Immunotherapeutic implication of IL-6 blockade

A case report of a patient with refractory adult-onset Still’s disease who was successfully treated with tocilizumab over 6 years

(2014) Hideko Nakahara et al.   Modern Rheumatology

Minimal influence of tocilizumab on IFN-γ synthesis by tuberculosis antigens

(2014) Atsushi Ogata et al.   Modern Rheumatology

Successful tocilizumab treatment in a patient with adult-onset Still’s disease complicated by chronic active hepatitis B and amyloid A amyloidosis

(2014) Dai Kishida et al.   Modern Rheumatology

Successful treatment of acquired hemophilia A, complicated by chronic GVHD, with tocilizumab

(2014) Sumiyuki Nishida et al.   Modern Rheumatology

Radiographic improvement of damaged large joints in children with systemic juvenile idiopathic arthritis following tocilizumab treatment

(2011) Y. Inaba et al.   ANNALS OF THE RHEUMATIC DISEASES

Impact of IL-6 receptor inhibition on human memory B cells in vivo: impaired somatic hypermutation in preswitch memory B cells and modulation of mutational targeting in memory B cells

(2011) K. Muhammad et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-interleukin 6 receptor therapy as rescue treatment for giant cell arteritis

(2011) C. Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy of abatacept and tocilizumab in patients with rheumatoid arthritis treated in clinical practice: results from the nationwide Danish DANBIO registry

(2011) H. C. Leffers et al.   ANNALS OF THE RHEUMATIC DISEASES

In vivo effects of the anti-interleukin-6 receptor inhibitor tocilizumab on the B cell compartment

(2011) Petra Roll et al.   ARTHRITIS AND RHEUMATISM

Role of interleukin-6 in a patient with tumor necrosis factor receptor-associated periodic syndrome: Assessment of outcomes following treatment with the anti-interleukin-6 receptor monoclonal antibody tocilizumab

(2011) Prashantha M. Vaitla et al.   ARTHRITIS AND RHEUMATISM

Tocilizumab for the Treatment of Steroid Refractory Graft-versus-Host Disease

(2011) William R. Drobyski et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Lower gastrointestinal perforation in rheumatoid arthritis patients treated with conventional DMARDs or tocilizumab: a systematic literature review

(2011) Taras Gout et al.   CLINICAL RHEUMATOLOGY

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Warren Strober et al.   GASTROENTEROLOGY

Ankylosing Spondylitis Refractory to Tumor Necrosis Factor Blockade Responds to Tocilizumab

(2011) J.-D. COHEN et al.   JOURNAL OF RHEUMATOLOGY

Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorated clinical symptoms and MRI findings of a patient with ankylosing spondylitis

(2011) Yoshihito Shima et al.   Modern Rheumatology

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Unresolved issues in biologic therapy for rheumatoid arthritis

(2011) Ronald F. van Vollenhoven   Nature Reviews Rheumatology

C-reactive protein in rheumatology: biology and genetics

(2011) Benjamin Rhodes et al.   Nature Reviews Rheumatology

Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica

(2011) Norio Chihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic effect of tocilizumab on two patients with polymyositis

(2011) M. Narazaki et al.   RHEUMATOLOGY

Mixed response to tocilizumab for ankylosing spondylitis

(2010) J. C. Henes et al.   ANNALS OF THE RHEUMATIC DISEASES

Effectiveness and safety of the interleukin 6-receptor antagonist tocilizumab after 4 and 24 weeks in patients with active rheumatoid arthritis: the first phase IIIb real-life study (TAMARA)

(2010) G. R. Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Endothelial activation and apoptosis mediated by neutrophil-dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis?

(2010) T. C. Barnes et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-6 receptor inhibition with tocilizumab and attainment of disease remission in rheumatoid arthritis: The role of acute-phase reactants

(2010) Josef S. Smolen et al.   ARTHRITIS AND RHEUMATISM

Delay in receiving rheumatology care leads to long-term harm

(2010) Vivian Bykerk et al.   ARTHRITIS AND RHEUMATISM

Tocilizumab in systemic lupus erythematosus: Data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study

(2010) Gabor G. Illei et al.   ARTHRITIS AND RHEUMATISM

Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: Results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structu

(2010) Joel M. Kremer et al.   ARTHRITIS AND RHEUMATISM

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus: analysis of IL-6 production and IL-6R expression

(2010) A. KITANI et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interleukin-6 Modulates Graft-versus-Host Responses after Experimental Allogeneic Bone Marrow Transplantation

(2010) I. Tawara et al.   CLINICAL CANCER RESEARCH

Etanercept-refractory adult-onset Still’s disease with thrombotic thrombocytopenic purpura successfully treated with tocilizumab

(2010) Keiichi Sumida et al.   CLINICAL RHEUMATOLOGY

A case of refractory adult-onset Still’s disease successfully controlled with tocilizumab and a review of the literature

(2010) Katja Perdan-Pirkmajer et al.   CLINICAL RHEUMATOLOGY

Excellent therapeutic effect of tocilizumab on intestinal amyloid a deposition secondary to active rheumatoid arthritis

(2010) Daichi Inoue et al.   CLINICAL RHEUMATOLOGY

IL-6: Regulator of Treg/Th17 balance

(2010) Akihiro Kimura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin 6 as a Key Regulator of Muscle Mass during Cachexia

(2010) James A. Carson et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses

(2010) Satoshi Hohki et al.   EXPERIMENTAL EYE RESEARCH

Tocilizumab: molecular intervention therapy in children with systemic juvenile idiopathic arthritis

(2010) Shumpei Yokota et al.   Expert Review of Clinical Immunology

Tocilizumab for the treatment of rheumatoid arthritis

(2010) Toshio Tanaka et al.   Expert Review of Clinical Immunology

Enhanced IL-6 Production in Aquaporin-4 Antibody Positive Neuromyelitis Optica Patients

(2010) Sema İİçöz et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Short-term effect of IL-6 inhibition in spondylarthritis

(2010) Daniel Wendling et al.   JOINT BONE SPINE

Tocilizumab in a patient with ankylosing spondylitis and Crohn's disease refractory to TNF antagonists

(2010) Laure Brulhart et al.   JOINT BONE SPINE

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

(2010) Shigeru Kotake et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A look at autoimmunity and inflammation in the eye

(2010) Rachel R. Caspi   JOURNAL OF CLINICAL INVESTIGATION

Effectiveness and Safety of Tocilizumab, an Anti–Interleukin-6 Receptor Monoclonal Antibody, in a Patient With Refractory GI Graft-Versus-Host Disease

(2010) Usama Gergis et al.   JOURNAL OF CLINICAL ONCOLOGY

Tocilizumab Ameliorates Clinical Symptoms in Polymyalgia Rheumatica

(2010) K. HAGIHARA et al.   JOURNAL OF RHEUMATOLOGY

Efficacy and tolerability of tocilizumab in rheumatoid arthritis patients seen in daily clinical practice in Japan: results from a retrospective study (REACTION study)

(2010) Hisashi Yamanaka et al.   Modern Rheumatology

Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: meta-analysis of six initial trials and five long-term extensions

(2010) Norihiro Nishimoto et al.   Modern Rheumatology

Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6

(2010) Akiyuki Uzawa et al.   Multiple Sclerosis Journal

AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance

(2010) Sven Jarius et al.   Nature Reviews Neurology

Takayasu arteritis—advances in diagnosis and management

(2010) Justin C. Mason   Nature Reviews Rheumatology

Systemic amyloidosis: a challenge for the rheumatologist

(2010) Federico Perfetto et al.   Nature Reviews Rheumatology

Immunotherapy of myositis: issues, concerns and future prospects

(2010) Marinos C. Dalakas   Nature Reviews Rheumatology

The effect of tocilizumab on the uptake of 18FDG-PET imaging in patients with adult-onset Still's disease

(2010) M. L. Cunha et al.   RHEUMATOLOGY

The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab

(2010) Y. Shima et al.   RHEUMATOLOGY

Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: a systematic literature review and meta-analysis of randomized controlled trials

(2010) L. Campbell et al.   RHEUMATOLOGY

Immunomodulation for inhibitors in hemophilia A: the important role of Treg cells

(2010) Carol H Miao   Expert Review of Hematology

Circulating cytokines in active polymyalgia rheumatica

(2009) L Alvarez-Rodriguez et al.   ANNALS OF THE RHEUMATIC DISEASES

Overproduced interleukin 6 decreases blood lipid levels via upregulation of very-low-density lipoprotein receptor

(2009) M. Hashizume et al.   ANNALS OF THE RHEUMATIC DISEASES

Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study

(2009) G. Jones et al.   ANNALS OF THE RHEUMATIC DISEASES

Rapid improvement of AA amyloidosis with humanised anti-interleukin 6 receptor antibody treatment

(2009) S Nishida et al.   ANNALS OF THE RHEUMATIC DISEASES

EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR)

(2009) O Kowal-Bielecka et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Interleukin-6 and type I interferon-regulated genes and chemokines mark disease activity in dermatomyositis

(2009) Hatice Bilgic et al.   ARTHRITIS AND RHEUMATISM

Successful treatment of reactive arthritis with a humanized anti–interleukin-6 receptor antibody, tocilizumab

(2009) Toshio Tanaka et al.   ARTHRITIS AND RHEUMATISM

Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A

(2009) Naoko Okiyama et al.   ARTHRITIS AND RHEUMATISM

Polymyalgia rheumatica prevalence in a population-based sample

(2009) S. Bernatsky et al.   ARTHRITIS AND RHEUMATISM

Advances in the understanding of acquired haemophilia A: implications for clinical practice

(2009) Peter W. Collins et al.   BRITISH JOURNAL OF HAEMATOLOGY

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Glucocorticoid and cyclosporine refractory adult onset Still’s disease successfully treated with tocilizumab

(2009) Kazuko Matsumoto et al.   CLINICAL RHEUMATOLOGY

Tocilizumab dramatically ameliorated life-threatening diarrhea due to secondary amyloidosis associated with rheumatoid arthritis

(2009) Hiroe Sato et al.   CLINICAL RHEUMATOLOGY

Behçet's disease – a contemporary review

(2009) Daniela Mendes et al.   JOURNAL OF AUTOIMMUNITY

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes

(2009) Timothy R. D. J. Radstake et al.   PLoS One

Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling

(2009) P. Pflegerl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment of a patient with remitting seronegative, symmetrical synovitis with pitting oedema with a humanized anti-interleukin-6 receptor antibody, tocilizumab

(2009) T. Tanaka et al.   RHEUMATOLOGY

Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis

(2009) T. Yoshimura et al.   RHEUMATOLOGY

Monitoring of therapeutic efficacy in a patient with RS3PE syndrome by serologic variables and radiographic methods

(2009) Shin-ya Kawashiri et al.   RHEUMATOLOGY INTERNATIONAL

Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations

(2009) Pravitt Gourh et al.   ARTHRITIS RESEARCH & THERAPY

Tocilizumab for multirefractory adult-onset Still's disease

(2008) M De Bandt et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial

(2008) P. Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study

(2008) Mark C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses

(2008) Minoru Fujimoto et al.   ARTHRITIS AND RHEUMATISM

Successful treatment of a patient with takayasu arteritis using a humanized anti-interleukin-6 receptor antibody

(2008) Norihiro Nishimoto et al.   ARTHRITIS AND RHEUMATISM

Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase

(2008) Keiichi Iwanami et al.   ARTHRITIS AND RHEUMATISM

Adult-onset Still disease

(2008) Bruno Fautrel   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Tocilizumab, a Humanized Anti-interleukin-6 Receptor Antibody, Ameliorates Joint Swelling in Established Monkey Collagen-Induced Arthritis

(2008) Yasushi Uchiyama et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Acquired factor VIII inhibitors

(2008) M. Franchini et al.   BLOOD

Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease

(2008) N. Nishimoto et al.   BLOOD

Nuanced roles of cytokines in three major human brain disorders

(2008) Lawrence Steinman   JOURNAL OF CLINICAL INVESTIGATION

Reiter's syndrome: The classic triad and more

(2008) Ines B. Wu et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Polymyalgia rheumatica and giant-cell arteritis

(2008) Carlo Salvarani et al.   LANCET

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial

(2008) Josef S Smolen et al.   LANCET

Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial

(2008) Shumpei Yokota et al.   LANCET

Masked early symptoms of pneumonia in patients with rheumatoid arthritis during tocilizumab treatment: a report of two cases

(2008) Hiroshi Fujiwara et al.   Modern Rheumatology

Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy

(2008) Norihiro Nishimoto et al.   Modern Rheumatology

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

(2008) Bente K. Pedersen et al.   PHYSIOLOGICAL REVIEWS

IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis

(2008) Satoshi Serada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantification of hardness, elasticity and viscosity of the skin of patients with systemic sclerosis using a novel sensing device (Vesmeter): a proposal for a new outcome measurement procedure

(2008) Y. Kuwahara et al.   RHEUMATOLOGY

IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-  and IL-17

(2008) M. Hashizume et al.   RHEUMATOLOGY

Sustained response to tocilizumab, anti-interleukin-6 receptor antibody, in two patients with refractory relapsing polychondritis

(2008) M. Kawai et al.   RHEUMATOLOGY