Article
Cardiac & Cardiovascular Systems
Roman Witzel, Annika Block, Solvey Pollmann, Leandra Oetzel, Fenja Fleck, Gabriel A. Bonaterra, Ralf Kinscherf, Anja Schwarz
Summary: This study aimed to investigate the regulatory effects of PACAP and its receptor VPAC1 in different macrophage subtypes in relation to inflammatory processes and lipid homeostasis. The results showed that PACAP played an important role in regulating inflammatory processes in atherosclerotic plaques and lipid homeostasis in different macrophage subtypes, affecting foam cell formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Chen Chen, Kaijing Wang, Chenglv Hong, Xiao Chen, Lu Lin, Xiangxiang Shi
Summary: The study found that atorvastatin can downregulate CCL20 expression in oxidized low-density lipoprotein-induced macrophages, with the NF-KB pathway being involved in CCL20 regulation, and CCL20 overexpression in macrophages activating NF-KB.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Pharmacology & Pharmacy
Anastasia V. Poznyak, Nikita G. Nikiforov, Alexander M. Markin, Dmitry A. Kashirskikh, Veronika A. Myasoedova, Elena V. Gerasimova, Alexander N. Orekhov
Summary: Cardiovascular pathologies are leading causes of mortality worldwide, with atherosclerosis being a chronic disease associated with serious complications. Inflammation and lipid metabolism alterations play crucial roles in atherogenesis, with recent investigations supporting the multiple LDL modification theory. Oxidized LDL may have both anti-inflammatory and pro-inflammatory properties, triggering inflammation through macrophage activation and other cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Weslley Fernandes-Braga, Edenil Costa Aguilar, Juliana Maria Navia-Pelaez, Danielle Lima Avila, Luisa Rezende, Luciana de Oliveira Andrade, Sued Eustaquio Mendes Miranda, Andre Luis Branco de Barros, Luciano dos Santos Aggum Capettini, Jacqueline Isaura Alvarez-Leite
Summary: Atherosclerosis is a disease characterized by lipid accumulation in arterial walls due to dysregulation of cholesterol homeostasis in macrophages triggered by oxidized low-density lipoprotein (oxLDL). Fucoidan, a sulfated polysaccharide from brown seaweeds, has been shown to have atheroprotective activities. This study investigated the impact of fucoidan on atherogenesis, oxLDL uptake by macrophages, and the expression of scavenger receptors. It was found that fucoidan reduced dyslipidemia and atherosclerosis in mice and inhibited foam cell formation in macrophages by downregulating SR-A1/2 and upregulating SR-B1.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Hematology
Georg Obermayer, Taras Afonyushkin, Laura Goederle, Florian Puhm, Waltraud Schrottmaier, Soreen Taqi, Michael Schwameis, Cihan Ay, Ingrid Pabinger, Bernd Jilma, Alice Assinger, Nigel Mackman, Christoph J. Binder
Summary: This study demonstrates that natural IgM antibodies can inhibit MV-induced coagulation, reducing thrombotic risk and potentially offering therapeutic potential in cardiovascular diseases.
Article
Immunology
Christine S. Hopp, Padmapriya Sekar, Ababacar Diouf, Kazutoyo Miura, Kristin Boswell, Jeff Skinner, Christopher M. Tipton, Mary E. Peterson, Michael J. Chambers, Sarah Andrews, Jinghua Lu, Joshua Tan, Shanping Li, Safiatou Doumbo, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Silvia Portugal, Peter D. Sun, Carole Long, Richard A. Koup, Eric O. Long, Adrian B. McDermott, Peter D. Crompton
Summary: In a Mali cohort, IgM antibodies dominate in memory B cells against malaria and expand and activate during malaria infection.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Hematology
Zheng Cai, Khalil Bdeir, Serge Yarovoi, Lubica Rauova, Gowthami M. Arepally, Sanjay Khandelwal, Jerome Rollin, Yves Gruel, Sergei Zaitsev, Mortimer Poncz, Mark I. Greene, Douglas B. Cines
Summary: This study found that the combination therapy of fondaparinux and humanized anti-PF4 antibody (hRTO) could help reduce blood clot formation and inhibit Fcγ receptor-mediated coagulation responses on platelets, neutrophils, and monocytes. This intervention method could improve efficacy, reduce medication dosage, shorten the duration of anticoagulant treatment, and prevent HIT.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Pharmacology & Pharmacy
Ingrid Yao Mattisson, Sara Rattik, Harry Bjorkbacka, Irena Ljungcrantz, Manuela Terrinoni, Michael Lebens, Jan Holmgren, Gunilla Nordin Fredrikson, Birgitta Gullstrand, Anders A. Bengtsson, Jan Nilsson, Maria Wigren
Summary: Patients with SLE have an increased risk of developing CVD, and targeting oxLDL may be a potential approach to prevent atherosclerosis. Strategies to promote LDL tolerance or using oxLDL-specific antibodies can reduce atherosclerosis.
VASCULAR PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Suzanne A. Nasser, Elham A. Afify, Firas Kobeissy, Bassam Hamam, Ali H. Eid, Mahmoud M. El-Mas
Summary: Atherosclerosis-related cardiovascular diseases are a leading global cause of death, with evidence supporting the role of vascular inflammation. Immune cells and lipid mediators play key roles in vascular inflammation, while sex hormones are implicated in the immune response and inflammation. Understanding the interaction between sex hormones and immune cells may lead to sex-based management strategies for atherosclerosis-related CVDs.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Cell Biology
Guiting Zhang, Chao He, Qianqian Wu, Guoying Xu, Ming Kuang, Ting Wang, Liangjie Xu, Hong Zhou, Wei Yuan
Summary: The oxLDL/beta 2GPI/anti-beta 2GPI complex inhibits endothelial autophagy, leading to endothelial dysfunction with increased inflammation, oxidative stress, and apoptosis. The inhibition of autophagy is associated with PI3K/AKT/mTOR and eNOS signaling pathways.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Immunology
Mark Chernyshev, Mateusz Kaduk, Martin Corcoran, Gunilla B. Karlsson Hedestam
Summary: This study quantified VDJ gene usage levels in the unmutated IgM repertoires of 45 macaques, revealing similar patterns of gene usage among macaque subgroups and individuals. Unlike humans, macaques showed a higher usage of IGHV4 family genes and evidence of evolutionary expansion of this gene family.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Renske J. E. van den Bijgaart, Fabian Schuurmans, Jurgen J. Futterer, Marcel Verheij, Lenneke A. M. Cornelissen, Gosse J. Adema
Summary: In situ tumor ablation techniques generate tumor debris serving as immunogenic antigens, but studies show modest tumor-directed immune responses. Immune stimuli provision and counteraction of immunosuppressive tumor microenvironment are crucial to enhance ablation-induced anti-tumor immunity. Novel multifunctional antibody formats offer potential in delivering immunomodulators and boosting anti-tumor immunity with reduced toxic side effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tulika Singh, Kwan-Ki Hwang, Andrew S. Miller, Rebecca L. Jones, Cesar A. Lopez, Sarah J. Dulson, Camila Giuberti, Morgan A. Gladden, Itzayana Miller, Helen S. Webster, Joshua A. Eudailey, Kan Luo, Tarra Von Holle, Robert J. Edwards, Sarah Valencia, Katherine E. Burgomaster, Summer Zhang, Jesse F. Mangold, Joshua J. Tu, Maria Dennis, S. Munir Alam, Lakshmanane Premkumar, Reynaldo Dietze, Theodore C. Pierson, Eng Eong Ooi, Helen M. Lazear, Richard J. Kuhn, Sallie R. Permar, Mattia Bonsignori
Summary: This study reveals the important role of plasma IgM in immunity against Zika virus during pregnancy. A specific pentameric IgM antibody, DH1017.IgM, was identified to have strong neutralizing capability against Zika virus. It offers a safe and effective immunotherapeutic option for Zika virus infection during pregnancy.
Article
Emergency Medicine
Peyman Saberian, Shahab Falahi, Alireza Baratloo, Parisa Hasani-Sharamin, Ali Ahmadzade, Mahnaz Jamshididana, Zohreh Ahmadihatam
Summary: This study investigated the temporal changes in incidence of COVID-19 IgM and IgG antibodies among emergency medical technicians (EMTs) during a specific time period. The results demonstrate a significant reduction in COVID-19 antibody seropositivity over time, indicating fluctuations in antibody levels among EMTs over the past year.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Medicine, General & Internal
Alex Bourguignon, Donald M. Arnold, Theodore E. Warkentin, James W. Smith, Tania Pannu, Jeffrey M. Shrum, Zainab A. A. Al Maqrashi, Anjali Shroff, Marie-Claude Lessard, Normand Blais, John G. Kelton, Ishac Nazy
Summary: The use of high-dose IVIG plus anticoagulation is recommended for the treatment of VITT, a rare side effect of adenoviral vector vaccines against Covid-19. Response to IVIG therapy in VITT patients showed reduced platelet activation and improvement in symptoms.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Fernando H. Y. Cesena, Antonio G. Laurinavicius, Viviane A. Valente, Raquel D. Conceicao, Khurram Nasir, Raul D. Santos, Marcio S. Bittencourt
AMERICAN JOURNAL OF CARDIOLOGY
(2018)
Meeting Abstract
Peripheral Vascular Disease
Marcio Bittencourt, Antonio Laurinavicius, Carolina Pereira, Fernando Cesena, Raquel Conceicao, Raul D. Santos
ATHEROSCLEROSIS SUPPLEMENTS
(2018)
Article
Cardiac & Cardiovascular Systems
Fernando H. Y. Cesena, Antonio Gabriele Laurinavicius, Viviane A. Valente, Raquel D. Conceicao, Raul D. Santos, Marcio S. Bittencourt
CLINICAL CARDIOLOGY
(2018)
Article
Endocrinology & Metabolism
Carolina Castro Porto Silva Janovsky, Antonio Laurinavicius, Fernando Cesena, Viviane Valente, Carlos Eduardo Ferreira, Cristovao Mangueira, Raquel Conceicao, Raul D. Santos, Marcio Sommer Bittencourt
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2018)
Article
Endocrinology & Metabolism
Patrick Timpel, Fernando Henpin Yue Cesena, Christiane da Silva Costa, Matheus Dorigatti Soldatelli, Emanuel Gois Jr, Eduardo Castrillon, Lina Johana Jaime Diaz, Gabriela M. Repetto, Fanath Hagos, Raul E. Castillo Yermenos, Kevin Pacheco-Barrios, Wafaa Musallam, Zilda Braid, Nesreen Khidir, Marcela Romo Guardado, Roberta Muriel Longo Roepke
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2018)
Editorial Material
Cardiac & Cardiovascular Systems
Marcio S. Bittencourt, Fernando H. Y. Cesena
Article
Peripheral Vascular Disease
Fernando H. Y. Cesena, Fernando C. Nary, Raul D. Santos, Marcio S. Bittencourt
JOURNAL OF CLINICAL HYPERTENSION
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Fernando H. Y. Cesena
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2021)
Article
Cardiac & Cardiovascular Systems
Glaucia Maria Moraes de Oliveira, Luisa Campos Caldeira Brant, Carisi Anne Polanczyk, Deborah Carvalho Malta, Andreia Biolo, Bruno Ramos Nascimento, Maria de Fatima Marinho de Souza, Andrea Rocha De Lorenzo, Antonio Aurelio de Paiva Fagundes Junior, Beatriz D. Schaan, Fabio Morato de Castilho, Fernando Henpin Yue Cesena, Gabriel Porto Soares, Gesner Francisco Xavier Junior, Jose Augusto Soares Barreto Filho, Luiz Guilherme Passaglia, Marcelo Martins Pinto Filho, M. Julia Machline-Carrion, Marcio Sommer Bittencourt, Octavio M. Pontes Neto, Paolo Blanco Villela, Renato Azeredo Teixeira, Roney Orismar Sampaio, Thomaz A. Gaziano, Pablo Perel, Gregory A. Roth, Antonio Luiz Pinho Ribeiro
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2022)
Article
Medicine, General & Internal
Rafael Mathias Pitta, Bruno Gion Cerazi, Luana Queiroga, Raphael Mendes Ritti Dias, Marco Tulio de Mello, Fernando Henpin Yue Cesena, Roberta Luksevicius Rica, Julien Steven Baker, Marcio Sommer, Gabriel Grizzo Cucato, Danilo Sales Bocalini, Oskar Kauffman
Summary: Sitting time and screen time are not directly associated with obstructive sleep apnea (OSA).
SAO PAULO MEDICAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Fernando H. Y. Cesena, Viviane A. Valente, Raul D. Santos, Marcio S. Bittencourt
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
Fernando Cesena, Viviane Valente, Raul Santos, Marcio S. Bittencourt
Meeting Abstract
Cardiac & Cardiovascular Systems
Fernando H. Cesena, Antonio G. Laurinavicius, Viviane A. Valente, Raquel D. Conceicao, Raul D. Santos, Marcio S. Bittencourt
Meeting Abstract
Cardiac & Cardiovascular Systems
Fernando H. Cesena, Antonio G. Laurinavicius, Fernando C. Nary, Viviane A. Valente, Raquel D. Conceicao, Raul D. Santos, Marcio S. Bittencourt
Meeting Abstract
Cardiac & Cardiovascular Systems
Carolina C. Janovsky, Fernando H. Cesena, Viviane A. Tabone, Raquel D. Conceicao, Raul D. Santos, Marcio S. Bittencourt