Letter
Oncology
Analu Barros de Oliveira, Tulio Morandin Ferrisse, Heitor Albergoni Silveira, Evanio Vilela Silva, Andreia Bufalino, Jorge Esquiche Leon, Fernanda Lourencao Brighenti
Summary: A rare case of intraoral atypical lentiginous melanocytic lesion affecting a pediatric patient was reported, diagnosed as lentiginous junctional melanocytic nevus with cytologic atypia. Excision is strongly recommended for melanocytic lesions showing features of atypical lentiginous growth pattern.
Article
Oncology
Rogier J. Nell, Nino V. Menger, Mieke Versluis, Gregorius P. M. Luyten, Robert M. Verdijk, Michele C. Madigan, Martine J. Jager, Pieter A. van der Velden
Summary: The findings suggest that CYSLTR2 is involved in both early and late development of uveal melanoma, with mutant CysLT(2)R potentially being an attractive therapeutic target.
Article
Hematology
A. Wehling, D. Loeffler, Y. Zhang, T. Kull, C. Donato, B. Szczerba, G. Camargo Ortega, M. Lee, A. Moor, B. Gottgens, N. Aceto, T. Schroeder
Summary: Identifying molecular programs initiating cell fate divergence (CFD) is challenging as current approaches miss molecular changes at its start. However, by studying diverging sister cells, which differ mainly in CFD properties, it is possible to identify cells at the start of CFD.
Review
Oncology
Kostas Palamaris, Evangelos Felekouras, Stratigoula Sakellariou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by aggressive behavior and resistance to chemotherapy, with emerging evidence pointing to epithelial to mesenchymal transition (EMT) as a key driver of disease progression and drug resistance. EMT allows cancer cells to transition to a more mesenchymal state, contributing to tumor dissemination and chemoresistance in PDAC.
Article
Endocrinology & Metabolism
Aoxing Cheng, Tian Xu, Weiyi You, Ting Wang, Dongming Zhang, Huimin Guo, Haiyan Zhang, Xin Pan, Yucai Wang, Liu Liu, Kaiguang Zhang, Jue Shi, Xuebiao Yao, Jing Guo, Zhenye Yang
Summary: Research has found that redox metabolites in cancer cells fluctuate during the cell cycle, but the functional impacts of these metabolic oscillations are still unknown. A mitosis-specific upsurge of nicotinamide adenine dinucleotide phosphate (NADPH) has been discovered, which is essential for tumor progression. This upsurge is produced by glucose 6-phosphate dehydrogenase (G6PD) upon mitotic entry and neutralizes elevated reactive oxygen species (ROS), preventing ROS-induced inactivation of mitotic kinases and chromosome missegregation. The study reveals that aneuploid cancer cells with high ROS levels depend on a G6PD-mediated NADPH upsurge during mitosis to protect against ROS-induced chromosome missegregation, making this upsurge a cell cycle-dependent metabolic vulnerability.
Article
Chemistry, Multidisciplinary
Bin Zhang, Zhi-yi Liu, Rui Wu, Cheng-ming Zhang, Kuan Cao, Wen-gang Shan, Zhen Liu, Ming Ji, Zi-lu Tian, Gautam Sethi, Heng-liang Shi, Ren-hao Wang
Summary: CTR9, a scaffold protein of the PAF1 complex, plays essential roles in hepatocellular carcinoma by promoting cell proliferation, invasion, and migration. CTR9 also promotes HCC development by enhancing the transcription of the oncogene PEG10. Targeting CTR9 may provide a novel therapeutic strategy for HCC.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Hematology
Yu Jia Shen, Yuji Mishima, Jiantao Shi, Romanos Sklavenitis-Pistofidis, Robert A. Redd, Michele Moschetta, Salomon Manier, Aldo M. Roccaro, Antonio Sacco, Yu-Tzu Tai, Francois Mercier, Yawara Kawano, Nang Kham Su, Brianna Berrios, John G. Doench, David E. Root, Franziska Michor, David T. Scadden, Irene M. Ghobrial
Summary: Clonal evolution plays a key role in tumor progression, dissemination, and relapse in multiple myeloma (MM). By developing a clone-tracking system, researchers studied clonal behavior in the bone marrow microenvironment, identifying specific clones able to adapt and colonize distant sites. RNA sequencing revealed a progression signature in MM tumor cells, leading to the prediction of 28 master regulators, with HMGA1 and PA2G4 validated as key players in MM progression and dissemination, impacting cell functions like proliferation, migration, and adhesion. This study successfully replicates key characteristics of human MM disease progression and suggests potential therapeutic targets.
Article
Pharmacology & Pharmacy
Etan Marks, Anais A. Badia, Matthew S. Goldberg
Summary: Ancillary tests such as immunohistochemistry (IHC) and gene expression profile (GEP) testing may be necessary for a definitive diagnosis of atypical melanocytic neoplasms. This case study highlights the importance of using 23-GEP testing to resolve ambiguous histopathological features and confirm a diagnosis of malignant melanoma.
PERSONALIZED MEDICINE
(2023)
Article
Oncology
Rosa-Maria Ferraiuolo, Bre-Anne Fifield, Caroline Hamm, Lisa A. Porter
Summary: Understanding the relationship between protein expression level and response to treatment is crucial for developing novel treatment options for breast cancer patients. The data shows a correlation between Spy1 and c-Myc protein levels in more aggressive breast cancer cells and patient samples. Additionally, targeting Spy1 may confer an advantage to current chemotherapies, even when c-Myc levels are elevated.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Medicine, General & Internal
Jing He, Xin Zhou, Xiaping Wang, Qing Zhang, Lan Zhang, Tongshan Wang, Wei Zhu, Ping Liu, Mingxia Zhu
Summary: The study revealed that CDCA5 is significantly overexpressed in multiple types of tumors and associated with poor survival, as well as correlated with immune cell infiltration, tumor mutation burden, and immune checkpoint expression.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Review
Biology
Mohammed El Dika, Damian Dudka, Malgorzata Kloc, Jacek Z. Kubiak
Summary: The kinetics of CDK1 activation must be precisely controlled for timely and accurate entry into mitosis. CDC6 and Xic1 act as critical components in the mitotic CDK1 activation cascade by inhibiting CDK1 activators Aurora A and PLK1. This article discusses the impact of the CDC6/Xic1 regulatory network on CDK1 function, the presence of two inhibitory mechanisms, and their interactions with CDK1 activators. The coordinated modulation of multiple inhibitors and activators ensures the robustness and flexibility of mitotic timing. A new model is proposed that integrates CDC6/Xic1-dependent inhibition into the CDK1-activation cascade, providing insights into the precise control of mitotic events.
Review
Dermatology
Marusa Selan, Daja Sekoranja, Mateja Starbek Zorko
Summary: A teenage girl presented with an atypical melanocytic lesion suspicious for melanoma, which was later diagnosed as pseudomelanoma after surgical excision. The irregular changes in the nevus may have been caused by a previous injury.
ACTA DERMATOVENEROLOGICA ALPINA PANNONICA ET ADRIATICA
(2021)
Article
Dermatology
Simona Kordeva, Valentina Broshtilova, Georgi Tchernev
Summary: Melanocytic lesions in delicate anatomical locations pose diagnostic challenges, as patients may delay examinations due to anxiety or discomfort. Surgical treatment, although not always preferred, often provides a definitive solution. Atypical genital nevi may be precursors to melanoma, especially when they extend beyond the labia majora. Careful physical examination is necessary, and surgical excision is recommended for prevention.
DERMATOLOGY REPORTS
(2023)
Article
Medicine, Research & Experimental
Yong Da, Ge Shen, Ming Zhou, Tao Wang, Dapeng Dong, Lina Bu, Yun Shao, Qiyun Sun, Ruoying Yu
Summary: There is heterogeneity in cancer patients' responses to immune checkpoint inhibitors (ICIs), including hyperprogression and pseudoprogression. This heterogeneity complicates clinical decisions. This study presents two cases that highlight the importance of biopsy examination when subcutaneous nodules appear after treatment with ICIs.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Svenja Ploehn, Matthias Hose, Anke Schlueter, Lars Michel, Salvador Diaz-Cano, Ulrike B. Hendgen-Cotta, Jasvinder Paul Banga, Nikolaos E. Bechrakis, Wiebke Hansen, Anja Eckstein, Utta Berchner-Pfannschmidt
Review
Genetics & Heredity
Santiago Ramon y Cajal, Marta Sese, Claudia Capdevila, Trond Aasen, Leticia De Mattos-Arruda, Salvador J. Diaz-Cano, Javier Hernandez-Losa, Josep Castellvi
JOURNAL OF MOLECULAR MEDICINE-JMM
(2020)
Review
Endocrinology & Metabolism
Georgios K. Dimitriadis, Delane S. Wajman, John Bidmead, Salvador J. Diaz-Cano, Sobia Arshad, Mohamed Bakhit, Dylan Lewis, Simon J. B. Aylwin
Article
Microbiology
Sajad Moshkelgosha, Hedda Luise Verhasselt, Giulia Masetti, Danila Covelli, Filippo Biscarini, Mareike Horstmann, Anke Daser, Astrid M. Westendorf, Christoph Jesenek, Svenja Philipp, Salvador Diaz-Cano, J. Paul Banga, Daryn Michael, Sue Plummer, Julian R. Marchesi, Anja Eckstein, Marian Ludgate, Utta Berchner-Pfannschmidt
Summary: The study demonstrates the role of gut microbiota in TSHR-induced disease, with profound effects on quantifiable GD endocrine and immune factors. The impact on GO cellular changes is more nuanced, holding translational potential for novel, improved treatments.
Article
Dermatology
Sophie Elizabeth Momen, Salvador Diaz-Cano, Sarah Walsh, Daniel Creamer
Summary: By analyzing clinical and dermatopathologic features of hospitalized DRESS patients, it was found that factors such as latency period, fever, reaction duration, facial edema, basal squamatization, dermal red blood cell extravasation, and interface inflammation can help distinguish between mild and severe forms of the disorder.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
K. Lithgow, H. Venkataraman, S. Hughes, H. Shah, J. Kemp-Blake, S. Vickrage, S. Smith, S. Humphries, M. Elshafie, P. Taniere, S. Diaz-Cano, B. V. M. Dasari, M. Almond, S. Ford, J. Ayuk, S. Shetty, T. Shah, I. Geh
Summary: Neuroendocrine neoplasms, particularly G3 tumors, exhibit heterogeneous behavior with poor prognosis, limited treatment options, and potential response to somatostatin analogs and chemotherapy. Further research is needed to compare the effectiveness of different treatment strategies for this disease.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Sola Adeleke, Aidan Haslam, Adrian Choy, Salvador Diaz-Cano, Joao R. Galante, Christos Mikropoulos, Stergios Boussios
Summary: We present a case study of a patient with Lynch syndrome and metastatic colorectal carcinoma (mCRC). The initial immunohistochemistry (IHC) test for mismatch repair deficiency yielded incorrect results, but subsequent testing confirmed the presence of microsatellite instability (MSI). The patient responded positively to immunotherapy, highlighting the importance of accurate testing strategies to guide therapy in mCRC. We advocate for the use of both IHC and MSI-PCR tests and the need for a better understanding of their limitations.
PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ye Lynn Ko, Vaishnavi Kumar, Juliane Lippert, Salvador Diaz-Cano, Kassiani Skordilis, Otilia Kimpel, Stefan Kircher, Miriam Asia, Yasir S. Elhassan, Barbara Altieri, Cristina L. Ronchi
Summary: This article reports three cases where sporadic ACC was identified in patients with coexistent or previous history of melanoma. The researchers found a higher incidence of ACC in patients with melanoma.
BMC ENDOCRINE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Helena Hanschell, Salvador Diaz-Cano, Alfredo Blanes, Nadia Talat, Gabriele Galata, Simon Aylwin, Klaus Martin Schulte
Summary: In this study, a simple and reliable tool, the SIZEPASS criterion, was developed to predict the malignant behavior of PPGLs based on the size of the tumors. The SIZEPASS criterion showed high accuracy and sensitivity in predicting malignancy in PPGLs.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Harriet Evans, Brendan O'Sullivan, Frances Hughes, Kathryn Charles, Lee Robertson, Philippe Taniere, Salvador Diaz-Cano
Summary: Immune checkpoint blockade drugs are effective for treating urothelial carcinoma, but the complexity of different drugs and diagnostic assays presents challenges in routine practice and limits cross-utility of assays.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)
Article
Endocrinology & Metabolism
Adrian Po Zhu Li, Sheela Sathyanarayan, Salvador Diaz-Cano, Sobia Arshad, Eftychia E. Drakou, Royce P. Vincent, Ashley B. Grossman, Simon J. B. Aylwin, Georgios K. Dimitriadis
Summary: A 49-year-old teacher presented with lethargy and lower limb weakness. Further examination revealed hypercalcaemia, hyperparathyroidism, hypokalaemia, and the presence of mediastinal and pancreatic masses. Genetic testing confirmed multiple endocrine neoplasia type 1.
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2022)
Article
Surgery
A. Emmanuel, A. Haji, S. Gulati, J. Moorhead, S. Papagrigoriadis, B. Hayee, S. Diaz-Cano
Summary: The study found that specific histopathological features in low-grade areas of large colorectal adenomas can predict the presence of coexistent invasive adenocarcinoma. An increasing number of these features is strongly associated with the presence of coexistent invasive cancer, with a sensitivity of 86% and specificity of 84%.
Meeting Abstract
Medicine, Research & Experimental
Fatima Al-Hashimi, Salvador Diaz-Cano
LABORATORY INVESTIGATION
(2020)
Meeting Abstract
Pathology
Fatima Al-Hashimi, Salvador Diaz-Cano
Meeting Abstract
Gastroenterology & Hepatology
Andrew Emmanuel, Salvador Diaz-Cano, Shraddha Gulati, Savvas Papagrigoriadis, Bu Hayee, Amyn Haji
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.
