Article
Biochemistry & Molecular Biology
Francesca Fata, Radosveta Gencheva, Qing Cheng, Rachel Lullo, Matteo Ardini, Ilaria Silvestri, Federica Gabriele, Rodolfo Ippoliti, Christina A. Bulman, Judy A. Sakanari, David L. Williams, Elias S. J. Arner, Francesco Angelucci
Summary: This study characterized the thioredoxin reductase (TrxR) selenoproteins from two filarial nematode parasites, providing insights on drug targets for lymphatic filariasis and onchocerciasis treatment.
Review
Biochemistry & Molecular Biology
Ajanta Chatterji, Rajib Sengupta
Summary: This article discusses the function of nitric oxide and its potential pathological effects, investigates the current research on cellular S-denitrosylases and their potential applications, and provides a detailed analysis of the importance of maintaining cellular redox homeostasis.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fernando Toshio Ogata, Alex Yuri Simoes Sato, Lucia Coppo, Roberto Jun Arai, Arnold Ira Stern, Hugo Pequeno Monteiro
Summary: The epithelial/mesenchymal transition (EMT) is associated with tumor metastasis. Cancer cells have high levels of antioxidants, such as the Trx/TrxR and GSH/Grx systems, to counteract oxidative and nitrosative stress. These systems play a significant role in EMT signaling and cancer cell progression.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Maria Martha Sainz, Carla Valeria Filippi, Guillermo Eastman, Jose Sotelo-Silveira, Omar Borsani, Mariana Sotelo-Silveira
Summary: Soybean plants establish symbiosis with rhizobacteria to perform biological nitrogen fixation (BNF). This study investigated the differential response of nodulated soybean plants to water-deficit stress and identified a greater number of differentially expressed genes (DEGs) under water deficit compared to nodulation condition. Additionally, the complete repertoire of thioredoxins (Trx) and glutaredoxins (Grx) in soybean was identified, and a network involving their interaction with nitrogen metabolism enzymes was revealed.
Review
Biochemistry & Molecular Biology
Mohamed Haddad, Vincent Herve, Mohamed Raafet Ben Khedher, Jean-Michel Rabanel, Charles Ramassamy
Summary: Glutathione plays a significant role as an antioxidant in the brain related to Alzheimer's disease, with alterations in its levels correlated with cognitive decline. Strategies have been developed to restore its intracellular level, but no significant benefits have been reported in clinical trials so far. Future directions include utilizing GSH-coupled nanocarriers for brain delivery and investigating its presence in exosomes for potential intercellular transfer.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Jing Li, Xuewen Tang, Xing Wen, Xiaoyuan Ren, Huihui Zhang, Yatao Du, Jun Lu
Summary: Acetaminophen overdose is a common cause of drug-induced liver injury. The reaction between APAP metabolite and thiol molecules is the main cause of APAP-induced hepatotoxicity, but the role of other thiol-related regulators is unclear. In this study, the deletion of the Glrx2 gene worsened APAP-induced liver damage by interrupting the thiol-redox compensatory response and enhancing the AIF pathway-mediated oxidative damage.
Article
Pharmacology & Pharmacy
Gaopan Dong, Xiaohan Ye, Shumei Wang, Wenhua Li, Rong Cai, Lupei Du, Xiaodong Shi, Minyong Li
Summary: This study reports a novel TrxR inhibitor Au-24 and its inhibitory ability to hepatocellular carcinoma in vitro and in vivo. Au-24 suppresses the proliferation of HepG2 cells through regulating multiple signaling pathways and inducing oxidative stress. In vivo experiments demonstrate that Au-24 is more effective than the traditional drug AA1 in inhibiting tumor growth.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Plant Sciences
Jean-Luc Montillet, Damien Rondet, Sabine Brugiere, Patricia Henri, Dominique Rumeau, Jean-Philippe Reichheld, Yohann Coute, Nathalie Leonhardt, Pascal Rey
Summary: Stomatal movements controlled by gas exchanges play a key role in plant growth in response to environmental stimuli. Thiol-reductases are involved in signaling pathways regulating guard cell movements and stomatal functioning, but their specific mechanisms remain poorly characterized.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Mirva J. Saaranen, Heli Alanen, Kirsi E. H. Salo, Emmanuel Nji, Pekka Karkkainen, Constanze Schmotz, Lloyd W. Ruddock
Summary: Proteins in the thioredoxin superfamily, such as protein disulfide isomerase (PDI) and glutaredoxins, have similar structures and catalytic mechanisms. PDI uses glutathione for oxidation/reduction in vitro, while glutaredoxins have a high affinity for glutathione. Mutating the active site of PDI to a more glutaredoxin-like motif increases its reactivity with glutathione.
Article
Biochemistry & Molecular Biology
Chengmeng Wang, Lu Zhang, Manqing Cao, Zhou Fu, Huaqi Wang, Su Zhang, Keyun Zhu, Zhenyu Hou, Jinfang Cui, Ping Yue, Hua Guo, Ti Zhang
Summary: Thioredoxin (TXN) plays a crucial role in promoting hepatocellular carcinoma (HCC) stemness properties in a non-redox-dependent manner. TXN is upregulated in HCC patients and is associated with poor prognosis. TXN promotes HCC stemness properties and HCC metastasis by interacting with BACH1 and stabilizing its expression through inhibition of ubiquitination. BACH1 activates the AKT/mTOR pathway to promote HCC stemness.
Article
Biochemistry & Molecular Biology
Natalia Sasoni, Matias D. Hartman, Guillermo Garcia-Effron, Sergio A. Guerrero, Alberto A. Iglesias, Diego G. Arias
Summary: This study reports the identification of two new redox factors, Lin1CGrx and Lin2CGrx, linked to GSH metabolism and iron homeostasis in L. interrogans. The biochemical characterization, kinetic and structural analysis of these proteins revealed their functions and structural features.
Article
Biochemistry & Molecular Biology
Esha Sircar, Sristi Raj Rai, Mark A. Wilson, Michael G. Schlossmacher, Rajib Sengupta
Summary: Parkinson's disease is a rapidly growing neurodegenerative disorder with a strong genetic component. Aberrant S-nitrosylation of proteins like Parkin, DJ-1, and PINK1 may contribute to the pathogenesis of PD, emphasizing the importance of this post-translational modification in neuronal health.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Cell Biology
Wen-Ya Huang, Zhi-Bin Liao, Jia-Cheng Zhang, Xin Zhang, Hong-Wei Zhang, Hui-Fang Liang, Zun-Yi Zhang, Tao Yang, Jia Yu, Ke-Shuai Dong
Summary: The study showed that TXNRD1 is upregulated in HCC tumors and correlates with poor patient survival. Functional studies demonstrated that TXNRD1 promotes HCC cell proliferation and metastasis. USF2 acts as a tumor suppressor by inhibiting TXNRD1 expression in HCC progression.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Esha Sircar, Detcho A. Stoyanovsky, Timothy R. Billiar, Arne Holmgren, Rajib Sengupta
Summary: Intracellular reduced glutathione (GSH) is the most abundant intracellular thiol with concentrations ranging from 1-10 mM, playing a crucial role as a potent cellular antioxidant and denitrosylating agent against redox stress. Our study demonstrates GSH mediated denitrosylation of protein nitrosothiols in HepG2 cells using a unique spin-trapping mechanism and identifies two previously unknown substrates of GSH mediated S-denitrosylation.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Natalia Sasoni, Matias D. Hartman, Sergio A. Guerrero, Alberto A. Iglesias, Diego G. Arias
Summary: This study identified MsrAs and MsrB enzymes in Leptospira interrogans, which are involved in the reduction of methionine sulfoxide and play a role in repairing oxidized macromolecules, supporting the existence of a redox metabolism pathway in this pathogen.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2021)
Article
Gastroenterology & Hepatology
Karl Bjorkstrom, Per Stal, Magnus Holmer, Bonnie Bengtsson, Annika Staaf, Johan Hoffstedt, Hannes Hagstrom
Summary: Improving glycemic control through a personalized treatment program is associated with a reduction in liver steatosis and stiffness in persons with advanced T2D.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Endocrinology & Metabolism
Stephan L. Haas, Patrik Lofgren, Per Stal, Johan Hoffstedt
Summary: In obese patients with type-2 diabetes, a very low-calorie diet can significantly reduce plasma glucagon levels, decrease body weight, blood glucose, insulin, liver fat, and liver stiffness.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2022)
Meeting Abstract
Oncology
Jean-Luc Van Laethem, Ivan Borbath, Mark Karwal, Chris Verslype, Hans Van Vlierberghe, Adel Kardosh, Vittorina Zagonel, Per Stal, Debashis Sarker, Daniel H. Palmer, Arndt Vogel, Julien Edeline, Stephane Cattan, Masatoshi Kudo, Ann-Lii Cheng, Sadahisa Ogasawara, Abby B. Siegel, Michael Jon Chisamore, Wang Anran, Andrew X. Zhu
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Hannes Hagstrom, Nelson Ndegwa, Molly Jalmeus, Mattias Ekstedt, Iris Posserud, Fredrik Rorsman, Nils Nyhlin, Daniel Klintman, Marten Werner, Hanns-Ulrich Marschall, Johan Askling, Per Stal
Summary: In Sweden, patients with HFE gene mutations were found to have an increased risk for hepatocellular carcinoma, hereditary haemochromatosis, cirrhosis, type 2 diabetes, osteoarthritis, and death during long-term follow-up, with excess mortality seen in men. No increased risk was observed for colorectal or breast cancer.
LIVER INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Hannes Hagstrom, Dawei Bu, Patrik Nasr, Mattias Ekstedt, Hannes Hegmar, Stergios Kechagias, Ningyan Zhang, Zhiqiang An, Per Stal, Philipp E. Scherer
Summary: The study suggests that serum endotrophin could be a valuable biomarker for diagnosing NASH in patients with NAFLD, but it is not significantly associated with detecting advanced fibrosis.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2021)
Meeting Abstract
Oncology
J-L. van Laethem, I. Borbath, M. Karwal, C. Verslype, H. Van Vlierberghe, A. Kardosh, V. Zagonel, P. Stal, D. Sarker, D. Palmer, A. Vogel, J. Edeline, S. Cattan, M. Kudo, A-L. Cheng, S. Ogasawara, A. B. Siegel, M. Chisamore, A. Wang, A. Zhu
ANNALS OF ONCOLOGY
(2021)
Article
Oncology
Gontran Verset, Ivan Borbath, Mark Karwal, Chris Verslype, Hans Van Vlierberghe, Adel Kardosh, Vittorina Zagonel, Per Stal, Debashis Sarker, Daniel H. Palmer, Arndt Vogel, Julien Edeline, Stephane Cattan, Masatoshi Kudo, Ann-Lii Cheng, Sadahisa Ogasawara, Bruno Daniele, Stephen L. Chan, Jennifer J. Knox, Shukui Qin, Abby B. Siegel, Michael Chisamore, Ken Hatogai, Anran Wang, Richard S. Finn, Andrew X. Zhu
Summary: This study aimed to evaluate the efficacy and tolerability of pembrolizumab in patients with advanced hepatocellular carcinoma (HCC) who had not received prior systemic therapy. The results showed that pembrolizumab demonstrated durable antitumor activity and a favorable safety profile in this patient population, supporting further evaluation of pembrolizumab-based regimens for HCC treatment.
CLINICAL CANCER RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Magnus Holmer, Mattias Ekstedt, Patrik Nasr, Robin Zenlander, Axel Wester, Federica Tavaglione, Stefano Romeo, Stergios Kechagias, Per Stal, Hannes Hagstrom
Summary: The study found that the PNPLA3 G/G genotype is associated with an increased rate of severe liver disease in patients with NAFLD, while overall mortality is not affected by any genetic variant.
LIVER INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Denisa Druvari, Ioanna Tzoumani, Zoi Piperigkou, Kyriaki Tzaferi, Dimitris Tselentis, Alexios Vlamis-Gardikas, Nikos K. Karamanos, Georgios Bokias, Joannis K. Kallitsis
Summary: Air pollution caused by pathogens has gained significant attention in recent years due to its impact on global health. In this study, researchers have developed a spray coating method to produce antibacterial air filters, effectively addressing the challenge of preventing secondary pollution in air-filtering devices. These filters exhibit strong and rapid antibacterial activity, making them promising candidates for filter coatings in air-purification devices.
Article
Nanoscience & Nanotechnology
Denisa Druvari, Fotini Kyriakopoulou, Georgia C. Lainioti, Alexios Vlamis-Gardikas, Joannis K. Kallitsis
Summary: Humidity-responsive materials have gained attention for various applications, but the susceptibility of poly(ionic liquid)s to microorganisms is often overlooked. This study focuses on the development of dual functional antimicrobial membranes derived from cross-linked copolymers functionalized with ionic liquids. The membranes exhibit high humidity responsiveness and effective inhibition of bacterial growth.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Gastroenterology & Hepatology
Hartwig Maetzel, Wiktor Rutkowski, Nikola Panic, Amir Mari, Aleksandra Hedstrom, Paula Kulinski, Per Stal, Sven Petersson, Torkel B. Brismar, J. Matthias Lohr, Miroslav Vujasinovic
Summary: This study found that the prevalence of non-alcoholic fatty pancreas disease (NAFPD) was 85% in patients with non-alcoholic fatty liver disease (NAFLD) and 55% in the control group. However, PEI was not diagnosed in either group. A literature review identified PEI in 9-56% of NAFPD patients.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Robin Zenlander, Claudia Fredolini, Jochen M. Schwenk, Ingvar Ryden, Peter Pahlsson, Christian Loewbeer, Gosta Eggertsen, Per Stal
Summary: In this study, α-fetoprotein, des-gamma-carboxy prothrombin, thioredoxin reductase 1, and fibroblast growth factor 21 were identified as proteins with good discriminatory performance between hepatocellular carcinoma and cirrhosis in patients.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Axel Wester, Ying Shang, Per Stal, Hannes Hagstrom
Summary: This study assessed the time trends in mortality and life expectancy in patients hospitalized with alcohol-associated cirrhosis. The results showed that mortality has improved somewhat when accounting for baseline characteristics, but the loss in life expectancy remains substantial.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yi-Hua Zhang, Katharina Brehmer, Anders Svensson, Gunnar Herlin, Per Stal, Torkel B. Brismar
Summary: Quantitative imaging techniques have shown the prognostic value of textural parameters for hepatocellular carcinoma (HCC). This study evaluated the reproducibility of textural parameters in HCC and hepatic tissue with different contrast medium timing, and found that the contrast medium timing does not affect the reproducibility of textural parameters. Therefore, it should not be a concern in CT texture analysis of HCC.
Article
Gastroenterology & Hepatology
Fredrik Aberg, Christopher J. Danford, Maja Thiele, Mats Talback, Ditlev Nytoft Rasmussen, Z. Gordon Jiang, Niklas Hammar, Patrik Nasr, Mattias Ekstedt, Anna But, Pauli Puukka, Aleksander Krag, Jouko Sundvall, Iris Erlund, Veikko Salomaa, Per Stal, Stergios Kechagias, Rolf Hultcrantz, Michelle Lai, Nezam Afdhal, Antti Jula, Satu Mannisto, Annamari Lundqvist, Markus Perola, Martti Farkkila, Hannes Hagstrom
Summary: The dynamic AAR score provides prospective predictions for the risk of incident severe liver outcomes in the general population and helps detect advanced liver fibrosis/cirrhosis.
HEPATOLOGY COMMUNICATIONS
(2021)
