Borrelia burgdorferi RNA Induces Type I and III Interferons via Toll-Like Receptor 7 and Contributes to Production of NF- B-Dependent Cytokines

A Critical Role for Type I IFN in Arthritis Development following Borrelia burgdorferi Infection of Mice

(2014) J. C. Miller et al.   JOURNAL OF IMMUNOLOGY

Macrophage Proinflammatory Response to Francisella tularensis Live Vaccine Strain Requires Coordination of Multiple Signaling Pathways

(2014) L. E. Cole et al.   JOURNAL OF IMMUNOLOGY

Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses

(2014) A. Forsbach et al.   JOURNAL OF IMMUNOLOGY

Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of human monocytes

(2013) Jorge L. Cervantes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial Pathogens Activate a Common Inflammatory Pathway through IFNλ Regulation of PDCD4

(2013) Taylor S. Cohen et al.   PLoS Pathogens

TRIF Mediates Toll-Like Receptor 2-Dependent Inflammatory Responses to Borrelia burgdorferi

(2012) Tanja Petnicki-Ocwieja et al.   INFECTION AND IMMUNITY

Type III IFNs Are Produced by and Stimulate Human Plasmacytoid Dendritic Cells

(2012) Z. Yin et al.   JOURNAL OF IMMUNOLOGY

Induction of Indoleamine 2,3-Dioxygenase by Uropathogenic Bacteria Attenuates Innate Responses to Epithelial Infection

(2012) Jennifer A. Loughman et al.   JOURNAL OF INFECTIOUS DISEASES

IRF3: a molecular switch in pathogen responses

(2012) Osamu Takeuchi   NATURE IMMUNOLOGY

Activation of Type III Interferon Genes by Pathogenic Bacteria in Infected Epithelial Cells and Mouse Placenta

(2012) Hélène Bierne et al.   PLoS One

Overview of the biology of type I interferons

(2012) George D Kalliolias et al.   ARTHRITIS RESEARCH & THERAPY

IL-28A (IFN-λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease

(2011) Ourania Koltsida et al.   EMBO Molecular Medicine

IRF7: activation, regulation, modification and function

(2011) S Ning et al.   GENES AND IMMUNITY

Phagosomal signaling byBorrelia burgdorferiin human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-β

(2011) Jorge L. Cervantes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Bacterial Protein Targets the BAHD1 Chromatin Complex to Stimulate Type III Interferon Response

(2011) A. Lebreton et al.   SCIENCE

Cytosolic DNA sensors regulating type I interferon induction

(2011) Sinead E. Keating et al.   TRENDS IN IMMUNOLOGY

Type I Interferon Production Induced by Streptococcus pyogenes-Derived Nucleic Acids Is Required for Host Protection

(2011) Nina Gratz et al.   PLoS Pathogens

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

The STING pathway and regulation of innate immune signaling in response to DNA pathogens

(2010) Hiroki Ishikawa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Recognition of viruses by cytoplasmic sensors

(2010) Courtney Wilkins et al.   CURRENT OPINION IN IMMUNOLOGY

The Lyme Disease Spirochete Borrelia burgdorferi Utilizes Multiple Ligands, Including RNA, for Interferon Regulatory Factor 3-Dependent Induction of Type I Interferon-Responsive Genes

(2010) J. C. Miller et al.   INFECTION AND IMMUNITY

Stimulator of IFN Gene Is Critical for Induction of IFN-β during Chlamydia muridarum Infection

(2010) Daniel Prantner et al.   JOURNAL OF IMMUNOLOGY

The Lambda Interferons: Guardians of the Immune–Epithelial Interface and the T-helper 2 Response

(2010) Grant Gallagher et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Inhibition of dynamin-dependent endocytosis interferes with type III IFN expression in bacteria-infected human monocyte-derived DCs

(2010) Taija E. Pietilä et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Japanese Encephalitis Virus Utilizes the Canonical Pathway To Activate NF- B but It Utilizes the Type I Interferon Pathway To Induce Major Histocompatibility Complex Class I Expression in Mouse Embryonic Fibroblasts

(2010) S. Abraham et al.   JOURNAL OF VIROLOGY

Human Integrin α3β1 Regulates TLR2 Recognition of Lipopeptides from Endosomal Compartments

(2010) Meghan L. Marre et al.   PLoS One

Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3

(2010) M. Sasai et al.   SCIENCE

Live Borrelia burgdorferi Spirochetes Elicit Inflammatory Mediators from Human Monocytes via the Toll-Like Receptor Signaling Pathway

(2009) V. A. Dennis et al.   INFECTION AND IMMUNITY

Selection of Molecular Structure and Delivery of RNA Oligonucleotides to Activate TLR7 versus TLR8 and to Induce High Amounts of IL-12p70 in Primary Human Monocytes

(2009) A. Ablasser et al.   JOURNAL OF IMMUNOLOGY

Recognition of Borrelia burgdorferi, the Lyme Disease Spirochete, by TLR7 and TLR9 Induces a Type I IFN Response by Human Immune Cells

(2009) M. M. Petzke et al.   JOURNAL OF IMMUNOLOGY

TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation

(2009) A. Larange et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

(2009) Giuseppe Mancuso et al.   NATURE IMMUNOLOGY

Activation of Human Monocytes by Live Borrelia burgdorferi Generates TLR2-Dependent and -Independent Responses Which Include Induction of IFN-β

(2009) Juan C. Salazar et al.   PLoS Pathogens

The performance of a glass bead shaking technique for the disruption of Escherichia coli cells

(2008) Ramakrishnan Nagasundara Ramanan et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Immune Recognition of Streptococcus pyogenes by Dendritic Cells

(2008) T. G. Loof et al.   INFECTION AND IMMUNITY

Distinct Roles for MyD88 and Toll-Like Receptors 2, 5, and 9 in Phagocytosis of Borrelia burgdorferi and Cytokine Induction

(2008) O. S. Shin et al.   INFECTION AND IMMUNITY

Group A Streptococcus Activates Type I Interferon Production and MyD88-dependent Signaling without Involvement of TLR2, TLR4, and TLR9

(2008) Nina Gratz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY