Tocilizumab for the treatment of rheumatoid arthritis

Current evidence for the management of rheumatoid arthritis with biological disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of RA

(2010) J. L. Nam et al.   ANNALS OF THE RHEUMATIC DISEASES

Tocilizumab in systemic lupus erythematosus: Data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study

(2010) Gabor G. Illei et al.   ARTHRITIS AND RHEUMATISM

Excellent therapeutic effect of tocilizumab on intestinal amyloid a deposition secondary to active rheumatoid arthritis

(2010) Daichi Inoue et al.   CLINICAL RHEUMATOLOGY

Tocilizumab Ameliorates Clinical Symptoms in Polymyalgia Rheumatica

(2010) K. HAGIHARA et al.   JOURNAL OF RHEUMATOLOGY

Empfehlungen der Deutschen Gesellschaft für Rheumatologie zum Einsatz von Tocilizumab bei der rheumatoiden Arthritis (Februar 2010)

(2010) A. Gause et al.   ZEITSCHRIFT FUR RHEUMATOLOGIE

Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study

(2009) G. Jones et al.   ANNALS OF THE RHEUMATIC DISEASES

Rapid improvement of AA amyloidosis with humanised anti-interleukin 6 receptor antibody treatment

(2009) S Nishida et al.   ANNALS OF THE RHEUMATIC DISEASES

Successful treatment of reactive arthritis with a humanized anti–interleukin-6 receptor antibody, tocilizumab

(2009) Toshio Tanaka et al.   ARTHRITIS AND RHEUMATISM

Rapid and sustained improvement in bone and cartilage turnover markers with the anti–interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate: Results from a substudy of the multicenter double-blind, placebo-controlled trial of tocilizumab in inadequate responders to methotrexate alone

(2009) Patrick Garnero et al.   ARTHRITIS AND RHEUMATISM

Glucocorticoid and cyclosporine refractory adult onset Still’s disease successfully treated with tocilizumab

(2009) Kazuko Matsumoto et al.   CLINICAL RHEUMATOLOGY

Anti-interleukin 6: first line in rheumatoid arthritis?

(2009) Luciana Marti et al.   CLINICAL RHEUMATOLOGY

Tocilizumab dramatically ameliorated life-threatening diarrhea due to secondary amyloidosis associated with rheumatoid arthritis

(2009) Hiroe Sato et al.   CLINICAL RHEUMATOLOGY

Will treatment of rheumatoid arthritis with an IL-6R inhibitor help facilitate the ‘age of remission’?

(2009) Robert J Moots et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Tocilizumab

(2009) Clemens Scheinecker et al.   NATURE REVIEWS DRUG DISCOVERY

Treatment of a patient with remitting seronegative, symmetrical synovitis with pitting oedema with a humanized anti-interleukin-6 receptor antibody, tocilizumab

(2009) T. Tanaka et al.   RHEUMATOLOGY

Tocilizumab for multirefractory adult-onset Still's disease

(2008) M De Bandt et al.   ANNALS OF THE RHEUMATIC DISEASES

When patients with rheumatoid arthritis fail tumour necrosis factor inhibitors: what is the next step?

(2008) J. S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study

(2008) N Nishimoto et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial

(2008) P. Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study

(2008) Mark C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Successful treatment of a patient with takayasu arteritis using a humanized anti-interleukin-6 receptor antibody

(2008) Norihiro Nishimoto et al.   ARTHRITIS AND RHEUMATISM

Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease

(2008) N. Nishimoto et al.   BLOOD

The recombinant humanized anti-IL-6 receptor antibody tocilizumab, an innovative drug for the treatment of rheumatoid arthritis

(2008) Yoshiyuki Ohsugi et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial

(2008) Josef S Smolen et al.   LANCET

Sustained response to tocilizumab, anti-interleukin-6 receptor antibody, in two patients with refractory relapsing polychondritis

(2008) M. Kawai et al.   RHEUMATOLOGY

Mycobacterial disease in patients with rheumatic disease

(2008) Jakko van Ingen et al.   Nature clinical practice. Rheumatology