The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells

A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking

(2011) Ebru Boslem et al.   BIOCHEMICAL JOURNAL

Dysregulation of sphingolipid metabolism in cancer

(2011) Lindsay K. Ryland et al.   CANCER BIOLOGY & THERAPY

Suppression of Glucosylceramide Synthase Restores p53-Dependent Apoptosis in Mutant p53 Cancer Cells

(2011) Y.-Y. Liu et al.   CANCER RESEARCH

Acid Ceramidase Expression Modulates the Sensitivity of A375 Melanoma Cells to Dacarbazine

(2011) Carmen Bedia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alteration of Ceramide Synthase 6/C16-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca2+and ER/Golgi Membrane Network

(2011) Can E. Senkal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy

(2010) S Lépine et al.   CELL DEATH AND DIFFERENTIATION

Anti-GD3 Chimeric sFv-CD28/T-Cell Receptor   Designer T Cells for Treatment of Metastatic Melanoma and Other Neuroectodermal Tumors

(2010) A. S. Y. Lo et al.   CLINICAL CANCER RESEARCH

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance

(2010) Suriyan Ponnusamy et al.   Future Oncology

A New Archaeal β-Glycosidase fromSulfolobus solfataricus

(2010) Beatrice Cobucci-Ponzano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The underrecognized progressive nature of N370S Gaucher disease and assessment of cancer risk in 403 patients

(2009) Tamar H. Taddei et al.   AMERICAN JOURNAL OF HEMATOLOGY

The natural marine anhydrophytosphingosine, Jaspine B, induces apoptosis in melanoma cells by interfering with ceramide metabolism

(2009) Yahya Salma et al.   BIOCHEMICAL PHARMACOLOGY

Disruption of Sphingosine 1-Phosphate Lyase Confers Resistance to Chemotherapy and Promotes Oncogenesis through Bcl-2/Bcl-xL Upregulation

(2009) S. Colie et al.   CANCER RESEARCH

Glycosynaptic microdomains controlling tumor cell phenotype through alteration of cell growth, adhesion, and motility

(2009) Sen-itiroh Hakomori   FEBS LETTERS

Acid β-Glucosidase 1 Counteracts p38δ-dependent Induction of Interleukin-6

(2009) Kazuyuki Kitatani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

(2009) María Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

Recent progress in understanding the pathology of malignant melanoma

(2009) Silke Kuphal et al.   JOURNAL OF PATHOLOGY

Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines

(2009) F. Guan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combining Nanoliposomal Ceramide with Sorafenib Synergistically Inhibits Melanoma and Breast Cancer Cell Survival to Decrease Tumor Development

(2008) M. A. Tran et al.   CLINICAL CANCER RESEARCH