Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple Sclerosis

Secukinumab: A Review in Moderate to Severe Plaque Psoriasis

(2015) Karly P. Garnock-Jones   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Deleterious versus protective autoimmunity in multiple sclerosis

(2015) Milos Kostic et al.   CELLULAR IMMUNOLOGY

T helper 9 cells induced by plasmacytoid dendritic cells regulate interleukin-17 in multiple sclerosis

(2015) Gabriella Ruocco et al.   CLINICAL SCIENCE

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

(2015) Andrew L. Croxford et al.   IMMUNITY

Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes

(2015) Guillaume Perriard et al.   Journal of Neuroinflammation

Decreased expression of IL-27 and its correlation with Th1 and Th17 cells in progressive multiple sclerosis

(2015) Shao-can Tang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial

(2015) Iain B McInnes et al.   LANCET

TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

(2015) Stephan Meller et al.   NATURE IMMUNOLOGY

Targeting the IL-17–TH17 pathway

(2015) Hilary S. Bartlett et al.   NATURE REVIEWS DRUG DISCOVERY

FAS-ligand regulates differential activation-induced cell death of human T-helper 1 and 17 cells in healthy donors and multiple sclerosis patients

(2015) M T Cencioni et al.   Cell Death & Disease

Revised diagnostic criteria of multiple sclerosis

(2014) Ron Milo et al.   AUTOIMMUNITY REVIEWS

Protective Immunity against Recurrent Staphylococcus aureus Skin Infection Requires Antibody and Interleukin-17A

(2014) Christopher P. Montgomery et al.   INFECTION AND IMMUNITY

Th22 cells are expanded in multiple sclerosis and are resistant to IFN-β

(2014) Simona Rolla et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Th17 cell based vaccines in mucosal immunity

(2013) Pawan Kumar et al.   CURRENT OPINION IN IMMUNOLOGY

Cutting Edge: The Pathogenicity of IFN- -Producing Th17 Cells Is Independent of T-bet

(2013) R. Duhen et al.   JOURNAL OF IMMUNOLOGY

IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis

(2013) Wen Xu et al.   JOURNAL OF NEUROIMMUNOLOGY

Act1 mediates IL-17–induced EAE pathogenesis selectively in NG2+ glial cells

(2013) Zizhen Kang et al.   NATURE NEUROSCIENCE

IL-17 cytokines in immunity and inflammation

(2013) Wei Jin et al.   Emerging Microbes & Infections

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

CD4+CD161+ T Lymphocytes Infiltrate Crohn’s Disease-Associated Perianal Fistulas and Are Reduced by Anti-TNF-a Local Therapy

(2012) Laura Maggi et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

(2012) Christina E. Zielinski et al.   NATURE

Targeting IL-17 and TH17 cells in chronic inflammation

(2012) Pierre Miossec et al.   NATURE REVIEWS DRUG DISCOVERY

IL-21 and IL-21 Receptor Expression in Lymphocytes and Neurons in Multiple Sclerosis Brain

(2011) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E

(2011) Seon Hee Chang et al.   IMMUNITY

Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

(2011) Pawel Muranski et al.   IMMUNITY

Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein

(2011) Tao Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Différenciation des lymphocytes TH17

(2011) Vassili Soumelis et al.   M S-MEDECINE SCIENCES

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

(2011) Laura A. Solt et al.   NATURE

IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens

(2011) Xinyang Song et al.   NATURE IMMUNOLOGY

The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells

(2011) Wataru Ise et al.   NATURE IMMUNOLOGY

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

(2011) Vladimir Ramirez-Carrozzi et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Early production of IL-17 protects against acute pulmonaryPseudomonas aeruginosainfection in mice

(2010) Jialin Liu et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

In Vivo Imaging of Partially Reversible Th17 Cell-Induced Neuronal Dysfunction in the Course of Encephalomyelitis

(2010) Volker Siffrin et al.   IMMUNITY

Synergistic activity of interleukin-17 and tumor necrosis factor-α enhances oxidative stress-mediated oligodendrocyte apoptosis

(2010) Manjeet K. Paintlia et al.   JOURNAL OF NEUROCHEMISTRY

IL-10 production by CD4+ effector T cells: a mechanism for self-regulation

(2010) D Jankovic et al.   Mucosal Immunology

The McDonald Criteria for Multiple Sclerosis: time for clarification

(2010) Christopher H Hawkes et al.   Multiple Sclerosis Journal

A phase 2, 24-week, randomized, placebo-controlled, double-blind study examining the efficacy and safety of an anti-interleukin-12 and -23 monoclonal antibody in patients with relapsing–remitting or secondary progressive multiple sclerosis

(2010) Timothy L Vollmer et al.   Multiple Sclerosis Journal

Proinflammatory T helper type 17 cells are effective B-cell helpers

(2010) M. Mitsdoerffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-β

(2009) Luca Durelli et al.   ANNALS OF NEUROLOGY

Abundant c-Fas-associated death domain-like interleukin-1-converting enzyme inhibitory protein expression determines resistance of T helper 17 cells to activation-induced cell death

(2009) Y. Yu et al.   BLOOD

Multiparametric analysis of cytokine-driven human Th17 differentiation reveals a differential regulation of IL-17 and IL-22 production

(2009) E. Volpe et al.   BLOOD

Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis

(2009) Verena Brucklacher-Waldert et al.   BRAIN

Neutralizing antibodies in multiple sclerosis patients treated with 375 μg interferon-β-1b

(2009) L Durelli et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

IL-9 as a mediator of Th17-driven inflammatory disease

(2009) Elizabeth C. Nowak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unlike Th1, Th17 Cells Mediate Sustained Autoimmune Inflammation and Are Highly Resistant to Restimulation-Induced Cell Death

(2009) G. Shi et al.   JOURNAL OF IMMUNOLOGY

IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells

(2009) C. Diveu et al.   JOURNAL OF IMMUNOLOGY

The AP-1 transcription factor Batf controls TH17 differentiation

(2009) Barbara U. Schraml et al.   NATURE

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Interleukin 17 acts in synergy with B cell–activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus

(2009) Agnès Doreau et al.   NATURE IMMUNOLOGY

The natural history of primary progressive multiple sclerosis

(2009) M. Koch et al.   NEUROLOGY

IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells

(2009) W. Elyaman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells

(2008) Yongpeng Gu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of T Helper 17 Differentiation by Orphan Nuclear Receptors: It's Not Just RORγt Anymore

(2008) Mark S. Sundrud et al.   IMMUNITY

Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

(2008) Ming O. Li et al.   IMMUNITY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells

(2008) Franca Gerosa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations inSTAT3andIL12RB1impair the development of human IL-17–producing T cells

(2008) Ludovic de Beaucoudrey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutralisation of IL12 p40 or IL23 p40 does not block inflammation in multiple sclerosis

(2008) Roland Martin   LANCET NEUROLOGY

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

(2008) Benjamin M Segal et al.   LANCET NEUROLOGY

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

Interleukin-17A Mediates Acquired Immunity to Pneumococcal Colonization

(2008) Ying-Jie Lu et al.   PLoS Pathogens

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY