Characterization of anti-CD20 monoclonal antibody produced by transgenic silkworms (Bombyx mori)

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity

(2015) Yasmina Noubia Abdiche et al.   mAbs

Complement Activation Plays a Key Role in Antibody-Induced Infusion Toxicity in Monkeys and Rats

(2014) T. Tawara et al.   JOURNAL OF IMMUNOLOGY

Taliglucerase alfa: An enzyme replacement therapy using plant cell expression technology

(2014) Gregory A. Grabowski et al.   MOLECULAR GENETICS AND METABOLISM

Development of a Cell-Based Assay Measuring the Activation of FcγRIIa for the Characterization of Therapeutic Monoclonal Antibodies

(2014) Minoru Tada et al.   PLoS One

Glyco-engineering for biopharmaceutical production in moss bioreactors

(2014) Eva L. Decker et al.   Frontiers in Plant Science

Effect of ATG initiation codon context motifs on the efficiency of translation of mRNA derived from exogenous genes in the transgenic silkworm, Bombyx mori

(2014) Ken-ichiro Tatematsu et al.   SpringerPlus

Glycosylation: impact, control and improvement during therapeutic protein production

(2013) Ana Rita Costa et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Enzyme Replacement Therapy for Lysosomal Diseases: Lessons from 20 Years of Experience and Remaining Challenges

(2012) R.J. Desnick et al.   Annual Review of Genomics and Human Genetics

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

(2012) Darius Ghaderi et al.   Biotechnology & Genetic Engineering Reviews

Minimizing immunogenicity of biopharmaceuticals by controlling critical quality attributes of proteins

(2012) Miranda M. C. van Beers et al.   Biotechnology Journal

The Immunologic Functions of the Neonatal Fc Receptor for IgG

(2012) Timo Rath et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Correlation of ADCC activity with cytokine release induced by the stably expressed, glyco-engineered humanized Lewis Y-specific monoclonal antibody MB314

(2012) Ralf Kircheis et al.   mAbs

Increased serum clearance of oligomannose species present on a human IgG1 molecule

(2012) Leslie Alessandri et al.   mAbs

Marketed therapeutic antibodies compendium

(2012) Janice M. Reichert   mAbs

With or Without Sugar? (A)glycosylation of Therapeutic Antibodies

(2012) Dmitrij Hristodorov et al.   MOLECULAR BIOTECHNOLOGY

Anti-CD20 Antibody Therapy for B-Cell Lymphomas

(2012) David G. Maloney   NEW ENGLAND JOURNAL OF MEDICINE

Comparativein vitroand experimentalin vivostudies of the anti-epidermal growth factor receptor antibody nimotuzumab and its aglycosylated form produced in transgenic tobacco plants

(2012) Meilyn Rodríguez et al.   PLANT BIOTECHNOLOGY JOURNAL

CHO cells in biotechnology for production of recombinant proteins: current state and further potential

(2011) Jee Yon Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans

(2011) A. M. Goetze et al.   GLYCOBIOLOGY

Neonatal Fc receptor and IgG-based therapeutics

(2011) Timothy T. Kuo et al.   mAbs

Glycosylation of Therapeutic Proteins

(2010) Ricardo J. Solá et al.   BIODRUGS

Transgenic silkworms that weave recombinant proteins into silk cocoons

(2010) Masahiro Tomita   BIOTECHNOLOGY LETTERS

Silkworm as a Host of Baculovirus Expression

(2010) Akihiro Usami et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The Silkworm—An Attractive BioResource Supplied by Japan

(2010) Yutaka BANNO et al.   EXPERIMENTAL ANIMALS

Comparison of recombinant protein expression in a baculovirus system in insect cells (Sf9) and silkworm

(2010) A. Usami et al.   JOURNAL OF BIOCHEMISTRY

Importance of Neonatal FcR in Regulating the Serum Half-Life of Therapeutic Proteins Containing the Fc Domain of Human IgG1: A Comparative Study of the Affinity of Monoclonal Antibodies and Fc-Fusion Proteins to Human Neonatal FcR

(2010) Takuo Suzuki et al.   JOURNAL OF IMMUNOLOGY

Development trends for human monoclonal antibody therapeutics

(2010) Aaron L. Nelson et al.   NATURE REVIEWS DRUG DISCOVERY

Production of antibodies in plants: status after twenty years

(2010) Benoit De Muynck et al.   PLANT BIOTECHNOLOGY JOURNAL

Silkworm expression system as a platform technology in life science

(2009) Tatsuya Kato et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Significance of Glycosylation Analysis in Development of Biopharmaceuticals

(2009) Nana Kawasaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The production of biopharmaceuticals in plant systems

(2009) Saskia R. Karg et al.   BIOTECHNOLOGY ADVANCES

European Community and US-FDA Approval of Recombinant Human Antithrombin Produced in Genetically Altered Goats

(2009) Cafer Adiguzel et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Production of a recombinant mouse monoclonal antibody in transgenic silkworm cocoons

(2009) Masashi Iizuka et al.   FEBS Journal

First US approval for a transgenic animal drug

(2009) Jim Kling   NATURE BIOTECHNOLOGY

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Construction of a binary transgenic gene expression system for recombinant protein production in the middle silk gland of the silkworm Bombyx mori

(2009) Ken-ichiro Tatematsu et al.   TRANSGENIC RESEARCH

Production of pharmaceutical proteins by transgenic animals

(2008) Louis-Marie Houdebine   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

(2008) T Shantha Raju   CURRENT OPINION IN IMMUNOLOGY

Human IgG1 expression in silkworm larval hemolymph using BmNPV bacmids and its N-linked glycan structure

(2008) Enoch Y. Park et al.   JOURNAL OF BIOTECHNOLOGY

Simultaneous glycosylation analysis of human serum glycoproteins by high-performance liquid chromatography/tandem mass spectrometry

(2008) A HARAZONO et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES