Article
Neurosciences
Sheng Zhang, Yan Wang, Xiaoqing Zhu, Lanying Song, Xinhua Zhan, Edric Ma, Jennifer McDonough, Hui Fu, Franca Cambi, Judith Grinspan, Fuzheng Guo
Summary: The study reveals that TCF7l2 promotes OL differentiation by repressing BMP4 gene transcription, reducing autocrine BMP4 secretion, and dampening BMP4 signaling. Specific deletion of BMP4 can rescue arrested OL differentiation caused by TCF7l2 disruption in the oligodendroglial lineage.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Oncology
Hui Liu, Mangaladoss Fredimoses, Peijia Niu, Tingting Liu, Yan Qiao, Xueli Tian, Xiaobing Chen, Dong Joon Kim, Xiang Li, Kangdong Liu, Zigang Dong
Summary: EPRS is frequently overexpressed in GC tissues and its overexpression is associated with poor prognosis in GC patients. High expression of EPRS positively correlates with GC development both in vitro and in vivo by enhancing the WNT/GSK-3 beta/beta-catenin signaling pathway. XA and 4-HD can directly bind to EPRS to block this signaling pathway and inhibit gastric cancer growth.
Article
Integrative & Complementary Medicine
Jian-Qiang Wang, Yu Dong, Zi-Meng Feng, Mei-Ling Fan, Jia-Yu Yang, Jun-Nan Hu, En-Bo Cai, Hong-Yan Zhu, Wei Li, Zi Wang
Summary: This study conducted a series of experiments in vivo and in vitro to investigate the protective effects and possible mechanisms of ginsenoside Re (G-Re) against chemotherapy-induced intestinal damage. The results showed that G-Re improved oxidative damage, cytotoxicity, and apoptosis caused by cisplatin, and inhibited the activation of Wnt/β-catenin signaling. Therefore, G-Re may be a potential candidate drug for the treatment of intestinal injury.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yidan Sun, Xiyu Ying, Ruomei Li, Mengjia Weng, Jiajun Shi, Zhenqi Chen
Summary: The study revealed that FGF9 promotes HAS2 expression through the Wnt/β-catenin/TCF7L2 pathway. TCF7L2 binds to the Has2 promoter, leading to transcriptional activation of Has2. Deletion of FGF9 resulted in cleft palate and significant reduction in TCF7L2 expression.
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Oncology
Yanqiu Bao, Jingshu Cui, Yuyang Yue, Shuxia Cao, Xiangdan Li, Lan Liu
Summary: Ebp1 is highly expressed in malignant melanoma and is associated with clinical stage and lymph node metastases. Knockdown of Ebp1 inhibits cell proliferation, migration, and invasion in melanoma. Ebp1 may promote the proliferation and metastasis of melanoma cells through activation of the Wnt/β-catenin pathway.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Abdallah Gendy, Ayman Soubh, Asmaa Al-Mokaddem, Mohamed Kotb El-Sayed
Summary: The study showed that DMFU protects the intestine from ischemia/reperfusion injury by enhancing Nrf2 and HO-1 expression, reducing GSK-3 beta expression, increasing beta-catenin expression, and modulating antioxidant and anti-inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Fei Song, Fei-Yu Chen, Sui-Yi Wu, Bo Hu, Xiao-liang Liang, Hao-Qin Yang, Jian-Wen Cheng, Peng-Xiang Wang, Wei Guo, Jian Zhou, Jia Fan, Zhong Chen, Xin-Rong Yang
Summary: This study revealed that the expression of MUC1 is significantly up-regulated in ICC, and is associated with the aggressiveness of tumors and patient prognosis. Further investigations showed that MUC1 promotes ICC progression by activating the Wnt/beta-catenin pathway.
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Xinbing Yang, Yajing Du, Lulu Luo, Xinru Xu, Shizheng Xiong, Xueni Yang, Li Guo, Tingming Liang
Summary: Dysregulated expression of specific non-coding RNAs (ncRNAs) has been strongly linked to tumorigenesis, cancer progression, and therapeutic resistance. Recent evidence suggests that ncRNAs can interact with the Wnt/beta-catenin signaling pathway, influencing the expression of Wnt target genes in cancer cells. This review aims to unravel the complex associations between ncRNAs and the Wnt/beta-catenin signaling pathway and explore their potential implications for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xiaobin Shang, Kai Oliver Boeker, Shahed Taheri, Thelonius Hawellek, Wolfgang Lehmann, Arndt F. Schilling
Summary: Osteoarthritis is a chronic disease that lacks disease-modifying treatment, with the Wnt/beta-catenin pathway playing a key role in its pathophysiology. Both excessive stimulation and suppression of this pathway can contribute to the development of OA. MicroRNAs have been found to regulate various cellular processes in different diseases, offering potential insights for the development of miRNA-based therapeutics for OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Qing Song, Zhifen Han, Xinnan Wu, Yan Wang, Lihong Zhou, Liu Yang, Ningning Liu, Hua Sui, Jianfeng Cai, Qing Ji, Qi Li
Summary: In colorectal cancer (CRC), beta-arrestin1 promotes migration and metastasis of CRC cells by regulating the EMT process through the Wnt/β-catenin signaling pathways. This provides a novel therapeutic target for CRC metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Rui Ma, Yaojuan Chu, Mengmeng Dou, Yilei Jing, Xiaoyu Zhao, Xinyu Li, Silu Li, Yuan Zhang, Limei Wang, Lin Zhu
Summary: In this study, it was found that matrine (MAT) treatment can promote the maturation of oligodendrocytes (OLs) and myelin repair by regulating the Wnt/β-catenin/TCF7L2 signaling pathway, leading to a reduction in the activation of Wnt3a and β-catenin in the central nervous system (CNS) of experimental autoimmune encephalomyelitis (EAE) mice. This finding is of significant importance for the repair of neurological damage in multiple sclerosis and EAE.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Oncology
Yi Hu, Chun Yang, Tania Amorim, Mohsin Maqbool, Jenny Lin, Chen Li, Chuanfeng Fang, Li Xue, Ariel Kwart, Hua Fang, Mei Yin, Allison J. Janocha, Daisuke Tsuchimoto, Yusaku Nakabeppu, Xiaofeng Jiang, Alex Mejia-Garcia, Faiz Anwer, Jack Khouri, Xin Qi, Qing Y. Zheng, Jennifer S. Yu, Shan Yan, Thomas LaFramboise, Kenneth C. Anderson, Leal C. Herlitz, Nikhil C. Munshi, Jianhong Lin, Jianjun Zhao
Summary: This study identified APE2 as a critical molecule upregulated in the kidney following cisplatin treatment, leading to MYH9 dysfunction in mitochondria and potential development of AKI. Knockout of APE2 attenuated cisplatin-induced kidney injury, suggesting a novel target for prophylactic treatment of AKI.
Article
Multidisciplinary Sciences
Hiroki Sakamoto, Koji Miyanishi, Shingo Tanaka, Ryo Ito, Kota Hamaguchi, Akira Sakurada, Masanori Sato, Tomohiro Kubo, Takahiro Osuga, Kazuyuki Murase, Kohichi Takada, Yusaku Nakabeppu, Masayoshi Kobune, Junji Kato
Summary: The study found that MUTYH deficiency is associated with the development of liver tumors in NASH-related conditions. In mouse experiments, MUTYH-null mice fed a high-fat high-cholesterol+high-iron diet were more likely to develop liver tumors and showed higher accumulation of oxidative stress markers. Gene expression analysis also indicated involvement of the Wnt/beta-catenin signaling pathway and increased c-Myc expression in MUTYH-null liver tissues.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Sugako Oka, Julio Leon, Kunihiko Sakumi, Nona Abolhassani, Zijing Sheng, Daisuke Tsuchimoto, Frank M. LaFerla, Yusaku Nakabeppu
Summary: 8-Oxoguanine accumulates in Alzheimer's disease brains, and deficiency of MTH1 and OGG1 can increase its accumulation, leading to microglial activation and neuronal loss. Minocycline can inhibit microglial activation and reduce neuroinflammation, providing a potential new approach for preventing and treating AD.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Guianfranco Mazzei, Ryohei Ikegami, Nona Abolhassani, Naoki Haruyama, Kunihiko Sakumi, Takashi Saito, Takaomi C. Saido, Yusaku Nakabeppu
Summary: The study found that high-fat diet caused cognitive impairment, increased A beta deposition, and microgliosis in transgenic mouse models of Alzheimer's disease, accompanied by insulin resistance in the hippocampus.
Article
Biochemistry & Molecular Biology
Teruya Nakamura, Kohtaro Okabe, Shogo Hirayama, Mami Chirifu, Shinji Ikemizu, Hiroshi Morioka, Yusaku Nakabeppu, Yuriko Yamagata
Summary: MUTYH is a crucial DNA repair enzyme, and mutations associated with colorectal cancer can lead to MAP disease. Studies have shown that MUTYH participates in base excision repair with PCNA during DNA replication and contains a binding motif related to proteins involved in DNA damage response.
NUCLEIC ACIDS RESEARCH
(2021)
Correction
Multidisciplinary Sciences
Erika Castillo, Julio Leon, Guianfranco Mazzei, Nona Abolhassani, Naoki Haruyama, Takashi Saito, Takaomi Saido, Masaaki Hokama, Toru Iwaki, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara, Kunihiko Sakumi, Frank M. LaFerla, Yusaku Nakabeppu
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Yukino Miyachi, Takayuki Fujii, Ryo Yamasaki, Daisuke Tsuchimoto, Kyoko Iinuma, Ayako Sakoda, Shoko Fukumoto, Takuya Matsushita, Katsuhisa Masaki, Noriko Isobe, Yusaku Nakabeppu, Jun-ichi Kira
Summary: This study aimed to investigate the impact of serum anti-oligodendrocyte antibodies on the clinical features of MS patients and validate whether these antibodies could serve as biomarkers for CNS tissue damage in MS patients. Results showed that anti-oligodendrocyte antibodies were positive in PPMS and SPMS patients, while absent in RRMS, NMOSD, OIND patients, and healthy controls.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jingwen Chen, Xin Wu, Yanyi Wang, Yunfeng Pan, Yan Ren, Yusaku Nakabeppu, Yimei Fan, Yaping Wang
Summary: This study demonstrates that Mutyh deficiency can lead to changes in mitochondrial structure and impair mitochondrial function through downregulation of Mfn2 and alteration of the ratio of L-Opa1/S-Opa1, accompanied by a reduction in alpha-ketoglutaric acid (alpha-KG). Further analysis reveals that Mutyh deficiency may cause downregulation of histone demethylases and DNA demethylases and inhibition of Mfn2 transcription. Interestingly, supplementation of alpha-KG can alleviate the damage associated with Mutyh deficiency, restore Mfn2 expression, and prevent degradation of L-Opa1.
FREE RADICAL RESEARCH
(2022)
Correction
Biochemistry & Molecular Biology
Takashi Ishii, Tatsuhiro Igawa, Hiroshi Hayakawa, Tsugumi Fujita, Mutsuo Sekiguchi, Yusaku Nakabeppu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Neurosciences
Yuri Mizuno, Nona Abolhassani, Guianfranco Mazzei, Takashi Saito, Takaomi C. Saido, Ryo Yamasaki, Jun-ichi Kira, Yusaku Nakabeppu
Summary: Oxidative stress is a major risk factor for Alzheimer's disease, characterized by the accumulation of 8-oxoG in the brain. Deficiency of MTH1 and OGG1 accelerates the accumulation of 8-oxoG in DNA and leads to reduced anxiety-related behavior in 6-month-old mice.
NEUROSCIENCE RESEARCH
(2022)
Article
Cell Biology
Chukwuemeka George Anene-Nzelu, Peter Yiqing Li, Tuan Danh Anh Luu, Shi Ling Ng, Zenia Tiang, Bangfen Pan, Wilson Lek Wen Tan, Matthew Ackers-Johnson, Ching Kit Chen, Yee Phong Lim, Rina Wang Miao Qin, Wee Woon Chua, Lim Xin Yi, Roger Sik-Yin Foo, Yusaku Nakabeppu
Summary: Doxorubicin, commonly used for cancer treatment, can cause cardiotoxicity. This study demonstrates that deficiency of OGG1 gene exacerbates doxorubicin-induced cardiac dysfunction and increases mortality in mice. Transcriptomic analysis reveals dysregulation of genes related to inflammation in the hearts of Ogg1 knockout mice.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Psychiatry
Kazuya Matsuo, Yasuharu Shinoda, Nona Abolhassani, Yusaku Nakabeppu, Kohji Fukunaga
Summary: This study explored molecular alterations in the hippocampus of rats with autism spectrum disorder (ASD) and the effects of chronic administration of intranasal oxytocin (OXT). The results revealed that prenatal valproic acid (VPA) exposure altered gene expression in the hippocampus, with some of these genes suggested as candidates for ASD and involved in memory, developmental processes, and epilepsy. OXT treatment partly improved the expression of these genes, which interacted with genes involved in social behaviors and hippocampal-dependent memory.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Teruya Nakamura, Yukari Koga-Ogawa, Kana Fujimiya, Mami Chirifu, Masataka Goto, Shinji Ikemizu, Yusaku Nakabeppu, Yuriko Yamagata
Summary: The human MTH1 protein recognizes substrates through the exchange of protonation states, and the protonation state change is related to its substrate binding ability.
Article
Neurosciences
Sayaka Okuzono, Fumihiko Fujii, Yuki Matsushita, Daiki Setoyama, Yohei Shinmyo, Ryoji Taira, Kousuke Yonemoto, Satoshi Akamine, Yoshitomo Motomura, Masafumi Sanefuji, Takeshi Sakurai, Hiroshi Kawasaki, Kihoon Han, Takahiro A. Kato, Hiroyuki Torisu, Dongchon Kang, Yusaku Nakabeppu, Yasunari Sakai, Shouichi Ohga
Summary: Epileptic seizures are common comorbidities in children with autism spectrum disorder (ASD), but little is known about the genes involved and their role in regulating neuronal excitability. This study found that Shank3, an ASD-associated gene, plays a unique role in protecting thalamocortical neurons from hyperexcitability during the early postnatal period. These findings have important implications for understanding the mechanisms underlying seizures in children with autism.
NEUROSCIENCE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xu Zheng, Wenhe Zhang, Yinchao Hu, Zhexuan Zhao, Jiaxin Wu, Xiaoqing Zhang, Fengqi Hao, Jinling Han, Jing Xu, Wenjing Hao, Ruoxi Wang, Meihong Tian, Zsolt Radak, Yusaku Nakabeppu, Istvan Boldogh, Xueqing Ba
Summary: Exercise-induced generation of 8-oxoG promotes muscle remodeling and adaptation by activating the Ras-MEK-MyoD signal pathway. This study reveals the signaling role of DNA repair metabolite 8-oxoG in muscle remodeling and adaptation, and suggests its potential therapeutic application in muscle damage-related disorders.
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)