Article
Engineering, Biomedical
M. Schumacher, P. Habibovic, S. van Rijt
Summary: Mesoporous bioactive glasses have promising properties for regenerative medicine due to their bioactivity and degradability, which are influenced by synthesis parameters and glass stoichiometry. Control of degradation and bioactivity over a broad range can be achieved through glass stoichiometry, allowing targeted material selection for specific regenerative medicine applications.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Ceramics
Luana Cristina Feitosa Alves, Jheimison Ferreira Gomes, Natacya Fontes Dantas, Maria Nayane Queiroz, Pablo Nabuco Portes, Francielle Sato, Nilma de Souza Fernandes, Karina Miyuki, Celso Vataru Nakamura, Alysson Steimacher, Franciana Pedrochi
Summary: This study evaluated the influence of CaF2 addition on the bioactivity of the samples. The results showed that the samples exhibited good bioactivity and cytocompatibility, making them suitable for biomedical applications.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2024)
Article
Materials Science, Ceramics
Lais Costa Alves da Silva, Floriano Guimaraes Neto, Satya Sthefany Cordeiro Pimentel, Raquel da Silva Palacios, Francielle Sato, Karina Miyuki Retamiro, Nilma Souza Fernandes, Celso Vataru Nakamura, Franciana Pedrochi, Alysson Steimacher
Summary: This study successfully prepared borate glasses doped with silver, which showed improved bioactivity and excellent antibacterial properties. The addition of silver enhanced the alkalinity of the glasses in simulated body fluid and led to the formation of hydroxyapatite and fluorapatite phases. Antibacterial tests demonstrated the efficiency of silver-doped borate glasses against both gram-negative and gram-positive bacteria.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2021)
Article
Materials Science, Ceramics
Fengjie Li, Yue Jiang, Minghui Chen, Bin Yu, Jinlong Wang, Fuhui Wang
Summary: This study investigates the effects of ZrO2 addition on the bioactivity and mechanical properties of a multicomponent bioactive glass-ceramic. The results show that ZrO2 reduces the crystallisation ability and bioactivity of the glass-ceramic, but the addition of YSZ particles leads to improved mechanical strength and bioactivity. These findings suggest a promising method for producing bioactive glass-ceramics for load-bearing clinical applications.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Cuilian Wen, Nuonan Bai, Lijin Luo, Jianxia Ye, Xuan Zhan, Yinggan Zhang, Baisheng Sa
Summary: Silicate bioglass is essential in bone engineering for its bioactivity and osteogenic effects. The study synthesized hydroxyapatite-like bioactive glass based on the xSiO2-CaO-P2O5 system and investigated its structural evolution, apatite-forming ability, and cytotoxicity. Higher heat treatment temperature and lower SiO2 content increase crystallinity tendency and sample compactness, with 30Si sample showing remarkable mesoporous structures and high specific surface area, demonstrating excellent hydroxyapatite formation and no inhibitory effect on hPDLCs.
CERAMICS INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hina Khalid, Natheer Aleesa, Mathilde Grosjean, Robert Hill, Ferranti Wong
Summary: The study demonstrated that the bioactive glass is capable of increasing pH and forming fluorapatite in phosphate-containing media. The release of ions and the phosphate content in the media influenced the formation of fluorapatite.
Article
Nanoscience & Nanotechnology
Baiyan Sui, Zhiyan Xu, Zhiyu Xue, Yong Xiang, Tian Zhou, Ana M. Beltraïn, Kai Zheng, Xin Liu, Aldo R. Boccaccini
Summary: A postgrafting strategy mediated by polydopamine (PDA) coating is proposed to incorporate different metal elements into mesoporous silicate bioactive glass nanoparticles (MBG NPs) while maintaining their stability. However, the PDA coating reduces the ion-binding free energy of MBG NPs for calcium and phosphate ions, resulting in minimal deposition of calcium phosphate clusters on the PDA@MBG NP surface after immersion in simulated body fluid for 7 days, indicating a lack of hydroxyapatite mineralization.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
M. Mohan Babu, P. Venkateswara Rao, Rajendra K. Singh, Hae-Won Kim, N. Veeraiah, Mutlu Oezcan, P. Syam Prasad
Summary: Bioactive phosphate glasses doped with Zn2+ demonstrated excellent bioactivity and bone regeneration potential in simulated body fluid. ZnO concentration and immersion time were found to impact the formation of hydroxyapatite (HAP) layer on the sample surface, while controlled release of Zn2+ ions could monitor the degradation rate. In vitro cell studies showed favorable outcomes in terms of rMSC cell proliferation. Antibacterial activity against E. coli and S. aureus was confirmed, highlighting the enhanced biological and antibacterial properties of the samples due to ZnO doping.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Materials Science, Ceramics
Yi-Ju Li, Kin Weng Wong, Ya-Chi Huang, Chi-Sheng Chien, Chi-Jen Shih
Summary: In this study, Ag/Cu mesoporous bioactive glass (AgCu/80S) was prepared by combining the antibacterial ability of silver (Ag) and the angiogenesis-promoting properties of copper (Cu) using a sol-gel method. The crystal phase, composition, and metal ion release ability of AgCu/80S were analyzed. The bioactivity, antibacterial ability, and angiogenesis-promoting properties of AgCu/80S were evaluated, indicating its potential in the field of biomedicine.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2023)
Article
Polymer Science
Asmaa M. Abd El-Aziz, Ahmed Abd El-Fattah, Azza El-Maghraby, Doaa A. Ghareeb, Sherif Kandil
Summary: Chemical cross-linking was used to create nanocomposite hydrogels composed of gelatin and borosilicate bioactive glass with different content. The nanocomposite scaffolds showed promising properties such as hydrophilicity, biodegradability, increased compressive modulus, and facilitated apatite formation in simulated body fluid. The nanocomposite hydrogels exhibited a self-standing elastic structure with greater storage modulus than loss modulus.
Article
Chemistry, Multidisciplinary
Johannes Morstein, Alice Capecchi, Konstantin Hinnah, ByungUk Park, Jerome Petit-Jacques, Reid C. Van Lehn, Jean-Louis Reymond, Dirk Trauner
Summary: Most bioactive molecules need to cross or be distributed into biological membranes, and natural products often have lipid modifications to facilitate molecule-membrane interactions. Lipidated natural products primarily contain saturated medium-chain lipids, and lipid conjugation can significantly modulate the permeability, cellular retention, subcellular localization, and bioactivity of small molecules.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Jian Xiao, Qianghua Wei, Jinhong Xue, Zide Yang, Zhicheng Deng, Fulai Zhao
Summary: In this study, a novel three-dimensional hollow mesoporous bioactive glass nanofiber scaffold was successfully synthesized and characterized. The scaffold exhibited nanofiber-like morphology and an interconnected three-dimensional network structure, with a large specific surface area and pore volume. It also showed excellent apatite-forming ability and cellular biocompatibility. The results suggest that this scaffold has great potential for bone tissue regeneration.
Article
Biotechnology & Applied Microbiology
Haiyan Yao, Jun Luo, Yunyun Deng, Zhihua Li, Junchao Wei
Summary: Surface modification of mesoporous bioactive glass (MBG) with alginate (ALG) can improve its properties, including drug loading efficiency and drug release time. The modified MBG surface allows ordered deposition of apatite and significantly promotes osteogenic differentiation of bone cells.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Zanko Rouein, Hassan Jafari, Fatemehsadat Pishbin, Fatemeh Mohandes, Abdolreza Simchi
Summary: This research evaluated the in vitro bioactivity and biocompatibility of a novel composite coating based on PMMA biopolymer and BG particles on a magnesium-based implant. The study demonstrated a significant reduction in the corrosion rate of magnesium implants coated with the composite film, highlighting the potential of this approach for successful bone tissue engineering applications.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Materials Science, Ceramics
Tamal Kanti Ghosh, Sujan Kumar Chakrabarti, Shatabdi Ghosh, Samrat Saha, Sanjit Dey, Sudip Kumar Das
Summary: In this study, a new group of bioactive glass and glass ceramics containing nano-zirconia was synthesized. The addition of nano-zirconia improved the thermal stability and micro-hardness of the materials, and their bioactivity and non-toxicity were confirmed.
CERAMICS INTERNATIONAL
(2023)
Article
Materials Science, Ceramics
Araceli de Pablos-Martin, Altair T. Contreras Jaimes, Stefanie Wahl, Sylke Meyer, Delia S. Brauer
Summary: Fluoride quantification in bioactive glasses and glass-ceramics was studied using LIBS, showing higher P2O5 concentrations led to greater fluorine loss in the glass, likely due to additional mechanisms involving phosphorus species volatilization.
INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Abeer Alaohali, Delia S. Brauer, Eileen Gentleman, Paul T. Sharpe
Summary: In this study, lithium-containing bioactive glass was created and used to modify GIC to promote tertiary dentine formation. The results showed that LithGlassGIC enhanced dentine regeneration and restored tooth structure by upregulating Wnt/β-catenin activity.
Review
Engineering, Biomedical
Chiara Micheletti, Ariana Hurley, Aurelien Gourrier, Anders Palmquist, Tengteng Tang, Furqan A. Shah, Kathryn Grandfield
Summary: This article provides a new perspective on bone structure, highlighting the ubiquitous presence of mineral ellipsoids in bones and their importance in terms of toughness and strength.
ACTA BIOMATERIALIA
(2022)
Article
Dentistry, Oral Surgery & Medicine
Shariel Sayardoust, Wilhelm Norstedt, Furqan A. Shah
Summary: The study evaluates the long-term impact of alveolar ridge preservation (ARP) on peri-implant health and its relationship with common risk indicators such as smoking and history of periodontitis. The findings suggest that peri-implant health can be maintained for at least 5 years in ARP(+) sites using deproteinized bovine bone mineral xenograft. Smoking is a major risk indicator for peri-implantitis, while the association between history of periodontitis and risk of peri-implantitis remains inconclusive.
CLINICAL AND EXPERIMENTAL DENTAL RESEARCH
(2022)
Review
Engineering, Biomedical
Anders Palmquist, Martina Jolic, Eduard Hryha, Furqan A. Shah
Summary: In the past decade, additive manufacturing technologies, particularly electron beam melting (EBM), have revolutionized the production of biomedical implants. EBM offers faster build rates and a high vacuum environment, making it advantageous for materials susceptible to oxidation and nitrogen pick-up. EBM manufactured implants have shown great potential in skeletal reconstruction, with anatomical mimickry and macro-porous architecture. The personalized design and diverse clinical applications of EBM in skeletal repair and prosthetic rehabilitation are discussed in this review.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Sapir Gershov, Jing Xie, Furqan A. Shah, Keren Shemtov-Yona, Daniel Rittel
Summary: A novel numerical spatio-temporal model is developed to assess the interaction between the implant, surrounding bone, and evolving interface. The study shows that load transfer between the bone and implant is hindered until the interface develops into a solid continuous bone, regardless of the BIC.
ACTA BIOMATERIALIA
(2022)
Review
Multidisciplinary Sciences
Martina Jolic, Sonali Sharma, Anders Palmquist, Furqan A. Shah
Summary: The success of metal implants in rehabilitation is due to osseointegration, the direct connection between living bone and the implant. Removal torque measurement can assess the extent of biomechanical anchorage between the implant and bone. Various pharmacological agents have been evaluated for their impact on osseointegration, with some substances showing positive effects on removal torque and others showing adverse effects. Factors such as bone quality play a role in the biomechanical anchorage of metal implants, and questions regarding drug metabolism, dosage, and treatment interruption remain unanswered.
Article
Engineering, Biomedical
Furqan A. Shah, Martina Jolic, Chiara Micheletti, Omar Omar, Birgitta Norlindh, Lena Emanuelsson, Hakan Engqvist, Thomas Engstrand, Anders Palmquist, Peter Thomsen
Summary: Calcium phosphates (CaP) are important biomaterials for bone regeneration. This study demonstrates how a multi-component CaP formulation can guide bone formation beyond the normal physiological range. The study shows successful bone formation and remodeling in sheep models using this CaP formulation, and the presence of woven bone and vascularized lamellar bone in the pores of the CaP material.
BIOACTIVE MATERIALS
(2023)
Article
Endocrinology & Metabolism
Chiara Micheletti, Liza-Anastasia DiCecco, Cecilia Larsson Wexell, Dakota M. Binkley, Anders Palmquist, Kathryn Grandfield, Furqan A. Shah
Summary: This study investigates the interface between necrotic bone and bacteria in medication-related osteonecrosis of the jaw (MRONJ) using a multimodal and multiscale characterization approach. The findings suggest that the bone-bacteria interface originates not only from uncontrolled mineralization but also from the direct action of bacteria degrading the bone matrix.
Article
Microscopy
Furqan A. Shah
Summary: The lacuno-canalicular space of apoptotic osteocytes in ageing bone becomes mineralised, forming hypermineralised osteocyte lacunae that indicate impaired bone function. The mineralised apoptotic debris in the lacuno-canalicular space consists of micrometre-sized nodules of magnesium-rich, carbonated apatite. Additionally, rhomboidal nodules of magnesium whitlockite have been observed in human alveolar bone exposed to the bisphosphonate alendronate. This study provides evidence of Mg-whitlockite formation in alveolar bone exposed to zoledronic acid.
Article
Multidisciplinary Sciences
Furqan Shah
Summary: This study investigates the differences in composition of acid phosphate, carbonate, hydroxyl, iron, and magnesium content between pigmented incisor enamel and unpigmented molar enamel of Sprague Dawley rats. The results reveal that iron-rich pigmented enamel has higher mineral crystallinity, higher levels of acid phosphate and hydroxyl, and no presence of iron oxides or oxy(hydroxides). These findings provide new insights into enamel biomineralization and the functional differences of ameloblasts between incisors and molars in rodents.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Heithem Ben Amara, Diana C. Martinez, Furqan A. Shah, Anna Johansson Loo, Lena Emanuelsson, Birgitta Norlindh, Regine Willumeit-Romer, Tomasz Plocinski, Wojciech Swieszkowski, Anders Palmquist, Omar Omar, Peter Thomsen
Summary: Using a rat soft tissue model, the researchers found that magnesium (Mg) implants exacerbated initial inflammation but also initiated chemotaxis and upregulated immunomodulatory markers, leading to tissue repair. The understanding of the relationship between Mg material properties and cellular processes provides a basis for interpretation of clinical observations and future improvements in Mg implants.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Dahiana Avila A. Salazar, Matvey Fedin, Wolfram Hartramph, Delia S. Brauer
Summary: This study aims to investigate the effects of the coordination environment of cobalt on the structure and properties of 45P(2)O(5)-(30 - x)CaO-25Na(2)O-xCoO (x: 0.01 to 10 mol%) glasses. The results show that the presence ratio of four-fold and six-fold coordinated Co2+ has an impact on the thermal properties and network strength of the glasses.
DALTON TRANSACTIONS
(2023)
Review
Endocrinology & Metabolism
Mari Sato, Furqan A. A. Shah
Summary: In recent years, there has been an evolution of imaging technologies for visualising cells and investigating their interactions with other cells, anatomical structures, and biomaterials. Resin cast etching (RCE) is a simple technique for observing the osteocyte lacuno-canalicular network in bone using scanning electron microscopy. RCE can be used to investigate various quantitative and qualitative parameters, including size and density of osteocytes, arrangement of osteocytes and canaliculi, and communication between osteocytes and implant surfaces. It has applications in studying bone-related diseases and evaluating the osseointegration potential of different materials.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Review
Cell & Tissue Engineering
Amna Riaz, Furqan A. Shah
Summary: Current clinical evidence suggests that in regenerative endodontics, the use of PRP or PRF does not provide a significant advantage over induced blood clots. The true nature of neoformed tissues and their response to insult or injury remains poorly characterized and unexplored.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Article
Materials Science, Multidisciplinary
Deyong Zheng, Huihui Jin, Yucong Liao, Pengxia Ji
Summary: In this study, a highly stable and efficient catalyst, fluorine-doped Co3O4 (F-Co3O4), was developed for hydrogen production by water electrolysis. The F-Co3O4 catalyst exhibited a remarkable reduction in overpotential and demonstrated excellent stability for over 100 hours.
Article
Materials Science, Multidisciplinary
Ziwen Lv, Jintao Wang, Fengyi Wang, Jianqiang Wang, Fuquan Li, Hongtao Chen
Summary: Adding Cu6Sn5 nano particles can effectively inhibit the overgrowth of intermetallic compounds at the interfaces of solder joints in electronic devices, providing a solution to this issue. A new growth mechanism of intermetallic compounds at the interfaces was identified.
Article
Materials Science, Multidisciplinary
Jun Wang, Jiawei Chen, Wanru Liao, Fangyang Liu, Min Liu, Liangxing Jiang
Summary: A BiOI/AgI/Ag plasmonic heterostructure photocathode was successfully designed through electrodeposition, ion-exchange, and illumination methods. This photocathode exhibits superior performance in photoelectrochemical water splitting.
Article
Materials Science, Multidisciplinary
Xiaoxiao Liu, Xianxian Zhou, Xiaotao Ma, Qinbo Yuan, Shibin Liu
Summary: In this study, the authors propose a method to accelerate the reaction of polysulfides in lithium-sulfur batteries using a Ni@OC Mott-Schottky heterojunction as a catalyst. The experimental results demonstrate that the charge redistribution at the Ni@OC interface accelerates electron transfer and enhances catalytic activity, leading to improved reaction kinetics and battery performance.
Article
Materials Science, Multidisciplinary
Dayou Ma, Mohammad Rezasefat, Joziel Aparecido da Cruz, Sandro Campos Amico, Marco Giglio, Andrea Manes
Summary: The matrix has a significant effect on the impact resistance of composite materials. Replacing a brittle polymer with a more flexible one can improve impact resistance, but it poses challenges to standard testing methods. This study designs a new fixture for testing the low-velocity impact of soft composites and investigates the effect of the fixture on the mechanical performance.
Article
Materials Science, Multidisciplinary
Lingchang Wang, Qihang Yang, Huzhen Li, Ming Wei, Qian Wang, Zhenzhong Hu, Mengmeng Zhen
Summary: Bronze titanium dioxide (TiO2(B)) is a promising anode material for lithium-ion batteries due to its high specific capacity. However, its practical applications are hindered by poor conductivity and limited electrochemical kinetics. In this study, TiO2(B)-carbon nanosheets heterostructures are synthesized to enhance the cycling performance and rate capability of TiO2(B).
Article
Materials Science, Multidisciplinary
Atul Thakur, Ritesh Verma, Ankush Chauhan, Fayu Wan, Preeti Thakur
Summary: In this study, BaFe12O19 and BaFe12O19: Epoxy (50:50) nanocomposites were synthesized using the co-precipitation method. The structural information and material properties, such as crystallite size and electrical conductivity, were characterized by XRD, FESEM, EDX, and TEM techniques.
Article
Materials Science, Multidisciplinary
Jingyu Wu, Xinyan Ma, Yong Yang
Summary: A well-defined CoS2@NC(CS-500) hierarchical binder-free catalyst cathode is constructed through in-situ grown of ZIF-67 on carbon cloth and high-temperature carbonization. The cathode shows excellent reaction kinetics and electrochemical performance, providing inspiration for developing advanced Li-CO2 battery catalysts.
Article
Materials Science, Multidisciplinary
Svetlana M. Posokhova, Vladimir A. Morozov, Kirill N. Boldyrev, Dina Deyneko, Erzhena T. Pavlova, Bogdan I. Lazoryak
Summary: This study explores the impact of synthesis method and composition on the structure and luminescence properties of K5Eu1-xHox(MoO4)4 with the palmierite-type matrix. The co-doping of Eu3+ and Ho3+ ions plays a critical role in manipulating charge transfer and luminescence efficiency in the visible and infrared regions.
Article
Materials Science, Multidisciplinary
Jian Wang, Yeting Tao, Jingsheng Wang, Youtian Tao
Summary: A new electron-transport material iTPyBI-CN is developed through non-catalytic C-N coupling reaction. It exhibits better electroluminescence efficiency in organic light-emitting diodes compared to the commercial material TPBI, due to its twisted geometry and higher energy levels.
Article
Materials Science, Multidisciplinary
Tao Zhu, Feng Huang, Shuo Li, Yang Zhou
Summary: This article combines XRD analysis and microscopic structural observation to investigate the changes in limestone after high-temperature treatment. It finds that 500 degrees C is the critical temperature for crystalline and spatial arrangement changes in limestone, and the thermal conductivity, specific heat capacity, and heat storage coefficient gradually decrease after thermal treatment.
Article
Materials Science, Multidisciplinary
Muhammad Haekal Habibie, Fransiska Sri Herwahyu Krismastuti, Abdi Wira Septama, Faiza Maryani, Vivi Fauzia
Summary: This study focuses on the synthesis of zinc oxide nanostructure from zinc recovered from galvanization ash and highlights its potential as a sustainable source of zinc and as an antibacterial agent.
Article
Materials Science, Multidisciplinary
Jingyi Li, Yixin Xing, Wei Gu, Shousi Lu
Summary: In this study, PC@CaP microparticles were fabricated using biomimetic mineralization. The results showed that under environmental stress, PC@CaP exhibited improved stability and antioxidative activity, indicating its potential use in high-added value fields.
Article
Materials Science, Multidisciplinary
Yan Liu, Shunyou Chen
Summary: In this study, TNTs were used as a drug carrier and modified with ZIF-8 and silk fibroin to obtain a new drug loading platform. The results showed that this drug-loaded platform had a good drug release effect in vitro and could promote cell proliferation and osteogenic differentiation.
Article
Materials Science, Multidisciplinary
Chunhui Zhu, Wentao Wang, Qing Zhen, Xinning Huang, Shixin Li, Shaochang Wang, Xiaoping Ma, Xiaoxia Liu, Yalong Jiao, Kai Sun, Zhuangzhi Li, Huaixin Yang, Jianqi Li
Summary: A type of stacking fault is revealed in e-InSe crystal, which is associated with a small stacking-fault energy and shows exceptional plasticity.
