The Hen or the Egg: Inflammatory Aspects of Murine MPN Models

Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells

(2015) M. Lu et al.   BLOOD

Activation of non-canonical TGF-β1 signaling indicates an autoimmune mechanism for bone marrow fibrosis in primary myelofibrosis

(2015) Fiorella Ciaffoni et al.   BLOOD CELLS MOLECULES AND DISEASES

Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: A critical role for IL-6/STAT3

(2015) Ming-Jiang Xu et al.   HEPATOLOGY

Critical role of IL-6 in dendritic cell-induced allergic inflammation of asthma

(2015) Yen-Lin Lin et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Myelodysplastic syndrome with extramedullary erythroid hyperplasia induced by loss of Tet2 in mice

(2014) Tomoya Muto et al.   LEUKEMIA & LYMPHOMA

Characterization of the TGF- 1 signaling abnormalities in the Gata1low mouse model of myelofibrosis

(2013) M. Zingariello et al.   BLOOD

JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFN 

(2013) S. Hasan et al.   BLOOD

Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice

(2013) J. Wang et al.   BLOOD

Transcription factor nuclear factor erythroid-2 mediates expression of the cytokine interleukin 8, a known predictor of inferior outcome in patients with myeloproliferative neoplasms

(2013) J. Wehrle et al.   HAEMATOLOGICA

MPN patients harbor recurrent truncating mutations in transcription factor NF-E2

(2013) Jonas S. Jutzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased prevalence of autoimmune phenomena in myelofibrosis: Relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns

(2013) Wilma Barcellini et al.   LEUKEMIA RESEARCH

A role of NF-E2 in chronic inflammation and clonal evolution in essential thrombocythemia, polycythemia vera and myelofibrosis?

(2013) Hans C. Hasselbalch   LEUKEMIA RESEARCH

Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia

(2013) Pedro Ramos et al.   NATURE MEDICINE

Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis: is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer?

(2012) H. C. Hasselbalch   BLOOD

Demand-adapted regulation of early hematopoiesis in infection and inflammation

(2012) H. Takizawa et al.   BLOOD

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2

(2012) Kai B. Kaufmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models

(2012) Hiroko Oshima et al.   JOURNAL OF GASTROENTEROLOGY

TNF  facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms

(2011) A. G. Fleischman et al.   BLOOD

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

(2011) Z. Li et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Circulating Interleukin (IL)-8, IL-2R, IL-12, and IL-15 Levels Are Independently Prognostic in Primary Myelofibrosis: A Comprehensive Cytokine Profiling Study

(2011) Ayalew Tefferi et al.   JOURNAL OF CLINICAL ONCOLOGY

Chronic Immune Stimulation Might Act As a Trigger for the Development of Acute Myeloid Leukemia or Myelodysplastic Syndromes

(2011) Sigurdur Y. Kristinsson et al.   JOURNAL OF CLINICAL ONCOLOGY

Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells

(2011) B. L. Esplin et al.   JOURNAL OF IMMUNOLOGY

AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2

(2010) W. Wang et al.   BLOOD

Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice

(2010) C. Marty et al.   BLOOD

Physiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells

(2010) Ann Mullally et al.   CANCER CELL

Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression

(2010) T. o. Ishikawa et al.   CARCINOGENESIS

Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis.

(2010) T.-o. Ishikawa et al.   CARCINOGENESIS

Inflammatory Bowel Disease as a Risk Factor for Colorectal Cancer

(2010) Milan Lukas   DIGESTIVE DISEASES

Of mice and men: Human RNA polymerase III promoter U6 is more efficient than its murine homologue for shRNA expression from a lentiviral vector in both human and murine progenitor cells

(2010) Roland Roelz et al.   EXPERIMENTAL HEMATOLOGY

Autoimmunity and the risk of myeloproliferative neoplasms

(2010) S. Y. Kristinsson et al.   HAEMATOLOGICA

Does auto-immunity contribute to anemia in myeloproliferative neoplasms (MPN)-associated myelofibrosis?

(2010) Giovanni Barosi et al.   LEUKEMIA RESEARCH

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis

(2010) Srdan Verstovsek et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-inflammatory cytokines hepatocyte growth factor and interleukin-11 are over-expressed in Polycythemia vera and contribute to the growth of clonal erythroblasts independently of JAK2V617F

(2010) M Boissinot et al.   ONCOGENE

Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis

(2010) W.-J. Chae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Blockade of a Chemokine, CCL2, Reduces Chronic Colitis-Associated Carcinogenesis in Mice

(2009) B. K. Popivanova et al.   CANCER RESEARCH

Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression

(2008) Mazin A. Al-Salihi et al.   CANCER LETTERS

Genetic Deletion of mPGES-1 Suppresses Intestinal Tumorigenesis

(2008) M. Nakanishi et al.   CANCER RESEARCH

The Interleukin-6 Family Cytokine Interleukin-11 Regulates Homeostatic Epithelial Cell Turnover and Promotes Gastric Tumor Development

(2008) Meegan Howlett et al.   GASTROENTEROLOGY

Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis

(2008) Boryana K. Popivanova et al.   JOURNAL OF CLINICAL INVESTIGATION

Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice

(2007) R. Tiedt et al.   BLOOD