Review
Genetics & Heredity
Ankita Sharma, Rafeeq Mir, Sanjeev Galande
Summary: This review discusses the role of the Wnt/beta-catenin pathway in cell proliferation, differentiation, and migration, as well as its impact on embryonic development, tissue regeneration, and cancer. It highlights the influence of epigenetic factors on the pathway and the crosstalk with other signaling pathways, particularly the Hippo/YAP pathway. The review also emphasizes recent advances in developing potential therapeutic interventions targeting the epigenetic machinery for treating various cancers and regenerative therapies.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Peng Liu, Jingyu Liu, Mengyang Ding, Yijing Liu, Yue Zhang, Xiaoming Chen, Zhenxu Zhou
Summary: This study found that the expression levels of FUT2 were higher in colorectal cancer (CRC) tissues compared to adjacent non-tumor tissues. Knockdown of FUT2 inhibited the proliferation, migration, and invasion of CRC cells and promoted apoptosis. FUT2 knockdown also affected the expression of several key proteins involved in CRC progression. These findings suggest that FUT2 could be a potential diagnostic biomarker and therapeutic target for CRC treatment.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Malak El Sabeh, Subbroto Kumar Saha, Sadia Afrin, Mostafa A. Borahay
Summary: The study revealed that simvastatin significantly reduced the expression of Wnt4 and LRP5 in leiomyoma cells, as well as decreasing the levels of total beta-catenin and nonphosphorylated beta-catenin. Simvastatin also inhibited the effects of estrogen and progesterone on the Wnt/beta-catenin pathway, as well as the expression of c-Myc. These results suggest that simvastatin may have a beneficial effect on uterine leiomyoma by suppressing the overactive Wnt/beta-catenin pathway.
Article
Cell Biology
Hao Zhang, Zheng Li, Juan Jiang, Yang Lei, Jingmao Xie, Yihui Liu, Bo Yi
Summary: In this study, integrative bioinformatics analyses were performed to identify genes associated with colorectal cancer metastasis. SNTB1 was identified as the most up-regulated gene in colon cancer samples and was found to be correlated with patient prognosis. Knockdown of SNTB1 in colorectal cancer cells inhibited malignant behaviors and EMT, and also suppressed tumor growth and metastasis in mice models. SNTB1 positively regulated YAP1 expression and the Wnt/beta-catenin/MYC signaling was involved in mediating SNTB1 functions on colorectal cancer.
Article
Biochemistry & Molecular Biology
Yuyuan Zi, Liyu Liu, Jie Gao, Xu Xu, Yidi Guan, Zhuoxian Rong, Zhen Cao, Mengwei Li, Zimei Zeng, Qi Fan, Feiyu Tang, Junju He, Dan Feng, Jionghuang Chen, Yuedi Dai, Yufeng Huang, Yingjie Nie, Haiping Pei, Qingping Cai, Zhi Li, Lunquan Sun, Yuezhen Deng
Summary: This study finds that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) is upregulated in colorectal cancer (CRC) and is significantly correlated with TNM stages and survival time. Knockout of PPDPF in the intestinal epithelium shortens crypts, decreases the number of stem cells, and inhibits CRC occurrence. Mechanistically, PPDPF interacts with CK1 alpha, disrupting its binding to Axin and activating the Wnt/beta-catenin pathway. Inflammatory signals mediated by IL6/JAK2 phosphorylate PPDPF, stabilizing the protein. Overall, PPDPF is a key molecule connecting inflammation to the Wnt/beta-catenin signaling pathway in CRC carcinogenesis and progression, suggesting it as a potential therapeutic target.
Article
Cell Biology
Yanlin Cai, Yi Hu, Furong Yu, Wenjuan Tong, Shufen Wang, Shunliang Sheng, Jiayu Zhu
Summary: Globally, ovarian cancer ranks as the second most common cause of gynecologic-related cancer deaths among women, with a poor prognosis. Research has shown that downregulation of AHNAK in ovarian cancer cells can significantly inhibit cell growth and metastasis, partly by dampening the Canonical Wnt cascade. Therefore, AHNAK may serve as a biomarker and potential treatment target for ovarian cancer.
Article
Biochemistry & Molecular Biology
Yung-Fu Wu, Chih-Yang Wang, Wan-Chun Tang, Yu-Cheng Lee, Hoang Dang Khoa Ta, Li-Chia Lin, Syu-Ruei Pan, Yi-Chun Ni, Gangga Anuraga, Kuen-Haur Lee
Summary: Colorectal cancer is a heterogeneous disease with genetic and epigenetic changes, and molecular assessment along with biomarker use for prognosis is gaining attention. This study identifies high mRNA levels of 10 upregulated genes in CRC cells and datasets, showing correlation with worse prognosis in CRC patients. CTNNB1 is found to be a key factor in the interaction with upregulated CRC-associated genes, particularly regulating NKD2, FOXQ1, and CEMIP, which when inhibited, can suppress CRC cell growth, providing efficient biomarkers for prognosis and a new molecular interaction network for CRC.
Article
Oncology
Meng-Shun Sun, Lan-Ting Yuan, Chia-Hao Kuei, Hui-Yu Lin, Yen-Lin Chen, Hui-Wen Chiu, Yuan-Feng Lin
Summary: The study revealed that RGL2 is commonly upregulated in primary tumors of CRC patients, serving as a poor prognostic marker and promoting metastatic progression by regulating Wnt/beta-catenin signaling axis and KRAS.
Review
Biochemistry & Molecular Biology
Sarah Koushyar, Valerie S. Meniel, Toby J. Phesse, Helen B. Pearson
Summary: Aberrant activation of the Wnt pathway is closely related to tumor formation, progression, and therapeutic resistance in prostate cancer. Targeting the Wnt pathway for prostate cancer treatment has shown potential efficacy. However, the functional consequences of activating the Wnt pathway during different stages of prostate cancer progression are still unclear. Preclinical research on targeting Wnt signaling in the treatment of prostate cancer is crucial for identifying effective treatment strategies and improving patient care.
Article
Plant Sciences
Weijia Zhang, Chang Peng, Jiahui Yan, Pengting Chen, Cheng Jiang, Shuyi Sang, Yuemei Yuan, Yanjun Hong, Meicun Yao
Summary: This study demonstrated that the aqueous extract of Sanguisorba officinalis Linn. could inhibit the growth and metastasis of colorectal cancer cells by suppressing the Wnt pathway, providing potential for clinical application as an anti-CRC drug.
Article
Medicine, Research & Experimental
Guoqiang Yan, Shiquan Li, Meng Yue, Chenyao Li, Zhenhua Kang
Summary: The study revealed that KDM5B is abundantly expressed in colorectal cancer tissues and cells, and high KDM5B expression is associated with poor prognosis. KDM5B activates the Wnt/beta-catenin pathway by downregulating CCL14, promoting the progression of colorectal cancer.
Article
Oncology
Yayu Liu, Pedro Lei, Ronel Z. Samuel, Anagha M. Kashyap, Theodore Groth, Wiam Bshara, Sriram Neelamegham, Stelios T. Andreadis
Summary: This study uncovers a previously unknown role of CDH11 in cancer progression. CDH11 stabilizes beta-catenin in the cytoplasm and facilitates its translocation to the nucleus, resulting in activation of Wnt signaling and increased proliferation, migration, and invasion potential in tumors.
MOLECULAR ONCOLOGY
(2023)
Article
Environmental Sciences
Xianzhe Li, Ye Lu, Penghao Wen, Yan Yuan, Zhenghong Xiao, Hengwei Shi, Eryan Feng
Summary: This study aimed to explore the biological role and potential underlying mechanism of the traditional Chinese medicine matrine in colorectal cancer. The results showed that matrine can inhibit colorectal cancer development by modulating AGRN and inhibiting the activation of the Wnt/beta-catenin pathway, thereby exerting its anti-tumor effects.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Jun Chen, Zhiguang Duan, Yannan Liu, Rongzhan Fu, Chenhui Zhu
Summary: This study found that ginsenoside Rh4 inhibits the metastasis of esophageal squamous cell carcinoma (ESCC) by regulating the Wnt/beta-catenin signaling pathway and the level of c-Myc. In vitro and in vivo experiments confirmed the inhibitory effect of Rh4 on ESCC metastasis.
Article
Oncology
PanFeng Feng, LongXun Zhu, Jing Jie, PengXiang Yang, Nan Sheng, XiangFan Chen, Xia Chen
Summary: The non-psychoactive phytocannabinoid cannabidiol (CBD) effectively inhibits the migration and metastasis of colorectal cancer (CRC) cells by regulating the EMT process and suppressing the Wnt/β-catenin signaling pathway. This study provides the first evidence for the molecular mechanism of CBD in inhibiting EMT and metastasis in CRC cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Ina Baehr, Lina Jaeschke, Katharina Nimptsch, Juergen Janke, Pia Herrmann, Dennis Kobelt, Heike Kielstein, Tobias Pischon, Ulrike Stein
Summary: This study found higher plasma MACC1 levels in obese individuals, which were positively correlated with body fat mass and body mass index. The MLU study showed that reducing body fat mass through dietary intervention and physical exercise decreased MACC1 expression levels. Obese Wistar rats with diet-induced obesity and colon cancer exhibited significantly higher MACC1 levels compared to non-obese rats.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Bjoern-O Gohlke, Fabian Zincke, Andreas Eckert, Dennis Kobelt, Saskia Preissner, Juliane Maria Liebeskind, Nikolas Gunkel, Kerstin Putzker, Joe Lewis, Sally Preissner, Benedikt Kortum, Wolfgang Walther, Cameron Mura, Philip E. Bourne, Ulrike Stein, Robert Preissner
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Felicitas Schmid, Mathias Dahlmann, Hanna Roehrich, Dennis Kobelt, Jens Hoffmann, Susen Burock, Wolfgang Walther, Ulrike Stein
Summary: The study identified S100P as a transcriptional target gene of MACC1, showing that the expression of S100P increases the metastatic potential of CRC cells in vitro and in vivo and serves as a prognostic biomarker for metastasis-free survival of CRC patients, highlighting novel therapeutic interventions targeting S100P.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Vincent Vuaroqueaux, Alexandra Musch, Dennis Kobelt, Thomas Risch, Pia Herrmann, Susen Burock, Anne-Lise Peille, Marie-Laure Yaspo, Heinz-Herbert Fiebig, Ulrike Stein
Summary: This study investigates the contribution of chromosomal instability and somatic copy number alterations (SCNA) to the dysregulation of MACC1 in colorectal cancer (CRC). The findings suggest that elevated MACC1 expression is largely driven by chromosomal instability (CIN), SCNA gains, and molecular subtypes, and it has prognostic and predictive impacts on metastasis and survival. These insights could potentially serve as a basis for personalized treatment decisions.
Article
Oncology
Christoph Treese, Jessica Werchan, Moritz von Winterfeld, Erika Berg, Michael Hummel, Lena Timm, Beate Rau, Ole Daberkow, Wolfgang Walther, Severin Daum, Dennis Kobelt, Ulrike Stein
Summary: MACC1 plays a negative prognostic role in esophageal and gastric adenocarcinomas and its effect can be inhibited by selumetinib.
Article
Cell Biology
Christoph Treese, Kimberly Hartl, Michelle Potzsch, Matthias Dahlmann, Moritz von Winterfeld, Erika Berg, Michael Hummel, Lena Timm, Beate Rau, Wolfgang Walther, Severin Daum, Dennis Kobelt, Ulrike Stein
Summary: S100A4 plays a key role in the metastasis of adenocarcinoma of the gastroesophageal junction and stomach, and its high expression is significantly correlated with poor prognosis and metastasis development.
Article
Oncology
Alireza Basti, Deeksha Malhan, Malti Dumbani, Mathias Dahlmann, Ulrike Stein, Angela Relogio
Summary: The study investigates the interaction between the biological clock and metastasis-associated gene MACC1 in colorectal cancer (CRC). Results show a reciprocal interplay between the circadian clock and MACC1, suggesting a potential regulation of CRC invasiveness through the circadian clock.
Article
Oncology
Tim Hohmann, Urszula Hohmann, Mathias Dahlmann, Dennis Kobelt, Ulrike Stein, Faramarz Dehghani
Summary: High expression of MACC1 in colon cancer is associated with metastasis, tumor cell migration, and increased proliferation. This study found that MACC1 expression promotes collective migration, which is caused by increased proliferation, without affecting single cell biomechanics. Targeting proliferation may offer additional effects on cell migration in high-MACC1-expressing tumors.
Article
Oncology
J. J. Staudacher, Alexander Arnold, A. A. Kuehl, M. Poetzsch, S. Daum, M. Winterfeld, E. Berg, M. Hummel, B. Rau, U. Stein, C. Treese
Summary: This study aimed to investigate the prognostic role of activin tumor protein expression in esophageal and gastric adenocarcinomas. The results showed that higher levels of activin subunits were associated with lower cancer stage and longer overall survival. Furthermore, tumors with higher activin subunit expression also had higher CD4(+) T-cell infiltration, and the longer overall survival effect was only observed in tumors with high CD4(+) T-cell infiltration.
Review
Biochemistry & Molecular Biology
Monica A. Kamal, Yasmine M. Mandour, Mostafa K. Abd El-Aziz, Ulrike Stein, Hend M. El Tayebi
Summary: Liver cancer is a common and limitedly treated type of cancer. Recently, new target proteins and pathways have been discovered, leading to the design of new drugs. This review provides an overview of these targets and compounds.
Article
Biochemistry & Molecular Biology
Benedikt Kortuem, Harikrishnan Radhakrishnan, Fabian Zincke, Christoph Sachse, Susen Burock, Ulrich Keilholz, Mathias Dahlmann, Wolfgang Walther, Gunnar Dittmar, Dennis Kobelt, Ulrike Stein
Summary: Colorectal cancer is the second most common malignant disease worldwide, and metastasis is the main cause of death in CRC patients. The study identified MACC1 and S100A4 as key genes promoting CRC metastasis and found repositioned drugs that can inhibit metastasis.
Article
Oncology
Peter Wust, Paraskevi D. Veltsista, Eva Oberacker, Prabhusrinivas Yavvari, Wolfgang Walther, Olof Bengtsson, Anja Sterner-Kock, Marie Weinhart, Florian Heyd, Patricia Grabowski, Sebastian Stintzing, Wolfgang Heinrich, Ulrike Stein, Pirus Ghadjar
Summary: Adding amplitude modulation to radiofrequency waves can enhance non-temperature-induced anticancer effects. The study demonstrated that radiofrequency electromagnetic fields, along with amplitude modulation, can effectively inhibit tumor growth and enhance apoptosis, with the latter being correlated with cell membrane stiffness.
Article
Biochemistry & Molecular Biology
Paul Curtis Schoepe, Viktoria Zinnow, Muhammad Ahtisham Ishfaq, Janice Smith, Pia Herrmann, Robert H. Shoemaker, Wolfgang Walther, Ulrike Stein
Summary: Colorectal cancer is a prevalent and deadly cancer worldwide, with metastasis being responsible for most deaths. Biomarkers like S100A4 and MACC1 help identify high-risk patients for metastasis. Cantharidin and norcantharidin, natural compounds extracted from blister beetles, have shown anti-cancer and anti-metastatic effects in various cancers. This study demonstrates that cantharidin and norcantharidin inhibit the expression of S100A4 and MACC1, suggesting their potential as promising compounds for personalized anti-metastatic therapy in cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Nazli Guellue, Janice Smith, Pia Herrmann, Ulrike Stein
Summary: This study investigated the effect of curcumin, a natural product, on the expression and tumor-promoting pathways of MACC1, a metastasis-associated gene in colorectal cancer (CRC). The findings showed that curcumin reduced MACC1 expression, restricted MACC1-induced cell proliferation, and decreased MACC1-induced cell motility, crucial for tumor dissemination. Additionally, the study demonstrated the MACC1-dependent effect of curcumin on clonogenicity and wound healing, which had not been previously reported.
Article
Gastroenterology & Hepatology
Alexander Arnold, Moritz von Winterfeld, Erika Berg, Michael Hummel, Beate Rau, Felix Krenzien, Ulrike Stein, Christoph Treese
Summary: The study found that only a minority of tumors in AEG/S tissues had high expression of NAMPT, and that NAMPT expression was more frequent in older patients, although not significantly correlated with survival.
GASTROINTESTINAL DISORDERS
(2022)
