Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics

Broadly Neutralizing Antiviral Antibodies

(2013) Davide Corti et al.   Annual Review of Immunology

The atypical lipopolysaccharide ofFrancisella

(2013) Nihal A. Okan et al.   CARBOHYDRATE RESEARCH

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

(2013) Florian Klein et al.   CELL

Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses

(2013) Natalie J. Thornburg et al.   JOURNAL OF CLINICAL INVESTIGATION

Antibody and Antigen Contact Residues Define Epitope and Paratope Size and Structure

(2013) J. W. Stave et al.   JOURNAL OF IMMUNOLOGY

Mechanism of Action and In Vivo Efficacy of a Human-Derived Antibody against Staphylococcus aureus α-Hemolysin

(2013) Davide Foletti et al.   JOURNAL OF MOLECULAR BIOLOGY

Functional Analysis of Antibodies against Dengue Virus Type 4 Reveals Strain-Dependent Epitope Exposure That Impacts Neutralization and Protection

(2013) S. Sukupolvi-Petty et al.   JOURNAL OF VIROLOGY

Anthrax drug first antibacterial mAb to win approval

(2013) Jeffrey L Fox   NATURE BIOTECHNOLOGY

A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin

(2013) Rui Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

(2013) Marie Pancera et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Designing Tomorrow's Vaccines

(2013) Gary J. Nabel   NEW ENGLAND JOURNAL OF MEDICINE

Rational Engineering of a Human Anti-Dengue Antibody through Experimentally Validated Computational Docking

(2013) Luca Simonelli et al.   PLoS One

Mapping the Epitopes of a Neutralizing Antibody Fragment Directed against the Lethal Factor of Bacillus anthracis and Cross-Reacting with the Homologous Edema Factor

(2013) Philippe Thullier et al.   PLoS One

Antibodies to Polymorphic Invasion-Inhibitory and Non-Inhibitory Epitopes of Plasmodium falciparum Apical Membrane Antigen 1 in Human Malaria

(2013) Cleopatra K. Mugyenyi et al.   PLoS One

Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency

(2013) K. Tharakaraman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen

(2013) Enrico Malito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

(2013) J. S. McLellan et al.   SCIENCE

Diversity Among Memory B Cells: Origin, Consequences, and Utility

(2013) D. Tarlinton et al.   SCIENCE

Antibodies in HIV-1 Vaccine Development and Therapy

(2013) F. Klein et al.   SCIENCE

Bactericidal antibody against a representative epidemiological meningococcal serogroup B panel confirms that MATS underestimates 4CMenB vaccine strain coverage

(2013) Giacomo Frosi et al.   VACCINE

Development of a Highly Protective Combination Monoclonal Antibody Therapy against Chikungunya Virus

(2013) Pankaj Pal et al.   PLoS Pathogens

Structural Analysis of a Protective Epitope of the Francisella tularensis O-Polysaccharide

(2012) Michael J. Rynkiewicz et al.   BIOCHEMISTRY

Antigen–antibody interface properties: Composition, residue interactions, and features of 53 non-redundant structures

(2012) Thiruvarangan Ramaraj et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Protective B-cell epitopes of Francisella tularensis O-polysaccharide in a mouse model of respiratory tularaemia

(2012) Zhaohua Lu et al.   IMMUNOLOGY

Molecular Recognition ofCandida albicans(1→2)-β-Mannan Oligosaccharides by a Protective Monoclonal Antibody Reveals the Immunodominance of Internal Saccharide Residues

(2012) Margaret A. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epitope Mapping of Broadly Neutralizing HIV-2 Human Monoclonal Antibodies

(2012) R. Kong et al.   JOURNAL OF VIROLOGY

Mechanistic Study of Broadly Neutralizing Human Monoclonal Antibodies against Dengue Virus That Target the Fusion Loop

(2012) J. M. Costin et al.   JOURNAL OF VIROLOGY

Structural and Biochemical Characterization of the Vaccinia Virus Envelope Protein D8 and Its Recognition by the Antibody LA5

(2012) M. H. Matho et al.   JOURNAL OF VIROLOGY

Passive immunity in the prevention of rabies

(2012) Leonard Both et al.   LANCET INFECTIOUS DISEASES

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

(2012) Jinghe Huang et al.   NATURE

Immune epitope database analysis resource

(2012) Y. Kim et al.   NUCLEIC ACIDS RESEARCH

Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses

(2012) D. R. Burton et al.   SCIENCE

Mechanism of Dengue Virus Broad Cross-Neutralization by a Monoclonal Antibody

(2012) Joseph J.B. Cockburn et al.   STRUCTURE

HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design

(2012) Mattia Bonsignori et al.   TRENDS IN MICROBIOLOGY

A Typical Preparation ofFrancisella tularensisO-Antigen Yields a Mixture of Three Types of Saccharides

(2011) Qi Wang et al.   BIOCHEMISTRY

Super-Resolution Dissection of Coordinated Events during Malaria Parasite Invasion of the Human Erythrocyte

(2011) David T. Riglar et al.   Cell Host & Microbe

Modulation of antibody effector function

(2011) John R. Desjarlais et al.   EXPERIMENTAL CELL RESEARCH

Protective immunity following vaccination: How is it defined?

(2011) Ian J. Amanna et al.   Human vaccines & immunotherapeutics

Characterization of Monoclonal Antibodies to Terminal and Internal O-Antigen Epitopes of Francisella tularensis Lipopolysaccharide

(2011) Marly I. Roche et al.   HYBRIDOMA

Identification and Characterization of an Immunogenic Hybrid Epitope Formed by both HIV gp120 and Human CD4 Proteins

(2011) G. K. Lewis et al.   JOURNAL OF VIROLOGY

Epitopes Immediately below the Base of the V3 Loop of gp120 as Targets for the Initial Autologous Neutralizing Antibody Response in Two HIV-1 Subtype B-Infected Individuals

(2011) H. Tang et al.   JOURNAL OF VIROLOGY

Antibody-based protection against HIV infection by vectored immunoprophylaxis

(2011) Alejandro B. Balazs et al.   NATURE

Broad neutralization coverage of HIV by multiple highly potent antibodies

(2011) Laura M. Walker et al.   NATURE

A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice

(2011) Ichiro Inoshima et al.   NATURE MEDICINE

MMDB: 3D structures and macromolecular interactions

(2011) T. Madej et al.   NUCLEIC ACIDS RESEARCH

Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin

(2011) J. R. R. Whittle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

(2011) X. Wu et al.   SCIENCE

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

(2011) S. J. Fleishman et al.   SCIENCE

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

(2011) R. Pejchal et al.   SCIENCE

Correlates of Protection Induced by Vaccination

(2010) S. A. Plotkin   Clinical and Vaccine Immunology

Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins

(2010) Steven J. Gamblin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capturing the Natural Diversity of the Human Antibody Response against Vaccinia Virus

(2010) J. Lantto et al.   JOURNAL OF VIROLOGY

Identification, Characterization and Immunogenicity of an O-Antigen Capsular Polysaccharide of Francisella tularensis

(2010) Michael A. Apicella et al.   PLoS One

Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge

(2010) G. Bommakanti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutralizing human monoclonal antibodies binding multiple serotypes of botulinum neurotoxin

(2010) C. Garcia-Rodriguez et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

(2010) T. Zhou et al.   SCIENCE

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

(2010) J. Steel et al.   mBio

Francisella tularensis Infection-Derived Monoclonal Antibodies Provide Detection, Protection, and Therapy

(2009) A. G. Savitt et al.   Clinical and Vaccine Immunology

Are current UK tetanus prophylaxis procedures for wound management optimal?

(2009) M W Cooke   EMERGENCY MEDICINE JOURNAL

Inhibition of Erythrocyte Invasion and Plasmodium falciparum Merozoite Surface Protein 1 Processing by Human Immunoglobulin G1 (IgG1) and IgG3 Antibodies

(2009) M. Lazarou et al.   INFECTION AND IMMUNITY

Generation of stable monoclonal antibody–producing B cell receptor–positive human memory B cells by genetic programming

(2009) Mark J Kwakkenbos et al.   NATURE MEDICINE

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Broadly Neutralizing Human Anti-HIV Antibody 2G12 Is Effective in Protection against Mucosal SHIV Challenge Even at Low Serum Neutralizing Titers

(2009) Ann J. Hessell et al.   PLoS Pathogens

Epitope Mapping of a Bactericidal Monoclonal Antibody against the Factor H Binding Protein of Neisseria meningitidis

(2008) Maria Scarselli et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

(2008) Jeffrey E. Lee et al.   NATURE

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One

Immunoproteomic identification of the hypothetical protein NMB1468 as a novel lipoprotein ubiquitous inNeisseria meningitidis with vaccine potential

(2008) Chi-An Hsu et al.   PROTEOMICS