Hormesis in Aging and Neurodegeneration—A Prodigy Awaiting Dissection

Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance

(2018) Mari-Carmen Gomez-Cabrera et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Activation of mitochondrial energy metabolism protects against cardiac failure

(2016) Tim J. Schulz et al.   Aging-US

Hormesis, cell death and aging

(2016) Isabelle Martins et al.   Aging-US

Caloric restriction: is mammalian life extension linked to p53?

(2016) Paola Tucci   Aging-US

Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil

(2013) Javier A. Menendez et al.   CELL CYCLE

Resveratrol and Cancer Treatment: Is Hormesis a Yet Unsolved Matter?

(2013) Adriana Borriello et al.   CURRENT PHARMACEUTICAL DESIGN

Reactive oxygen species and the free radical theory of aging

(2013) Stefan I. Liochev   FREE RADICAL BIOLOGY AND MEDICINE

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

(2013) Antero Salminen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of mitochondrial DNA mutations and free radicals in disease and ageing

(2013) M. Lagouge et al.   JOURNAL OF INTERNAL MEDICINE

Hormesis

(2012) Soledad Matus et al.   Autophagy

Increased Levels of Hydrogen Peroxide Induce a HIF-1-dependent Modification of Lipid Metabolism in AMPK Compromised C. elegans Dauer Larvae

(2012) Meng Xie et al.   Cell Metabolism

Growth Factors, Nutrient Signaling, and Cardiovascular Aging

(2012) Luigi Fontana et al.   CIRCULATION RESEARCH

Mitochondrial Control of Cellular Life, Stress, and Death

(2012) Lorenzo Galluzzi et al.   CIRCULATION RESEARCH

Alzheimers Disease: From Pathogenesis to Disease-Modifying Approaches

(2012) Daniela Galimberti et al.   CNS & Neurological Disorders-Drug Targets

Calorie restriction increases cerebral mitochondrial respiratory capacity in a NO•-mediated mechanism: Impact on neuronal survival

(2012) Fernanda M. Cerqueira et al.   FREE RADICAL BIOLOGY AND MEDICINE

Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: Implication in autosomal recessive juvenile Parkinsonism

(2012) Leonardo Bonilla-Ramirez et al.   GENE

Neuroglobin, a Novel Target for Endogenous Neuroprotection against Stroke and Neurodegenerative Disorders

(2012) Zhanyang Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Radiation hormesis: Autophagy and other cellular mechanisms

(2012) Irena Szumiel   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Resveratrol Inhibits the Proliferation of Neural Progenitor Cells and Hippocampal Neurogenesis

(2012) Hee Ra Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alcohol Consumption and the Risk of Hypertension in Men and Women: A Systematic Review and Meta-Analysis

(2012) Alexandros Briasoulis et al.   Journal of Clinical Hypertension

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Nicotine effects on human endothelial intercellular communication via α4β2 and α3β2 nicotinic acetylcholine receptor subtypes

(2012) Nicole Duerrschmidt et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Activation of the Unfolded Protein Response Is an Early Event in Alzheimer’s and Parkinson’s Disease

(2012) Jeroen J.M. Hoozemans et al.   Neurodegenerative Diseases

The effects of nicotine on nitric oxide induced anxiogenic-like behaviors in the dorsal hippocampus

(2012) Morteza Piri et al.   NEUROSCIENCE LETTERS

Mitochondrial Hormesis in PancreaticβCells: Does Uncoupling Protein 2 Play a Role?

(2012) Ning Li et al.   Oxidative Medicine and Cellular Longevity

Caenorhabditis elegans Battling Starvation Stress: Low Levels of Ethanol Prolong Lifespan in L1 Larvae

(2012) Paola V. Castro et al.   PLoS One

Is the fear of dioxin cancer more harmful than dioxin?

(2012) Jouko Tuomisto et al.   TOXICOLOGY LETTERS

Genetic Background Specific Hypoxia Resistance in Rat is Correlated with Balanced Activation of a Cross-Chromosomal Genetic Network Centering on Physiological Homeostasis

(2012) Lei Mao   Frontiers in Genetics

Low-Dose-Rate, Low-Dose Irradiation Delays Neurodegeneration in a Model of Retinitis Pigmentosa

(2011) Atsushi Otani et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial Stress Signals Revise an Old Aging Theory

(2011) Dong Kyun Woo et al.   CELL

Nutritional Antioxidants and Adaptive Cell Responses: An Update

(2011) A. Speciale et al.   CURRENT MOLECULAR MEDICINE

Mitochondria, reactive oxygen species, and chronological aging: A message from yeast

(2011) Yong Pan   EXPERIMENTAL GERONTOLOGY

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroglobin is up-regulated in the cerebellum of pups exposed to maternal epileptic seizures

(2011) Daiana Correia Lima et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

(2011) Eugenia Morselli et al.   JOURNAL OF CELL BIOLOGY

Resveratrol improves cognitive function in mice by increasing production of insulin-like growth factor-I in the hippocampus

(2011) Naoaki Harada et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity

(2011) Vittorio Calabrese et al.   MOLECULAR ASPECTS OF MEDICINE

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

(2011) Silvestre Alavez et al.   NATURE

Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity

(2011) Candice E Paulsen et al.   Nature Chemical Biology

Mitochondria-mediated hormetic response in life span extension of calorie-restricted Saccharomyces cerevisiae

(2010) Praveen Kumar Sharma et al.   AGE

ER stress and hormetic regulation of the aging process

(2010) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

(2010) Vittorio Calabrese et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial energy metabolism and ageing

(2010) Ivana Bratic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

(2010) Seung-Jae Lee et al.   CURRENT BIOLOGY

Perspectives on the mitochondrial etiology of replicative aging in yeast

(2010) Ana Ugidos et al.   EXPERIMENTAL GERONTOLOGY

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Radiation hormesis - A remedy for fear

(2010) Zbigniew Jaworowski   HUMAN & EXPERIMENTAL TOXICOLOGY

Dose response biology: The case of resveratrol

(2010) Edward J Calabrese et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beneficial Effects of Mild Stress (Hormetic Effects): Dietary Restriction and Health

(2010) Katsuyasu Kouda et al.   Journal of Physiological Anthropology

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity

(2010) A. Mesquita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

The coordination of nuclear and mitochondrial communication during aging and calorie restriction

(2009) Lydia W.S. Finley et al.   AGEING RESEARCH REVIEWS

Effects of vitamins C and E and β-carotene on the risk of type 2 diabetes in women at high risk of cardiovascular disease: a randomized controlled trial

(2009) Yiqing Song et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effects of antioxidant supplements on cancer prevention: meta-analysis of randomized controlled trials

(2009) S.-K. Myung et al.   ANNALS OF ONCOLOGY

Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1

(2009) Yong Zuo et al.   CELL RESEARCH

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

Feeding a ROS-generator to Caenorhabditis elegans leads to increased expression of small heat shock protein HSP-16.2 and hormesis

(2009) Kai Hartwig et al.   Genes and Nutrition

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Antioxidants prevent health-promoting effects of physical exercise in humans

(2009) M. Ristow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging

(2008) Thore C. Brink et al.   BIOGERONTOLOGY

Stress-Response Hormesis and Aging: “That which Does Not Kill Us Makes Us Stronger”

(2008) David Gems et al.   Cell Metabolism

Is there a role for supplemented antioxidants in the prevention of atherosclerosis?

(2008) Niki Katsiki et al.   CLINICAL NUTRITION

Quality control of mitochondria: protection against neurodegeneration and ageing

(2008) Takashi Tatsuta et al.   EMBO JOURNAL

Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling

(2008) J. C. Juarez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?

(2008) Hirokazu Fukui et al.   TRENDS IN NEUROSCIENCES

Hormesis in aging

(2007) Suresh I.S. Rattan   AGEING RESEARCH REVIEWS