factor involved in the interaction between cholangiocarcinoma cells and cancer-associated fibroblasts

(2012) Hirohisa Okabe et al.   INTERNATIONAL JOURNAL OF CANCER

Angiotensin II enhances epithelial-to-mesenchymal transition through the interaction between activated hepatic stellate cells and the stromal cell-derived factor-1/CXCR4 axis in intrahepatic cholangiocarcinoma

(2012) KOICHI OKAMOTO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Role of the stromal-derived factor-1 (SDF-1)–CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma

(2012) Alessandra Gentilini et al.   JOURNAL OF HEPATOLOGY

Exome sequencing of liver fluke–associated cholangiocarcinoma

(2012) Choon Kiat Ong et al.   NATURE GENETICS

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Stage-specific expression, immunolocalization of Clonorchis sinensis lysophospholipase and its potential role in hepatic fibrosis

(2012) Fan Zhang et al.   PARASITOLOGY RESEARCH

What are regulatory T cells (Treg) regulating in cancer and why?

(2012) Theresa L. Whiteside   SEMINARS IN CANCER BIOLOGY

Elevated Plasma IL-6 Associates with Increased Risk of Advanced Fibrosis and Cholangiocarcinoma in Individuals Infected by Opisthorchis viverrini

(2012) Banchob Sripa et al.   PLoS Neglected Tropical Diseases

Tumor Lymphangiogenesis as a Potential Therapeutic Target

(2012) Tam Duong et al.   Journal of Oncology

Cancer-promoting tumor-associated macrophages: New vistas and open questions

(2011) Alberto Mantovani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors

(2011) Jesper B. Andersen et al.   GASTROENTEROLOGY

New staging system and a registry for perihilar cholangiocarcinoma

(2011) Michelle L. DeOliveira et al.   HEPATOLOGY

Myofibroblast-derived PDGF-BB promotes hedgehog survival signaling in cholangiocarcinoma cells

(2011) Christian D. Fingas et al.   HEPATOLOGY

Targeting PDGFR-β in Cholangiocarcinoma

(2011) Christian D. Fingas et al.   LIVER INTERNATIONAL

The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma

(2011) Alphonse E. Sirica   Nature Reviews Gastroenterology & Hepatology

Clinical diagnosis and staging of cholangiocarcinoma

(2011) Boris Blechacz et al.   Nature Reviews Gastroenterology & Hepatology

Loss of EBP50 stimulates EGFR activity to induce EMT phenotypic features in biliary cancer cells

(2011) A Clapéron et al.   ONCOGENE

Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist

(2011) Chu-Biao Xue et al.   ACS Medicinal Chemistry Letters

Hepatic Stellate Cells Accelerate the Malignant Behavior of Cholangiocarcinoma Cells

(2010) Hirohisa Okabe et al.   ANNALS OF SURGICAL ONCOLOGY

Natural killer cells and cancer: Regulation by the killer cell Ig-like receptors (KIR)

(2010) Amanda K. Purdy et al.   CANCER BIOLOGY & THERAPY

Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma

(2010) Horlad Hasita et al.   CANCER SCIENCE

Involvement of MMP-9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1-dependent DNA damage in a hamster model

(2010) Suksanti Prakobwong et al.   INTERNATIONAL JOURNAL OF CANCER

GLI3-dependent repression of DR4 mediates hedgehog antagonism of TRAIL-induced apoptosis

(2010) S Kurita et al.   ONCOGENE

Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14+CD16+ Monocytes to Inflammation and Human Liver Fibrosis

(2010) Henning W. Zimmermann et al.   PLoS One

Hepatic Stellate Cells May Relate to Progression of Intrahepatic Cholangiocarcinoma

(2009) Hirohisa Okabe et al.   ANNALS OF SURGICAL ONCOLOGY

Role of the extracellular matrix in lymphocyte migration

(2009) Eva Korpos et al.   CELL AND TISSUE RESEARCH

Cancer-associated fibroblasts and tumor growth – bystanders turning into key players

(2009) Arne Östman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

(2009) G. Solinas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interaction of B7-H1 on intrahepatic cholangiocarcinoma cells with PD-1 on tumor-infiltrating T cells as a mechanism of immune evasion

(2009) Yufu Ye et al.   JOURNAL OF SURGICAL ONCOLOGY

A review of human carcinogens—Part B: biological agents

(2009) Véronique Bouvard et al.   LANCET ONCOLOGY

Molecular characterization of a novel Clonorchis sinensis secretory phospholipase A2 and investigation of its potential contribution to hepatic fibrosis

(2009) Fengyu Hu et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Experimental model in rats for study on transmission dynamics and evaluation of Clonorchis sinensis infection immunologically, morphologically, and pathologically

(2009) Xiaoyun Wang et al.   PARASITOLOGY RESEARCH

Advances in diagnosis, treatment and palliation of cholangiocarcinoma: 1990-2009

(2009) Murad Aljiffry et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

The hedgehog pathway regulates remodelling responses to biliary obstruction in rats

(2008) A Omenetti et al.   GUT

HB-EGF is a paracrine growth stimulator for early tumor prestages in inflammation-associated hepatocarcinogenesis

(2008) Sandra Sagmeister et al.   JOURNAL OF HEPATOLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Chemokine-directed immune cell infiltration in acute and chronic liver disease

(2008) Karlin Raja Karlmark et al.   Expert Review of Gastroenterology & Hepatology

Validation of HB-EGF and amphiregulin as targets for human cancer therapy

(2007) Fusanori Yotsumoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS