Genetics of Oxidative Stress in Obesity

Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort

(2018) Masafumi Kuzuya et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Are Catalase −844A/G Polymorphism and Activity Associated with Childhood Obesity?

(2013) Azahara I. Rupérez et al.   ANTIOXIDANTS & REDOX SIGNALING

High-Fat-Fed Obese Glutathione Peroxidase 1-Deficient Mice Exhibit Defective Insulin Secretion but Protection from Hepatic Steatosis and Liver Damage

(2013) Troy L. Merry et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase

(2013) Yuhong Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Correlation of Peroxisome Proliferator-Activated Receptor (PPAR-γ) mRNA Expression with Pro12Ala Polymorphism in Obesity

(2013) Rym Berhouma et al.   BIOCHEMICAL GENETICS

Paraoxonase 1 activities and genetic variation in childhood obesity

(2013) A. I. Rupérez et al.   BRITISH JOURNAL OF NUTRITION

Impaired paraoxonase-1 status in obese children. Relationships with insulin resistance and metabolic syndrome

(2013) Natàlia Ferré et al.   CLINICAL BIOCHEMISTRY

Plasma resistin levels are associated with homocysteine, endothelial activation, and nitrosative stress in obese youths

(2013) Pilar Codoñer-Franch et al.   CLINICAL BIOCHEMISTRY

Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human

(2013) Yi-Cheng Chang et al.   EMBO Molecular Medicine

Pro12Ala variant of thePPARG2gene increases body mass index: An updated meta-analysis encompassing 49,092 subjects

(2013) C. Galbete et al.   Obesity

Genomic Structure and Variation of Nuclear Factor (Erythroid-Derived 2)-Like 2

(2013) Hye-Youn Cho   Oxidative Medicine and Cellular Longevity

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

(2013) Paul Trayhurn   PHYSIOLOGICAL REVIEWS

Generalization of adiposity genetic loci to US Hispanic women

(2013) M Graff et al.   Nutrition & Diabetes

Association Between Insulin Resistance and 
Oxidative Stress Parameters in Obese Adolescents with Non-Alcoholic Fatty Liver Disease

(2013) Pirgon Özgür et al.   Journal of Clinical Research in Pediatric Endocrinology

Nutrigenetics and Modulation of Oxidative Stress

(2012) Laura A. Da Costa et al.   ANNALS OF NUTRITION AND METABOLISM

Genetic Polymorphisms in Oxidative Stress Pathway Genes and Modification of BMI and Risk of Non-Hodgkin Lymphoma

(2012) C. Kim et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Inflammatory cytokines in vitro production are associated with Ala16Val superoxide dismutase gene polymorphism of peripheral blood mononuclear cells

(2012) Marco Aurélio Echart Montano et al.   CYTOKINE

CYBAC242T polymorphism is associated with obesity and diabetes mellitus in Brazilian hypertensive patients

(2012) R. Schreiber et al.   DIABETIC MEDICINE

A malfunction in triglyceride transfer from the intracellular lipid pool to apoB in enterocytes of SOD1-deficient mice

(2012) Toshihiro Kurahashi et al.   FEBS LETTERS

NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes

(2012) Emilie E. Vomhof-DeKrey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance

(2012) Akshaya K. Meher et al.   FREE RADICAL BIOLOGY AND MEDICINE

Methionine sulfoxide reductase A affects insulin resistance by protecting insulin receptorfunction

(2012) JennaLynn Styskal et al.   FREE RADICAL BIOLOGY AND MEDICINE

High Dietary Fat Selectively Increases Catalase Expression within Cardiac Mitochondria

(2012) Paul M. Rindler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PGC1  and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders

(2012) S. Austin et al.   JOURNAL OF CELL SCIENCE

Oxidative stress in obese children and its relation with insulin resistance

(2012) Ilker Tolga Ozgen et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Oxidative stress and inflammation interactions in human obesity

(2012) Isabel Bondia-Pons et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Loss of the Oxidative Stress Sensor NPGPx Compromises GRP78 Chaperone Activity and Induces Systemic Disease

(2012) Pei-Chi Wei et al.   MOLECULAR CELL

Association of Obesity-related Genetic Variants With Endometrial Cancer Risk: A Report From the Shanghai Endometrial Cancer Genetics Study

(2011) R. J. Delahanty et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Peroxiredoxin 3 Is a Key Molecule Regulating Adipocyte Oxidative Stress, Mitochondrial Biogenesis, and Adipokine Expression

(2011) Joo Young Huh et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation

(2011) Pilar Codoñer-Franch et al.   ATHEROSCLEROSIS

Nrf2 Represses FGF21 During Long-Term High-Fat Diet-Induced Obesity in Mice

(2011) D. V. Chartoumpekis et al.   DIABETES

Predominant role of obesity/insulin resistance in oxidative stress development

(2011) Massimo D’Archivio et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis

(2011) Yongyong Hou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Obesity reduces methionine sulphoxide reductase activity in visceral adipose tissue

(2011) Eric O. Uthus et al.   FREE RADICAL RESEARCH

Relationship between the paraoxonase (PON1) L55M and Q192R polymorphisms and obesity in a Mexican population: a pilot study

(2011) Maria Fernanda Martínez-Salazar et al.   Genes and Nutrition

Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations

(2011) R Dorajoo et al.   INTERNATIONAL JOURNAL OF OBESITY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

An Integrative Genomics Approach Identifies Activation of Thioredoxin/Thioredoxin Reductase-1-Mediated Oxidative Stress Defense Pathway and Inhibition of Angiogenesis in Obese Nondiabetic Human Subjects

(2011) Swapan K. Das et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population

(2011) Kikuko Hotta et al.   JOURNAL OF HUMAN GENETICS

Associations between glutathione peroxidase-1 Pro198Leu polymorphism, selenium status, and DNA damage levels in obese women after consumption of Brazil nuts

(2011) Cristiane Cominetti et al.   NUTRITION

SDCCAG8 Obesity Alleles and Reduced Weight Loss After a Lifestyle Intervention in Overweight Children and Adolescents

(2011) André Scherag et al.   Obesity

Implications of Central Obesity-Related Variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on Quantitative Metabolic Traits in Adult Danes

(2011) Dorthe S. Bille et al.   PLoS One

Epidemiology and Economic Impact of Obesity and Type 2 Diabetes

(2011) Hazem Shamseddeen et al.   SURGICAL CLINICS OF NORTH AMERICA

Caloric restriction improves coagulation and inflammation profile in obese mice

(2011) H. Roger Lijnen et al.   THROMBOSIS RESEARCH

Hydrogen peroxide: a Jekyll and Hyde signalling molecule

(2011) D R Gough et al.   Cell Death & Disease

Genetic polymorphisms in non-alcoholic fatty liver disease in obese Egyptian children

(2011) NehalM El-Koofy et al.   Saudi Journal of Gastroenterology

Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: The hunt goes on

(2010) Lucio G. Costa et al.   BIOCHEMICAL PHARMACOLOGY

Inter-individual variation in DNA damage and base excision repair in young, healthy non-smokers: effects of dietary supplementation and genotype

(2010) Fiona Caple et al.   BRITISH JOURNAL OF NUTRITION

Pro198Leu Polymorphism of GPx-1 Gene and Activity of Erythrocytic Glutathione Peroxidase and Lipid Peroxidation Products

(2010) Yu. A. Shuvalova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Q192R polymorphism of the paraoxonase-1 gene as a risk factor for obesity in Portuguese women

(2010) Luísa Veiga et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Increased plasma isoprostane is associated with visceral fat, high molecular weight adiponectin, and metabolic complications in obese children

(2010) Shunsuke Araki et al.   EUROPEAN JOURNAL OF PEDIATRICS

Increased oxidative stress and altered substrate metabolism in obese children

(2010) Stacy R. Oliver et al.   International Journal of Pediatric Obesity

Deficiency in the Nuclear Factor E2-related Factor-2 Transcription Factor Results in Impaired Adipogenesis and Protects against Diet-induced Obesity

(2010) Jingbo Pi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population

(2010) Kikuko Hotta et al.   JOURNAL OF HUMAN GENETICS

The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases

(2010) Carmela Rita Balistreri et al.   MEDIATORS OF INFLAMMATION

The Combination of Genetic Variations in the PRDX3 Gene and Dietary Fat Intake Contribute to Obesity Risk

(2010) Masako Hiroi et al.   Obesity

Relation of circulating oxidized LDL to obesity and insulin resistance in children

(2010) Aaron S Kelly et al.   PEDIATRIC DIABETES

Human Paraoxonase-1 Activity in Childhood Obesity and Its Relation to Leptin and Adiponectin Levels

(2010) Péter Koncsos et al.   PEDIATRIC RESEARCH

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups

(2010) André Scherag et al.   PLoS Genetics

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

(2009) Andrew G. Cox et al.   BIOCHEMICAL JOURNAL

Reactive Oxygen Species Enhance Insulin Sensitivity

(2009) Kim Loh et al.   Cell Metabolism

PGC-1α Gly482Ser Polymorphism Is Associated with the Plasma Adiponectin Level in Type 2 Diabetic Men

(2009) Yukiyoshi OKAUCHI et al.   ENDOCRINE JOURNAL

Non-diabetic metabolic syndrome and obesity do not affect serum paraoxonase and arylesterase activities but do affect oxidative stress and inflammation

(2009) Suzan Tabur et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

(2009) Soona Shin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular characterization and expression analysis of the porcine paraoxonase 3 (PON3) gene

(2009) Benoît Labrecque et al.   GENE

A haplotype of the catalase gene confers an increased risk of essential hypertension in Chinese Han

(2009) Zhimin Wang et al.   HUMAN MUTATION

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

G allele of the −930A>G polymorphism of the CYBA gene is associated with insulin resistance in obese subjects

(2009) M. C. Ochoa et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice

(2009) Y. C. Jang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Gly482Ser polymorphism in the peroxisome proliferator–activated receptor γ coactivator–1α gene is associated with oxidative stress and abdominal obesity

(2009) Shao-Wen Weng et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Association between manganese superoxide dismutase (MnSOD) gene polymorphism and elderly obesity

(2009) Marco Aurélio Echart Montano et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Insulin resistance is a cellular antioxidant defense mechanism

(2009) K. L. Hoehn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

(2009) Cecilia M. Lindgren et al.   PLoS Genetics

Evolutionary and Structural Insights Into the Multifaceted Glutathione Peroxidase (Gpx) Superfamily

(2008) Stefano Toppo et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure and physiological functions of the human peroxisome proliferator-activated receptor γ

(2008) Andrzej Zieleniak et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Advanced oxidation protein products (AOPPs) in juvenile overweight and obesity prior to and following weight reduction

(2008) Malgorzata Krzystek-Korpacka et al.   CLINICAL BIOCHEMISTRY

Enhanced short-term improvement of insulin response to a low-caloric diet in obese carriers the Gly482Ser variant of the PGC-1α gene

(2008) Estibaliz Goyenechea et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Glutathione peroxidase family - an evolutionary overview

(2008) Rogerio Margis et al.   FEBS Journal

Association Between Circulating Oxidized Low-Density Lipoprotein and Incidence of the Metabolic Syndrome

(2008) Paul Holvoet   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dysregulation of Adipose Glutathione Peroxidase 3 in Obesity Contributes to Local and Systemic Oxidative Stress

(2008) Yun Sok Lee et al.   MOLECULAR ENDOCRINOLOGY

Adipose tissue-specific PPARγ deficiency increases resistance to oxidative stress

(2007) Weijia Luo et al.   EXPERIMENTAL GERONTOLOGY