The Genetics of Crohn's Disease

A role for Nod-like receptors in autophagy induced byShigellainfection

(2014) Toshihiko Suzuki et al.   Autophagy

Differential Regulation of Chemokines by IL-17 in Colonic Epithelial Cells

(2014) J. W. Lee et al.   JOURNAL OF IMMUNOLOGY

IL-12R 2 Promotes the Development of CD4+CD25+ Regulatory T Cells

(2014) Z. Zhao et al.   JOURNAL OF IMMUNOLOGY

Germline variants of IRGM in childhood-onset Crohn's disease

(2009) J Van Limbergen et al.   GUT

Association of TNFSF15 With Crohn's Disease in Koreans

(2008) Suk-Kyun Yang et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

ATG16L1andIL23RAre Associated With Inflammatory Bowel Diseases but Not With Celiac Disease in The Netherlands

(2008) Rinse K. Weersma et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

TheATG16L1Gene Variants rs2241879 and rs2241880 (T300A) Are Strongly Associated With Susceptibility to Crohn's Disease in the German Population

(2008) Jürgen Glas et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

ATG16L1 T300A Shows Strong Associations With Disease Subgroups in a Large Australian IBD Population: Further Support for Significant Disease Heterogeneity

(2008) Elizabeth V. Fowler et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Genetic Analysis of Innate Immunity in Crohn's Disease and Ulcerative Colitis Identifies Two Susceptibility Loci Harboring CARD9 and IL18RAP

(2008) Alexandra Zhernakova et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Effects of Muclin (Dmbt1) deficiency on the gastrointestinal system

(2008) Robert C. De Lisle et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Protein Tyrosine Phosphatases in Autoimmunity

(2008) Torkel Vang et al.   Annual Review of Immunology

Unresolved ER Stress Inflames the Intestine

(2008) Averil Ma   CELL

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

MEKK4 Sequesters RIP2 to Dictate NOD2 Signal Specificity

(2008) Nivedita M. Clark et al.   CURRENT BIOLOGY

A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease

(2008) William J. Sandborn et al.   GASTROENTEROLOGY

Infectious Gastroenteritis and Risk of Developing Inflammatory Bowel Disease

(2008) Chad K. Porter et al.   GASTROENTEROLOGY

TL1A (TNFSF15) Regulates the Development of Chronic Colitis by Modulating Both T-Helper 1 and T-Helper 17 Activation

(2008) Hidetoshi Takedatsu et al.   GASTROENTEROLOGY

Definition of Phenotypic Characteristics of Childhood-Onset Inflammatory Bowel Disease

(2008) Johan Van Limbergen et al.   GASTROENTEROLOGY

Microbial Influences in Inflammatory Bowel Diseases

(2008) R. Balfour Sartor   GASTROENTEROLOGY

MAST3: a novel IBD risk factor that modulates TLR4 signaling

(2008) C Labbé et al.   GENES AND IMMUNITY

Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort

(2008) R K Weersma et al.   GUT

JC viral loads in patients with Crohn's disease treated with immunosuppression: can we screen for elevated risk of progressive multifocal leukoencephalopathy?

(2008) J Verbeeck et al.   GUT

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

(2008) T Kobayashi et al.   GUT

Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients

(2008) K Yamazaki et al.   GUT

Regulation of Hierarchical Clustering and Activation of Innate Immune Cells by Dendritic Cells

(2008) Suk-Jo Kang et al.   IMMUNITY

Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohnʼs disease in an Australian population

(2008) Georgia E. Hume et al.   INFLAMMATORY BOWEL DISEASES

IL23R haplotypes provide a large population attributable risk for Crohnʼs disease

(2008) Kent D. Taylor et al.   INFLAMMATORY BOWEL DISEASES

Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohnʼs disease

(2008) John B. Beckly et al.   INFLAMMATORY BOWEL DISEASES

Contribution of TNFSF15 gene variants to Crohnʼs disease susceptibility confirmed in UK population

(2008) Mark Tremelling et al.   INFLAMMATORY BOWEL DISEASES

IL-23/IL-17 immunity as a hallmark of Crohnʼs disease

(2008) Veera Hölttä et al.   INFLAMMATORY BOWEL DISEASES

The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation

(2008) Elisa Greggio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

(2008) Bhanu P. Pappu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Structure of Interleukin-23 Reveals the Molecular Basis of p40 Subunit Sharing with Interleukin-12

(2008) Patrick J. Lupardus et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

(2008) Edward D. Plowey et al.   JOURNAL OF NEUROCHEMISTRY

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(2008) Bart Ferwerda et al.   MOLECULAR MEDICINE

Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis

(2008) P Goyette et al.   Mucosal Immunology

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Induction and effector functions of TH17 cells

(2008) Estelle Bettelli et al.   NATURE

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

(2008) Jelena Nedjic et al.   NATURE

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

The development of allergic inflammation

(2008) Stephen J. Galli et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

New susceptibility genes for ulcerative colitis

(2008) Patrick C Dubois et al.   NATURE GENETICS

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

(2008) Andre Franke et al.   NATURE GENETICS

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

(2008) Sheila A Fisher et al.   NATURE GENETICS

Newly identified genetic risk variants for celiac disease related to the immune response

(2008) Karen A Hunt et al.   NATURE GENETICS

Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease

(2008) Subra Kugathasan et al.   NATURE GENETICS

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

(2008) Steven A McCarroll et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Differentiation of human TH-17 cells does require TGF-β!

(2008) Anne O'Garra et al.   NATURE IMMUNOLOGY

The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-γ-induced cell death

(2008) Carl G Feng et al.   NATURE IMMUNOLOGY

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

(2008) Yongzhong Liu et al.   NATURE IMMUNOLOGY

Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma

(2008) Emmanuelle Bouzigon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impaired Autophagy of an Intracellular Pathogen Induced by a Crohn's Disease Associated ATG16L1 Variant

(2008) Petric Kuballa et al.   PLoS One

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

(2008) Michelle M. A. Fernando et al.   PLoS Genetics

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

(2008) Chad K Heazlewood et al.   PLOS MEDICINE

Protein Kinase C θ Plays a Fundamental Role in Different Types of Chronic Colitis

(2007) Kiyotaka Nagahama et al.   GASTROENTEROLOGY

Crohn’s disease patients homozygous for the 3020insC NOD2 mutation have a defective NOD2/TLR4 cross-tolerance to intestinal stimuli

(2007) Bart Jan Kullberg et al.   IMMUNOLOGY

Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohnʼs disease in Northern Europe

(2007) J. Van Limbergen et al.   INFLAMMATORY BOWEL DISEASES

Innate immune recognition at the epithelial barrier drives adaptive immunity: APCs take the back seat

(2007) Jörg H. Fritz et al.   TRENDS IN IMMUNOLOGY