Article
Immunology
Carlos Plaza-Sirvent, Bei Zhao, Alisha W. Bronietzki, Marina C. Pils, Neda Tafrishi, Marc Schuster, Till Strowig, Ingo Schmitz
Summary: Autophagy plays a crucial role in regulating T cells, especially in maintaining gut homeostasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim
Summary: Patients with rheumatoid arthritis (RA) have higher levels of interleukin-18 (IL-18) and lower levels of IL-18 binding protein (IL-18BP) in their serum and synovial fluid compared to those with osteoarthritis (OA) or healthy controls. In vitro studies show that IL-18BP can correct the Th17/Treg imbalance in CD4(+) T cells of RA patients and reduce IL-17-induced osteoclastogenesis, suggesting therapeutic potential for RA treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Joris van der Veeken, Clarissa Campbell, Yuri Pritykin, Michail Schizas, Jacob Verter, Wei Hu, Zhong-Min Wang, Fanny Matheis, Daniel Mucida, Louis-Marie Charbonnier, Talal A. Chatila, Alexander Y. Rudensky
Summary: The role of Foxp3 in peripheral pTreg cells and the mechanisms supporting their differentiation remain poorly understood. This study used genetic tracing to identify microbiota-induced pTreg cells and found that many of their distinguishing features were Foxp3 independent. While Foxp3 was critical for the suppression of certain diseases, pTreg cells could suppress colonic effector T cell expansion in a Foxp3-independent manner. Thus, Foxp3 and the tolerogenic signals preceding and promoting its expression confer distinct facets of pTreg functionality.
Article
Biotechnology & Applied Microbiology
Ai Yan, Ying Zhang, Xiaocong Wang, Yueling Cui, Wei Tan
Summary: IL-35 protects against proliferative diabetic retinopathy by reducing IL-17 levels and inhibiting Th17 cell differentiation.
Review
Immunology
Jorge L. Trujillo-Ochoa, Majid Kazemian, Behdad Afzali
Summary: Regulatory T cells (T-reg cells) are regulated by multiple transcription factors, including FOXP3, which control their differentiation and function. The heterogeneity of T-reg cells arises from the expression of different transcription factors that fine-tune their properties. Understanding the imprinting of T-reg cell identity and function is crucial for understanding autoimmunity and developing new drugs.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Cell Biology
Ling Wang, Wei Chen, Fu-Biao Kang, Ya-Hui Zhang, Li-Li Qi, Ying-Ze Zhang
Summary: Hip fracture patients experience immunological changes, with blood transfusion potentially helping to rebalance the immune response and improve prognosis.
Article
Immunology
Zhihui Zhang, Kai Zhang, Mi Zhang, Xiaomin Zhang, Rongxin Zhang
Summary: This study demonstrates the important immunosuppressive effect of parthenolide (PTL) on autoimmune inflammation. PTL can alleviate clinical symptoms by inhibiting inflammatory cell infiltration, reducing inflammation, and demyelination. It also regulates the immune response by inhibiting the reactivation of specific T cells and the differentiation of CD4(+) T cells into pathogenic Th17 cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Kotona Furuyama, Yuya Kondo, Masaru Shimizu, Masahiro Yokosawa, Seiji Segawa, Akira Iizuka, Reona Tanimura, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida
Summary: This study reveals the crucial role of Tr17 cells in regulating autoimmune arthritis by suppressing Th17-mediated inflammation. Tr17 cells increase during the development of arthritis and accumulate in inflamed joints. Tr17 cells upregulate CCR6, CD25, CTLA-4, GITR, and ICOS expression, as well as IL-10-producing cells, Blimp-1(+) cells, and T-bet(+) cells.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Manman Wang, Tiantian Su, Hanfei Sun, Huijuan Cheng, Chunru Jiang, Paipai Guo, Zhenduo Zhu, Ruhong Fang, Feng He, Mingli Ge, Qiuyun Guan, Wei Wei, Qingtong Wang
Summary: This study investigated the therapeutic effect and primary pharmacological mechanism of Ziyuglycoside I on collagen-induced arthritis mice. The results showed that Ziyuglycoside I effectively improved arthritis symptoms by inhibiting mTOR activation and regulating Th17/Treg balance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Monica Martinez-Blanco, Daniel Lozano-Ojalvo, Leticia Perez-Rodriguez, Sara Benede, Elena Molina, Rosina Lopez-Fandino
Summary: The study demonstrated that under the influence of IL-2 and TGF-beta, IL-6 can induce the generation of Foxp3(+) and double positive Foxp3(+)ROR gamma t(+) T cells. Furthermore, the presence of RA helps to stabilize the phenotype of these cells and promote the suppressive function of Foxp3(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Hanan E. Alrashidi, Amna A. Alotiby
Summary: This study found that zinc supplementation can increase the number of T regulatory cells (Tregs) and slightly decrease the number of T helper 17 cells (Th17). Zinc can reduce the production of IFN gamma, but its effect on IL10 is not significant. In mixed lymphocyte cultures, zinc supplementation significantly increases the expression of Tregs-specific transcription factors.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yana Yang, Wenhui Qi, Yanyan Zhang, Ruining Wang, Mingyue Bao, Mengyuan Tian, Xing Li, Yuan Zhang
Summary: ROR gamma t is a crucial transcription factor for the differentiation of pro-inflammatory Th17 cells. In this study, a natural compound called 2,2',4'-trihydroxychalcone (TDC) was found to directly bind to the ligand binding domain of ROR gamma t and inhibit its transcriptional activation activity. TDC administration effectively alleviated the disease development in three different mouse models of Th17-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Lixing Zhou, Meiling Ge, Yan Zhang, Xiaochu Wu, Mi Leng, Chunmei Gan, Yi Mou, Jiao Zhou, C. Alexander Valencia, Qiukui Hao, Bin Zhu, Biao Dong, Birong Dong
Summary: The distribution of CD4(+) T cell subsets changes in centenarians, with a decrease in the Th17/Treg cell ratio and a shift towards anti-inflammatory secretory phenotypes, suggesting an alleviation of inflammaging.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Klaus Tenbrock, Thomas Rauen
Summary: T cells play a crucial role in the development of SLE, and their abnormalities provide potential targets for therapeutic intervention.
CLINICAL IMMUNOLOGY
(2022)
Article
Pathology
Soheila Fattahi, Monireh Karimi, Mahdi Ghatreh-Samani, Fatemeh Taheri, Hedayatollah Shirzad, Faramarz Mohammad Alibeigi, Maryam Anjomshoa, Nader Bagheri
Summary: Bladder cancer is a common and potentially fatal cancer worldwide. This study found that the number of Foxp3(+) Treg and Th17 cells is significantly higher in bladder tumor tissues compared to non-tumor tissues. Additionally, there is a correlation between AHR and Foxp3(+) Tregs, and the percentage of these cells is correlated with the grade and stage of bladder cancer.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Biaolong Deng, Weiqi Zhang, Yicheng Zhu, Yangyang Li, Dan Li, Bin Li
Summary: Regulatory T (Treg) cells play a critical role in maintaining immune homeostasis and their dysfunction in aged patients may contribute to age-related diseases. Immune therapies targeting Treg cells show promising results in treating cancers and autoimmune diseases. Understanding Treg cell function better may help in developing new immune therapies against aging.
Article
Immunology
Youxiang Zhang, De-Hui Xiong, Yangyang Li, Guina Xu, Baoxin Zhang, Yang Liu, Shan Zhang, Qing Huang, Simin Chen, Fansheng Zeng, Jingyi Guo, Bin Li, Zhiqiang Qin, Zuping Zhang
Summary: The study showed that USP21 plays a crucial role in regulating immune interactions between Schistosoma and its host, with potential implications for treating hepatic fibrosis in patients with schistosomiasis. This was evidenced by changes in Th1 and Th17 responses amplified by Tregs and reduced levels of liver immunopathology in USP21 knockout mice.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Review
Immunology
Youkun Qian, Yicheng Zhu, Yangyang Li, Bin Li
Summary: This article discusses the importance of lung resident memory T cells in secondary immune responses and how they help enhance immunity against SARS-CoV-2. Studies show that these cells can rapidly respond to reinfection, limit tumor growth, but may also lead to pathologic immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ying Lu, Yangyang Li, Qi Liu, Na Tian, Peng Du, Fangming Zhu, Yichao Han, Xinnan Liu, Xisheng Liu, Xiao Peng, Xiaoxia Wang, Yuchen Wu, Lingfeng Tong, Yakui Li, Yemin Zhu, Lifang Wu, Ping Zhang, Ye Xu, Hanbei Chen, Bin Li, Xuemei Tong
Summary: In colorectal cancer, intratumoral regulatory T cells (Tregs) exhibit low activity of the MondoA-thioredoxin-interacting protein (TXNIP) axis and increased glucose uptake. While MondoA-deficient Tregs promoted Th1 responses in a subcutaneous colorectal cancer model, Treg-specific MondoA knockout mice were more susceptible to colorectal cancer induction.
Article
Cell Biology
Xisheng Liu, Xiaole Meng, Xiao Peng, Qianlan Yao, Fangming Zhu, Zhongyi Ding, Hongze Sun, Xueni Liu, Dan Li, Ying Lu, Huamei Tang, Bin Li, Zhihai Peng
Summary: The global downregulation of miRNA expression, potentially due to defects in miRNA processing machinery, is a hallmark of human cancer. In colorectal cancer (CRC), downregulation of the key regulator of miRNA processing, Argonaute 2 (AGO2), has been found to promote epithelial-mesenchymal transition (EMT) and indicate poor prognosis. Knockdown of AGO2 in CRC cells enhanced migration, invasion, and metastasis, while integrated analyses revealed neuropilin 1 (NRP1) as a new substrate of AGO2 via miR-185-3p. Therapeutically targeting the AGO2/miR-185-3p/NRP1 axis may offer a potential treatment approach for CRC.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Yikong Lin, Di Zhang, Yangyang Li, Yunyun Li, Bin Li, Meirong Du
Summary: This study revealed a crucial role of NR2F2 in regulating maternal-fetal immune tolerance through promoting Th2 differentiation of decidual CD4(+)T cells, with decreased NR2F2 expression associated with unexplained recurrent spontaneous abortion. The interaction between GATA-3 and NR2F2 was confirmed, suggesting GATA-3 may play an important role in the immunoregulatory process mediated by NR2F2, providing a potential biomarker for prediction and prevention of clinical unexplained RSA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mengdi Yang, Qianru Huang, Changcan Li, Zhiyuan Jiang, Jing Sun, Zhiyu Wang, Rui Liang, Dan Li, Bin Li, Hui Zhao
Summary: TOX is a novel tumor suppressor in colorectal cancer (CRC) that is associated with tumor stage and overall survival, suppressing mTOR signaling pathway and affecting cell proliferation, migration, invasion, and epithelial-mesenchymal transition. High expression of TOX is related to tumor stability, immune score, stromal score, and microsatellite instability in CRC, highlighting its therapeutic potential in combination with mTOR inhibitor or PD1 inhibitor in CRC treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Weiqi Zhang, Xu Liu, Yicheng Zhu, Xinnan Liu, Yunting Gu, Xueyu Dai, Bin Li
Summary: Regulatory T (Treg) cells and T helper type 17 (Th17) cells play crucial roles in immune responses, antagonizing each other in immune disorders. Restoring Th17/Treg balance by modifying the enzymatic activities of ROR gamma t and FOXP3 binding partners may be therapeutically applied to treat severe immune disorders.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Heng Xu, Zhu Zhu, Jian Hu, Jiawei Sun, Yan Wo, Xianshu Wang, Hongzhi Zou, Bin Li, Yixin Zhang
Summary: This study found that downregulation of cytotoxic CD8(+) T cells is a specific signature of keloids. Additionally, the upregulation of the NKG2A/CD94 complex and high levels of soluble human leukocyte antigen-E (sHLA-E) were associated with keloid formation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Zoology
Lei Bao, Xiao-Chen Bo, Huai-Wen Cao, Chen Qian, Zeng Wang, Bin Li
Summary: Chimeric antigen receptor T cells (CAR-T cells) are engineered T cells used in the treatment of various diseases, including autoimmune diseases. Regulatory T cells (Treg) have gained attention for their potential application in CAR-T therapy.
ZOOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Piotr Konieczny, Yue Xing, Ikjot Sidhu, Ipsita Subudhi, Kody P. Mansfield, Brandon Hsieh, Douglas E. Biancur, Samantha B. Larsen, Michael Cammer, Dongqing Li, Ning Xu Landen, Cynthia Loomis, Adriana Heguy, Anastasia N. Tikhonova, Aristotelis Tsirigos, Shruti Naik
Summary: Mammalian cells activate HIFs to survive in low-oxygen environments, but injury-induced hypoxia is unable to activate HIF1 alpha. However, IL-17A derived from ROR gamma t(+) gamma delta T cells can activate HIF1 alpha. The IL-17A-HIF1 alpha axis promotes glycolysis for wound healing in epithelial cells, and loss of IL-17RC, HIF1 alpha, or blockade of glycolysis disrupts the repair process. These findings highlight the interconnectedness of inflammation, metabolism, and migration programs, as well as the role of immune cell-derived inputs in cellular adaptation to hypoxic stress during repair.
Review
Immunology
Yimeng Yu, Hongyu Bai, Fenglin Wu, Jieqiong Chen, Bin Li, Yangyang Li
Summary: This review focuses on the tissue adaptation of adipose tissue-resident regulatory T cells (AT Treg cells) and their response to various environmental signals. The transcriptional cascades triggered by these signals ultimately establish unique transcriptional modules in adipose tissue Treg cell subsets.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Yi Lu, Yi Wang, Yang Wang, Yu Wu, Yazhuo Huang, Xingtong Liu, Shuo Zhang, Sisi Zhong, Yinwei Li, Bin Li, Jing Sun, Sijie Fang, Huifang Zhou
Summary: This study investigated the immunophenotypes of orbital-infiltrating macrophages and their modulatory effects on orbital fibroblasts (OFs) in Graves' orbitopathy (GO). The results showed the presence of different immunophenotypes of macrophages in GO orbital connective tissues and their promotion effects on OFs through the IL-6/sIL-6R signaling pathway. These findings provide molecular rationale for the potential therapeutic use of blocking sIL-6R in GO.
Article
Cell Biology
Chenbo Ding, Zhibin Yu, Esen Sefik, Jing Zhou, Eleanna Kaffe, Gaoyang Wang, Bin Li, Richard A. Flavell, Weiguo Hu, Youqiong Ye, Hua-Bing Li
Summary: This study identified a T-reg-specific long noncoding RNA called Altre, which plays a role in regulating the mitochondrial function of T-reg cells in the liver of old mice by binding to Yin Yang 1. Deletion of Altre accelerates aging-associated liver pathogenesis.
Letter
Biochemistry & Molecular Biology
Yahui Liu, Juan Du, Xinnan Liu, Lingbiao Wang, Yichao Han, Chunrong Huang, Rui Liang, Fang Zheng, Guochao Shi, Bin Li
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
