The Significance of Meaning: Why Do Over 90% of Behavioral Neuroscience Results Fail to Translate to Humans, and What Can We Do to Fix It?

Randomized Block Experimental Designs Can Increase the Power and Reproducibility of Laboratory Animal Experiments

(2014) M. F. W. Festing   ILAR JOURNAL

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Olfactory exposure to males, including men, causes stress and related analgesia in rodents

(2014) Robert E Sorge et al.   NATURE METHODS

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

An automated maze task for assessing hippocampus-sensitive memory in mice

(2013) Elsa Y. Pioli et al.   BEHAVIOURAL BRAIN RESEARCH

Six red flags for suspect work

(2013) C. Glenn Begley   NATURE

Reply to: "Reanalysis of Richter et al. (2010) on reproducibility"

(2013) Hanno Würbel et al.   NATURE METHODS

Energy Reallocation to Breeding Performance through Improved Nest Building in Laboratory Mice

(2013) Brianna N. Gaskill et al.   PLoS One

Whole Animal Experiments Should Be More Like Human Randomized Controlled Trials

(2013) Beverly S. Muhlhausler et al.   PLOS BIOLOGY

The naked truth: Breeding performance in nude mice with and without nesting material

(2012) Brianna N. Gaskill et al.   APPLIED ANIMAL BEHAVIOUR SCIENCE

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

In search of preclinical robustness

(2012) Ian S. Peers et al.   NATURE REVIEWS DRUG DISCOVERY

Animal systems in the development of treatments for Alzheimer's disease: challenges, methods, and implications

(2012) Jonathan J. Sabbagh et al.   NEUROBIOLOGY OF AGING

Heat or Insulation: Behavioral Titration of Mouse Preference for Warmth or Access to a Nest

(2012) Brianna N. Gaskill et al.   PLoS One

Reverse-translational biomarker validation of Abnormal Repetitive Behaviors in mice: An illustration of the 4P's modeling approach

(2011) Joseph P. Garner et al.   BEHAVIOURAL BRAIN RESEARCH

Erroneous analyses of interactions in neuroscience: a problem of significance

(2011) Sander Nieuwenhuis et al.   NATURE NEUROSCIENCE

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Challenges for pharmaceutical industry: new partnerships for sustainable human health

(2011) J. Hunter   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Effect of Population Heterogenization on the Reproducibility of Mouse Behavior: A Multi-Laboratory Study

(2011) S. Helene Richter et al.   PLoS One

Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis Causes Cancer Remission and Inhibition

(2010) Lei Cao et al.   CELL

Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice

(2010) Shau-Kwaun Chen et al.   CELL

The standardization-generalization dilemma: a way out

(2010) F. Josef van der Staay et al.   GENES BRAIN AND BEHAVIOR

Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice

(2010) Sergey V Shmelkov et al.   NATURE MEDICINE

Systematic variation improves reproducibility of animal experiments

(2010) S Helene Richter et al.   NATURE METHODS

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

Nutritional up-regulation of serotonin paradoxically induces compulsive behavior

(2010) Brett D. Dufour et al.   NUTRITIONAL NEUROSCIENCE

‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

(2010) Kathleen R. Zahs et al.   TRENDS IN NEUROSCIENCES

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Amyloid precursor protein transgenic mouse models and Alzheimer's disease: Understanding the paradigms, limitations, and contributions

(2009) Tyler A. Kokjohn et al.   Alzheimers & Dementia

N-Acetylcysteine, a Glutamate Modulator, in the Treatment of Trichotillomania

(2009) Jon E. Grant et al.   ARCHIVES OF GENERAL PSYCHIATRY

Of Mice and Men

(2009) Hugo Geerts   CNS DRUGS

Reverse translational strategies for developing animal models of bipolar disorder

(2009) O. Malkesman et al.   Disease Models & Mechanisms

Environmental standardization: cure or cause of poor reproducibility in animal experiments?

(2009) S Helene Richter et al.   NATURE METHODS

Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals

(2009) Carol Kilkenny et al.   PLoS One

Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors

(2009) Gretchen L. Hermes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Some like it hot: Mouse temperature preferences in laboratory housing

(2008) Brianna N. Gaskill et al.   APPLIED ANIMAL BEHAVIOUR SCIENCE

Standards for the publication of mouse mutant studies

(2008) W. E. Crusio et al.   GENES BRAIN AND BEHAVIOR

Reciprocal Affiliation Among Adolescent Rats During a Mild Group Stressor Predicts Mammary Tumors and Lifespan

(2008) Jason R. Yee et al.   PSYCHOSOMATIC MEDICINE

Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

(2008) Malcolm R. Macleod et al.   STROKE