Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

358 Constitutive Inhibition of Hedgehog (HH) Signaling Causes Intestinal Villus Atrophy, Spontaneous Small Intestinal Inflammation, and Dermatitis: A Mouse Phenocopy of Human Celiac Disease?

(2009) William J. Zacharias et al.   GASTROENTEROLOGY

Paracrine Hedgehog Signaling in Stomach and Intestine: New Roles for Hedgehog in Gastrointestinal Patterning

(2009) Åsa Kolterud et al.   GASTROENTEROLOGY

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Ulcerative colitis–risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study

(2009) Mark S Silverberg et al.   NATURE GENETICS

A Crohn's disease–associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1

(2009) Eiichiro Noguchi et al.   NATURE IMMUNOLOGY

Association of TNFSF15 With Crohn's Disease in Koreans

(2008) Suk-Kyun Yang et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

ATG16L1andIL23RAre Associated With Inflammatory Bowel Diseases but Not With Celiac Disease in The Netherlands

(2008) Rinse K. Weersma et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Association Between Genetic Variants in theIL-23RGene and Early-Onset Crohn's Disease: Results From a Case-Control and Family-Based Study Among Canadian Children

(2008) Devendra K. Amre et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

TheATG16L1Gene Variants rs2241879 and rs2241880 (T300A) Are Strongly Associated With Susceptibility to Crohn's Disease in the German Population

(2008) Jürgen Glas et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Recent Advances in the Genetics of Autoimmune Disease

(2008) Peter K. Gregersen et al.   Annual Review of Immunology

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

ATG16L1 and IL23 receptor (IL23R) genes are associated with disease susceptibility in Hungarian CD patients

(2008) P.L. Lakatos et al.   DIGESTIVE AND LIVER DISEASE

Characterization of sonic hedgehog as a novel NF-κB target gene that promotes NF-κB-mediated apoptosis resistance and tumor growth in vivo

(2008) Hubert Kasperczyk et al.   FASEB JOURNAL

Accumulation of Hedgehog-Responsive Progenitors Parallels Alcoholic Liver Disease Severity in Mice and Humans

(2008) Youngmi Jung et al.   GASTROENTEROLOGY

TL1A (TNFSF15) Regulates the Development of Chronic Colitis by Modulating Both T-Helper 1 and T-Helper 17 Activation

(2008) Hidetoshi Takedatsu et al.   GASTROENTEROLOGY

Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort

(2008) R K Weersma et al.   GUT

Use of sirolimus (rapamycin) to treat refractory Crohn's disease

(2008) D C O Massey et al.   GUT

Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients

(2008) K Yamazaki et al.   GUT

Reduced  -defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease

(2008) L A Simms et al.   GUT

The hedgehog pathway regulates remodelling responses to biliary obstruction in rats

(2008) A Omenetti et al.   GUT

IL23R and IL12B polymorphisms in spanish IBD patients: No evidence of interaction

(2008) Ana Márquez et al.   INFLAMMATORY BOWEL DISEASES

Association of IL23R, TNFRSF1A, and HLA-DRB1*0103 allele variants with inflammatory bowel disease phenotypes in the Finnish population

(2008) Maarit Lappalainen et al.   INFLAMMATORY BOWEL DISEASES

CARD15 and IL23R influences Crohnʼs disease susceptibility but not disease phenotype in a Brazilian population

(2008) Márcia Luiza Baptista et al.   INFLAMMATORY BOWEL DISEASES

Survival and function of human thymic dendritic cells are dependent on autocrine Hedgehog signaling

(2008) A. Varas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

(2008) Edward D. Plowey et al.   JOURNAL OF NEUROCHEMISTRY

Early combined immunosuppression in Crohn's disease

(2008) Charlie W Lees et al.   LANCET

Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial

(2008) Geert D'Haens et al.   LANCET

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Progress and challenges in genome-wide association studies in humans

(2008) Peter Donnelly   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

(2008) Andre Franke et al.   NATURE GENETICS

Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer

(2008)   NATURE GENETICS

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

(2008) Albert Tenesa et al.   NATURE GENETICS

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

(2008) Sheila A Fisher et al.   NATURE GENETICS

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

(2008) Andre Franke et al.   NATURE GENETICS

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS

Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease

(2008) Subra Kugathasan et al.   NATURE GENETICS

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

(2008) Ian PM Tomlinson et al.   NATURE GENETICS

Common variants near MC4R are associated with fat mass, weight and risk of obesity

(2008) Ruth J F Loos et al.   NATURE GENETICS

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

(2008) Steven A McCarroll et al.   NATURE GENETICS

Genome-wide association analysis identifies 20 loci that influence adult height

(2008) Michael N Weedon et al.   NATURE GENETICS

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

(2008) Eleftheria Zeggini et al.   NATURE GENETICS

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

(2008) Gudmar Thorleifsson et al.   NATURE GENETICS

Identification of ten loci associated with height highlights new biological pathways in human growth

(2008) Guillaume Lettre et al.   NATURE GENETICS

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

(2008) Cristen J Willer et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS

Replication of interleukin 23 receptor and autophagyrelated 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy

(2008) Anna Latiano et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Analysis of Germline GLI1 Variation Implicates Hedgehog Signalling in the Regulation of Intestinal Inflammatory Pathways

(2008) Charlie W Lees et al.   PLOS MEDICINE

New links to the pathogenesis of Crohn disease provided by genome-wide association scans

(2007) Christopher G. Mathew   NATURE REVIEWS GENETICS