Article
Medicine, General & Internal
Jeffrey R. Curtis, Stacey S. Cofield, S. Louis Bridges, John Bassler, Atul Deodhar, Theresa L. Ford, Joseph Huffstutter, Allen Jankeel, Alan Kivitz, Shaila Kamal, Stephen Lindsey, Ilhem Messaoudi, Norma Mendoza, Kaleb Michaud, Ted R. Mikuls, David Ridley, William Shergy, Sarah A. R. Siegel, Kevin L. Winthrop
Summary: This study aimed to evaluate the safety and immunogenicity of the live attenuated zoster vaccine (ZVL) in patients receiving TNF inhibitors (TNFis), the trial showed no confirmed cases of varicella infection within 6 weeks post-vaccination, with a cumulative incidence of varicella infection or shingles at 0%, and an increase in gpELISA and ELISpot from baseline to 6 weeks post-vaccination.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Rheumatology
Paul Studenic, Daniel Aletaha, Maarten de Wit, Tanja A. Stamm, Farideh Alasti, Diane Lacaille, Josef S. Smolen, David T. Felson
Summary: This study aimed to externally validate a revised Boolean remission criteria using a higher patient global assessment (PtGA) threshold and validate the provisionally endorsed index-based criteria. The results showed that using the higher PtGA threshold increased the proportion of patients classified as achieving remission under the "Boolean2.0" criteria, improved agreement with index-based criteria, and did not compromise predictive value for radiographic or functional outcomes. The study findings were endorsed by ACR and EULAR.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Kieran Murray, Sean Quinn, Matthew Turk, Anna O'Rourke, Eamonn Molloy, Lorraine O'Neill, Ann Barbara Mongey, Ursula Fearon, Douglas J. Veale
Summary: The rate of COVID-19 positivity in Irish rheumatic musculoskeletal disease patients was similar to the general population. Patients on immunosuppressive medication and adherent to medication guidelines tended to have lower COVID-19 symptoms. Respondents were supportive of health authority advice and the use of virtual clinics.
Article
Pediatrics
Jeffrey W. Lai, Timothy Ford, Sarah Cherian, Anita J. Campbell, Christopher C. Blyth
Summary: The incidence of neonatal varicella has decreased significantly since the introduction of the varicella vaccination, but the risk and treatment of neonatal varicella acquired from maternal zoster reactivation still need to be addressed.
FRONTIERS IN PEDIATRICS
(2021)
Article
Immunology
Shivam K. Purohit, Alexandra J. Corbett, Barry Slobedman, Allison Abendroth
Summary: This study demonstrates that mucosal associated invariant T (MAIT) cells are susceptible to varicella zoster virus (VZV) infection and exhibit changes in the expression of functional markers. Infected MAIT cells are capable of transferring infectious virus to other permissive cells and retain the ability to migrate and activate in skin sites.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Renske C. F. Hebing, Marry Lin, Maja Bulatovic Calasan, Ittai B. Muller, Sohaila Mahmoud, Sandra Heil, Eduard A. Struys, Bart J. F. van den Bemt, Jos W. R. Twisk, Willem Lems, Michael T. Nurmohamed, Gerrit Jansen, Robert de Jonge
Summary: This study investigates the pharmacokinetics of methotrexate polyglutamate (MTX-PG) accumulation in red blood cells (RBCs) and peripheral blood mononuclear cells (PBMCs) in patients with early rheumatoid arthritis (RA) after oral and subcutaneous MTX treatment. The results show that there are disparate pharmacokinetic profiles between PBMCs and RBCs, with higher accumulation of MTX-PG in PBMCs. The distribution profile of MTX-PG in PBMCs remains constant over 6 months, while in RBCs, the main PG-moiety changes from MTX-PG(1) to MTX-PG(3).
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Delila Singh, Nina Hesse, Alla Skapenko, Hendrik Schulze-Koops
Summary: Methotrexate is associated with rare bone lesions that are often misdiagnosed as osteoporotic fractures. Early diagnosis is crucial for treatment and prevention of further osteopathology. This case highlights the importance of raising awareness and taking appropriate therapeutic measures, including discontinuing methotrexate.
Article
Chemistry, Analytical
Junqing He, Junyan Wang, Min Zhang, Guoyue Shi
Summary: As a folate antagonist, methotrexate (MTX) has been widely used in clinics for treating various tumors and inflammatory diseases. However, the dosage and clearance of MTX vary between individuals, and it may cause life-threatening side effects at high doses. Therefore, a convenient and simple method for MTX sensing is highly demanded.
Article
Immunology
Marco Krasselt, Christoph Baerwald, Uwe G. Liebert, Olga Seifert
Summary: The study revealed that VZV IgG antibody concentrations in SLE patients were comparable to healthy controls but higher than in RA patients. Young SLE patients aged between 30 and 39 had the highest antibody levels, while RA patients had the lowest concentrations.
Article
Rheumatology
Clement Triaille, Gaelle Tilman, Tatiana Sokolova, Axelle Loriot, Joelle Marchandise, Stephanie De Montjoye, Adrien Nzeusseu-Toukap, Laurent Meric de Bellefon, Caroline Bouzin, Christine Galant, Patrick Durez, Bernard R. Lauwerys, Nisha Limaye
Summary: This study used transcriptomic profiling to explore clinically relevant subgroups in early, untreated rheumatoid arthritis (RA) patients. The synovial transcriptome closely mirrored clinical disease activity, and the ratio of M2:M1 macrophages was inversely correlated with inflammation and disease activity, suggesting a protective role for tissue resident macrophages in RA.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Claire Daien, Marek Krogulec, Paul Gineste, Jean-Marc Steens, Laurence Desroys du Roure, Sophie Biguenet, Didier Scherrer, Julien Santo, Hartmut Ehrlich, Patrick Durez
Summary: This study evaluated the safety and efficacy of ABX464 in patients with moderate-to-severe active rheumatoid arthritis. The results showed that ABX464 at a 50 mg dose was safe, well tolerated, and showed promising efficacy. The 100 mg dose had a high dropout rate due to gastrointestinal adverse events.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Siddharth Jain, Varun Dhir, Amita Aggarwal, Ranjan Gupta, Bidyalaxmi Leishangthem, Shankar Naidu, Aastha Khullar, Supriya Maurya, Veena Dhawan, Shefali Khanna Sharma, Aman Sharma, Sanjay Jain
Summary: This study compared the efficacy and safety of different dose escalation strategies of oral MTX in RA patients over a period of 16-24 weeks. The results showed that a faster escalation strategy was not more effective than the usual strategy, but was associated with higher gastrointestinal adverse events in the initial phase.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Virology
Vincent Guiraud, Henri Thevenet, David Boutolleau
Summary: This study demonstrates that varicella zoster virus DNA can commonly be detected in the blood of immunocompromised patients during the prodromal phase of herpes zoster. Early screening of VZV DNA in the blood of high-risk immunocompromised patients may improve the therapeutic management of herpes zoster.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Helen R. Gosselt, Costanza L. Vallerga, Pooja R. Mandaviya, Erik Lubberts, Johanna M. W. Hazes, Robert de Jonge, Sandra G. Heil
Summary: The study did not identify genome-wide significant differences as biomarkers for Methotrexate (MTX) therapy response, necessitating meta-analyses.
Article
Rheumatology
Ulf Lindstrom, Daniela di Giuseppe, Sofia Exarchou, Gerd-Marie Alenius, Tor Olofsson, Eva Klingberg, Lennart Jacobsson, Johan Askling, Johan K. Wallman
Summary: This study aimed to compare the treatment outcomes of patients with newly diagnosed psoriatic arthritis (PsA) and rheumatoid arthritis (RA) using methotrexate (MTX) monotherapy. The results showed that PsA patients were less likely to continue the use of MTX compared to RA patients, and the effectiveness of MTX was also lower in PsA.
Article
Immunology
Elizabeth M. Klinken, Paul E. Gray, Bethany Pillay, Lisa Worley, Emily S. J. Edwards, Kathryn Payne, Bruce Bennetts, Dorothy Hung, Ben A. Wood, Jonathan J. Chan, Glenn M. Marshall, Richard Mitchell, Gulbu Uzel, Cindy S. Ma, Stuart G. Tangye, Andrew McLean-Tooke
JOURNAL OF CLINICAL IMMUNOLOGY
(2020)
Review
Rheumatology
Luckshman R. Ganeshanandan, Anna M. Brusch, Jason M. Dyke, Andrew P. C. McLean-Tooke
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2020)
Editorial Material
Medicine, General & Internal
Jessica Ryan, Joanna Tieu, Bhadran Bose, Ross Francis, Michael Gingold, Liang Goh, James Gray, Catherine L. Hill, Pravin Hissaria, Sadia Jahan, Daman Langguth, Jennifer Li, Andrew McLean-Tooke, Chen A. Peh, Mukhlesur Rahman, Tony Sammel, Lisa K. Stamp, Mark Street, Sanjay Swaminathan, Nikki L. Wong, Richard Kitching
INTERNAL MEDICINE JOURNAL
(2020)
Article
Pathology
Grace Thompson, Zubin Grover, Richard Loh, Catherine Mews, Madhur Ravikumara, Gareth Jevon, Lloyd D'Orsogna, Andrew McLean-Tooke
Article
Pediatrics
Stephanie Richards, Andrew R. Gennery, E. Graham Davies, Melanie Wong, Peter J. Shaw, Jane Peake, Chris Fraser, Paul Gray, Shannon Brothers, Jan Sinclair, Tim Prestidge, Kahn Preece, Patrick Quinn, Shanti Ramachandran, Richard Loh, Andrew McLean-Tooke, Richard Mitchell, Theresa Cole
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2020)
Article
Medical Laboratory Technology
Teng Hoo, Ee Mun Lim, Mina John, Lloyd D'Orsogna, Andrew McLean-Tooke
Summary: Calculated globulin fraction, derived from liver function tests, can assist in identifying hypogammaglobulinaemia or hypergammaglobulinaemia, reducing diagnostic delays.
ANNALS OF CLINICAL BIOCHEMISTRY
(2021)
Article
Immunology
Grace Thompson, Andrew McLean-Tooke, Michaela Lucas
Summary: Current understanding of cross-reactivity in severe cutaneous adverse reactions to beta-lactam antibiotics is limited, and the underlying immunopathogenesis of these reactions is not completely understood. Research has shown that cross-reactivity or co-reactivity commonly occurred among the beta-lactam antibiotic class, but further investigation is needed to understand and investigate patterns of cross-reactivity.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Allergy
Jovanka R. King, Zubin Grover, Nazneen Irani, Andrew McLean-Tooke
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Letter
Immunology
Natasha Moseley, Jovanka King, Ben Van Dort, Simon Williams, Victoria Rodriguez-Casero, Shanti Ramachandran, Sharon Choo, Theresa Cole, Andrew McLean-Tooke
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Review
Dermatology
Erin Somerville, Kurt Gebauer, Andrew Mclean-Tooke
Summary: Pemphigus is a rare and severe skin disease that can be effectively treated with the use of rituximab, an anti-CD20 monoclonal antibody. Despite overwhelming evidence supporting this treatment, Australia still recommends traditional therapies. It is proposed that rituximab be included in the formularies of Australian Public Hospitals and on the Pharmaceutical Benefits Scheme to improve treatment outcomes for moderate to severe pemphigus.
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2022)
Article
Pathology
William Kermode, Dianne De Santis, Linh Truong, Erika Della Mina, Sam Salman, Grace Thompson, David Nolan, Richard Loh, Dominic Mallon, Andrew Mclean-Tooke, Mina John, Stuart G. Tangye, Michael O'Sullivan, Lloyd J. D'Orsogna
Summary: This study used a targeted NGS panel to identify disease-causing variants in a CVID cohort. Pathogenic or likely pathogenic variants were found in 27% of patients, along with variants of uncertain significance. The findings have implications for understanding the genetic mechanisms of CVID and potential targeted therapeutic strategies.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2022)
Article
Medicine, General & Internal
Alexander Shivarev, Anastasia Phillips, Sam Brophy-Williams, Tim Ford, Peter Richmond, Paul Effler, Andrew McLean-Tooke
Summary: Within the first 4 months of the Western Australian COVID-19 immunisation programme, there were 49 reported cases of suspected anaphylaxis in the vaccine safety surveillance system. Out of these, 12 cases met the Brighton Collaboration case definition, corresponding to rates of 15.9 and 17.7 per million doses of Vaxzevria and Comirnaty administered respectively.
INTERNAL MEDICINE JOURNAL
(2023)
Meeting Abstract
Medicine, General & Internal
Constance H. Katelaris, Andrew McLean-Tooke, Katherine Nicholls, William Smith, Fiona A. Perram, Naomi Drew, Fiona Wardman, Michaela Lucas
INTERNAL MEDICINE JOURNAL
(2022)
Article
Medicine, General & Internal
Danielle Lam, Shirley Jansen, Jonathan Tibballs, Andrew McLean-Tooke
Meeting Abstract
Medicine, General & Internal
Warren Raymond, Georgia Ngo, Milica Ognjenovic, Ian Li, Patrick Cheah, Aron Chakera, Andrew McLean-Tooke, Johannes Nossent
INTERNAL MEDICINE JOURNAL
(2020)
