Article
Biochemistry & Molecular Biology
Juliet N. E. Baidoo, Sumit Mukherjee, Khosrow Kashfi, Probal Banerjee
Summary: Curcumin can repolarize tumor-associated macrophages, induce nitric oxide production, recruit NK cells and Tc cells to eliminate cancer cells, potentially in a NO-dependent manner. Even low levels of curcumin in vivo are sufficient to cause repolarization of TAM and recruitment of NK cells and Tc cells to eliminate the tumor. This approach may serve as a general strategy to fight cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
Shumin Yan, Yufei Huang, Le Xu, Xiaoyu Dong, Shuang Wang, Xue Jiao, Ming Yuan, Guoyun Wang
Summary: The development of endometriosis is closely associated with macrophages, particularly the M1 type, which is believed to inhibit its progression. Escherichia coli induces macrophage polarization towards M1 in various diseases and shows differences in the reproductive tract of patients with and without endometriosis; however, its specific role in endometriosis development remains unknown.
MOLECULAR HUMAN REPRODUCTION
(2023)
Article
Medicine, Research & Experimental
Ting Jiang, Hongji Zhang, Yiming Li, Preethi Jayakumar, Hong Liao, Hai Huang, Timothy R. Billiar, Meihong Deng
Summary: TLR9 agonist can enhance the efficacy of anti-PD-1 therapy for colorectal peritoneal metastases by suppressing retinoid metabolism genes expression, reducing PRMs numbers, and enhancing CD8+ T cell antitumor immunity.
Review
Biochemistry & Molecular Biology
Tamara N. Ramirez-Pavez, Maria Martinez-Esparza, Antonio J. Ruiz-Alcaraz, Pilar Marin-Sanchez, Francisco Machado-Linde, Pilar Garcia-Penarrubia
Summary: Endometriosis, an estrogen-dependent gynecological disorder, involves immune dysregulation and the role of macrophages in its pathology. Further research on the characteristics of the peritoneal immune system is needed to enhance diagnostic and therapeutic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Carlos Ardavin, Natalia Alvarez-Ladron, Margarita Ferriz, Alejandra Gutierrez-Gonzalez, Adrian Vega-Perez
Summary: Large peritoneal macrophages (LPMs) are tissue-resident macrophages with important roles in defense against peritoneal pathologies and maintenance of self-tolerance. Recent research in mice has revealed the mechanisms by which LPMs repair peritoneal injuries, control infections, and protect against tumor metastasis. However, peritoneal tumors can subvert LPM function and promote tumor growth. The plasticity of LPMs can be harnessed to develop immunotherapeutic approaches against peritoneal tumor metastasis based on macrophage reprogramming.
Article
Cardiac & Cardiovascular Systems
Verena Wilmes, Ivan M. Kur, Andreas Weigert, Marcel A. Verhoff, Elise Gradhand, Silke Kauferstein
Summary: This study examines the expression of iNOS and NT production in postmortem human myocardial infarction hearts. The results demonstrate that resident macrophages are the main source of iNOS expression in these hearts, and there is a correlation between iNOS and NT production, indicating the involvement of iNOS in oxidative stress.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Immunology
Lara K. Abramowitz, John A. Hanover
Summary: Inflammation is an immune response to harmful stimuli, but excessive inflammation can lead to chronic inflammatory diseases. Macrophages play a crucial role in this process, responding to the local microenvironment by polarizing into M1 or M2 phenotypes. Elevated O-GlcNAc levels in M1 polarized macrophages are associated with increased expression of pro-inflammatory cytokines. O-GlcNAc interacts with iNOS and affects its activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Chaiwat Monmai, JeongUn Choi, Weerawan Rod-in, Tae Ho Lee, Woo Jung Park
Summary: This study evaluated the anti-inflammatory activities of fermented rice cake containing strawberry powder, and found that it can effectively suppress inflammatory reactions and gene expression, as well as inhibit paw edema in mice.
Article
Multidisciplinary Sciences
Mokarram Hossain, Raymond Shim, Woo-Yong Lee, Arlene H. Sharpe, Paul Kubes
Summary: Emerging evidence suggests that resident macrophages within tissues play a role in tumor growth. In this study, the authors discovered that GATA6(+) large peritoneal macrophages can invade growing metastases in the liver and promote tumor growth.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Zhi-Hu Lin, Jinsong Hu, Huagang Shi, Chia-Ching Liaw, Wei-Lun Qiu, Wei-Hung Hsu, Tung-Yi Lin
Summary: The study demonstrated that water extract of medical ink (WEMI) had no cytotoxic effect on murine macrophage Raw264.7 cells and slightly rescued LPS-suppressed cell viability. WEMI did not induce NO production or IL-6 secretion, but significantly induced secretion of TNF-alpha. Additionally, WEMI effectively reduced LPS-induced NO production.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Oncology
Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Angela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Irene Olivera, Elizabeth Bolanos, Jose Gonzalez-Gomariz, Maite Alvarez, Inaki Etxeberria, Belen Palencia, Alvaro Teijeira, Ignacio Melero, Pedro Berraondo, Fernando Aranda
Summary: Previous studies have found that local delivery of tumor antigen-specific CD8(+) T lymphocytes transiently expressing single-chain IL-12 mRNA is highly effective in treating tumors. In this study, intracavitary adoptive T cell therapy was used to treat peritoneal dissemination of B16-OVA and PANC02-OVA tumors, and it was found that intraperitoneal administration of T cells promoted homing to the omentum more effectively than intravenous administration. Transient IL-12 expression resulted in a favorable reprogramming of the tumor immune microenvironment and longer persistence of transferred T lymphocytes, leading to the development of immunity to endogenous antigens after primary tumor eradication.
Article
Plant Sciences
Monica Zuzarte, Catia Sousa, Carlos Cavaleiro, Maria Teresa Cruz, Ligia Salgueiro
Summary: Portuguese lavenders remain undervalued in global markets due to the lack of high-quality end-products and scarcity of scientific-based studies validating their bioactive potential. This study assessed the anti-inflammatory potential of L. luisieri and L. pedunculata, two prevalent species in Portugal, and correlated it with their chemical variability. The results demonstrated that L. luisieri essential oil with low quantities of necrodane derivatives was the most effective at inhibiting inflammation.
Article
Biochemistry & Molecular Biology
Huijeong Ahn, Gilyoung Lee, Byung-Cheol Han, Seung-Ho Lee, Geun-Shik Lee
Summary: This study found that maltol can inhibit the activation of inflammasomes, thus reducing inflammation. By inhibiting ROS production and Casp1 activity, maltol exerts its anti-inflammatory effects.
Article
Multidisciplinary Sciences
Natalia Kulach, Ewelina Pilny, Tomasz Cichon, Justyna Czapla, Magdalena Jarosz-Biej, Marek Rusin, Alina Drzyzga, Sybilla Matuszczak, Stanislaw Szala, Ryszard Smolarczyk
Summary: The study demonstrated that MSC are effective carriers of IL-12 cytokine, showing anti-tumor effects in primary and metastatic melanoma models. The use of MSC as carriers allowed for intravenous administration of IL-12 without toxic side effects, resulting in reduced tumor growth and metastases, decreased vascular density, and increased immune response in treated mice. Therapeutic properties of IL-12 cytokine were successfully exerted by modified MSC without inducing toxicity.
SCIENTIFIC REPORTS
(2021)
Article
Developmental Biology
Tomoko Makabe, Kaori Koga, Hiroshi Nagabukuro, Mari Asada, Erina Satake, Ayumi Taguchi, Arisa Takeuchi, Mariko Miyashita, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Osamu Wada-Hiraike, Tomoyuki Fujii, Yutaka Osuga
Summary: Selective prostaglandin E-2 (PGE-2) receptor antagonists can reduce DNA synthesis and the expression of proinflammatory cytokines like interleukin in endometriosis cells, showing potential as a new therapeutic strategy for treating endometriosis.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Multidisciplinary Sciences
Yasuhiro Omata, Reiji Aoki, Ayako Aoki-Yoshida, Keiko Hiemori, Atsushi Toyoda, Hiroaki Tateno, Chise Suzuki, Yoshiharu Takayama
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Reiji Aoki, Ayako Aoki-Yoshida, Chise Suzuki, Yoshiharu Takayama
JOURNAL OF IMMUNOLOGY
(2018)
Article
Agriculture, Multidisciplinary
Naoko Yamagishi, Yasuhiro Omata, Ayako Aoki-Yoshiida, Naoko Moriya, Tatsuhiko Goto, Atsushi Toyoda, Reiji Aoki, Chise Suzuki, Yoshiharu Takayama
JARQ-JAPAN AGRICULTURAL RESEARCH QUARTERLY
(2019)
Article
Microbiology
Hirotoshi Sushida, Hiroaki Sakai, Naoko Moriya, Kazuma Nakano, Noriko Ashimine, Maiko Minami, Hinako Tamotsu, Tetsuhiro Nakanishi, Shun Ohki, Kuniko Teruya, Takashi Hirano, Seishi Yamasaki, Chise Suzuki, Kazuhito Satou, Hiromi Kimoto-Nira
Summary: The complete genome sequence of Lactococcus cremoris strain 7-1, isolated from Mongolian traditional milk product urum, has been reported in this study. Strain 7-1 was found to adhere to porcine gastric mucin in a carbon source-dependent manner. The genome consists of a circular chromosome and two circular plasmids.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2022)
Article
Biochemistry & Molecular Biology
Ayako Aoki, Reiji Aoki, Madoka Yatagai, Toshiyuki Kawasumi
Summary: MicroRNAs play a crucial role in the communication between microbiota and host. This study identified 48 differentially expressed microRNAs in the whole colons of specific pathogen-free mice and germ-free mice, with gene ontology analysis revealing a strong association with GTPases and nerves.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Naoko Moriya, Naoko Yamagishi, Tatsuhiko Goto, Hikari Otabi, Hiromi Nira-Kimoto, Atsushi Toyoda, Chise Suzuki
Summary: Chronic social defeat stress was found to influence gastric motility in mice, with stressed mice exhibiting social avoidance behavior in social interaction tests and increased gastric emptying rates in gastric emptying tests.
JARQ-JAPAN AGRICULTURAL RESEARCH QUARTERLY
(2021)
Article
Food Science & Technology
Yuka Kimura, Reiji Aoki, Yoshiharu Takayama, Chise Suzuki, Yoshihito Suzuki
FOOD SCIENCE AND TECHNOLOGY RESEARCH
(2020)
Article
Microbiology
Yui Asahina, Akino Shiroma, Kazuma Nakano, Hinako Tamotsu, Noriko Ashimine, Misuzu Shinzato, Maiko Minami, Makiko Shimoji, Tetsuhiro Nakanishi, Shun Ohki, Kuniko Teruya, Kazuhito Satou, Miho Kobayashi, Tatsuro Hagi, Naoko Moriya, Chise Suzuki, Atsushi Tajima, Masaru Nomura, Takashi Hirano
GENOME ANNOUNCEMENTS
(2018)
Article
Biochemistry & Molecular Biology
Junpei Nakase, Yuuichi Ukawa, Syoji Takemoto, Takayoshi Kubo, Yuko M. Sagesaka, Ayako Aoki-Yoshida, Mamoru Totsuka
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Yoshiharu Takayama, Reiji Aoki, Ryo Uchida, Atsushi Tajima, Ayako Aoki-Yoshida
BIOCHEMISTRY AND CELL BIOLOGY
(2017)
Article
Microbiology
Shun Ohki, Tatsuro Hagi, Kazuma Nakano, Akino Shiroma, Hinako Tamotsu, Makiko Shimoji, Misuzu Shinzato, Noriko Ashimine, Maiko Minami, Tetsuhiro Nakanishi, Kuniko Teruya, Kazuhito Satou, Naoko Moriya, Miho Kobayashi, Masaru Nomura, Chise Suzuki, Takashi Hirano
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2018)
Article
Kazuma Nakano, Maiko Minami, Misuzu Shinzato, Makiko Shimoji, Noriko Ashimine, Akino Shiroma, Shun Ohki, Tetsuhiro Nakanishi, Hinako Tamotsu, Kuniko Teruya, Kazuhito Satou, Naoko Moriya, Hiromi Kimoto-Nira, Miho Kobayashi, Tatsuro Hagi, Masaru Nomura, Chise Suzuki, Takashi Hirano
GENOME ANNOUNCEMENTS
(2018)
Article
Naoko Moriya, Kazuma Nakano, Akino Shiroma, Misuzu Shinzato, Noriko Ashimine, Maiko Minami, Hinako Tamotsu, Makiko Shimoji, Tetsuhiro Nakanishi, Shun Ohki, Kuniko Teruya, Kazuhito Satou, Takashi Hirano, Tatsuro Hagi, Miho Kobayashi, Masaru Nomura, Hiromi Kimoto-Nira, Kiyoshi Tajima, Yimin Cai, Chise Suzukia
GENOME ANNOUNCEMENTS
(2018)