FIG4 is a hepatitis C virus particle-bound protein implicated in virion morphogenesis and infectivity with cholesteryl ester modulation potential

Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome

(2015) Nam-Joon Cho et al.   GASTROENTEROLOGY

Modulation of Triglyceride and Cholesterol Ester Synthesis Impairs Assembly of Infectious Hepatitis C Virus

(2014) Jolanda M. P. Liefhebber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis C virus infection mediates cholesteryl ester synthesis to facilitate infectious particle production

(2014) S. A. Read et al.   JOURNAL OF GENERAL VIROLOGY

Mapping of Functional Domains of the Lipid Kinase Phosphatidylinositol 4-Kinase Type III Alpha Involved in Enzymatic Activity and Hepatitis C Virus Replication

(2014) C. Harak et al.   JOURNAL OF VIROLOGY

Role of the phosphoinositide phosphatase FIG4 gene in familial epilepsy with polymicrogyria

(2014) S. Baulac et al.   NEUROLOGY

Yunis-Varón Syndrome Is Caused by Mutations in FIG4, Encoding a Phosphoinositide Phosphatase

(2013) Philippe M. Campeau et al.   AMERICAN JOURNAL OF HUMAN GENETICS

PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism

(2013) Marion Peyrou et al.   JOURNAL OF HEPATOLOGY

Very-Low-Density Lipoprotein (VLDL)-Producing and Hepatitis C Virus-Replicating HepG2 Cells Secrete No More Lipoviroparticles than VLDL-Deficient Huh7.5 Cells

(2013) B. Jammart et al.   JOURNAL OF VIROLOGY

Genome-Wide Analysis of Host mRNA Translation during Hepatitis C Virus Infection

(2013) H. Colman et al.   JOURNAL OF VIROLOGY

Morphological and Biochemical Characterization of the Membranous Hepatitis C Virus Replication Compartment

(2013) D. Paul et al.   JOURNAL OF VIROLOGY

Ultrastructural analysis of hepatitis C virus particles

(2013) Maria Teresa Catanese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication

(2012) Leen Delang et al.   BIOCHEMICAL PHARMACOLOGY

Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma

(2012) Hashem B. El-Serag   GASTROENTEROLOGY

Elevated lipogenesis and diminished cholesterol synthesis in patients with hepatitis C viral infection compared to healthy humans

(2012) Jennifer E. Lambert et al.   HEPATOLOGY

Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration

(2012) C. J. Ferguson et al.   HUMAN MOLECULAR GENETICS

Role of Phosphatidylinositol 4-Phosphate (PI4P) and Its Binding Protein GOLPH3 in Hepatitis C Virus Secretion

(2012) Bryan Bishé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinctive genetic and clinical features of CMT4J: a severe neuropathy caused by mutations in the PI(3,5)P2 phosphatase FIG4

(2011) Garth Nicholson et al.   BRAIN

Hepatitis c virus and host cell lipids: An intimate connection

(2011) Gualtiero Alvisi et al.   RNA Biology

Biochemical and Morphological Properties of Hepatitis C Virus Particles and Determination of Their Lipidome

(2010) Andreas Merz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Annexin A2 in the Production of Infectious Hepatitis C Virus Particles

(2010) P. Backes et al.   JOURNAL OF VIROLOGY

Assembly of infectious hepatitis C virus particles

(2010) Ralf Bartenschlager et al.   TRENDS IN MICROBIOLOGY

Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS

(2009) Clement Y. Chow et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function

(2009) Stephen K. Dove et al.   BIOCHEMICAL JOURNAL

Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening

(2009) Maud Trotard et al.   FASEB JOURNAL

Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles

(2009) Wagane J. A. Benga et al.   HEPATOLOGY

The heat shock cognate protein 70 is associated with hepatitis C virus particles and modulates virus infectivity

(2009) Romain Parent et al.   HEPATOLOGY

Role of Oxysterol Binding Protein in Hepatitis C Virus infection

(2009) Y. Amako et al.   JOURNAL OF VIROLOGY

Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication

(2009) K. L. Berger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein C1 Association with Hepatitis C Virus

(2008) J.-C. Meunier et al.   JOURNAL OF VIROLOGY