Three decades of low-dose methotrexate in rheumatoid arthritis: Can we predict toxicity?

The time course of gastric methotrexate intolerance in patients with rheumatoid arthritis and psoriatic arthritis

(2014) Ediz Dalkilic et al.   Modern Rheumatology

Thymidylate synthase polymorphisms are associated to therapeutic outcome of advanced non-small cell lung cancer patients treated with platinum-based chemotherapy

(2014) Aurea Lima et al.   MOLECULAR BIOLOGY REPORTS

Identification of Risk Factors for Elevated Transaminases in Methotrexate Users Through an Electronic Health Record

(2014) Gabriela Schmajuk et al.   ARTHRITIS CARE & RESEARCH

Association of Functional Polymorphism rs2231142 (Q141K) in the ABCG2 Gene With Serum Uric Acid and Gout in 4 US Populations

(2013) Lili Zhang et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update

(2013) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Old drugs, old problems: where do we stand in prediction of rheumatoid arthritis responsiveness to methotrexate and other synthetic DMARDs?

(2013) Vasco Crispim Romão et al.   BMC Medicine

Molecular Basis for Pharmacokinetics and Pharmacodynamics of Methotrexate in Rheumatoid Arthritis Therapy

(2013) Katsuhisa Inoue et al.   Drug Metabolism and Pharmacokinetics

SLC19A180G allele as a biomarker of methotrexate-related gastrointestinal toxicity in Portuguese rheumatoid arthritis patients

(2013) Aurea Lima et al.   PHARMACOGENOMICS

Methotrexate and Lung Disease in Rheumatoid Arthritis: A Meta-Analysis of Randomized Controlled Trials

(2013) Richard Conway et al.   Arthritis & Rheumatology

Association of the TYMS 3G/3G genotype with poor response and GGH 354GG genotype with the bone marrow toxicity of the methotrexate in RA patients

(2012) Biljana Jekic et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacogenetic Polymorphisms Contributing to Toxicity Induced by Methotrexate in the Southern Spanish Population with Rheumatoid Arthritis

(2012) José Cristian Plaza-Plaza et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Genetic variation in the SLC19A1 gene and methotrexate toxicity in rheumatoid arthritis patients

(2012) Petra Bohanec Grabar et al.   PHARMACOGENOMICS

Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients

(2012) S A Owen et al.   PHARMACOGENOMICS JOURNAL

Subcellular localization and distribution of the reduced folate carrier in normal rat tissues

(2011) M. Hinken et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Effect of genetic polymorphisms in the folate pathway on methotrexate therapy in rheumatic diseases

(2011) Lisa K Stamp et al.   PHARMACOGENOMICS

MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with rheumatoid arthritis: analysis of key polymorphisms and meta-analysis of C677T and A1298C polymorphisms

(2011) S A Owen et al.   PHARMACOGENOMICS JOURNAL

Methylenetetrahydrofolate reductase polymorphisms, C677T and A1298C, are associated with methotrexate-related toxicities in Korean patients with rheumatoid arthritis

(2011) Jung-Yoon Choe et al.   RHEUMATOLOGY INTERNATIONAL

The C677T polymorphism in theMTHFRgene is associated with the toxicity of methotrexate in a Spanish rheumatoid arthritis population

(2011) R Cáliz et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Genetic determinants of methotrexate treatment in rheumatoid arthritis patients: a study of polymorphisms in the adenosine pathway

(2010) P. B. Grabar et al.   ANNALS OF THE RHEUMATIC DISEASES

Predictors of response to methotrexate in early DMARD naive rheumatoid arthritis: results from the initial open-label phase of the SWEFOT trial

(2010) S. Saevarsdottir et al.   ANNALS OF THE RHEUMATIC DISEASES

MRP1 Polymorphisms Associated With Citalopram Response in Patients With Major Depression

(2010) Sung Hee Lee et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Methotrexate Drug Interactions in the Treatment of Rheumatoid Arthritis: A Systematic Review

(2010) J. BOURRE-TESSIER et al.   JOURNAL OF RHEUMATOLOGY

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(2010) Yvonne Wettergren et al.   MOLECULAR MEDICINE

Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate

(2010) Lisa K. Stamp et al.   Pharmacogenetics and Genomics

Functional polymorphisms and methotrexate treatment outcome in recent-onset rheumatoid arthritis

(2010) Wouter M Kooloos et al.   PHARMACOGENOMICS

Polymorphisms C677T and A1298C in the MTHFR gene in Mexican patients with rheumatoid arthritis treated with methotrexate: implication with elevation of transaminases

(2010) J P Mena et al.   PHARMACOGENOMICS JOURNAL

Adverse events and factors associated with toxicity in patients with early rheumatoid arthritis treated with methotrexate tight control therapy: the CAMERA study

(2009) S. M. M. Verstappen et al.   ANNALS OF THE RHEUMATIC DISEASES

Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide

(2009) Joost W. van der Heijden et al.   ARTHRITIS AND RHEUMATISM

A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function

(2009) King Leung Fung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review

(2009) S. Prey et al.   BRITISH JOURNAL OF DERMATOLOGY

Functionally Overlapping Roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the Elimination of Methotrexate and Its Main Toxic Metabolite 7-Hydroxymethotrexate In vivo

(2009) M. L.H. Vlaming et al.   CLINICAL CANCER RESEARCH

ORIGINAL ARTICLE: Lack of association between elevated mean red cell volume and haematological toxicity in patients receiving long-term methotrexate for rheumatoid arthritis

(2009) D. H. N. White et al.   INTERNAL MEDICINE JOURNAL

Gene–gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis

(2009) Thierry Dervieux et al.   Pharmacogenetics and Genomics

Methotrexate, rheumatoid arthritis and infection risk--what is the evidence?

(2009) A. McLean-Tooke et al.   RHEUMATOLOGY

Can clinical factors at presentation be used to predict outcome of treatment with methotrexate in patients with early inflammatory polyarthritis?

(2008) S L Hider et al.   ANNALS OF THE RHEUMATIC DISEASES

Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature

(2008) K Visser et al.   ANNALS OF THE RHEUMATIC DISEASES

Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative

(2008) K Visser et al.   ANNALS OF THE RHEUMATIC DISEASES

Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research

(2008) C Salliot et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: a study of polymorphisms affecting methotrexate transport and folate metabolism

(2008) Petra Bohanec Grabar et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX

(2008) S. L. Hider et al.   RHEUMATOLOGY