Small Molecule Inhibitors of AI-2 Signaling in Bacteria: State-of-the-Art and Future Perspectives for Anti-Quorum Sensing Agents

Identification of Ground Beef–Derived Fatty Acid Inhibitors of Autoinducer-2–Based Cell Signaling

(2016) KAMLESH A. SONI et al.   JOURNAL OF FOOD PROTECTION

Structural Basis for Phosphorylated Autoinducer-2 Modulation of the Oligomerization State of the Global Transcription Regulator LsrR fromEscherichia coli

(2013) Minhao Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic Insights into the LsrK Kinase Required for Autoinducer-2 Quorum Sensing Activation

(2013) Jie Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploiting Quorum Sensing To Confuse Bacterial Pathogens

(2013) B. LaSarre et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A cell-cell communication signal integrates quorum sensing and stress response

(2013) Jasmine Lee et al.   Nature Chemical Biology

2012 FDA drug approvals

(2013) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Structures and biofilm inhibition activities of brominated furanones for Escherichia coli and Pseudomonas aeruginosa

(2013) Gauri S. Shetye et al.   MedChemComm

Altering the Communication Networks of Multispecies Microbial Systems Using a Diverse Toolbox of AI-2 Analogues

(2012) Sonja Gamby et al.   ACS Chemical Biology

Uncharacterized 4,5-Dihydroxy-2,3-Pentanedione (DPD) Molecules Revealed Through NMR Spectroscopy: Implications for a Greater Signaling Diversity in Bacterial Species

(2012) Daniel Globisch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

AI-2 analogs and antibiotics: a synergistic approach to reduce bacterial biofilms

(2012) Varnika Roy et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Synthesis and evaluation of thiazolidinedione and dioxazaborocane analogues as inhibitors of AI-2 quorum sensing in Vibrio harveyi

(2012) Gilles Brackman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel AI-2 quorum sensing inhibitors in Vibrio harveyi identified through structure-based virtual screening

(2012) Peng Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A flexible approach to 1,4-di-substituted 2-aminoimidazoles that inhibit and disperse biofilms and potentiate the effects of β-lactams against multi-drug resistant bacteria

(2012) Robert E. Furlani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

C4-Alkoxy-HPD: A Potent Class of Synthetic Modulators Surpassing Nature in AI-2 Quorum Sensing

(2012) Kyoji Tsuchikama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

2011 FDA drug approvals

(2012) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Small molecule control of bacterial biofilms

(2012) Roberta J. Worthington et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Quorum Sensing-Disrupting Brominated Thiophenone with a Promising Therapeutic Potential to Treat Luminescent Vibriosis

(2012) Tom Defoirdt et al.   PLoS One

A Pro-Drug Approach for Selective Modulation of AI-2-Mediated Bacterial Cell-to-Cell Communication

(2012) Min Guo et al.   SENSORS

Synthetic Polymers for Simultaneous Bacterial Sequestration and Quorum Sense Interference

(2011) Xuan Xue et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quorum Sensing Inhibitors Increase the Susceptibility of Bacterial Biofilms to Antibiotics In Vitro and In Vivo

(2011) Gilles Brackman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effects on Membrane Lateral Pressure Suggest Permeation Mechanisms for Bacterial Quorum Signaling Molecules

(2011) Kishore Kamaraju et al.   BIOCHEMISTRY

Inhibition of LuxS by S-ribosylhomocysteine analogues containing a [4-aza]ribose ring

(2011) Venkata L.A. Malladi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Stereochemical diversity of AI-2 analogs modulates quorum sensing in Vibrio harveyi and Escherichia coli

(2011) Fabio Rui et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Probing Autoinducer-2 Based Quorum Sensing: The Biological Consequences of Molecules Unable To Traverse Equilibrium States

(2011) Kyoji Tsuchikama et al.   JOURNAL OF ORGANIC CHEMISTRY

Helicobacter pylori perceives the quorum-sensing molecule AI-2 as a chemorepellent via the chemoreceptor TlpB

(2011) B. A. Rader et al.   MICROBIOLOGY-SGM

2010 FDA drug approvals

(2011) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Structure-Activity Relationship of Cinnamaldehyde Analogs as Inhibitors of AI-2 Based Quorum Sensing and Their Effect on Virulence of Vibrio spp

(2011) Gilles Brackman et al.   PLoS One

A Quorum Sensing Regulated Small Volatile Molecule Reduces Acute Virulence and Promotes Chronic Infection Phenotypes

(2011) Meenu Kesarwani et al.   PLoS Pathogens

An efficient synthesis of the precursor of AI-2, the signalling molecule for inter-species quorum sensing

(2010) Osvaldo S. Ascenso et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and bioluminescence-inducing properties of autoinducer (S)-4,5-dihydroxypentane-2,3-dione and its enantiomer

(2010) Manikandan Kadirvel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Zoospore interspecific signaling promotes plant infection by Phytophthora

(2010) Ping Kong et al.   BMC MICROBIOLOGY

Quorum Sensing in Gram-Negative Bacteria: Small-Molecule Modulation of AHL and AI-2 Quorum Sensing Pathways

(2010) Warren R. J. D. Galloway et al.   CHEMICAL REVIEWS

Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules

(2010) Herman O Sintim et al.   Future Medicinal Chemistry

Antibiotic resistance of bacterial biofilms

(2010) Niels Høiby et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Chemotaxis to the Quorum-Sensing Signal AI-2 Requires the Tsr Chemoreceptor and the Periplasmic LsrB AI-2-Binding Protein

(2010) M. Hegde et al.   JOURNAL OF BACTERIOLOGY

Design and Synthesis of Potent “Sulfur-Free” Transition State Analogue Inhibitors of 5′-Methylthioadenosine Nucleosidase and 5′-Methylthioadenosine Phosphorylase

(2010) Alistair I. Longshaw et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Analogs Tailor Native AI-2 Signaling Across Bacterial Species

(2010) Varnika Roy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quorum sensing in bacterial virulence

(2010) L. C. M. Antunes et al.   MICROBIOLOGY-SGM

Indirect Pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in Polymicrobial Otitis Media Occurs via Interspecies Quorum Signaling

(2010) C. E. Armbruster et al.   mBio

Cross Species Quorum Quenching Using a Native AI-2 Processing Enzyme

(2009) Varnika Roy et al.   ACS Chemical Biology

Bacterial Quorum-Sensing Network Architectures

(2009) Wai-Leung Ng et al.   Annual Review of Genetics

A new phenothiazine structural scaffold as inhibitors of bacterial quorum sensing in Vibrio harveyi

(2009) Nanting Ni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position

(2009) Stanislaw F. Wnuk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of Pseudomonas aeruginosa quorum sensing by AI-2 analogs

(2009) Hadas Ganin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A naturally occurring brominated furanone covalently modifies and inactivates LuxS

(2009) Tianzhu Zang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of Quorum Sensing inVibrio harveyiby Boronic Acids

(2009) Nanting Ni et al.   Chemical Biology & Drug Design

Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

(2009) Jacqueline A. I. Smith et al.   CHEMICAL COMMUNICATIONS

Synthesis and Evaluation of New Antagonists of Bacterial Quorum Sensing inVibrio harveyi

(2009) Hanjing Peng et al.   ChemMedChem

Temperature, not LuxS, mediates AI-2 formation in hydrothermal habitats

(2009) Jason D. Nichols et al.   FEMS MICROBIOLOGY ECOLOGY

Biological activity and identification of a peptide inhibitor of LuxS fromStreptococcus suisserotype 2

(2009) Xiangan Han et al.   FEMS MICROBIOLOGY LETTERS

Identification of Functional LsrB-Like Autoinducer-2 Receptors

(2009) C. S. Pereira et al.   JOURNAL OF BACTERIOLOGY

Magnesium-Catalyzed Asymmetric Direct Aldol Addition of Ethyl Diazoacetate to Aromatic, Aliphatic, and α,β-Unsaturated Aldehydes

(2009) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exogenous Yersinia pestis quorum sensing molecules N-octanoyl-homoserine lactone and N-(3-oxooctanoyl)-homoserine lactone regulate the LcrV virulence factor

(2009) H. Carl Gelhaus et al.   MICROBIAL PATHOGENESIS

AI-2 quorum-sensing inhibitors affect the starvation response and reduce virulence in several Vibrio species, most likely by interfering with LuxPQ

(2009) G. Brackman et al.   MICROBIOLOGY-SGM

The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA

(2009) Robert C Kelly et al.   Nature Chemical Biology

Transition state analogs of 5′-methylthioadenosine nucleosidase disrupt quorum sensing

(2009) Jemy A Gutierrez et al.   Nature Chemical Biology

Brominated Furanones Inhibit Biofilm Formation by Salmonella enterica Serovar Typhimurium

(2008) J. C. A. Janssens et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification of boronic acids as antagonists of bacterial quorum sensing in Vibrio harveyi

(2008) Nanting Ni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi

(2008) Nanting Ni et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

LuxS-independent formation of AI-2 from ribulose-5-phosphate

(2008) Timothy J Tavender et al.   BMC MICROBIOLOGY

Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR

(2008) Gilles Brackman et al.   BMC MICROBIOLOGY

Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria

(2008) Grant D. Geske et al.   CHEMICAL SOCIETY REVIEWS

Structure-Based Discovery and Experimental Verification of Novel AI-2 Quorum Sensing Inhibitors againstVibrio harveyi

(2008) Minyong Li et al.   ChemMedChem

Insights onEscherichia colibiofilm formation and inhibition from whole-transcriptome profiling

(2008) Thomas K. Wood   ENVIRONMENTAL MICROBIOLOGY

An Unexpected Switch in the Modulation of AI-2-Based Quorum Sensing Discovered through Synthetic 4,5-Dihydroxy-2,3-pentanedione Analogues

(2008) Colin A. Lowery et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Probing the Catalytic Mechanism ofS-Ribosylhomocysteinase (LuxS) with Catalytic Intermediates and Substrate Analogues

(2008) Bhaskar Gopishetty et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Establishing bacterial communities by 'word of mouth': LuxS and autoinducer 2 in biofilm development

(2008) Kim Rachael Hardie et al.   NATURE REVIEWS MICROBIOLOGY

Oxazaborolidine derivatives inducing autoinducer-2 signal transduction in Vibrio harveyi

(2007) R. Aharoni et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium

(2003) Michiko E. Taga et al.   MOLECULAR MICROBIOLOGY