Article
Plant Sciences
Satish Sarfare, Shabana I. Khan, Fazila Zulfiqar, Srivedavyasasri Radhakrishnan, Zulfiqar Ali, Ikhlas A. Khan
Summary: Phytochemical investigation of corn silk led to the identification of multiple compounds, including flavone C-glycosides and triterpenoids. Some of these compounds showed activity against macrophages and chondrocytes in the experiments conducted.
Article
Chemistry, Applied
Pham Thi Mai Huong, Tran Thi Hong Hanh, Tran Hong Quang, Nguyen Xuan Cuong, Dong-Sung Lee, Nguyen Hoai Nam, Chau Van Minh
Summary: Chemical investigation of corn silk led to the discovery of nine secondary metabolites, including a new ent-kaurane diterpenoid with potential anti-diabetic activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Multidisciplinary Sciences
Aiko Sano, Yutaka Inoue, Ryuichiro Suzuki
Summary: The formation of advanced glycation end products is linked to aging and diabetic complications, and inhibiting their formation could prevent and treat related diseases. Corn silk, a traditional medicine used in Japan and China, has been found to possess anti-glycation activity, specifically through its polyphenol content. The active components in the water extract of corn silk were identified as lignin-carbohydrate complex, which showed significant anti-glycation activity.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Zead Helmi Abudayeh, Uliana Karpiuk, Viktoriia Kyslychenko, Qais Abualassal, Loay Khaled Hassouneh, Sami Qadus, Ahmad Talhouni
Summary: The technological parameters and quality indicators of corn silk were evaluated in this study, and a technology for obtaining a liquid extract of corn silk was developed. The obtained liquid extract was found to contain various biologically active substances and exhibited hemostatic efficacy. This study has important implications for the development of therapeutic drugs for various diseases.
JOURNAL OF CHEMISTRY
(2022)
Article
Food Science & Technology
Xiaodan Hu, Haiying Liu, Yongtao Yu, Gaoke Li, Xitao Qi, Yuliang Li, Tong Li, Xinbo Guo, Rui Hai Liu
Summary: The study found that the phenolic and flavonoid contents in different genotypes of sweet corn kernels increased from 10 to 30 days after pollination, with higher levels in the YT28 genotype possibly due to higher expression of the CHS gene. Sweet corn has competitive phenolic contents, antioxidant capacities, and antiproliferative abilities, with its bioactive potential and nutritional value increasing during the maturation process.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Xiaodan Hu, Tianran Yang, Xitao Qi, Xinbo Guo, Jianguang Hu
Summary: This study demonstrated that drying methods can greatly improve the levels of phenolic and flavonoid. Shade-drying had the best results with higher phenolic and antioxidant activity. Light may cause stress signals and increase the contents of bound flavonoid.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Chemistry, Applied
Natan R. S. da Hora, Lucia F. Santana, Victor Diogenes A. da Silva, Silvia L. Costa, Leonardo Zambotti-Villela, Pio Colepicolo, Caline G. Ferraz, Paulo R. Ribeiro
Summary: In this study, a large-scale chemical characterization of corn silk extracts was conducted, and chemometrics was used to identify potential candidate metabolites for antioxidant and anti-glioma activities. The results indicate that two flavone glycosides and one O-methylated anthocyanidin are likely the main contributors to the biological activities of the corn silk extracts.
Article
Chemistry, Multidisciplinary
Yi-Han Zhang, Chun-Yao Li, Guo-Jun Zou, Jun-Yi Xian, Quan Zhang, Bang-Xian Yu, Ling-Hong Huang, Hong-Xing Liu, Xin-Yuan Sun
Summary: This study aimed to explore the inhibition of endocytosis of nano-sized calcium oxalate monohydrate (nano-COM) crystals and the cell protection of corn silk polysaccharides (CCSPs) with different carboxyl contents. The results showed that CCSPs could inhibit the endocytosis of nano-COM crystals and reduce cell oxidative damage. CCSP3, with the highest carboxyl content, showed the best biological activity.
Article
Food Science & Technology
Estefania J. Carrera, Maria Jesus Cejudo-Bastante, Nelson Hurtado, Francisco J. Heredia, M. Lourdes Gonzalez-Miret
Summary: Colombian purple corn Zea mays L. by-products were chemically characterized after purification and fractionation. Cob and leaves showed a more complete flavonoid profile with higher content of anthocyanins and flavonols compared to grains, resulting in the highest reducing power and radical scavenging activity. The antioxidant fractions corresponded to higher molecular weight compounds. This study provides the first chemical and antioxidant characterization of purple corn by-products, as well as pure fractions of Zea mays L. for various industries.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Agronomy
Josemar Foresti, Renata R. Pereira, Paulo A. Santana, Taline Nc Neves, Paulo R. Silva, Jaedino Rosseto, Ademar Novais Istchuk, Tamylin K. Ishizuka, Wagner Harter, Matheus H. Schwertner, Marcelo C. Picanco
Summary: This study investigates the within-field spatial distribution and factors associated with the abundance of Dalbulus maidis, the primary pest in cornfields. The results show that infestations of D. maidis are higher at the boundaries of the central pivot, indicating an edge-biased distribution. The ranges vary and the spatial dependency is strong to moderate. Air temperature has a positive effect on the population of D. maidis, while rainfall has a negative effect.
PEST MANAGEMENT SCIENCE
(2022)
Article
Agronomy
Josinaldo Lopes Araujo, Jackson de Mesquita Alves, Railene Herica Carlos Rocha, Jose Zilton Lopes Santos, Rodolfo dos Santos Barbosa, Francisco Marcelo Nascimento da Costa, Geovani Soares de Lima, Leandro Nunes de Freitas, Adriana Silva Lima, Antonio Elizeneudo Peixoto Nogueira, Andre Alisson Rodrigues da Silva, Leonidas Canuto dos Santos, Francisco Bezerra Neto, Francisco Vanies da Silva Sa
Summary: Water scarcity negatively affects the growth and productivity of corn, but the use of beneficial microorganisms can attenuate water stress. This study evaluated the effect of beneficial microorganisms and water deficit on corn growth, gas exchange, grain yield, and soil microbial activity. The results showed that a 50% reduction in irrigation severely restricted corn growth and decreased grain yield. However, inoculation with beneficial microorganisms increased corn productivity and soil microbial activity under water stress. The inoculation of plants with beneficial microorganisms can alleviate the adverse effects of water deficit in maize.
Article
Chemistry, Applied
Yanan Jia, Zihan Xue, Yajie Wang, Yangpeng Lu, Ruilin Li, Nannan Li, Qirou Wang, Min Zhang, Haixia Chen
Summary: This study aimed to explore the effect of different corn silk polysaccharide fractions obtained by ethanol precipitation on their physicochemical properties and biological activities. The results showed that the fractions exhibited differences in physical properties and activities, with CSP80 showing stronger antioxidant activity and alpha-glucosidase inhibitory activity. Enzyme kinetic analysis indicated that CSP80 inhibited alpha-glucosidase by mixed type and reversible mechanisms, and fluorescence intensity measurements confirmed changes in the secondary structure of alpha-glucosidase due to the binding of CSP80. Isothermal titration calorimetry results illustrated that the binding of CSP80 to alpha-glucosidase complex was driven by enthalpy and hydrogen bonds played a major role in the binding process.
CARBOHYDRATE POLYMERS
(2021)
Article
Agronomy
Jesus Rodriguez-Miranda, Arely Carlos-Isidr, Cecilia E. Martinez-Sanche, Erasmo Herman-Lara, Juan G. Torruco-Uco, Ruben Santiago-Adame, Betsabe Hernandez-Santos
Summary: This study evaluated the phytochemical screening, polyphenols content, and antioxidant activity of different parts of white and purple corn. The results suggested that agroindustry wastes from corn can be considered as a potential source of fiber, carbohydrates, and bioactive compounds with antioxidant capacity.
EMIRATES JOURNAL OF FOOD AND AGRICULTURE
(2022)
Article
Chemistry, Multidisciplinary
Vasu Sujitha, Kadarkarai Murugan, Chellasamy Panneerselvam, Al Thabiani Aziz, Fuad A. Alatawi, Subrata Trivedi, Zuhair M. Mohammedsaleh, Hatem A. Al-Aoh, Fayez M. Saleh, Suhair A. Bani-Atta, Giulia Bonacucina, Filippo Maggi
Summary: Corn silk is an important waste material that can be recycled. This study shows that silver nanoparticles fabricated from corn silk are effective in killing mosquito larvae and pupae. They also have positive effects on the ecological environment and biofilm inhibition.
GREEN PROCESSING AND SYNTHESIS
(2022)
Article
Agriculture, Multidisciplinary
Katherin Castro-Rios, Claudia Nohemy Montoya-Estrada, Maria Marcela Martinez-Miranda, Sebastian Hurtado Cortes, Gonzalo Taborda-Ocampo
Summary: In this study, ultrasound, UV radiation, electrolyzed water, and sodium bicarbonate were used to treat corn grains contaminated with aflatoxins and Aspergillus niger. The results showed that sodium bicarbonate was the most effective in reducing aflatoxins and inhibiting mycelial growth of A. niger.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Chemistry, Organic
Ismail Celik, Meryem Erol, Ozlem Arpaci, Fatma Senol, Ilkay Orhan
Summary: This study evaluated the in vitro inhibitory activity of benzoxazole derivatives with p-tert-butyl at position 2 and acetamide bridged 4-substituted piperazine/piperidine at position 5 against important targets in reducing the adverse effects of Alzheimer's disease. The most active compound, 1 g, inhibited BChE by 54 +/- 0.75% at a concentration of 50 mu M. Molecular docking studies showed that Schrodinger docking scores were more consistent. The compounds exhibited compatible ADME profiles and bioactivity scores with Lipinski and other limiting rules.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Review
Pharmacology & Pharmacy
Ilkay E. Orhan, Fatma S. S. Deniz
Summary: The study suggests that natural compounds such as phenolics, tannins, chalcones, triterpenes, stilbenes, and alkaloids have the potential to be new XO inhibitors for treating gout. In addition, not only plants but other biological sources like microfungi, macrofungi, lichens, and insects seem to be promising sources of novel XO inhibitors.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Chemistry, Medicinal
Taibi Ben Hadda, Fatma Sezer Senol Deniz, Ilkay Erdogan Orhan, Hsaine Zgou, Abdur Rauf, Yahia Nasser Mabkhot, Brahim Bennani, Dalia R. Emam, Nabila Abdelshafy Kheder, Abdulrhman Asayari, Abdullatif Bin Muhsinah, Aneela Maalik
Summary: The study investigated spiro heterocyclic compounds as potential agents for Alzheimer's disease, revealing some of them show potential to inhibit cholinesterases. One compound exhibited the highest activity and metal chelation capacity among the tested compounds.
MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Yan Wang, Muhammad Aamer, Meral Aslay, Bilge Sener, Farooq-Ahmad Khan, Atia-tul Wahab, Atta-ur Rahman, Muhammad Iqbal Choudhary
Summary: A new steroidal alkaloid michainine and nine known compounds were isolated from Fritillaria michailovskyi for the first time, including ribonucleosides, steroids, and fatty acids. Michainine showed positive inhibitory activity on butyrylcholinesterase and non-cytotoxicity against 3T3 cell line.
NATURAL PRODUCT RESEARCH
(2022)
Review
Chemistry, Medicinal
Ilkay Erdogan Orhan, Abdur Rauf, Muhammad Saleem, Anees Ahmed Khalil
Summary: This review summarizes the potential therapeutic applications of natural plant extracts and their bioactive constituents as PDE inhibitors. The most promising class of compounds with PDE-inhibiting property belongs to phenolics, including flavonoids, while other plant compounds like coumarins, saponins, lignans, terpenes, anthraquinones, and alkaloids have also shown inhibitory effects. Further clinical studies exploring the synergistic use of different therapies are recommended to achieve multi-targeted results.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Serena Fiorito, Francesco Epifano, Lorenzo Marchetti, Lucia Palumbo, Ilkay Erdogan Orhan, Majid Sharifi-Rad, Salvatore Genovese
Summary: This comprehensive review explores the pharmacological activities and modulatory properties of O-Prenylcoumarins and their potential to regulate lipid and sugar metabolism. The study highlights their presence in common fruits and vegetables, emphasizing their nutraceutical role in promoting health.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Plant Sciences
Mehtap Kilic, Ilkay Erdogan Orhan, Gokcen Eren, Emine Sukran Okudan, Alden S. Estep, James J. Bencel, Nurhayat Tabanca
Summary: Ethanolic extracts from 47 macroalgae species were tested for their effects on insect vitality-related enzymes, with only one extract showing notable inhibition of butyrylcholinesterase. Furthermore, 11 extracts displayed high larvicidal and adulticidal activities against the mosquito vector Aedes aegypti, indicating the potential of macroalgae and their metabolites as novel insecticidal agents.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Medicine, General & Internal
Abdur Rauf, Muslim Raza, Muhammad Humayun Khan, Hassan A. Hemeg, Yahya S. Al-Awthan, Omar Bahattab, Sami Bawazeer, Saima Naz, Faika Basoglu, Muhammad Saleem, Majid Khan, Hosseini Seyyedamirhossein, Mohammad S. Mubarak, Ilkay Erdogan Orhan
Summary: This study focused on the isolation, in vitro and in silico studies of two natural bio-active flavonoids (1 & 2) isolated from Euphorbia pulcherrima bark for the first time. The chemical structures of the isolated compounds were confirmed, and their bioactivity was evaluated. The results showed promising inhibitory potential against urease and tyrosinase enzymes, as well as anti-glycation and phosphodiesterase inhibitory activities. Docking study indicated the structural features of the compounds are in accordance with their bioactivity.
ANNALS OF MEDICINE
(2022)
Article
Chemistry, Applied
Hasya Nazli Gok, Simon Vlad Luca, Saadet Tugrul Ay, Lukasz Komsta, Ramin Ekhteiari Salmas, Ilkay Erdogan Orhan, Krystyna Skalicka-Wozniak
Summary: The ethanol extracts of five Origanum species showed significant cholinesterase inhibition and antioxidant effects, with the phytochemical composition of 60 extracts analyzed. The study also identified a correlation between certain compounds and bioactivity. Additionally, molecular docking data suggested that caffeoylarbutin had the lowest binding energy against both AChE and BChE.
Article
Chemistry, Medicinal
Serkan Yigitkan, Abdulselam Ertas, Ramin Ekhteiari Salmas, Mehmet Firat, Ilkay Erdogan Orhan
Summary: This study investigated the HMG-CoA reductase inhibitory potential of extracts from the roots and aerial parts of Salvia multicaulis Vahl. and identified 7-acetoxyhorminone as the most effective inhibitory compound.
Article
Medicine, Research & Experimental
Shynggys Sergazy, Anastassiya Vetrova, Ilkay Erdogan Orhan, Fatma Sezer Senol Deniz, Ahmet Kahraman, Jian-Ye Zhang, Mohamad Aljofan
Summary: This study is the first to report the potential antiproliferative effects of ethanol extracts of several Geraniaceae species. Four of the tested species showed potential antitumor action against all the tumor cells used, by inducing cellular defense mechanisms called autophagy and apoptosis.
Article
Biochemistry & Molecular Biology
Milena Polumackanycz, Pawel Konieczynski, Ilkay Erdogan Orhan, Nurten Abaci, Agnieszka Viapiana
Summary: The study compared the chemical composition and biological activity of water and hydromethanolic extracts of R. rosea commercial samples. The hydromethanolic extracts were found to be rich in phenolic compounds and exhibited higher antioxidant and neurobiological activity, while the water extracts contained higher levels of determined elements.
Article
Environmental Sciences
Nurten Abaci, F. Sezer Senol Deniz, Ramin Ekhteiari Salmas, Fatma Uysal Bayar, Kenan Turgut, Ilkay Erdogan Orhan
Summary: The ethanol extracts of Salvia fruticosa Mill.'s leaves from two new cultivars, Uysal-SFU and Turgut-SFT, were found to be promising inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) relevant to Alzheimer's disease. The extracts showed IC50 values of 30.62 +/- 3.27 and 32.97 +/- 2.33 μg/mL against AChE for SFU and SFT, respectively, and IC50 values of 69.91 +/- 1.08 and 86.55 +/- 1.26 μg/mL against BChE. The essential oils in the extracts exhibited weak inhibition against AChE and no inhibition against BChE. Additionally, the extracts showed strong DPPH radical scavenging activity and ferric-reducing antioxidant power.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Review
Chemistry, Medicinal
Abdulselam Ertas, Serkan Yigitkan, Ilkay Erdogan Orhan
Summary: Salvia species, particularly hydroalcoholic extracts and essential oils of S. officinalis and S. lavandulaefolia leaves, have shown positive effects on cognitive dysfunction in patients with mild to moderate Alzheimer's disease in clinical studies. However, further long-term clinical studies with larger sample sizes and standardized sage preparations are needed to validate these effects.
Meeting Abstract
Physiology
Ahmet Onur Dastan, Okan Arihan, Asli San Dagli Gul, Gulderen Yilmaz, Aysen Erdem
